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Doctor insights on: Lupus Versus Mixed Connective Tissue Disease

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Labs are coming back suggestive of Lupus or Mixed Connective Tissue Disease. What is the difference between the two?

Labs are coming back suggestive of Lupus or Mixed Connective Tissue Disease. What is the difference between the two?

Mystery of....: rheumatology! Lupus difficult to diagnose because of many manifestations and wide range of severity. No clear diagnostic criteria. Diagnosis made on clinical grounds with supporting labs- requires a great deal of expertise and exclusion of other causes for symptoms. If your doc cannot confidently diagnose lupus then you may be given an alternative Dx such as MCTD or undifferentiated CTD. ...Read more

Tissue (Definition)

The body is composed of tissue that are classically described as beiing derived from three basic embyonic layers known as the endoderm, mesoderm and ectoderm that then differentiate into the structures that compose the body such as skin, soft tissues, bone, muscle, organs, etc. Stem cells are not differentiated and have the potential to ...Read more


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Does kidney stones go along with having lupus and mixed connective tissue disease?

Does kidney stones go along with having lupus and mixed connective tissue disease?

No, . ...: To find and establish a connection of a disease with others is essential in medical care with a mind of prevention, but not easy. In the case of kidney stone with le, I have exhausted my recollection of studies, articles, professional meeting and discussion over my 45-yr study and practice in urology, but I have never come across such concern that you raised. So, I would say "no." for now. ...Read more

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What's the difference between connective tissue disease and lupus?

What's the difference between connective tissue disease and lupus?

Not the same.: Systemic lupus is one of the so called "connective tissue diseases, " which includes many other diseases, some related to sle, and other's which are not. The term connective tissue disease more broadly means autimmune disease and the term is somewhat antiquated! ...Read more

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How would I be diagnosed with a connective tissue disease (lupus)?

Symptoms and test: To diagnose lupus you need certain combination of symptoms and positive blood test, very typical symptoms oflupus are "butterfly rash" over the nose, join pain/swelling, oral sores, eyes symptoms, lupus can also give lung, heart, kidneys involvment, blood with anemia, low WBC counts. Blood test that can be positive in lupus is ANA (95% patient), anti-dsdna, also blood and urine testing may suggest. ...Read more

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Could undifferentiated connective tissue disease (poss sjogrens +\or lupus) cause increased feeling of being winded when it is humid outside?

Could undifferentiated connective tissue disease (poss sjogrens +\or lupus) cause increased feeling of being winded when it is humid outside?

Difficult question: And one that probably can not be answered on this sit specific to you. Some kinds of connective tissue diseases can cause constriction and make you feel short of breath, others not. It is vert variable. The ones you mentioned probably not ...Read more

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How does connective tissue disease with lupus factor affect the eyes?

How does connective tissue disease with lupus factor affect the eyes?

In several ways!: Lupus can be associated with dry-eye syndrome, typically more severe in sjogren's syndrome. Very severe lupus can causes optic neuritis, but this is quite rare. The most common problem with the eye in lupus patients is the development of cataracts from treatment with steroids, one of many reasons doses should be kept low. Plaquenyl eye toxicity is nill, by using less than 6 mg/kg of body weight. ...Read more

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I think I have had many symptoms of lupus, Crohn's or a mixed connective tissue disorder for over a year. Can I have one if all tests have been neg.?

I think I have had many symptoms of lupus, Crohn's or a mixed connective tissue disorder for over a year. Can I have one if all tests have been neg.?

Health psychologist: Most lab tests have some degree of error, but they are probably correct. In any case, it might really help to have sessions w/ a therapist specializing in challenging, elusive physical symptoms and medical diagnosis problems. There are many patients who have difficulty finding DX and tx - learning to deal with it is often helpful. ...Read more

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If I have mixed connective tissue disorder with the lupus anticoagulant antibody can I take nsaids?

If I have mixed connective tissue disorder with the lupus anticoagulant antibody can I take nsaids?

Yes: The real question is should you be on long term anticoagulation. If you have had a pulmonary embolis, stroke or heart attack, the answer is usually yes andyou might need to treat simultaneously with aspirin, coumadin (rat poiison) and heparin. Sometimes a very tough disease tocontrol. ...Read more

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I have just been diagnosed with a connective tissue disease (lupus arthritis). Can I claim disability?

I have just been diagnosed with a connective tissue disease (lupus arthritis). Can I claim disability?

Insurance: You are asking an insurance question. You must know the terms of your policy to answer. If you are talking about ssi, contact your social security office and ask what their criteria is regarding this disorder. ...Read more

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My ANA keeps coming back too low, vit d deficient, and stomach biopsy came back positive for connective tissue disease. Could I have lupus?

My ANA keeps coming back too low, vit d deficient, and stomach biopsy came back positive for connective tissue disease. Could I have lupus?

Check with GI: I would discuss this further with your gastroenterologist or the doctor who performed your biopsy. There are other autoimmune diseases that can be diagnosed on stomach biopsy, but lupus is not one of them. A skin biopsy of the rash can usually identify if the rash is due to lupus. ...Read more

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Do you think all connective tissue diseases (lupus, sjogrens, scleroderma) are more alike than doctors realize since they tend to overlap so much?

Do you think all connective tissue diseases (lupus, sjogrens, scleroderma) are more alike than doctors realize since they tend to overlap so much?

