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Doctor insights on: Low Dose Tricyclic Antidepressants

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What's the difference between tricyclic antidepressants and monocyclic antidepressants?

What's the difference between tricyclic antidepressants and monocyclic antidepressants?

Rings: The designation refers to the chemical structure. Monocyclic antidepressants, such as bupropion or fluvoxamine, have a molecular structure with only one ring of atoms whereas tricyclic antidepressants, such as Imipramine and desipramine, have three rings of atoms in their structure. ...Read more

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What are some tricyclic antidepressants (tcas)?

Tricyclic Antidepres: Amitriptyline, Amoxapine, Clomipramine, Desipramine, Dosulepin, Doxepin, Imipramine, Lofepramine, Maprotiline, Nortriptyline & Trimipramine are tricyclic antidepressants. ...Read more

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How do tricyclic antidepressants compare to ssri's?

How do tricyclic antidepressants compare to ssri's?

Side effects: Both classes of medications are effective in the treatment of depression. However, the tricyclic antidepressants typically have more side effects and are lethal on overdose. ...Read more

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Could a specialist please explain tricyclic antidepressants to me?

TCAs replaced : Tricyclic agents (TCAs) are used primarily as antidepressants. The TCAs were first discovered in the early 1950s and were introduced later in the decade;[ In recent times, the TCAs have been largely replaced in clinical use by the newer antidepressants which have more favorable side-effects profiles. TCAs neg. effects are-- cognitive dully, danger if overdosed, wt. gain, CVS & antichol. effects ...Read more

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What's the difference between ssri antidepressants and tricyclic antidepressants?

What's the difference between ssri antidepressants and tricyclic antidepressants?

SSRI's vs Tricyclics: The ssri's focus on blocking serotonin reuptake, and the tricyclics are non-selective in their receptor activity. Histamine blockade and others in tca's causes more sedation; there can also be postural hypotension with tca's. Ssri's may be safer in overdose, less likely to cause arrhythmia -- could be important in patients w/heart disease. Ssri's have their own side effect profile though. ...Read more

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Will tricyclic antidepressants cause man boobs?

Will  tricyclic antidepressants cause man boobs?

Rarely: There have been rare reports of gynecomastia with tcas; i can not think of a clear cut case in the patients I have treated however. ...Read more

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Why do tricyclic antidepressants prevent migraines?

Why do tricyclic antidepressants prevent migraines?

Serotonin modulation: An excellent question. Amitriptyline affects multiple neurotransmitters, and it is believed that its modulation of serotonin calms the nerves that stimulate migraines. ...Read more

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Why are tricyclic antidepressants considered unsafe?

They are not unsafe.: Tricyclic antidepressants are still used. However, they typically have a lot of uncomfortable side effects and because of this other antidepressants are preferred. ...Read more

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What are the differences between tricyclic antidepressants and snris?

Neurotransmitters: Tricyclic antidepressants are probably the most effective antidepressants we have. They affect a number of neurotransmitters and multiple circuits in the brain, alleviating depression, anxiety, migraines, and various pain syndromes. The down side to them is side effects and potential for stopping the heart in overdose. The serotonin-norepinephrine antidepressants are much safer. ...Read more

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How can ssri's, maoi's and tricyclic antidepressants differ in the way they work?

Oh my!: I don't know that this can be answered in 400 characters or less. The best way to address such a complex issue may be to google the mechanisms of action for them separately. ...Read more