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Doctor insights on: Low Lipase

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What causes low lipase?

What causes low lipase?

No disease: Low lipase is not a pathologic state. You did not state the actual level and the normal ranges that the lab would have reported. ...Read more

Dr. Todd Igel
347 doctors shared insights

Lipase (Definition)

Lipases, such as lipoprotein lipase and endothelial lipase, are enzymes that breakdown circulating triglycerides (tg). Specifically, lipases degrade tg rich lipoproteins including chylomicrons, very low density lipoprotein (vldl) and remnant particles produced by breakdown of chylomicron and vldl particles. Decreased lipase function leads to accumulation of ...Read more


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What are the signs and symptoms of pancreatitis? Is flattulance one of them? Is low lipase levels one?

Yes: Pancreatitis can be acute and chronic. Acute pancreatitis is life threatening, its major symptom is abdominal pain and will typically present with a very high lipase. Chronic pancreatitis will present with bouts of recurrent abdominal pain and may associate flatulence. Pancreatic insufficiency, specifically lipase, may cause flatulence also. Dietary changes along with enzyme replacement may help. ...Read more

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I have an increasing ca 19 9 but low lipase and amylase levels. Could this indicate PC?

I have an increasing ca 19 9 but low lipase and amylase levels. Could this indicate PC?

CA 19-9: This is a tumor marker that is often used in the setting of symptoms pointing to pancreatic cancer to differentiate this from pancreatitis. If elevated, it can be useful in following response to treatment. But there are much better tests now such as pancreas protocol CT, or EUS- FNA. No one would treat for cancer based on the findings you describe, but it should lead to more investigation. ...Read more

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What causes low lipase levels on blood test? Lipase 7 IU/L (range is 15-60) Amylase 38 IU/L (range is 28-100) Would this cause symptoms?

What causes low lipase levels on blood test?
Lipase 7 IU/L (range is 15-60)
Amylase 38 IU/L (range is 28-100)

Would this cause symptoms?

Means nothing: Reference ranges are set so that several percent of healthies fall outside on either end. Unless you're obviously sick with bad maldigestion, I would make nothing of this ...Read more

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Discomfort on the up abdomen rad to the back, but showed high total bilirubin (1.5 mg/dL); low amylase (24 U/L), and low lipase (12 U/L).  What is it?

Discomfort on the up abdomen rad to the back, but showed high total bilirubin (1.5 mg/dL); low amylase (24 U/L), and low lipase (12 U/L).  What is it?

Many Possibilities: There are many unanswered questions, ei: characteristic of pain, relieving factors, precipitating factors and duration of pain to name a few. Having said this, the slightly elevated total bilirubin might suggest a gallbladder issue, ei:biliary colic from gallstones. See you primary doctor and answer the above questions, this will guide appropriate work up and treatment. ...Read more

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35/F - intermittent LUQ pain 2wks, fatigue. Amylase norm, Low: Lipase Stool dark/small/soft. Worried about PaCancer Are these symptoms suggestive?

35/F - intermittent LUQ pain 2wks, fatigue.
Amylase norm, Low: Lipase
Stool dark/small/soft.
Worried about PaCancer

Are these symptoms suggestive?

Nonspecific : The symptoms you describe are too nonspecific. Amylase and lipase levels rarely correlate with pancreatic cancer. You're very young to have pancreatic cancer. Is there a family history or other reason you are concerned? In general, however, persistent pain warrants further investigation. ...Read more

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Luq pain, yellow soft stools, liver labs normal, low lipase, oral&iv contrast CT negative. 35/f, no alcohol, former smoker. Is this pancreas cancer?

Luq pain, yellow soft stools, liver labs normal, low lipase, oral&iv contrast CT negative. 35/f, no alcohol, former smoker. Is this pancreas cancer?

Not pancreas cancer: These symptoms are not typical of pancreas cancer, it is rare among people 35 years old, and (if present) would be detectable by abdominal CT scan. ...Read more

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Trouble digesting fat: lipase low fasting; no change after lundh meal. Lipase should peak to 5x basal level after meal; i need quantitative ref range.

Trouble digesting fat: lipase low fasting; no change after lundh meal. Lipase should peak to 5x basal level after meal; i need quantitative ref range.

Incorrect info: Lipase levels do not increase five fold after a meal. Five fold increase would be diagnostic of pancreatitis. How do you know you have trouble digesting fat? It may help to see your doctor and may request a referral to a gastroenterologist. See this site for lipase info. http://www.nlm.nih.gov/medlineplus/ency/article/003465.htm. ...Read more