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Doctor insights on: Lupus And High Iron Low Ferritin

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Dr. Richard Roberts
332 doctors shared insights

Ferritin (Definition)

Ferritin is protein complex that binds iron and controls iron levels inside all of our cells. Low levels in the serum is a useful marker of iron deficiency. Macrophages are cells that contain large amounts of ferritin, and this that helps them scavenge RBC at sites of old hemorrhage. High serum ferritin levels occurs from macrophage activation and is a ...Read more


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Elevated ferritin levels, but i'm chronically anemic-missed 6 venofer injections, what are possible causes? Is lupus possibility?

Elevated ferritin levels, but i'm chronically anemic-missed 6 venofer injections, what are possible causes? Is lupus possibility?

What's going on?: If you have an elevated serum ferritin, then you are almost certainly not iron-deficient and should not be receiving injectable iron. It can kill you. I am not joking. Please get with someone who knows how to work up an anemia properly. I'm betting on one of the milder thalassemia variants, but there are literally hundreds of other possibilities. ...Read more

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Hi ck, &blood creatinine(3x),low ferritin, pos ana,&rf, neg lupus,other autoimm. Progressive pain in right wrist, fingers, brachial 3+ yrs - no dx!

Hi ck, &blood creatinine(3x),low ferritin, pos ana,&rf, neg lupus,other autoimm. Progressive pain in right wrist, fingers, brachial 3+ yrs - no dx!

See details: Have you seen a rheumatologist? If no, then do so. There is certainly an issue here with possible diagnosis being one of the connective tissue disorders. Consider seeing a rheumatologist at one of the major medical centers in NYC. ...Read more

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Ferritin level 301, platelets 74, vit d 13 ng/ml hemoglobin is 14.2 good. B12 is bit on the low side at 354 but ok. Gastric bypass in 2003. Lupus?

Ferritin level 301, platelets 74, vit d 13 ng/ml   hemoglobin is 14.2 good.  B12 is bit on the low side at 354 but ok. Gastric bypass in 2003. Lupus?

Lupus: What makes you think it is lupus? Did you have a blood test for anti-nuclear antibodies or any other autoimmune workup? Or do you have any symptoms? If you have concerns, go see a rheumatologist. ...Read more

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My Serum Ferritin is: 7,7umol/L (ref:9-26) & TIBC is 10 umol/L (43-86). Should the TIBC not be high as i have low iron?What could cause it to be low?

My Serum Ferritin is: 7,7umol/L (ref:9-26) & TIBC is 10 umol/L (43-86). Should the TIBC not be high as i have low iron?What could cause it to be low?

Agreed: Based on a low Ferritin and Iron I too would expect a high TIBC. However, tests are not always in agreement with logic. On face value it would appear you are iron deficient, however I do not know you blood counts and several other labs. Please return to your physician to discuss, as this will help you better understand what is going on. Good luck!! ...Read more

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What causes these results? High iron 49 umol/l, tibc normal 70, high saturation 70 umol/l, and low ferritin 11 ug/l? Dr didn't explain. Anaemia?

What causes these results? High iron 49 umol/l, tibc normal 70,  high saturation 70 umol/l, and low ferritin 11 ug/l? Dr didn't explain.  Anaemia?

Out of context: One cannot take one small part of a lab report and get any kind of valid interpretation. Too much is missing here. The other lab values. The reasons for the tests. The past medical history. ...Read more

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HFE mutation with low *6.7* ferritin and 61% sat. Do I need high sats AND high ferritin for iron deposits in body? Concern for low ferritin? Thanks!

Can be Iron def: Hemochromatosis results in increased iron absorption from diet. But it will not stop iron deficiency if you are losing iron/blood such as menstruation or pregnancy. Low ferritin says iron stores are low. High transferrin sat says you absorb excess iron from what you eat. Women with homozygous HC get organ damage about a decade later than men for this reason. If you are anemic take (!) iron briefly ...Read more

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Can you please tell me what it means from my Iron Studies blood test - when my Ferritin levels are low 25 (Ref 30-300) and my Sat is high 63 (10-45)?

Can you please tell me what it means from my Iron Studies blood test - when my Ferritin levels are low 25 (Ref 30-300) and my Sat is high 63 (10-45)?

Repeat the tests: Any evidence of iron deficiency is very serious especially at your age even if you're not anemic. You need to be screened for GI / GU bleeding, have your diet reviewed (if you are a vegetarian, please reconsider), and have a history. There may also be a lab error. High serum Fe / sat can happen if you take a few iron pills before seeing the doctor "for your health". ...Read more

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My labs were Iron:197 with high TIbC and low ferritin levels what does this mean?

My labs were Iron:197 with high TIbC and low ferritin levels what does this mean?

