Doctor insights on:
Lupus And Familial Mediterranean Fever
See an internist: Or a geneticist. There are specialized dna testing techniques which can assist with this. But first, before spending a great deal of money, make sure you have had intermittent episodes of self-remitting fevers, belong to one of the ethnic groups in which this occurs, and have no other source for your symptoms. This is an uncommon condition. See a good internist. ...Read more
Off and on attacks: Signs and symptoms of familial mediterranean fever usually begin during childhood. In fact, 90 percent of all people initially diagnosed with fmf are younger than 20 years old. The signs and symptoms, which are collectively referred to as attacks, often occur with little warning. Generally, the attacks last two to three days. ...Read more
An internist: Or a geneticist. There are specialized dna testing techniques which can assist with this. But first, before spending a great deal of money, make sure you have had intermittent episodes of self-remitting fevers, belong to one of the ethnic groups in which this occurs, and have no other source for your symptoms. This is an uncommon condition. See a good internist. ...Read more
MEDITERRANEAN FEVER: Familial mediterranean fever, also called familial paroxysmal or recurrent polyserositis is an inherited condition characterized by transient recurring attacks of abdominal pain, fever, pleurisy (chest pain), arthritis, and rash. The condition is asymptomatic between attacks. ...Read more
More than one type of gene defect can cause familial mediterranean fever. Two common defective genes are
mefv and saa1, and are located on short arms of chromosome 16 and 11 respectively. See this site for more info.
http://ghr. Nlm. Nih. Gov/condition/familial-mediterranean-fever. ...Read more
See below: FMF is one of a group of recessively inherited diseases that is characterized by episodes of fever, very painful arthritis, pleuritis with chest pain, serositis with abdominal pain, red inflamed skin lesions, and sometimes amyloidosis. It occurs in Armenians, Arabs, Turks and some Semitic people. It is well controlled by colchicine which also prevents amyloidosis. ...Read more
Yes: Because fmf is a relatively rare condition there are few studies of large numbers to answer this really well. Colchicine is used for symptom control in fmf. Data suggest now real difference in pregnancy outcome in treated vs untreated groups, but treatment helps with symptoms. Genetic testing for offspring is recommended. Increased infertility rates and miscarriages (~25%) with this disease. ...Read more
Not really.: The diagnosis of this disorder is made with a combination of clinical analysis and testing. A history of typical attacks of fever and abdominal or joint pain in mediterranian groups like armenians or arabs is highly suggestive, with acutely high levels of c-reactive protein, wbc, and possibly evidence of renal failure. Genetic tests to detect mefv gene mutations and Metaraminol test can be done. ...Read more
Rare condition: Fmf often presents as fever of undetermined origin. If you are of appropriate ethnic background, have episodes of fever with abdominal pain and other suggestions of polyserositis and are without symptoms between attacks the illness is suspected and there are now molecular testing techniques for hereditary periodic fevers. Without these symptoms, very difficult to suspect. ...Read more
It is an inherited disorder causing fever and pain and swelling at multiple sites. There is no cure but symptoms can be controlled. See this site for more info.
http://www. Mayoclinic. Com/health/familial-mediterranean-fever/ds00766. ...Read more
Serious illness: This is a genetic defect in pyrin, which is a protein left behind by angry neutrophils that go to a scene of acute injury to let the other neutrophils know they can maybe stay behind. Inflammatory responses are exaggerated. Most serious is a tendency to late amyloidosis which is horrible. If you're diagnosed comply with your medical regimen scrupulously. Best wishes. ...Read more
No: This is a genetic disease caused in most cases by deficiency in pyrin. Replacing the protein won't help as it's needed only in certain areas where neutrophils have begun to congregate. Thankfully, if you're complaint with medication even when you feel well, you can usually avoid the horrible late consequence of the disease -- amyloidosis. ...Read more
No, but...: They mimic each other, since both are prone to cause serositis unexpectedly. The most important thing to know about fmf -- if you actually have it -- is to comply with your treatment even if you do not feel sick. It will make you much less likely to get amyloidosis, which is a miserable way to go. Best wishes. ...Read more
Chromosome 16: The mefv gene is located on the short (p) arm of chromosome 16 at position 13.3, from base pair 3, 292, 027 to 3, 306, 626 (per wikipedia). ...Read more
No: Fmf is more a gastrointestinal inflammatory disease, usually hereditary. I have several patients with fmf who have been successfully pregnant as long as the disease is under control. ...Read more
Hi. I want to know. What is the best treatment for familial mediterranean fever other than tacking colchicine, my brother is 24 years old, ?
