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Doctor insights on: Lupus Ana Test

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Dr. Pierre Moeser Dr. Moeser
Internal Medicine - Rheumatology
years in practice
1

1
I have been diagnosed with fibromyalgia, but have a lot of lupus symptoms. My ANA test came back as "indeterminate". What does this mean?

I have been diagnosed with fibromyalgia, but have a lot of lupus symptoms. My ANA test came back as "indeterminate". What does this mean?

Better test: Still the better test to determine the difference between lupus and fibromyalgia (fms) is a history and physical exam done by a rheumatologist. Lupus and fms have some similar symptoms but are very different. Lupus - autoimmune disease. Fms - not autoimmune. The ANA is not the deciding factor between the two. The ANA never makes a definite diagnosis. Other blood tests (by rheumatologist) can help. ...Read more

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Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more


Dr. Ronald Krauser Dr. Krauser
Internal Medicine - Rheumatology
48 years in practice
Wake Forest University School of Medicine
2

2
Can you have symptoms of lupus years before the ANA test positive?

Can you have symptoms of lupus years before the ANA test positive?

No: If the ANA and other autoantibodies are negative, it is very unlikely that you have lupus. ...Read more

Dr. John Feola Dr. Feola
Internal Medicine
27 years in practice
Georgetown University School of Medicine
3

3
I have pos ANA and all other lupus test normal but have symptoms of lupus can you have lupus with only pos ANA test and other lupus test negative?

LUPUS: A low positive ANA alone may be non diagnostic. If all other labs are normal, it can be repeated in a 2-3 mth window. Lupus also has a list of criteria that needs to be met to fulfill the diagnosis. Follow up with your doctor and if still concerned see a rheumatologist. ...Read more

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Dr. Benson Yu Dr. Yu
Internal Medicine
27 years in practice
Georgetown University School of Medicine
4

4
Can you have lupus with a negative ANA test? What about other autoimmune disorders?

Can you have lupus with a negative ANA test? What about other autoimmune disorders?

ANA testing: ANA is a screening test for autoimmune disease, (generally present in 80-90% of cases). A higher titer over 1:160 is more significant. There are more definite testing for lupus such as anti-smith antibody and anti ds dna antbody. There are many more other specific testing for other specific autoimmune disorders. Syphilis and lyme disease can give false positive ANA test as well. See your md. ...Read more

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Dr. Liawaty Ho Dr. Ho
Internal Medicine - Hematology & Oncology
19 years in practice
Udayana University Faculty of Medicine
5

5
Unexplained high platelets (572), WBC (17.2), leukocytes, neutrophils, low hemaglobin. Bone marrow, jak2 and lupus test negative, ANA positive. Help?!

Reactive/ autoimmune: Discuss further with your hematologist. Certain conditions like iron deficiency , infection /inflammation vs autoimmune vs. Other solid tumor need to be ruled out. Need to check iron level, bcr/abl, imaging study like ct scan chest /abd/ pelvis will be needed. If you smoke - will suggest you to quit smoking., need to do work - up to find the anemia as well. If iron is low - GI w/u is needed. ...Read more

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Dr. Atul Singh Dr. Singh
Internal Medicine - Nephrology & Dialysis
24 years in practice
Gujarat University, B. J. Medical College
6

6
I have fibromyalgia. I have many symptoms of autoimmune diseases.Lupus & RA test normal.ANA & CRP test are positive and elevated.What does this mean?

Exam: You should see a rheumatologist to undergo a full history and exam. No single test can diagnose a rheumatological disease. ANA alone is not indicative of sle. The titer and type is imp. High CRP again in a non specific sign of inflammation. So should see a rheumatologist and have this a exam. ...Read more

Dr. Al Hegab Dr. Hegab
Internal Medicine - Allergy & Immunology
36 years in practice
Ain Shams University Faculty of Medicine
7
Dr. EVAN Leibowitz Dr. Leibowitz
Internal Medicine - Rheumatology
21 years in practice
University of Sheffield Medical School, Faculty of Medicine and Dentistry
8

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Will mild lupus show up on a ANA test?

It depends: Lupus has many different symptoms. There are varieties of lupus limited to the skin. In these types, the ANA can be negative. However there are more severe forms of lupus, that can effect almost any part of the body. Commonly effected organs include the joints, kidneys, lungs, brain, and blood vessels. In these forms of lupus, the ANA test is almost always positive ...Read more

Dr. Nayla Mumneh Dr. Mumneh
Internal Medicine - Allergy & Immunology
25 years in practice
State University of New York Downstate Medical Center College of Medicine
9

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Can ANA test be false negative for lupus?

