Top
20
Doctor insights on: Lupus Versus Mixed Connective Tissue Disease

Share
Dr. Dan Fisher Dr. Fisher
Internal Medicine
23 years in practice
Uniformed Services University of the Health Sciences F. Edward Hebert School of Medicine
1

1
Labs are coming back suggestive of Lupus or Mixed Connective Tissue Disease. What is the difference between the two?

Labs are coming back suggestive of Lupus or Mixed Connective Tissue Disease. What is the difference between the two?

Mystery of....: rheumatology! Lupus difficult to diagnose because of many manifestations and wide range of severity. No clear diagnostic criteria. Diagnosis made on clinical grounds with supporting labs- requires a great deal of expertise and exclusion of other causes for symptoms. If your doc cannot confidently diagnose lupus then you may be given an alternative Dx such as MCTD or undifferentiated CTD.

See 1 more doctor answer

Tissue (Definition)

The body is composed of tissue that are classically described as beiing derived from three basic embyonic layers known as the endoderm, mesoderm and ectoderm that then differentiate into the structures that compose the body such as skin, soft tissues, bone, muscle, organs, etc. Stem cells are not differentiated and have the potential to ...Read more


Dr. James Lin Dr. Lin
Urology
47 years in practice
Kaohsiung Medical University
2

2
Does kidney stones go along with having lupus and mixed connective tissue disease?

Does kidney stones go along with having lupus and mixed connective tissue disease?

No, . ...: To find and establish a connection of a disease with others is essential in medical care with a mind of prevention, but not easy. In the case of kidney stone with le, I have exhausted my recollection of studies, articles, professional meeting and discussion over my 45-yr study and practice in urology, but I have never come across such concern that you raised. So, I would say "no." for now.

See 1 more doctor answer
Dr. Thomas Namey Dr. Namey
Internal Medicine - Rheumatology
44 years in practice
Washington University School of Medicine
3

3
What's the difference between connective tissue disease and lupus?

What's the difference between connective tissue disease and lupus?

Not the same.: Systemic lupus is one of the so called "connective tissue diseases, " which includes many other diseases, some related to sle, and other's which are not. The term connective tissue disease more broadly means autimmune disease and the term is somewhat antiquated!

See 1 more doctor answer
Dr. Ed Friedlander Dr. Friedlander
Pathology
40 years in practice
Northwestern University Feinberg School of Medicine
4

4
Is there a connection between lupus and connective tissue disease?

Old term: The term "connective tissue disease" is an obsolete one covering systemic lupus, scleroderma, and a few others.

Dr. Magdalena Sikora Dr. Sikora
Internal Medicine - Nephrology & Dialysis
15 years in practice
Medical Academy of Wroclaw
5

5
How would I be diagnosed with a connective tissue disease (lupus)?

Symptoms and test: To diagnose lupus you need certain combination of symptoms and positive blood test, very typical symptoms oflupus are "butterfly rash" over the nose, join pain/swelling, oral sores, eyes symptoms, lupus can also give lung, heart, kidneys involvment, blood with anemia, low WBC counts. Blood test that can be positive in lupus is ANA (95% patient), anti-dsdna, also blood and urine testing may suggest.

Dr. Marsha Davis Dr. Davis
Internal Medicine
24 years in practice
Medical College of Wisconsin
6

6
Could undifferentiated connective tissue disease (poss sjogrens +\or lupus) cause increased feeling of being winded when it is humid outside?

Could undifferentiated connective tissue disease (poss sjogrens +\or lupus) cause increased feeling of being winded when it is humid outside?

Difficult question: And one that probably can not be answered on this sit specific to you. Some kinds of connective tissue diseases can cause constriction and make you feel short of breath, others not. It is vert variable. The ones you mentioned probably not

Dr. Thomas Namey Dr. Namey
Internal Medicine - Rheumatology
44 years in practice
Washington University School of Medicine
7

7
How does connective tissue disease with lupus factor affect the eyes?

How does connective tissue disease with lupus factor affect the eyes?

In several ways!: Lupus can be associated with dry-eye syndrome, typically more severe in sjogren's syndrome. Very severe lupus can causes optic neuritis, but this is quite rare. The most common problem with the eye in lupus patients is the development of cataracts from treatment with steroids, one of many reasons doses should be kept low. Plaquenyl eye toxicity is nill, by using less than 6 mg/kg of body weight.

See 1 more doctor answer
Dr. Joseph Gutman Dr. Gutman
Internal Medicine
39 years in practice
Universidad Central del Caribe School of Medicine
8
Dr. Martin Morell Dr. Morell
Internal Medicine - Rheumatology
25 years in practice
Ponce School of Medicine
9

9
Lupus and scleroderma are connective tissue diseases but eds is also. What exactly is connective tissue disease? Is lichen sclerosis related

Lupus and scleroderma are connective tissue diseases but eds is also. What exactly is connective tissue disease? Is lichen sclerosis related

SLE and: Scleroderma are autoimmune diseases, eds is a 'flaw' of development of elements in the connective tissue. Part of the connective tissue may be affected by immune cells interactions..

Dr. Lynne Weixel Dr. Weixel
Clinical Psychology
32 years in practice
University of Connecticut School of Medicine
11

11
I think I have had many symptoms of lupus, Crohn's or a mixed connective tissue disorder for over a year. Can I have one if all tests have been neg.?

