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Doctor insights on: Lupus And Elevated Ig M Alt

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I am being tested for Lupus my APTT ratio was 1.16 slightly raised and my cardiolipin IGM was 102ug/l ESR raised but ANA was normal.

I am being tested for Lupus my APTT ratio was 1.16 slightly raised  and my cardiolipin IGM was 102ug/l ESR raised but ANA was normal.

Need more data : This will depend on more information that I have at this point. then ANA could be negative if only a binding essay was used rather than an immunofluorescent assay. You may fulfill criteria for lupus anticoagulant . You will need to have your physician clarify these tests which Lab did them and how accurate they are. ...Read more

Dr. Gregory Lanza
816 doctors shared insights

Immunoglobulin M (Definition)

There are 5 classes of immune proteins: igg, iga, igm, ige and igd. Igm fights infection. If you produce too little then infections may occur and you have hypogammaglobulinemia. If you have too much you ...Read more


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I have a very high ANA titre (1:2560 homogenous), but normal immunoglobulins (IgG, IgA, and IgM) and normal CRP. Could I still have lupus?

I have a very high ANA titre (1:2560 homogenous), but normal immunoglobulins (IgG, IgA, and IgM) and normal CRP. Could I still have lupus?

False positive: Repeat the test. Other meds and conditions may cause this if the result is real and repeatable. If real and no other explanation, you need follow up by your doc as you may have an autoimmune disease that is too early to diagnose. Best wishes! ...Read more

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Can I still have lupus if my ANA and other antibodies are negative except the cardiolipin IgM and lupus coagulant! I have all the symptoms for lupus.

Can I still have lupus if my ANA and other antibodies are negative except the cardiolipin IgM and lupus coagulant! I have all the symptoms for lupus.

Yes,amongst other Dx: Anti-cardiolipin antibodies are antibodies often directed against cardiolipin & found in several diseases, including syphilis,antiphospholipid syndrome,livedoid vasculitis, vertebrobasilar insufficiency,Beh├žet's syndrome,idiopathic spontaneous abortion,] and systemic lupus erythematosus(SLE).They are a form of anti-mitochondrial antibody. In SLE,anti-DNA Abs &anti-cardiolipin Abs act independently ...Read more

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SLE pt. Bouts of pleurisy and pericarditis. Dr says I am now low on IgG and IgA. IgM on lower side of norm. Low C3 for yrs. Norm for lupus?

SLE pt. Bouts of pleurisy and pericarditis. Dr says I am now low on IgG and IgA. IgM on lower side of norm. Low C3 for yrs. Norm for lupus?

Lupus: Low C3 is expected in lupus due to disease activity and consuming up complement proteins cascade, which C3 is one of these proteins, the low immunoglobulins can very well be secondary to the immuosuppressants you're on, please keep a close follow up with your doctor and possibly an immnologist input would help, up to your rheumatologist ...Read more

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My cardiolipin IgM has come back high 3 times, neutrophils slightly raised & ANA negative. symptoms indicative of Lupus, MCTD?? Gp not worried.

My cardiolipin IgM has come back high 3 times, neutrophils slightly raised & ANA negative. symptoms indicative of Lupus, MCTD?? Gp not worried.

See a rheumatologist: The lab tests may be unreliable especially at hospital labs. Even if negative the anticardiolipin ab may be a concern depending on your symptoms. IgM anticardiolipin Anyibody us also for many not a problem. It us best if you are having symptoms to see a specialist and get their opinion. ...Read more

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Tested for anti cardiolipin IgM is negative(0.7) but IgG is positive (54.8) normal range of lupus anticoagulant, protein S and protein C activity help?

Tested for anti cardiolipin IgM is negative(0.7) but IgG is positive (54.8) normal range of lupus anticoagulant, protein S and protein C activity help?

Not sure: I am not sure I understand the question. I suspect you are being evaluated for a blood clotting disorder and you have an elevated anticardiolipin IgG. One test however does not make the diagnosis of anti-phospholipid syndrome. ...Read more

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Positif ANA IF, Anti-B2 glicoprotein igM, anti-CMV igG, Lupus Anticoagulants, history of DVT. Dr suspect Antiphospholipid Syndrome (APS). Possible?

Positif ANA IF, Anti-B2 glicoprotein igM, anti-CMV igG, Lupus Anticoagulants, history of DVT. Dr suspect Antiphospholipid Syndrome (APS). Possible?

POSSIBLE: Your lab outcomes plus the prior DVT, seem consistent, but other labs may further assist such as changes in PTT. Might get additional opinion to confirm your diagnosis, and exclude other problems, but certainly antiphospholipid antibody syndrome seems high on list. ...Read more

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Have lupus. Being tested for possible autoimmune liver diseases. Recent blood work showed immunoglobulin M elevated at 470 (range 26-217). ?

Have lupus. Being tested for possible autoimmune liver diseases. Recent blood work showed immunoglobulin M elevated at 470 (range 26-217). ?

See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, a single test like slightly elevated IgM is not meaningful. Lupus is a complicated illness and the individual needs to be treated, not a lab test result. Wish you good health. ...Read more

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Lupus patient- last round of tests show abnormally high bilirubin levels and abnormally low AST and ALT. What would cause this and what would it mean?

Obstructive jaundice: You may have a "blockage" of your liver ducts due to your Lupus or one of the medication you are taking! This needs further study ASAP A Rheumatologist should be consulted Good Luck Hope this helps Dr Z ...Read more

Sgpt (Definition)

Liver enzyme that has a metabolic function, its elevated when ...Read more