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Doctor insights on: Lupus Negative Ana Test

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Can you have lupus with a negative ANA test? What about other autoimmune disorders?

Can you have lupus with a negative ANA test? What about other autoimmune disorders?

ANA testing: ANA is a screening test for autoimmune disease, (generally present in 80-90% of cases). A higher titer over 1:160 is more significant. There are more definite testing for lupus such as anti-smith antibody and anti ds dna antbody. There are many more other specific testing for other specific autoimmune disorders. Syphilis and lyme disease can give false positive ANA test as well. See your md. ...Read more

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Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more


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Unexplained high platelets (572), WBC (17.2), leukocytes, neutrophils, low hemaglobin. Bone marrow, jak2 and lupus test negative, ANA positive. Help?!

Reactive/ autoimmune: Discuss further with your hematologist. Certain conditions like iron deficiency , infection /inflammation vs autoimmune vs. Other solid tumor need to be ruled out. Need to check iron level, bcr/abl, imaging study like ct scan chest /abd/ pelvis will be needed. If you smoke - will suggest you to quit smoking., need to do work - up to find the anemia as well. If iron is low - GI w/u is needed. ...Read more

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Can ANA test be false negative for lupus?

Lupus: Has specific criteria for diagnosis, ANA is just one of them and canot be relied on by itself for a diagnosis. ...Read more

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Could a person with 2 different negative ANA tests have lupus?

Yes, but ANA: negative lupus is uncommon. ANA is one of the criteria for diagnosing lupus, but a negative ANA does not rule out lupus. See this site for more info. http://www.webmd.com/lupus/guide/laboratory-tests-used-diagnose-evaluate-sle ...Read more

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Is lupus possible with a negative ANA? DR GAVE ME "working" dx due to other neg tests and sx

Is lupus possible with a negative ANA? DR GAVE ME "working" dx due to other neg tests and sx

Yes: There is such a thing as ANA negative lupus. The ANA is nehative in 5-10% of lupus patients. ...Read more

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I have pos ANA and all other lupus test normal but have symptoms of lupus can you have lupus with only pos ANA test and other lupus test negative?

LUPUS: A low positive ANA alone may be non diagnostic. If all other labs are normal, it can be repeated in a 2-3 mth window. Lupus also has a list of criteria that needs to be met to fulfill the diagnosis. Follow up with your doctor and if still concerned see a rheumatologist. ...Read more

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I have had multiple positive ANA and they do the next step tests to check for lupus and it comes back negative. Why do they keep checking my ana?

I don't know: Imo, there is no need to constantly repeat an ana. It is a waste of time and money. Positive is positive and constantly repeating it will not change that. ...Read more

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I had a negative ANA test but positive double stranded DNA test do I have lupus?

Not enough data: The diagnosis of luppus is made on the basis of clinical signs and symptoms confirmed by specific lab tests including the dna antibody. This antibody can also be positive in other auto immune diseases. Since you did not mention symptoms, there is no way to answer your question. ...Read more

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I recently had a positive ANA test. My dr tested folupus but it was negative. I have all the symptoms except rash. Can u have a false neg lupus test?

I recently had a positive ANA test. My dr tested folupus but it was negative. I have all the symptoms except rash. Can u have a false neg lupus test?

Keep working: Lupus is defined by a series of criteria, of which a strongly positive ANA is one. No specific test turning out negative rules out lupus. Perhaps you were tested for anti-smith(sm), which if positive hands us the diagnosis but is only positive in 1 of 3 patients. Perhaps there is a misunderstanding or you can request consultation. Lupus requires great courage -- will be thinking of you. ...Read more

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