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Doctor insights on: Lupus High Complement Levels

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Can you have lupus with completely normal bloodwork? ANA, ENA neg, Complement levels normal, CBC normal. ESR of 2 and normal CRP

Can you have lupus with completely normal bloodwork? ANA, ENA neg, Complement levels normal, CBC normal. ESR of 2 and normal CRP

ANA negative lupus: There is an entity called ANA negative lupus. Please visit this site for diagnostic criteria for SLE. From what you have described, it is unlikely that you have lupus. http://www.lupusresearchinstitute.org/lupus-facts/lupus-diagnosis ...Read more

Dr. Sheila Smith
17 doctors shared insights

Complement Levels (Definition)

Total complement activity (CH50, CH100) looks at the overall activity of the complement system. Typically, other tests that are more specific for the suspected disease are performed first. C3 and C4 are the most commonly measured complement components. A complement test may be used to monitor patients with an autoimmune disorder and to see if treatment for their condition is working. For example, patients with active lupus erythematosus may have lower-than-normal levels of the complement ...Read more


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Should I see a rheumatologist if I have elevated complement levels?

Should I see a rheumatologist if I have elevated complement levels?

Don t think so: Complement is an acute phase reactantant , having high complement levels only means there is a reaction , probably inflammatory . If the diagnosis is ulcerative colitis , but you don t have arthritis youndont need to see the rheumatologist for high complement leves. ...Read more

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Could someone have lupus with homogeneous ANA 1:320 but elevated complement 3 and 4?

Yes: Do not place a lot of emphasis serum complement levels. They only rarely influence diagnostic decisions unless there are other abnormalities as well. ...Read more

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The result of my blood test for C3 complement is high and CPK result is too low, so do I have lupus?

The result of my blood test for C3 complement is high and CPK result is too low, so do I have lupus?

Incomplete : Information. High c3 is an acute phase reactant and may be elevated in any case of inflammation. CPK is an indicator of muscle damage and there is no value that is too low. Diagnosis of lupus is based on a number of parameters and is a combination of clinical findings and lab tests. Please consult your doctor for a proper evaluation. ...Read more

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The result of my blood test for C3 complement is high and CPK result is too low, does this mean I have symptoms of lupus?

The result of my blood test for C3 complement is high and CPK result is too low, does this mean I have symptoms of lupus?

No: High c3 is not expected in lupus. More likely it could be normal or low. CPK is high in some connective tissue diseases such as poly myosotis, dermatomyositis, and overlap syndrome of myosotis and lupus. It most definitely is not low. ...Read more

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Esr, c3, c4, total hemolytic complement are all high, negative ana, malar rash, could it be lupus?

Esr, c3, c4, total hemolytic complement are all high, negative ana, malar rash, could it be lupus?

Very unlikely: Only a few patients with a malar rash on their cheeks have lupus. You have had appropriate laboratory tests and none are suggestive of lupus except the elevated esr, which is a very nonspecific measure of inflammation. See a dermatologist if you have done already done so. ...Read more

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41 year-old woman having lupus-like symptoms, angioedema and low complement levels.....?

41 year-old woman having lupus-like symptoms, angioedema and low complement levels.....?

?: Low complement levels can result from auto-immune activity and consumption, angioedema can co-exist with auto-immune disorders, hereditary angioedema though is different, here only C4 is low, and not necessarily accompanied by an auto-immune disorder, kindly see a rheumatologist/allergist for evaluation, check aaaai.org or acaai.org for an allergist in your area, wish you wellness ...Read more

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What would having low complement levels indicate?

What would having low complement levels indicate?

Low complement: Low levels of complement are seen in persons with complement deficiency who are prone to recurrent infections as well as in certain autoimmune conditions, inherited angioedema conditions, and hives associated with vasculitis (inflammed blood vessels). These can all be serious. Collection of blood to measure complement is tricky and needs to be done right or low level could occur. ...Read more

Complement (Definition)

The complement system is an important effector mechanism of both humoral and innate immunity. Its functions are to promote phagocytosis of microbes, to stimulate inflammation, and to induce lysis of these organisms. The system is highly complex and comprised of over 50 effector and regulatory molecules. It is activated via one of three pathways: antibody, lectin, or by ...Read more