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Doctor insights on: Lung Paraneoplastic Syndromes Rash

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Lung (Definition)

Deoxygenated blood enters the lungs from the right side of the heart and travels to the lungs. When you inspire, oxygen flows into the lungs, transverses the capilliares and attaches to hemoglobin down a gradient. At the same time, co2 diffuses into the capilaries and is expelled with exhalation. Oxygen rich blood then flows to the left side of the heart and into the ...Read more


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Is there research into any genetic, autoimmune or other condition that links nerve sheath disorders (tarlov cysts, nerve sheath tumor) with autoimmune hypophysitis targeting acth cells? Ctla-4 gene?

Is there research into any genetic, autoimmune or other condition that links nerve sheath disorders (tarlov cysts, nerve sheath tumor) with autoimmune hypophysitis targeting acth cells? Ctla-4 gene?

None that I find: I cannot locate any literature on the two conditions being studied simultaneously. Perhaps one of my more research savvy colleagues here will come up with something . Great question by the way. ...Read more

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What type if cancer related to paraneoplastic neurology syndrome?

What type if cancer related to paraneoplastic neurology syndrome?

More info needed: There are about 8 or 9 different paraneoplastic syndromes with neurological symptoms ranging from encephalitis to opsoclonus to myoclonus, to ataxia to neuropathy. You need to narrow things down to generate a list of cancers that may cause the symptoms. ...Read more

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A friend had chronic demyelinating polyneuropathy (cidp), then got chronic lymphocytic leukemia 2 years later. Is cidp paraneoplastic syndrome sometimes?

A friend had chronic demyelinating polyneuropathy (cidp), then got chronic lymphocytic leukemia 2 years later. Is cidp paraneoplastic syndrome sometimes?

Not likely: Chronic inflammatory demyelinating polyradiculopathy (cidp) is almost always an autoimmune condition incited by some antecedent infection--c. Jejuni, ebv, cmv, or another infection. Antibodies produced against the virus/ bacteria/ pathogen cross-react with the myelin sheath on the nerve roots, first causing guillain-barre (aidp), then later cidp. It's exceedingly rare that cancer could cause this. ...Read more

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Does paraneoplastic neurological syndrome cause tachycardia?

Does paraneoplastic neurological syndrome cause tachycardia?

Well it can. : paraneoplastic syndromes of the nervous system usually can have varying symptoms of all kinds depending on the body part being injured. one of the things that can be injured is known as Dysautonomia. This means injury to the body functions that are involuntary that includes heart rate. ...Read more

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Which percentage of diagnosed lupus cases are sle, systemic lupus erythmatosus?

Which percentage of  diagnosed lupus cases are sle, systemic lupus erythmatosus?

Lupus: Lupus comes in 4 major types: systemic, discoid (skin only), neonatal, and drug-induced. Some people who have an abnormality in their immune system and fail to make a body defense protein called complement are also at risk for developing lupus. It has been estimated that 1.5 million people in the US have one of these lupus forms. Women are 2-3 times more likely to develop this disease than men. ...Read more

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How is mast cell activation syndrome diagnostically differentiated from carcinoid syndrome?

How is mast cell activation syndrome diagnostically differentiated from carcinoid syndrome?

Totally different: The chemical mediators for these two conditions are totally different even though both can cause flushing. MCAS can be diagnosed by a blood test, carcinoid usually a urine test. ...Read more

Dr. Liawaty Ho Dr. Ho
3 doctors agreed:
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Severe HPV (plantars), sarcoidosis w/ atypical lung nodules 8mm with suv of 10.9 what are chances of cancer? No lung bx done other site pos for sarc

Dr. Liawaty Ho Dr. Ho
3 doctors agreed:
Severe HPV (plantars), sarcoidosis w/ atypical lung nodules 8mm with suv of 10.9 what are chances of cancer? No lung bx done other site pos for sarc

Hard to say: Do you have significant risk for lung cancer? Are you a smoker? If yes, you need to stop smoking . The lung nodule is likely sarcoidosis of the lung although if you are also a heavy smoker, lung cancer is possible. I will suggest you to have a follow up ct scan to ensure stability if it is rapidly growing, while your sarcoidosis is quite without symptom perhaps biopsy can be considered then. ...Read more

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What kind of test can diagnose Peripheral neuropathy- Paraneoplastic syndromes of the nervous system?

What kind of test can diagnose Peripheral neuropathy- Paraneoplastic syndromes of the nervous system?

Physical & labs: If physical exam suggests peripheral neuropathy, the workup will include assays for a few of the paraneoplastic autoantibodies known to cause it, and a diligent search for an underlying cancer should be undertaken. This is a difficult workup for physician and patient alike, and I wish you luck. Stay proactive. ...Read more

Dr. Alfred Kim Dr. Kim
2 doctors agreed:
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What gene causes lupus erythematosus?