Lupus: Has specific criteria for diagnosis, ANA is just one of them and canot be relied on by itself for a diagnosis. ...Read more

Dr. Ronald Krauser Dr. Krauser
Internal Medicine - Rheumatology
48 years in practice
Wake Forest University School of Medicine
10

10
Will my ANA test positive if my lupus is mild?

Yes: The degree of ANA positivity does not correlate with disease activity. ...Read more

Dr. Gurmukh Singh Dr. Singh
Pathology
45 years in practice
University of Pune, Armed Forces Medical College
11

11
Could a person with 2 different negative ANA tests have lupus?

Yes, but ANA: negative lupus is uncommon. ANA is one of the criteria for diagnosing lupus, but a negative ANA does not rule out lupus. See this site for more info. http://www.webmd.com/lupus/guide/laboratory-tests-used-diagnose-evaluate-sle ...Read more

Dr. Ronald Krauser Dr. Krauser
Internal Medicine - Rheumatology
48 years in practice
Wake Forest University School of Medicine
12

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Is lupus possible with a negative ANA? DR GAVE ME "working" dx due to other neg tests and sx

Yes: There is such a thing as ANA negative lupus. The ANA is nehative in 5-10% of lupus patients. ...Read more

Dr. Al Hegab Dr. Hegab
Internal Medicine - Allergy & Immunology
36 years in practice
Ain Shams University Faculty of Medicine
13

13
Is it the ANA test that can definitely or almost always tell a dr whether or not u have lupus?

ANA: positive ANA test indicates that there would a connective tissue disease, which needs confirmation by other tests and/or clinically, lupus is one sort of connective tissue disease, ANA is a good screening test 95 - 100% of the time, i.e. Has good sensitivity, meaning it is a good way to rule out connective tissue disease, but not to confirm it, hope that answers your question ...Read more

Dr. Nela Cordero Dr. Cordero
Pediatrics
50 years in practice
University of Santo Tomas Faculty of Medicine and Surgery
14

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I have classic lupus symptoms, worse over time. I had a + ANA test last year. It's normal this year. Could I still have lupus? What else mimics lupus?

LUPUS: It is very important to find out what kind of lupus you have. Is it discoid or systemic? Your lab should be positive to lupus test not only ana. The worse one is when it affects your kidney. Please see your md for advice. ...Read more

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Dr. Ronald Krauser Dr. Krauser
Internal Medicine - Rheumatology
48 years in practice
Wake Forest University School of Medicine
15

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What tests can be done besides ANA to diagnose lupus at a very early stage?

See details: The diagnosis depends on a history and physical exam consistent with the diagnosis of lupus. If the ANA is negative the diagnosis becomes unlikely. One can check other antibodies including DNA, ENA, SSA and SSB. ...Read more

Dr. Bruce Rothschild Dr. Rothschild
Internal Medicine - Rheumatology
37 years in practice
University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School
16
Dr. Gurmukh Singh Dr. Singh
Pathology
45 years in practice
University of Pune, Armed Forces Medical College
17

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Ana test results question - how many people have ANA positive but don't ever get lupus?

Age and gender: Positive ANA test is commoner in older people and women. Up to 25% of the people may have positive ANA test at some time or the other. Only 0.1-0.15% of the population has systemic lupus. ...Read more

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Dr. Ronald Krauser Dr. Krauser
Internal Medicine - Rheumatology
48 years in practice
Wake Forest University School of Medicine
18

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I have +ve ANA 1/320 and borderline antidsdna. My other tests are -ve and i feel fine. My cousin has lupus.How can I prevent it from happening to me?

You can't: The ANA has no clinical significance unless the clinical picture is consistent with lupus. The presence of the ANA does not increase your risk of developing lupus in the future. A borderline dna also means nothing. ...Read more

Dr. EVAN Leibowitz Dr. Leibowitz
Internal Medicine - Rheumatology
21 years in practice
University of Sheffield Medical School, Faculty of Medicine and Dentistry
19

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How many times does the ANA test is positive in a lupus patient? How long does it stay positive? And does the test needs to be repeated over the years

Positive ANA test: The ANA once positive, usually stays positive for life. The ANA can be helpful to diagnose an autoimmune disease like lupus. Once lupus is diagnosed, however, there is no need to repeat the test. ...Read more

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Dr. Ronald Krauser Dr. Krauser
Internal Medicine - Rheumatology
48 years in practice
Wake Forest University School of Medicine
20

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I have had multiple positive ANA and they do the next step tests to check for lupus and it comes back negative. Why do they keep checking my ana?

I don't know: Imo, there is no need to constantly repeat an ana. It is a waste of time and money. Positive is positive and constantly repeating it will not change that. ...Read more