I think I have had many symptoms of lupus, Crohn's or a mixed connective tissue disorder for over a year. Can I have one if all tests have been neg.?

Health psychologist: Most lab tests have some degree of error, but they are probably correct. In any case, it might really help to have sessions w/ a therapist specializing in challenging, elusive physical symptoms and medical diagnosis problems. There are many patients who have difficulty finding DX and tx - learning to deal with it is often helpful.

Dr. Jeffrey Miller Dr. Miller
Internal Medicine - Rheumatology
47 years in practice
Temple University School of Medicine
12

12
If I have mixed connective tissue disorder with the lupus anticoagulant antibody can I take nsaids?

If I have mixed connective tissue disorder with the lupus anticoagulant antibody can I take nsaids?

Yes: The real question is should you be on long term anticoagulation. If you have had a pulmonary embolis, stroke or heart attack, the answer is usually yes andyou might need to treat simultaneously with aspirin, coumadin (rat poiison) and heparin. Sometimes a very tough disease tocontrol.

Dr. Marc Zimmermann Dr. Zimmermann
Psychiatry
18 years in practice
Keck School of Medicine of University of Southern California
13

13
I have just been diagnosed with a connective tissue disease (lupus arthritis). Can I claim disability?

I have just been diagnosed with a connective tissue disease (lupus arthritis). Can I claim disability?

Insurance: You are asking an insurance question. You must know the terms of your policy to answer. If you are talking about ssi, contact your social security office and ask what their criteria is regarding this disorder.

Dr. Christine Hom Dr. Hom
Pediatrics
26 years in practice
New York University School of Medicine
14

14
My ANA keeps coming back too low, vit d deficient, and stomach biopsy came back positive for connective tissue disease. Could I have lupus?

My ANA keeps coming back too low, vit d deficient, and stomach biopsy came back positive for connective tissue disease. Could I have lupus?

Check with GI: I would discuss this further with your gastroenterologist or the doctor who performed your biopsy. There are other autoimmune diseases that can be diagnosed on stomach biopsy, but lupus is not one of them. A skin biopsy of the rash can usually identify if the rash is due to lupus.

See 1 more doctor answer
Dr. Brett Fink Dr. Fink
Orthopedic Surgery
28 years in practice
Washington University School of Medicine
15

15
Do you think all connective tissue diseases (lupus, sjogrens, scleroderma) are more alike than doctors realize since they tend to overlap so much?

Do you think all connective tissue diseases (lupus, sjogrens, scleroderma) are more alike than doctors realize since they tend to overlap so much?

Yes and no: Autoimmune diseases are all as different as the people who get them. These conditions all result from the body's immune system attacking different parts of your cells and tissues. Each person's disease will reflect the tissues that are being damaged. It is likely that everyone who has one of these conditions has a different spectrum of tissue damage which may be similar in some ways..

Dr. John Goldman Dr. Goldman
Internal Medicine - Rheumatology
51 years in practice
University of Cincinnati College of Medicine
17

17
What are ways to cope with mixed connective tissue disease?

Many ways: Different people have different mechanisms of mctd activity. The therapy is tailored to the individual activity. Knowledge is the best way to cope with mctd. The more you know your type of mctd the better you can cope. I sometimes refer to it as "mixed up" connective tissue disease.

Dr. Angus Worthing Dr. Worthing
Internal Medicine
14 years in practice
University of Minnesota Medical School
18

18
I know this dude who has mixed connective tissue disease. What is that?

I know this dude who has mixed connective tissue disease. What is that?

Lupus/scleroderma: Mixed connective tissue disease (mctd) is an autoimmune disease that usually has features of lupus and scleroderma. Many people have raynaud's (fingers change color) and puffy fingers, and a positive ANA with a more specific test called "rnp" and may also have rashes, arthritis, or inflammation in other organs. It is treated a lot like lupus. Seeing a rheumatologist is helpful.

Dr. John Goldman Dr. Goldman
Internal Medicine - Rheumatology
51 years in practice
University of Cincinnati College of Medicine
19

19
What are the major presenting symptoms of mixed connective tissue disease?

What are the major presenting symptoms of mixed connective tissue disease?

Joint, skin, interna: Mctd can have a variety of signs and sympotms whichcan change with times. By the name it is a mixture of a variety of connective tissue diseases: systemic lupus erythematosus, scleroderma, polymyositis and rheumatoid arthritis. Depending on which condition is prominent at the time. When you are evaluated your physician will look for causes of the symptoms from these categories.

Dr. John Goldman Dr. Goldman
Internal Medicine - Rheumatology
51 years in practice
University of Cincinnati College of Medicine
20

20
What is the definition or description of: Mixed connective tissue disease?

What is the definition or description of: Mixed connective tissue disease?

Overlap syndrome: This is an overlap syndrome with manifestations that can include those of rheumatoid arthritis systemic lupus, scleroderma, and polymyositis. Different patients will have different combination of these components, over the long term it appears that many can get scleroderma like findings. Two or more components can occur. It has a variety of specific laboratory studies especially the RNP blood test

Connective Tissue (Definition)

There are many types of connective tissue, but in general it is a mass of fibers and thick "goopy" fluids secreted by specialized cells. The body often uses connective tissue to help ...Read more