Doctor insights on:
Lupus Anticoagulant And Factor V Leiden
My mum has lupus i have been tested and tould i have factor v Leiden can someone please explain what it is and how it will affect me in my life?
Depends: The risk of blood clot development depends on weather you have one or two copies of the gene for Factor V deficiency, A person with 2 copies of the gene have increase in risk of DVT, pregnancy loss and pregnancy complications. Your physician can give you more information based on your test results. ...Read more
Agents which slow ;/or break down blood clot formation in up to 3 different ways (they do not decrease blood viscosity; thickness.) (1) some inhibit platelet function (e.g. Aspirin, clopidogrel, etc.). (2) others interfere with some of the clot forming proteins (warfarin, dabigatran, rivaroxaban, etc.), (3) others stimulate the blood clot destruction ...Read more
I have factor v and lupus anticoagulant syndrome....For the past year my face has darkening spots on my cheeks..Fingers hurt..My hair is thinning bad?
APL vs Medication : There are many options. This could be related to an associated lupus like syndrome in your settings or it could be due to your medications or both. Your evaluation will be able to clarify these issues. ...Read more
Are any of the new anticoags useful for factor v leiden and lupus anticoag. Antibody. On lovenox (enoxaparin) 100mg bid. Venous and arterial clotting and pes. ?
Maybe: The newer medications to prevent blood clots are not approved for use in the us for your condition. There is published research in europe showing that these medications can be used effectively for your type of problem. My personal bias is that you should wait until more research has been done. Your doctor can help advise you as to the status of this research as it evolves. ...Read more
No: Positive is positive. However, it is the degree of positivity that is clinically important. Low positive values are generally not clinically important. ...Read more
Had a lupus anticoagulant test done all was normal except for a high thrombin time at 22.8 is this serious? Factor 5 also runs in my family.
I have lupus anticoagulant and dr. Is wanting to put me on xorelto! i've read mixed reviews mostly against, & cost is a factor? What is your opinion?
Use caution: Xarelto is awesome if you listen to the manufacturer. Unlike coumadin, (warfarin) you do not require regular blood draws to evaluate effect. However, there is also no clear reversal agent if one does sustain a bleed. It can be a terrible situation when someone has a brain hemorrhage, etc, from relatively trivial fall. ...Read more
Depends: If your father is homozygous for the mutation, you are heterozygous for factor v leiden. If your father is heterozygous for the mutation you have a 50% chance of being heterozygous. This is assuming that your mother does not have the mutation. Even heterozygotes/carriers have about 5 fold greater risk of thrombosis. T. ...Read more
Dr Hoepfner, I was diagnosed with an enlarged spleen at 13.4 cm is that something to be alarmed about? I am a Factor V Leiden def. patient who takes
That measurement: is borderline and could be normal in a particular patient. ...Read more
My sis tested (+) factor V Leiden and her Dr suggested I get tested. I was fixing to start Clomid (clomiphene) 4 secondary hypergonadism. R SERMS contraindicated?
FH Leiden factor: Estrogens increase the risk of clotting. Clomid (clomiphene) is a non steroidal selective estrogen receptor modulator.It is not an estrogen. It has not been associated with significant increase in clotting to date, so should be OK. With FH of Leiden positive (I assume means deficient in Leiden V) which increases the risk of clots, get tested and let your doctor know of the results prior to starting. ...Read more
I have factor v leiden was wondering what contraception methods could people with this condition use?
No: Both are very common and this is probably a coincidence. The factor v gene isn't part of the pathway by which new vessels form, and this speaks against there being any correlation. There are a few other genetic syndromes with distinctive hemangiomas, but factor v has not been linked to any. ...Read more
I have factor V Leiden. no longer have insurance can I take asprin 2x a day to help thin my blood?
Can I take advil if I have a heterozygote mutation of factor V leiden? Any extra increase risk of clot? Thank you
No extra risk:
Advil will not increase your risk for clots.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex. ...Read more
I can't seat for extended periods of time w/out my lft leg hurting really bad when I try to get up&move. Could this be the factor v Leiden disorder?
