Doctor insights on:
Lupus And Elevated Ig M Alt
I am being tested for Lupus my APTT ratio was 1.16 slightly raised and my cardiolipin IGM was 102ug/l ESR raised but ANA was normal.
Need more data : This will depend on more information that I have at this point. then ANA could be negative if only a binding essay was used rather than an immunofluorescent assay. You may fulfill criteria for lupus anticoagulant . You will need to have your physician clarify these tests which Lab did them and how accurate they are. ...Read more
I have a very high ANA titre (1:2560 homogenous), but normal immunoglobulins (IgG, IgA, and IgM) and normal CRP. Could I still have lupus?
Can I still have lupus if my ANA and other antibodies are negative except the cardiolipin IgM and lupus coagulant! I have all the symptoms for lupus.
Yes,amongst other Dx: Anti-cardiolipin antibodies are antibodies often directed against cardiolipin & found in several diseases, including syphilis,antiphospholipid syndrome,livedoid vasculitis, vertebrobasilar insufficiency,Behçet's syndrome,idiopathic spontaneous abortion,] and systemic lupus erythematosus(SLE).They are a form of anti-mitochondrial antibody. In SLE,anti-DNA Abs &anti-cardiolipin Abs act independently ...Read more
SLE pt. Bouts of pleurisy and pericarditis. Dr says I am now low on IgG and IgA. IgM on lower side of norm. Low C3 for yrs. Norm for lupus?
Lupus: Low C3 is expected in lupus due to disease activity and consuming up complement proteins cascade, which C3 is one of these proteins, the low immunoglobulins can very well be secondary to the immuosuppressants you're on, please keep a close follow up with your doctor and possibly an immnologist input would help, up to your rheumatologist ...Read more
My cardiolipin IgM has come back high 3 times, neutrophils slightly raised & ANA negative. symptoms indicative of Lupus, MCTD?? Gp not worried.
See a rheumatologist: The lab tests may be unreliable especially at hospital labs. Even if negative the anticardiolipin ab may be a concern depending on your symptoms. IgM anticardiolipin Anyibody us also for many not a problem. It us best if you are having symptoms to see a specialist and get their opinion. ...Read more
Tested for anti cardiolipin IgM is negative(0.7) but IgG is positive (54.8) normal range of lupus anticoagulant, protein S and protein C activity help?
Positif ANA IF, Anti-B2 glicoprotein igM, anti-CMV igG, Lupus Anticoagulants, history of DVT. Dr suspect Antiphospholipid Syndrome (APS). Possible?
Have lupus. Being tested for possible autoimmune liver diseases. Recent blood work showed immunoglobulin M elevated at 470 (range 26-217). ?
See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, a single test like slightly elevated IgM is not meaningful. Lupus is a complicated illness and the individual needs to be treated, not a lab test result. Wish you good health. ...Read more
Lupus patient- last round of tests show abnormally high bilirubin levels and abnormally low AST and ALT. What would cause this and what would it mean?
Obstructive jaundice: You may have a "blockage" of your liver ducts due to your Lupus or one of the medication you are taking! This needs further study ASAP A Rheumatologist should be consulted Good Luck Hope this helps Dr Z ...Read more