Doctor insights on:
Lupus Versus Mixed Connective Tissue Disease
Labs are coming back suggestive of Lupus or Mixed Connective Tissue Disease. What is the difference between the two?
Mystery of....: rheumatology! Lupus difficult to diagnose because of many manifestations and wide range of severity. No clear diagnostic criteria. Diagnosis made on clinical grounds with supporting labs- requires a great deal of expertise and exclusion of other causes for symptoms. If your doc cannot confidently diagnose lupus then you may be given an alternative Dx such as MCTD or undifferentiated CTD. ...Read more
The body is composed of tissue that are classically described as beiing derived from three basic embyonic layers known as the endoderm, mesoderm and ectoderm that then differentiate into the structures that compose the body such as skin, soft tissues, bone, muscle, organs, etc. Stem cells are not differentiated and have the potential to ...Read more
No, . ...: To find and establish a connection of a disease with others is essential in medical care with a mind of prevention, but not easy. In the case of kidney stone with le, I have exhausted my recollection of studies, articles, professional meeting and discussion over my 45-yr study and practice in urology, but I have never come across such concern that you raised. So, I would say "no." for now. ...Read more
Symptoms and test: To diagnose lupus you need certain combination of symptoms and positive blood test, very typical symptoms oflupus are "butterfly rash" over the nose, join pain/swelling, oral sores, eyes symptoms, lupus can also give lung, heart, kidneys involvment, blood with anemia, low WBC counts. Blood test that can be positive in lupus is ANA (95% patient), anti-dsdna, also blood and urine testing may suggest. ...Read more
Could undifferentiated connective tissue disease (poss sjogrens +\or lupus) cause increased feeling of being winded when it is humid outside?
In several ways!: Lupus can be associated with dry-eye syndrome, typically more severe in sjogren's syndrome. Very severe lupus can causes optic neuritis, but this is quite rare. The most common problem with the eye in lupus patients is the development of cataracts from treatment with steroids, one of many reasons doses should be kept low. Plaquenyl eye toxicity is nill, by using less than 6 mg/kg of body weight. ...Read more
Lupus like symptoms resolved on Methotrexate. Current diagnosis in chart is undifferentiated connective tissue disease. My rheumMD say we don't have name yet. Unusual?
Actually: This is very common... Until symptoms are more typical and laboratory tests are confirmatory ...Read more
Lupus and scleroderma are connective tissue diseases but eds is also. What exactly is connective tissue disease? Is lichen sclerosis related
How can lupus/undiff connective tissue disease affect the cerebral spinal fluid & cause CNS symptoms? My md thinks it's causing my neuro symptoms
Cerebritis: Your doctor may be looking for lupus cerebritis. ...Read more
I think I have had many symptoms of lupus, Crohn's or a mixed connective tissue disorder for over a year. Can I have one if all tests have been neg.?
Health psychologist: Most lab tests have some degree of error, but they are probably correct. In any case, it might really help to have sessions w/ a therapist specializing in challenging, elusive physical symptoms and medical diagnosis problems. There are many patients who have difficulty finding DX and tx - learning to deal with it is often helpful. ...Read more
If I have mixed connective tissue disorder with the lupus anticoagulant antibody can I take nsaids?
Yes: The real question is should you be on long term anticoagulation. If you have had a pulmonary embolis, stroke or heart attack, the answer is usually yes andyou might need to treat simultaneously with aspirin, coumadin (rat poiison) and heparin. Sometimes a very tough disease tocontrol. ...Read more
I have just been diagnosed with a connective tissue disease (lupus arthritis). Can I claim disability?
My ANA keeps coming back too low, vit d deficient, and stomach biopsy came back positive for connective tissue disease. Could I have lupus?
Check with GI: I would discuss this further with your gastroenterologist or the doctor who performed your biopsy. There are other autoimmune diseases that can be diagnosed on stomach biopsy, but lupus is not one of them. A skin biopsy of the rash can usually identify if the rash is due to lupus. ...Read more
Do you think all connective tissue diseases (lupus, sjogrens, scleroderma) are more alike than doctors realize since they tend to overlap so much?