Not likely: What you describe is more concerning for some compromise of the nerve(s) of the spine. Alternatively, it could just be increased muscle tone/spasm related to prolonged sitting. Factor V leiden predisposes people to blood clots and blood clots, if going to cause pain, usually cause pain whether seated or standing. ...Read more
I have factor v leiden deficiency and take 20mg warfarin daily. Can i take ace?(it's a appetite suppressant)
I would not: Recommend as dietary changes can significantly alter warfarin metabolism. ...Read more
I have factor v leiden, I'm having horrible cramping during my periods. Could this be caused from factor v, if so what should I do?
No association: Factor 5 Leiden is a disorder that increases your risk of clotting. Although I understand why you might think that this might affect your period, it is unlikely that they are associated. However you can lighting or eliminate your period by getting on a birth control method such as an IUD or using a combined hormonal methods. Please consult a gynecologist for more details. ...Read more
I have factor v leiden and have been experiencing some tightness and pain on my right calf, somewhat like a charlie horse, should I worry?
Conservative: Most gastrocnemius muscle strains are treated non operatively with protected weightbearing and temporary immobilization. The factor deficiency doesn't change the plan but increases the risk of bleeding or hematoma. If it swells a lot you may need factor treatments to control bleedeing. ...Read more
Blood clots: People with leiden variant of clotting factor v have tendency to form clots in blood vessels and develop thromboses in veins that cause pulmonary emboli. Women on birth control pills are more susceptible to clot formation if they have factor v leiden. ...Read more
Talking to your fict: I'm so sorry but I really think this is a question you should ask your own doctor. He/she knows you best. ...Read more
What to do if I have factor v leiden was wondering what contraception methods people with this condition use?
Do not use the pill: There are other contraceptive methods like IUD, diaphragm, condoms, and if you are done with childbearing, ligation of fallopian tubes. Also please abstain from using tobacco in any form. ...Read more
I found out I have Factor V Deficiency. My mother has Factor V leiden. What is the difference between those?
Huge difference: Factor V deficiency of a clotting factor which can result in a hemophilia like illness with excessive bleeding. On the other hand Factor V Leiden refers to a mutation which increases the risk of clotting and thrombosis. The distinction is very important. Women with Factor V Leiden should not take hormonal contraception. Please clarify your diagnosis with your physician as soon as possible! ...Read more
Im 5 weeks pregnant and have factor v leiden is it safe dor me to fly can you please advise me on this matter. Thank you?
Yes: If you have not had any miscarriage, nor episodes of venous thromboembolism (vte), then you are fortunate. Hydration with water, using 20-30 mm hg compression hose, taking baby Aspirin prior flying, doing calf-muscle exercises, walking around the plane should help decrease risk for vte. If you have had miscarriage, vte before, see your obstetrician. ...Read more
"i have factor v leiden from both parents, i'm 25 and have an 8 yo. Want another, does age affect pregnancy statistics with this disorder?
No: Age has nothing to do with factor v leiden. You can try again, but be aware that if you do carry the bad gene you are definitely more prone to developing clots at the time of pregnancy as it naturally increases the chance of clot development even in women without factor v leiden genes. ...Read more
Thrombosis: People who inherit the leiden variant of coagulation factor v are at incresed risk of venous thrombosis. Those who are heterozygotes their risk is 5-10 fold higher, homozygotes are about 50 fold greater risk. Women on birth contol pills are partiuclarly susceptible to thrombosis if they have leiden factor v. If the affected individual develops thromobsis, life long anti-coagulation may be needed. ...Read more
Risk for blood clots:
People homozygous for factor v leiden are about 50 times more at risk of developing blood clots in their veins and complications related to that. See this site for more info.
http://www.mayoclinic.org/diseases-conditions/factor-v-leiden/basics/definition/con-20032637. ...Read more
Anticoagulants are any of a variety of drugs which decrease the body's ability to make or sustain blood clots. They fall, generally, into two categories. Drugs like Aspirin and clopidogrel (plavix) prevent platelets from forming the initial stages of a clot. Drugs like warfarin (coumadin) and dabigatran (pradaxa) block the later process ...Read more
If your "lupus anticoagulant" test is positive, it indicates that your blood may clot more easily than it should (long story on the reason for the backwards name). It is important to know that this is only one of several tests for abnormal clotting that a person with an autoimmune ...Read more