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Doctor insights on: Lupus Negative Ana Test

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Can you have lupus with a negative ANA test? What about other autoimmune disorders?

Can you have lupus with a negative ANA test? What about other autoimmune disorders?

ANA testing: ANA is a screening test for autoimmune disease, (generally present in 80-90% of cases). A higher titer over 1:160 is more significant. There are more definite testing for lupus such as anti-smith antibody and anti ds dna antbody. There are many more other specific testing for other specific autoimmune disorders. Syphilis and lyme disease can give false positive ANA test as well. See your md. ...Read more

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Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more


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Unexplained high platelets (572), WBC (17.2), leukocytes, neutrophils, low hemaglobin. Bone marrow, jak2 and lupus test negative, ANA positive. Help?!

Reactive/ autoimmune: Discuss further with your hematologist. Certain conditions like iron deficiency , infection /inflammation vs autoimmune vs. Other solid tumor need to be ruled out. Need to check iron level, bcr/abl, imaging study like ct scan chest /abd/ pelvis will be needed. If you smoke - will suggest you to quit smoking., need to do work - up to find the anemia as well. If iron is low - GI w/u is needed. ...Read more

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Can ANA test be false negative for lupus?

Lupus: Has specific criteria for diagnosis, ANA is just one of them and canot be relied on by itself for a diagnosis. ...Read more

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Could a person with 2 different negative ANA tests have lupus?

Yes, but ANA: negative lupus is uncommon. ANA is one of the criteria for diagnosing lupus, but a negative ANA does not rule out lupus. See this site for more info. http://www.webmd.com/lupus/guide/laboratory-tests-used-diagnose-evaluate-sle ...Read more

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Is lupus possible with a negative ANA? DR GAVE ME "working" dx due to other neg tests and sx

Is lupus possible with a negative ANA? DR GAVE ME "working" dx due to other neg tests and sx

Yes: There is such a thing as ANA negative lupus. The ANA is nehative in 5-10% of lupus patients. ...Read more

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I have pos ANA and all other lupus test normal but have symptoms of lupus can you have lupus with only pos ANA test and other lupus test negative?

LUPUS: A low positive ANA alone may be non diagnostic. If all other labs are normal, it can be repeated in a 2-3 mth window. Lupus also has a list of criteria that needs to be met to fulfill the diagnosis. Follow up with your doctor and if still concerned see a rheumatologist. ...Read more

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I have had multiple positive ANA and they do the next step tests to check for lupus and it comes back negative. Why do they keep checking my ana?

I don't know: Imo, there is no need to constantly repeat an ana. It is a waste of time and money. Positive is positive and constantly repeating it will not change that. ...Read more

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I had a negative ANA test but positive double stranded DNA test do I have lupus?

Not enough data: The diagnosis of luppus is made on the basis of clinical signs and symptoms confirmed by specific lab tests including the dna antibody. This antibody can also be positive in other auto immune diseases. Since you did not mention symptoms, there is no way to answer your question. ...Read more

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I recently had a positive ANA test. My dr tested folupus but it was negative. I have all the symptoms except rash. Can u have a false neg lupus test?

I recently had a positive ANA test. My dr tested folupus but it was negative. I have all the symptoms except rash. Can u have a false neg lupus test?

Keep working: Lupus is defined by a series of criteria, of which a strongly positive ANA is one. No specific test turning out negative rules out lupus. Perhaps you were tested for anti-smith(sm), which if positive hands us the diagnosis but is only positive in 1 of 3 patients. Perhaps there is a misunderstanding or you can request consultation. Lupus requires great courage -- will be thinking of you. ...Read more

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Blood test result- ANA by EIA=negative. Is this reassuring as far as lupus or other autoimmune problem?

Mostly: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, your tests are reassuring but do not 100% exclude autoimmune disorders as there are may such disorders that occur without ANA. ...Read more

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What do these mean? lupus anticoagulant weakly present at 1.30; positive ANA Test 1:40 speckled pattern; negative anticardioliptin and beta2

Not much: A weakly present lupus anticoagulant and an ANA of 1:40 are common in the general population, and usually not an indication of an autoimmune disorder. You should visit with the physician who ordered these tests to review them with you however. A test alone does not give any answers. Doctors will need both a patient's history and tests to determine further management. ...Read more

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I have had all lupus symptoms for 6 months but repeated blood tests are showing nothing. Negative ana, ena, normal sed rate etc. I'm so confused?

I have had all lupus symptoms for 6 months but repeated blood tests are showing nothing. Negative ana, ena, normal sed rate etc. I'm so confused?

NOT LUPUS: Seek a second opinion from a rheumatologist. You may have other medical conditions that mimic lupus. You will need additional blood and urine testing. ...Read more

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Any tests that can be done to diagnose lupus when skin rash not active? ANA historically negative. Had biopsy sugg. of early conn. tissue disease.

SLE diagnosis. : The diagnosis of lupus is really clinical, supported by consistent blood test findings. That being said, relevant blood testing for lupus includes ESR, cRP, ANA, dsDNA and anti-Sm. ...Read more

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Negative ANA blood test but positive anti-dsDNA antibodies. Do I have lupus? What causes this? Very symptomatic.

Negative ANA blood test but positive anti-dsDNA antibodies. Do I have lupus? What causes this? Very symptomatic.

Rheumatologist: This test alone is insufficient to diagnose lupus. It has to be supplemented with appropriate symptoms and physical findings. A rheumatologist is best qualified to evaluate, advise, and treat you, if needed. ...Read more

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Can an ANA test be negative and an Dsdna test be undetermined and i still have lupus? Also my vitamin d was low. I have all other symptoms of lupus.

Possible yes: Still you should be evaluated by a rheumatologist to make that decision. ANA testing if negative most of the time ( even more than 90 %) means that you will not have lupus, but they are many other autoimmune disorders that may mimic lupus which further testing and evaluation is needed. Again getting to see a rheumatologist would be the best answer to all of these questions. ...Read more

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I have a positive lupus ban test but a negative ANA test. My primary care doctor said I have sero negative lupus and told me not to see a specialist?

I have a positive lupus ban test but a negative ANA test. My primary care doctor said I have sero negative lupus and told me not to see a specialist?

See a rheumatologist: A positive lupus band test on a skin biopsy suggests cutaneous lupus but not necessarily systemic lupus. See a rheumatologist. It is presumptuous for a primary care physician to tell you what he/she did. ...Read more

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If a lupus panel was negative and awaiting serum electrophise test what would that tell ? My sed rate is elevated and ANA positive w/ speckled pattern

Nothing specific : These findings are not specific. This will depend on your total evaluation and why these tests being done. The test alone do not make a diagnosis. ...Read more

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SM 5 RNP 9 SSA 14 SSB 7 SCL-70 10 JO-1 7 Histone 3 Centromere 3 CCP 1 ANA 1:320 DNA neg..Do these blood tests indicate lupus?

+ ANA: This may indicate Lupus, you need to f/u with your Rheumatologist to get a complete explanation of all of your results. It looks like you definitely have some kind of autoimmune disorder. Are you having any kind of pain in your joints? What is your RA factor? Let your Dr. know about this. Good Luck ...Read more