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Doctor insights on: Lupus And Adrenal Function

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Kidney function and testosterone?

Kidney function and testosterone?

Clarify: I'm not sure what your question is. Testosterone should be used with caution in patients with conditions involving edema, such as impaired kidney function, as the hormone may worsen edema. One of the adverse effects of testosterone is an increase in serum creatinine concentration. ...Read more

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How does continuous anxiety affect a person with primary addison's disease and zero adrenal function?

How does continuous anxiety affect a person with primary addison's disease and zero adrenal function?

Worry: Anyone with generalized anxiety is likely to have a heightened sense of apprehension and worry (even to the point of paranoia), which is likely to become more apparent when faced with a medical problem. Simply getting a new medical diagnosis will probably worsen the anxiety. There is no direct connection between addison's disease and anxiety. ...Read more

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Can adrenal hypo function affect the heart rate?

Can adrenal hypo function affect the heart rate?

Yes: Symptoms of adrenal insufficiency include hypoglycemia, dehydration, weight loss, and disorientation. Symptoms may also include weakness, tiredness, dizziness, low blood pressure that falls further when standing (orthostatic hypotension), cardiovascular collapse (failure), muscle aches, nausea, vomiting, diarrhea, etc... Heart rate can increase if there is dehydration or low blood pressure. ...Read more

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For patients with partial adrenal insufficiency, does hydrocortisone replacement of 20-30 mg daily cause iatrogenic cushings given that the pituitary and adrenals still function to some degree?

For patients with partial adrenal insufficiency, does hydrocortisone replacement of 20-30 mg daily cause iatrogenic cushings given that the pituitary and adrenals still function to some degree?

Depends: It really depeds what you mean by cushings. You may get some of the characteristics..Weight gain, immune dysfunction, but the classic physical signs are likely absent. The dose of 20-30 mg of hc is actually a bit above the "physiologic " dose of hc that would be similar to what the adrenals normally produce. As a result, the pituitary/adrenal are essentially shut down. ...Read more

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Is central diabetes insipidus related to adrenal insuffiency? Im having an ACTH test to check adrenal function.

Is central diabetes insipidus related to adrenal insuffiency? Im having an ACTH test to check adrenal function.

Can be: Hi. If you have Addison's (skin, crease, gum, and scar darkening, malaise, nausea, dizziness, vital signs abnormalities, electrolyte abnormalities, etc), your ACTH will be very high. Addison's is most commonly an autoimmune disease. At least a subset of idiopathic central DI appears to be autoimmune in nature, and the risk of that goes up with other autoimmune diseases. If real, you got 2 rare 1's ...Read more

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Has anyone seen a patient with adrenal insufficiency, intermittent ovarian failure, intermittent glucose intolerance, and thyroid values in normal range? Perhaps also with a pituitary tumor?

Pituitary tumors: You need an endocrinologist to sort this out. A big pituitary tumor (>10 mm) can wipe out other hormones; you could lose some (eg reproductive) but not others. Typically the last to go from a pituitary insult is TSH and acth (thyroid and adrenal), but odd things can occur. A micro tumor does not usually damage the rest of the pituitary, but may produce excess hormone (eg. Prolactin, acth). ...Read more

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Renal disease and anemia affects what other organs?

Renal disease and anemia affects what other organs?

Renal disease: It depends on what type of kidney disease. ...Read more

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Can a positive ANA mean adrenal glands are damaged or addison's disease ?

Can a positive ANA mean adrenal glands are damaged or addison's disease ?

Usually not: Most low-titer-positive ana's mean nothing, and no lab means anything except in conjunction with a real human being. Having said this, i'm glad you're thinking of addison's -- lab diagnosis is reasonably easy. ...Read more

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Can you have both underlying adrenal insufficiency and thyroid disease, while treated with levoxyl (thyroxine)?

Can you have both underlying adrenal insufficiency and thyroid disease, while treated with levoxyl (thyroxine)?

Yes you can: And it will fall under the condition called autoimmune polyglandular syndrome type 2 (aps 2), also called schmidt disease. Risk of autoimmune diabetes is also higher in type 2 ( versus type 1, much rarer here in the us). ...Read more

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In context of cryofibrinogenemia, lupus-type ctd and adrenal insufficiency, what could cause increase in GI symptoms, nausea, and vomiting with adrenal crisis, when estrogen/progestin drugs are taken?

In context of cryofibrinogenemia, lupus-type ctd and adrenal insufficiency, what could cause increase in GI symptoms, nausea, and vomiting with adrenal crisis, when estrogen/progestin drugs are taken?

Cortisol deficiency : With true adrenal insufficiency diagnosed by an endocrinologist, one would need to be taking cortisol replacement therapy. Nausea, abdominal pain, vomiting and weight loss are classic symptoms of adrenal insufficiency which estrogen and Progesterone replacement don't address. Many with primary adrenal insufficiency also look like they have a deep tan. ...Read more

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Ana 160:1 with u1rnp 5 u/ml. Other lupus screens negative. Pulmonary hypertension, Renal failure reverses with bicarbonate (sodium bicarbonate). Can it be mtcd/sjogren?

Ana 160:1 with u1rnp 5 u/ml. Other lupus screens negative. Pulmonary hypertension, Renal failure reverses with bicarbonate (sodium bicarbonate).  Can it be mtcd/sjogren?

Unlikely: None of these would be typical presentations of either MCTD or Sjogren's syndrome. You need a good internist or rheumatologist on your care team to help winnow the possibilities and care for your extant medical problem. Best wishes. ...Read more

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What hormone imbalances can cause excessive face/head sweating? I have underactive thyroid, kidney disease, & low cortisol levels. Can these diseases?

What hormone imbalances can cause excessive face/head sweating? I have underactive thyroid, kidney disease, & low cortisol levels. Can these diseases?

Any of them: Sweating from overactie thyroid. It could also be from hormonal changes with estrogen or testosterone, and with kidney disease you could have an imbalance of those. ...Read more

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Does adrenal fatigue interact directly with your thyroid?

Does adrenal fatigue interact directly with your thyroid?

Maybe: "adrenal fatigue" is not a specific medical diagnosis. Hypothyroidism can indeed produce fatigue, weight gain, etc. See a good medical doctor for a thorough workup and treatment plan. ...Read more

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Serum cortisol 145 ng/ml and acth plasma 25.00. I'm showing strong symptoms of adrenal insufficiency mainly skin bronzing. What domy results indicate?

Serum cortisol 145 ng/ml and acth plasma 25.00. I'm showing strong symptoms of adrenal insufficiency mainly skin bronzing. What domy results indicate?

Units of measure: Cortisol level is completely normal for a random morning sample and not suggestive of adrenal insufficiency. Acth units of measure are missing. Is this pmol/l or pg/ml? Even in extremely rare cases of acth resistance, nearly all patients are cortisol deficient. But your cortisol result is fine for morning random. Other things can cause bronzing like certain medication and hemochromatosis. ...Read more