Related: Autoimmune disease such as lupus and Sjögren's syndrome are indeed related by the fact that it is the immune system that is attacking the body itself. However, different disease have different but overlapping targets of the misguided immune attack. For example, there can be joint pain in lupus, a symptom that overlaps with rheumatoid arthritis. However, the joint involvements are different. ...Read more
Can connective tissue diseases like sjrogrens or lupus cause debilitating headaches? My md did a CT scan to rule out major problems. If the report comes out to be negative, could it be due to ctd?
Sure: Ctd folks have a lot of aches and pains. But severe ha not common--what does your md think? ...Read more
Many ways: Different people have different mechanisms of mctd activity. The therapy is tailored to the individual activity. Knowledge is the best way to cope with mctd. The more you know your type of mctd the better you can cope. I sometimes refer to it as "mixed up" connective tissue disease. ...Read more
Lupus/scleroderma: Mixed connective tissue disease (mctd) is an autoimmune disease that usually has features of lupus and scleroderma. Many people have raynaud's (fingers change color) and puffy fingers, and a positive ANA with a more specific test called "rnp" and may also have rashes, arthritis, or inflammation in other organs. It is treated a lot like lupus. Seeing a rheumatologist is helpful. ...Read more
Joint, skin, interna: Mctd can have a variety of signs and sympotms whichcan change with times. By the name it is a mixture of a variety of connective tissue diseases: systemic lupus erythematosus, scleroderma, polymyositis and rheumatoid arthritis. Depending on which condition is prominent at the time. When you are evaluated your physician will look for causes of the symptoms from these categories. ...Read more
Overlap syndrome: This is an overlap syndrome with manifestations that can include those of rheumatoid arthritis systemic lupus, scleroderma, and polymyositis. Different patients will have different combination of these components, over the long term it appears that many can get scleroderma like findings. Two or more components can occur. It has a variety of specific laboratory studies especially the RNP blood test ...Read more
Little to more.: Mctd has its detractors believing it will eventually morph into another ctd. My treatment is based on treating what exists. Most pts do well on plaquenyl and an nsaid, if joint aching is a problem. ...Read more
I display all symptoms of mixed connective tissue disease but ANA tests were only slightly above average. Can this still be what I have?
In a diagnosis of mixed connective tissue disease, is it the anas alone that makes one feel crummy during flares if the other labs are normal?
Not likely so..: Antinuclear antibodies (ANA) is helpful in the innitial work-up and diagnosis of a rheamatologic disease, but ANA does not indicate the level of disease actitivies. Once positive for ana, this will always be so. The esr, crp, rf (in rhematoid arthritis) levels do correlate with disease activities and likely how you feel. U should check for thyroid, lyme, mono, depression, insomnia etc. Good luck. ...Read more
Partly: The exact cause of this disease is still unknown. We believe that there is a genetic or inherited predisposition and a second enviorental trigger for this disease. It is rate to see 2 family members with this disease. Basically this means it is not an inherited disease. The abity to get this disease may be inherited but not the disease itself. ...Read more
Mixed CT Disease: There's no cure for mixed connective tissue disease, but medication can help manage the signs and symptoms of the disease. Mild forms of mixed connective tissue disease may not require treatment. You may require treatment only during flares or, if you have a more serious form of the disease, you may require continuous medication. ...Read more
Mixed CT Disease: The medications include nonsteroidal anti-inflammatory drugs (nsaids), cortisone drugs/steroids (such as prednisone), antimalarial drugs (hydroxychloroquine), and cytotoxic drugs (such as methotrexate, azathioprine, and cyclophosphamide). Organ damage, such as in the kidneys, can require additional treatments directed at high blood pressure, etc. ...Read more
See details: It really depends on the severity of the disease and the specific areas involved. With proper treatment there can be a normal life expectancy in most cases. ...Read more
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