A great mimic: This is a hereditary deficiency in pyrin, which is the brakes on the acute inflammatory response. Episodes of pain in one place -- one side of the chest, the abdomen, a joint, etc -- are accompanied by fever. It seems mild, but especially untreated, tends to produce amyloidosis which is first crippling and then lethal. A few genetic diseases are similar, and fmf often takes years to diagnose. ...Read more
Subtle: Brief episodes of fever, generally beginning in childhood, with discomfort in different parts of the body (one side of the chest, the abdomen, a joint, maybe elsewhere) each time. Worse, especially if untreated, the disease often eventually causes amyloidosis, which will first ruin your life, then end it. Genetic testing clinches the diagnosis. Good luck. ...Read more
Not directly: Fmf does not cause death directly (like say for example cancer or coronary artery disease). Patients with fmf do have higher rates of related diseases however, such as nephrotic syndrome or amyloidosis (also subfertility and miscarriages). These other diseases can all contribute to earlier death if the fmf is not treated regularly. ...Read more
Yes: Fmf is an inherited genetic condition. If a family member has already been diagnosed with fmf then other family members can undergo genetic testing to see if they have the mutation before symptoms start. Early management may prevent some of the long term complications of the disease. ...Read more
Genetic tests can detect susceptibility to familal mediterranean fever though there is a risk of false negatives. See this site for more info.
http://www. Mayoclinic. Com/health/familial-mediterranean-fever/ds00766/dsection=tests-and-diagnosis. ...Read more
What to do if I have familial mediterranean fever and taking colchicine, 1mg. Recently discovered coronary calcium builtup?
See Cardiologist: Familial Mediterranean Fever is treated effectively in most patients with colchicine. Colchicine is not involved in calcium deposits in the coronary arteries. Suggest to see a Cardiologist regarding cause, importance and possible treatment. You undoubtedly have had arthritis with this and the treatment is appropriate. ...Read more
About familial mediterranean fevermy greetings to youi want to ask about fmf as I made amyloid a (saa) and the result was 41 and the doctor diag?
Misunderstanding?: Tricky call. Serum amyloid-associated protein levels won't establish a diagnosis of familial mediterranean fever; today you want a geneticist or genetics lab to do this for you. It's an important diagnosis not to miss or to make in error; lifelong rx will make the fatal complication of amylodosis less likely, while an erroneous diagnosis results in lifelong unnecessary rx. Be proactive. ...Read more
I have familial mediterranean fever and I am on colchicine I noticed that every time my period ends I get the fmf is that normal? What's threlation?
I read it's common: Fmf attacks are triggered by the complex hormonal system of our bodies, a chaotic system that defies full analysis. From my reading, maybe 15% of women get an attack with each period. Whether you want to up your rx at this time is between you and your physician. Compliance with your prescription is important to prevent deadly amyloidosis as a complication -- but you know that. Stay proactive. ...Read more
What type?: "mediterranean fever" classically refers to an infection from contact with animals carrying the brucella bacteria ("brucellosis), and is treated with antibiotics. There is also a "familial mediterranean fever" which is a genetic disorder that causes an autoimmune type of inflammation related to defects in a protein known as pyrin. There is no specific "treatment" per se for this disease. ...Read more
Never cured: Familial mediterranean fever and its less common mimics are among the most treacherous of illnesses; they can mimic anything, diagnosis is often delayed for years, episodes are short, and patients feel well in-between. They are never cured, and noncompliant patients often end up with amyloidosis which will first make your life utterly miserable, then end it. Be smart & stay proactive. ...Read more
Is there any interaction or damage may happened by using cholshisine (famelial Mediterranean fever) and amino acid supplements?
Comply: If the diagnosis is established, you have a choice. Probably you will be put on maintenance colchicine. It is not pleasant. It will make your attacks fewer, and it will protect you in the long run fairly well for the fatal amyloidosis that often kills you people. If you decide you're not going to comply, you are likely to pay with your life. ...Read more
I've been told that I have mediterranean fever and I would like to know what can I eat and also I was told tablets for the rest of my life help me!
FMF: I am going to assume that the diagnosis of familial mediterranean fever has been established. You are right to question whether you need to be on lifelong medication for what seems to be a mild episodic disease. You do. Colchicine is fairly effective in preventing amyloidosis, which complicated untreated fmf and (forgive me) is a miserable way to die. Be proactive, learn about fmf, and good luck. ...Read more
I need to find someone that specializes in Mediterranean fever and its symptoms... I am 40 years old and I am in constant pain... Can anyone help?
FMF: Colchicine and other anti-inflammatories may be used for this incurable genetic condition. Familial Mediterranean fever is an inherited disorder that usually occurs in people of Mediterranean origin — including Sephardic Jews, Arabs, Italians, Armenians and Turks. But it may affect any ethnic group. Please see either a rheumatologist or an infectious diseases specialist. ...Read more
Lupus? Received positive 1:160 homogenous ANA. Familial history of lupus, breathing pain, extreme fatigue, joint pain, constant low grade fever
Cannot diagnose: This clinical history suggests a need for you to be seen by an astute clinician or even a rheumatologist. Need more info and further testing and examination before a diagnosis can be offered. What you describe can fit numerous conditions. Go soon and be evaluated. Good luck and best wishes. ...Read more
Fever: Sle is an inflammatory condition in which fevers are not uncommon. Would not, however, make the assumption that the fever in any given individual is due to their sle, since they are more susceptible to infection than the normal person, and the drugs they are taking may make them even more liable to infection. They should be seen by a doctor and evaluated thoroughly. ...Read more
I have lupus (sle) I have had a fever all week but only at night is this unusual for a lupus flare? Should I be concerned?
Lupus flare?: Could be. Discuss with your Dr. Anyone else ill at home? ...Read more
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