Doctor insights on:
Lupus Versus Mixed Connective Tissue Disease
Labs are coming back suggestive of Lupus or Mixed Connective Tissue Disease. What is the difference between the two?
Mystery of....: rheumatology! Lupus difficult to diagnose because of many manifestations and wide range of severity. No clear diagnostic criteria. Diagnosis made on clinical grounds with supporting labs- requires a great deal of expertise and exclusion of other causes for symptoms. If your doc cannot confidently diagnose lupus then you may be given an alternative Dx such as MCTD or undifferentiated CTD.See 1 more doctor answer
The body is composed of tissue that are classically described as beiing derived from three basic embyonic layers known as the endoderm, mesoderm and ectoderm that then differentiate into the structures that compose the body such as skin, soft tissues, bone, muscle, organs, etc. Stem cells are not differentiated and have the potential to ...Read more
No, . ...: To find and establish a connection of a disease with others is essential in medical care with a mind of prevention, but not easy. In the case of kidney stone with le, I have exhausted my recollection of studies, articles, professional meeting and discussion over my 45-yr study and practice in urology, but I have never come across such concern that you raised. So, I would say "no." for now.See 1 more doctor answer
Not the same.: Systemic lupus is one of the so called "connective tissue diseases, " which includes many other diseases, some related to sle, and other's which are not. The term connective tissue disease more broadly means autimmune disease and the term is somewhat antiquated!See 1 more doctor answer
Symptoms and test: To diagnose lupus you need certain combination of symptoms and positive blood test, very typical symptoms oflupus are "butterfly rash" over the nose, join pain/swelling, oral sores, eyes symptoms, lupus can also give lung, heart, kidneys involvment, blood with anemia, low WBC counts. Blood test that can be positive in lupus is ANA (95% patient), anti-dsdna, also blood and urine testing may suggest.
Could undifferentiated connective tissue disease (poss sjogrens +\or lupus) cause increased feeling of being winded when it is humid outside?
Difficult question: And one that probably can not be answered on this sit specific to you. Some kinds of connective tissue diseases can cause constriction and make you feel short of breath, others not. It is vert variable. The ones you mentioned probably not
In several ways!: Lupus can be associated with dry-eye syndrome, typically more severe in sjogren's syndrome. Very severe lupus can causes optic neuritis, but this is quite rare. The most common problem with the eye in lupus patients is the development of cataracts from treatment with steroids, one of many reasons doses should be kept low. Plaquenyl eye toxicity is nill, by using less than 6 mg/kg of body weight.See 1 more doctor answer
Lupus like symptoms resolved on Methotrexate. Current diagnosis in chart is undifferentiated connective tissue disease. My rheumMD say we don't have name yet. Unusual?
Actually: This is very common... Until symptoms are more typical and laboratory tests are confirmatory
Lupus and scleroderma are connective tissue diseases but eds is also. What exactly is connective tissue disease? Is lichen sclerosis related
I think I have had many symptoms of lupus, Crohn's or a mixed connective tissue disorder for over a year. Can I have one if all tests have been neg.?
Health psychologist: Most lab tests have some degree of error, but they are probably correct. In any case, it might really help to have sessions w/ a therapist specializing in challenging, elusive physical symptoms and medical diagnosis problems. There are many patients who have difficulty finding DX and tx - learning to deal with it is often helpful.
If I have mixed connective tissue disorder with the lupus anticoagulant antibody can I take nsaids?
I have just been diagnosed with a connective tissue disease (lupus arthritis). Can I claim disability?
Insurance: You are asking an insurance question. You must know the terms of your policy to answer. If you are talking about ssi, contact your social security office and ask what their criteria is regarding this disorder.
My ANA keeps coming back too low, vit d deficient, and stomach biopsy came back positive for connective tissue disease. Could I have lupus?
Check with GI: I would discuss this further with your gastroenterologist or the doctor who performed your biopsy. There are other autoimmune diseases that can be diagnosed on stomach biopsy, but lupus is not one of them. A skin biopsy of the rash can usually identify if the rash is due to lupus.See 1 more doctor answer
Do you think all connective tissue diseases (lupus, sjogrens, scleroderma) are more alike than doctors realize since they tend to overlap so much?
Yes and no: Autoimmune diseases are all as different as the people who get them. These conditions all result from the body's immune system attacking different parts of your cells and tissues. Each person's disease will reflect the tissues that are being damaged. It is likely that everyone who has one of these conditions has a different spectrum of tissue damage which may be similar in some ways..
Can connective tissue diseases like sjrogrens or lupus cause debilitating headaches? My md did a CT scan to rule out major problems. If the report comes out to be negative, could it be due to ctd?
Sure: Ctd folks have a lot of aches and pains. But severe ha not common--what does your md think?See 3 more doctor answers
Many ways: Different people have different mechanisms of mctd activity. The therapy is tailored to the individual activity. Knowledge is the best way to cope with mctd. The more you know your type of mctd the better you can cope. I sometimes refer to it as "mixed up" connective tissue disease.
Lupus/scleroderma: Mixed connective tissue disease (mctd) is an autoimmune disease that usually has features of lupus and scleroderma. Many people have raynaud's (fingers change color) and puffy fingers, and a positive ANA with a more specific test called "rnp" and may also have rashes, arthritis, or inflammation in other organs. It is treated a lot like lupus. Seeing a rheumatologist is helpful.
Joint, skin, interna: Mctd can have a variety of signs and sympotms whichcan change with times. By the name it is a mixture of a variety of connective tissue diseases: systemic lupus erythematosus, scleroderma, polymyositis and rheumatoid arthritis. Depending on which condition is prominent at the time. When you are evaluated your physician will look for causes of the symptoms from these categories.
Overlap syndrome: This is an overlap syndrome with manifestations that can include those of rheumatoid arthritis systemic lupus, scleroderma, and polymyositis. Different patients will have different combination of these components, over the long term it appears that many can get scleroderma like findings. Two or more components can occur. It has a variety of specific laboratory studies especially the RNP blood test
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