Doctor insights on:
Lupus High Complement Levels
Can you have lupus with completely normal bloodwork? ANA, ENA neg, Complement levels normal, CBC normal. ESR of 2 and normal CRP
Total complement activity (CH50, CH100) looks at the overall activity of the complement system. Typically, other tests that are more specific for the suspected disease are performed first. C3 and C4 are the most commonly measured complement components. A complement test may be used to monitor patients with an autoimmune disorder and to see if treatment for their condition is working. For example, patients with active lupus erythematosus may have lower-than-normal levels of the complement ...Read more
What do you think it means when your complement level comes back high (176) but you test a "low" postive for lupus? This is for my 18 month old son.
Need more: A diagnosis of lupus requires way more testing than this. ...Read more
Don t think so: Complement is an acute phase reactantant , having high complement levels only means there is a reaction , probably inflammatory . If the diagnosis is ulcerative colitis , but you don t have arthritis youndont need to see the rheumatologist for high complement leves. ...Read moreSee 2 more doctor answers
The result of my blood test for C3 complement is high and CPK result is too low, does this mean I have symptoms of lupus?
The result of my blood test for C3 complement is high and CPK result is too low, so do I have lupus?
Incomplete : Information. High c3 is an acute phase reactant and may be elevated in any case of inflammation. CPK is an indicator of muscle damage and there is no value that is too low. Diagnosis of lupus is based on a number of parameters and is a combination of clinical findings and lab tests. Please consult your doctor for a proper evaluation. ...Read moreSee 1 more doctor answer
Esr, c3, c4, total hemolytic complement are all high, negative ana, malar rash, could it be lupus?
Very unlikely: Only a few patients with a malar rash on their cheeks have lupus. You have had appropriate laboratory tests and none are suggestive of lupus except the elevated esr, which is a very nonspecific measure of inflammation. See a dermatologist if you have done already done so. ...Read moreSee 1 more doctor answer
?: Low complement levels can result from auto-immune activity and consumption, angioedema can co-exist with auto-immune disorders, hereditary angioedema though is different, here only C4 is low, and not necessarily accompanied by an auto-immune disorder, kindly see a rheumatologist/allergist for evaluation, check aaaai.org or acaai.org for an allergist in your area, wish you wellness ...Read more
Yes and no: Tinea versicolor is a fungal infection. It may present due to a decrease in the immune system (low complement). Lichen planus is an autoimmune disorder of unknown origin. Various autoimmune illnesses are associated with increased incidence in lichen planus. Secondary raynaud's disease also has been linked with some autoinmune disorders such as lupus, rheumatoid arthritis and sjogren's syndrome. ...Read moreSee 1 more doctor answer
The complement system is an important effector mechanism of both humoral and innate immunity. Its functions are to promote phagocytosis of microbes, to stimulate inflammation, and to induce lysis of these organisms. The system is highly complex and comprised of over 50 effector and regulatory molecules. It is activated via one of three pathways: antibody, lectin, or by ...Read more
Lupus erythematosus is a name given to a collection of autoimmune diseases, in which the human immune system becomes hyperactive and attacks normal, healthy tissues.Symptoms of these diseases can affect many different body systems, including joints, skin, kidneys, blood ...Read more
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