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Doctor insights on: Lupus Ana Negative

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Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more


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Is it possible for a person to be diagnosed with lupus if they are ANA negative?

Rare: Ana's are sometimes done wrong even by good, big labs. If you are speaking of systemic lupus and the person has the classic clinical picture, then i would question the reliability of the lab's ANA and try a different lab or proceed as if lupus was indeed present. ...Read more

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Please I need help. I have most symptoms of lupus but negative ANA so no one wants to help me. Life is going down fast. Almost always bed fast. ?

Please I need help. I have most symptoms of lupus but negative ANA so no one wants to help me. Life is going down fast. Almost always bed fast. ?

See details: Have you seen a rhematologist? If not, do so. If you have, get a second rheumatology opinion. If the doc has ruled out lupus ask for your diagnosis and treatment options. ...Read more

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Unexplained high platelets (572), WBC (17.2), leukocytes, neutrophils, low hemaglobin. Bone marrow, jak2 and lupus test negative, ANA positive. Help?!

Unexplained high platelets (572), WBC (17.2), leukocytes, neutrophils, low hemaglobin. Bone marrow, jak2 and lupus test negative, ANA positive. Help?!

Reactive/ autoimmune: Discuss further with your hematologist. Certain conditions like iron deficiency , infection /inflammation vs autoimmune vs. Other solid tumor need to be ruled out. Need to check iron level, bcr/abl, imaging study like ct scan chest /abd/ pelvis will be needed. If you smoke - will suggest you to quit smoking., need to do work - up to find the anemia as well. If iron is low - GI w/u is needed. ...Read more

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I had 3 dr say a red inflaimed lump on face look like lupus. Ana came back negative i'm tired joint muscle pain depressed get mood swings it comes goe?

I had 3 dr say a red inflaimed lump on face look like lupus. Ana came back negative i'm tired joint muscle pain depressed get mood swings it comes goe?

See specialists: See rheumatologist for lupus. Do you have butterfly like redness across nose n eyes? See dermatologist because a bad skin infection on your face can give you some of those symptoms. ...Read more

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Why do u think my md still suspects sjogrens vs lupus(ana 1:640, negative lip biopsy, raynauds, fatigue, photosens, rashes, jt/muscle pain, sicca ?

Why do u think my  md still suspects sjogrens vs lupus(ana 1:640, negative lip biopsy, raynauds, fatigue, photosens, rashes, jt/muscle pain, sicca ?

Undifferentiated CTD: Clinical presenation can be classified as an undifferentiated connective tissue disease (uctd). Likely not primary sjogren's since lip biopsy (usually gold standard for diagnosis of sjogren's) was negative. Would recommend additional evaluation including specific antibodies such as dsdna and ena. Also would recommend rheumatology consult. ...Read more

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I have 10 out of 12 symptoms of lupus but a negative ana. Can my ANA be negative one time and positive another?

ANA negative SLE: About 5% of the patients with systemic lupus are ANA negative. Read the information at the site given below. Please discuss the issue with your doctor sle is not a topic for self diagnosis. http://www.lupus.org/webmodules/webarticlesnet/templates/new_aboutfaq.aspx?articleid=380&zoneid=19. ...Read more

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Can you have lupus with a negative ANA test? What about other autoimmune disorders?

ANA testing: ANA is a screening test for autoimmune disease, (generally present in 80-90% of cases). A higher titer over 1:160 is more significant. There are more definite testing for lupus such as anti-smith antibody and anti ds dna antbody. There are many more other specific testing for other specific autoimmune disorders. Syphilis and lyme disease can give false positive ANA test as well. See your md. ...Read more

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