Iron deficiency: Ferritin is an indicator of long term storage fo iron and the TIBC is the chemical in the blood that binds and transports iron. TIBC usually increases when total body iron stores are low but can also increase with hormone supplements or pregnancy. Iron supplements are recommended and are available OTC. They may color BM's black and cause some constipation, so stool softeners are helpful. ...Read more

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High serum Fe 208,high sat 68,high/norm Hg,HC & low/norm ferritin 46,d/c FeGlucconate (27mg elm)x12days ago. Am I not storing the iron?

Big picture: High iron / iron sat is meaningless as a measure of storage iron if you're taking ferrous gluconate. Why were you on it in the first place? If it's to correct heavy monthly iron loss, ask your physician whether to continue it prophylactically so you don't get a recurrence. ...Read more

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I'm very confused . My tibc is high (430) normal being 225-390 and my iron is also high 171 normal being 37-145. However my ferritin is normal low. ?

I'm very confused .  My tibc is high (430) normal being 225-390 and my iron is also high 171 normal being 37-145.  However my ferritin is normal low. ?

More information: Serum iron varies from hour to hour depending on diet / popping a vitamin pill. These labs mean little in the absence of clinical information or knowing why these were even ordered. Before your physician goes looking for rare iron metabolism issues, perhaps it would be best to repeat the labs or if warranted, conclude there isn't an iron problem. ...Read more

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Iron panel- UIBC: 109 (low), Iron serum: 170 (high), Iron saturation: 61% (high), TIBC: normal, Ferritin: 40 (normal). What can cause this?

May be normal: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, there does not seem to be anything extraordinary in your lab results. Generally it is a good idea to treat the person and not the lab results. ...Read more

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Ferritin 4.6 , iron 27 , transferrin saturation 6 , tibc 437 . . . Is everything is low why is tibc high? What does this mean ? What do I do now?

Ferritin 4.6 , iron 27 , transferrin saturation 6 , tibc 437 . . . Is everything is low why is tibc high? What does this mean ? What do I do now?

Iron binding: Capacity. Tibc is the abbreviation for total iron binding capacity. When iron is low the iron binding capacity is high and vice versa. Given your diagnoses, it would be prudent to consult your doctor for next steps. However, you have iron deficiency and may take over the counter iron supplements. ...Read more

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Dr Fischer-They don't know why I have low ferritin and high iron saturation. Endoscopy needed?iron avid?. I am a H63D heterozygote for hemachromatis

See hematologist: The heterozygosity for hemochromatosis should not cause iron storage disease, but the high saturation with low ferritin (iron stores) suggests a problem with bleeding or blood cell formation. Sometimes microscopic exam of the blood is a useful first step before other tests. ...Read more

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Is a ferritin reading of 284 very high for a 58 year old woman who used to have low iron levels?

Is  a ferritin reading of 284  very high for a 58 year old woman who used to have low iron levels?

Yes it is high: It is high as normal ferritin level in women is 12to150ng/ml.Discuss the result along with hemoglobin, and iron level etc with your doctor. ...Read more

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Used to chronic blood loss. I fixed that. Ferritin was low, took iron pills. Now ferritin normal. But serum iron is high. Stopped pills. Implication?

Used to chronic blood loss. I fixed that. Ferritin was low, took iron pills. Now ferritin normal. But serum iron is high. Stopped pills. Implication?

Manage it: I'm really glad you found the cause of your chronic bleeding. The serum iron isn't anything to worry about while you're taking oral iron. Each pill causes a spike in the value. Keep following this, and I"m glad you're better. Best wishes. ...Read more

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How is it possible my serum iron can be elevated and my ferritin be low at the same time?

Fluctuations: Serum iron is sensitive to diet, supplements, injury and a host of day-to-day variables. Low serum ferritin is usually a more reliable indicator of available stores, and if mine were quite low, i'd be looking for why i might be losing iron / bleeding rather than have the serum iron think i'd been misled. ...Read more

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What does it mean when your eos, rbc and rdw are high and mcc, mch,mchc ferritin iron sat are low?

Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, if your hemoglobin is also low, you likely have iron deficiency anemia which is not uncommon in women of reproductive age. Consult the doctor who ordered the tests. You may take iron and multivitamin supplements. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex, if you have sex. ...Read more

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Iron serum high (180) yet ferritin levels low (113). Suffering symptoms akin to haemochromatosis. Can treatment (phlebotomy) be justified?

Not necessarily: Serum iron levels are not a good test to make treatment decisions as it is very variable and do not reflect inappropriate iron deposition. Ferritin level is the standard. If there is a concern for hemachromatosis genetic test is available. If indicated, liver biopsy with iron studies can be considered. ...Read more

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My ferritin level is very low at 9 and has not changed after 3 months of high dose oral iron supplements. Are iron suppositories more effective?

Not more effective: Your situation suggests inadequate nutrition. Despite a plentiful source of iron, your body is not producing protein needed to handle it. ...Read more

Iron (Definition)

In the metal group ...Read more