Related: Autoimmune disease such as lupus and Sjögren's syndrome are indeed related by the fact that it is the immune system that is attacking the body itself. However, different disease have different but overlapping targets of the misguided immune attack. For example, there can be joint pain in lupus, a symptom that overlaps with rheumatoid arthritis. However, the joint involvements are different. ...Read more

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What are ways to cope with mixed connective tissue disease?

Many ways: Different people have different mechanisms of mctd activity. The therapy is tailored to the individual activity. Knowledge is the best way to cope with mctd. The more you know your type of mctd the better you can cope. I sometimes refer to it as "mixed up" connective tissue disease. ...Read more

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I know this dude who has mixed connective tissue disease. What is that?

I know this dude who has mixed connective tissue disease. What is that?

Lupus/scleroderma: Mixed connective tissue disease (mctd) is an autoimmune disease that usually has features of lupus and scleroderma. Many people have raynaud's (fingers change color) and puffy fingers, and a positive ANA with a more specific test called "rnp" and may also have rashes, arthritis, or inflammation in other organs. It is treated a lot like lupus. Seeing a rheumatologist is helpful. ...Read more

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What are the major presenting symptoms of mixed connective tissue disease?

What are the major presenting symptoms of mixed connective tissue disease?

Joint, skin, interna: Mctd can have a variety of signs and sympotms whichcan change with times. By the name it is a mixture of a variety of connective tissue diseases: systemic lupus erythematosus, scleroderma, polymyositis and rheumatoid arthritis. Depending on which condition is prominent at the time. When you are evaluated your physician will look for causes of the symptoms from these categories. ...Read more

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What is the definition or description of: Mixed connective tissue disease?

What is the definition or description of: Mixed connective tissue disease?

Overlap syndrome: This is an overlap syndrome with manifestations that can include those of rheumatoid arthritis systemic lupus, scleroderma, and polymyositis. Different patients will have different combination of these components, over the long term it appears that many can get scleroderma like findings. Two or more components can occur. It has a variety of specific laboratory studies especially the RNP blood test ...Read more

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What is the treatment for mixed connective tissue disease?

What is the treatment for mixed connective tissue disease?

Little to more.: Mctd has its detractors believing it will eventually morph into another ctd. My treatment is based on treating what exists. Most pts do well on plaquenyl and an nsaid, if joint aching is a problem. ...Read more

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What's the difference between mixed connective tissue disease and fibromyalgia? I'm confused.

What's the difference between mixed connective tissue disease and fibromyalgia? I'm confused.

Unrelated: These two issues are unrelated. Mctd is an autoimmune disease. Fibromyalgia is a disorder of chronic widespread pain manifesting as tender points and fatigue. ...Read more

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In a diagnosis of mixed connective tissue disease, is it the anas alone that makes one feel crummy during flares if the other labs are normal?

In a diagnosis of mixed connective tissue disease, is it the anas alone that makes one feel crummy during flares if the other labs are normal?

Not likely so..: Antinuclear antibodies (ANA) is helpful in the innitial work-up and diagnosis of a rheamatologic disease, but ANA does not indicate the level of disease actitivies. Once positive for ana, this will always be so. The esr, crp, rf (in rhematoid arthritis) levels do correlate with disease activities and likely how you feel. U should check for thyroid, lyme, mono, depression, insomnia etc. Good luck. ...Read more

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Is Mixed Connective Tissue Disease Hereditary?

Is Mixed Connective Tissue Disease Hereditary?

Partly: The exact cause of this disease is still unknown. We believe that there is a genetic or inherited predisposition and a second enviorental trigger for this disease. It is rate to see 2 family members with this disease. Basically this means it is not an inherited disease. The abity to get this disease may be inherited but not the disease itself. ...Read more

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What are the tests for mixed connective tissue disease?

What are the tests for mixed connective tissue disease?

Not my definition!: Mctd is a non-serious problem for most. The lab definition is usually an rnp antibody without a smith (sm) antibody. ...Read more

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What medicines work best for mixed connective tissue disease?

What medicines work best for mixed connective tissue disease?

Mixed CT Disease: There's no cure for mixed connective tissue disease, but medication can help manage the signs and symptoms of the disease. Mild forms of mixed connective tissue disease may not require treatment. You may require treatment only during flares or, if you have a more serious form of the disease, you may require continuous medication. ...Read more

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What are the new methods for treating mixed connective tissue disease?

What are the new methods for treating mixed connective tissue disease?

Mixed CT Disease: The medications include nonsteroidal anti-inflammatory drugs (nsaids), cortisone drugs/steroids (such as prednisone), antimalarial drugs (hydroxychloroquine), and cytotoxic drugs (such as methotrexate, azathioprine, and cyclophosphamide). Organ damage, such as in the kidneys, can require additional treatments directed at high blood pressure, etc. ...Read more

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Is mixed connective tissue disease considered a separate disease entity?

Is mixed connective tissue disease considered a separate disease entity?

Yes: If diagnosed solely on basis of anti-rnp antibodies, no; but if diagnosed clinically on the basis of signs of multiple connective tissue diseases, but which do not allow a specific one to be diagnosed. ...Read more

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What is the life expectancy for someone with mixed connective tissue disease?

See details: It really depends on the severity of the disease and the specific areas involved. With proper treatment there can be a normal life expectancy in most cases. ...Read more

Connective Tissue (Definition)

There are many types of connective tissue, but in general it is a mass of fibers and thick "goopy" fluids secreted by specialized cells. The body often uses connective tissue to help ...Read more