Dr. Alfred Kim Dr. Kim
2 doctors agreed:
What gene causes lupus erythematosus?

Many genes: The previous answer is right with several genes associated with lupus, but no one knows how those genes cause disease. I think it's important to remember that there is likely many ways to develop lupus symptoms, and this will vary between people. So some of these known genes will be important for some, and not important for others. As we sequence more patients, we'll have more answers. ...Read more

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Multilobulated pulmonary mass w/calcifications in left upper lobe. Neoplastic disease vs inflammatory/infectious process. rule out metastatic disease ?

Multilobulated pulmonary mass w/calcifications in left upper lobe. Neoplastic disease vs inflammatory/infectious process. rule out metastatic disease ?

In general...: IN GENERAL, a multilobulated mass is more likely malignant, one with calcifications is less likely. As in much else, size matters, with bigger being more worrisome. If you're smoker, more likely malignant, if from place of endemic TB or histoplasmosis, risk of chronic infection rises. You'll need to be evaluated by a pulmonologist, who will very likely recommend biopsy. ...Read more

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Does having 1 autoimmune disorder predispose u2 others? Mom with hoshimoto's>psoriatic arthritis>viral hepatitis>acute myeloid leukemia.

Does having 1 autoimmune disorder predispose u2 others? Mom with hoshimoto's>psoriatic arthritis>viral hepatitis>acute myeloid leukemia.

Yes: The presence of an autoimmune disorder points to dysregulation of the immune system and thus one is far more likely to have other autoimmune diseases . However, it is not directly linked to viral hepatitis or AML. ...Read more

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What neurological symptoms are associated with paraneoplastic syndrome?

What neurological symptoms are associated with paraneoplastic syndrome?

Many: Neurologic paraneoplastic syndromes are caused by an abnormal immune response to the tumor, which makes the body accidentally attack its own nervous tissue. Muscle weakness, stiff limbs, dizziness, coordination problems, vision problems, confusion, difficulty swallowing, memory problems and numbness are some of the many possible symptoms. ...Read more

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What type of exam can diagnose Paraneoplastic Neurological Syndromes?

What type of exam can diagnose Paraneoplastic Neurological Syndromes?

Depends on type: There r many paraneoplastic neurologic syndromes, each associated with specific types of cancers. Thus, there's no generic answer to ur question. Paraneoplastic lymphomas, 4 instance, can produce specific antibodies which can b detected by blood tests or lumbar puncture, depending. The best "test"? A thorough history & physical by some1 knowledgeable (oncologist, neurologist) who can guide u more ...Read more

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Can small cell lung cancer cause malabsorption through zolinger Ellison syndrome. Would this be a presenting sign of sclc before it shows on ct scan?

Can small cell lung cancer cause malabsorption through zolinger Ellison syndrome. Would this be a presenting sign of sclc before it shows on ct scan?

Uncommon: Most Zollinger-Ellison / gastrinoma are from islet cell tumors of the foregut. Oat cell carcinoma can produce other paraneoplastic syndromes, famously the anti-nerve cell ones, before being visible on chest ray, but it announces itself fast enough. And what are you going to without a localized tumor? Take out both lungs? Look for some other cause for any suggestive symptoms. Good question Gill. ...Read more

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Ana positive strong family history of lupus. Lupus symptoms. Could it be sarcoidosis instead of lupus.

Maybe: ANA positive diseases are related. Diagnosis is based not just on serologic testing, but also on your clinical symptoms. You should be evaluated by a rheumatologist in order to receive an accurate diagnosis and then receive the most appropriate treatment. ...Read more

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What is the best indicator of cancer: "tumor markers" or "paraneoplastic autoantibodies"? I have signs of cancer and neurological autoimmunity.

What is the best indicator of cancer: "tumor markers" or "paraneoplastic autoantibodies"? I have signs of cancer and neurological autoimmunity.

Neither: There are only a handful of very rare circumstances where a "tumor marker" blood test can prove that someone has a cancer. This is because many tumor markers can be elevated by other causes. Paraneoplastic autoantibodies do not diagnose cancer but are called that when a patient with a known cancer has autoantibodies without another known cause. ...Read more

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Dr. Lois Freisleben-Cook
29 doctors shared insights

Paraneoplastic Syndromes (Definition)

Paraneoplastic syndrome refers to a remote effect of a malignancy. It is a problem not caused by invasion of a body part by cancer, but instead a dysfunction occuring because of the cancer. Examples in nerve and muscle problems, abnormal blood clotting, ...Read more


Dr. John Chiu
2,697 doctors shared insights

Rash (Definition)

A skin rash is a symptom in which a person has changes on part or all of his skin, such as color changes, bumps, blisters, oozing, peeling, ...Read more