Doctor insights on:
Lovastatin Causing Cytokine Storms
CytoKine storm: When our body detects foreign microorganisms indicating an infection, our body might respond by over-protecting the site of infection. The body may race so many antibodies to the infection site that they collect in a cytokine storm. When the infection is in the lungs, for example, a cytokine storm can potentially block airways and result in suffocation. Medical researchers have identified the caus. ...Read more
What mechanism that high potassium causes cardiac arrest? I just know high k+ causes hyper excitability of cells?
Cell repolarization: When cardiac muscle cells fire, they use up part of the electrochemical gradient they maintain in life. They are repolarized by an outward potassium (K+) flux across the plasma membrane. This outward K+ current depends on the K+ electrochemical gradient. If the "outside" K+ (in blood & interstitial fluid) is very high, that destroys the K+ electrochemical gradient, the cells can't repol; they stop ...Read more
Which viruses, bacteria, and/or fungi are causative factors in channelopathies [transient receptor potential (trp) channels, in particular]?
The cause if: These rare abnormalities are though to be genetic and/or autoimmune, not secondary to an infection, but you should discuss it with your diagnosing physician. ...Read more
Transient receptor potential cation (trp) channels r involved in which diseases that r associated with neuropathic pain and/or cold/heat intolerance?
Yes. Great Question!: The Amino Acid glutamate plays a central role in nitrogen metabolism & participates in multiple biochemical pathways. Disease examples: autoantibodies to the glutamate receptor kill neurons via activation of the receptor ion channel. Anti-nmda receptor encephalitis is a treatment-responsive inflammatory encephalopathic autoimmune disease associated with anti-nmda receptor antibodies. ...Read more
What are some pathogens that negatively affect transient receptor potential cation (trp) channels in regards to causing neuropathic pain?
It is not known: No pathogens were described that would affect trpa1. ...Read more
Can dehydratrion from chronic sweating causing muscle pain an stiffness........or lack of estrogen, progesterone, testosterone , cause it... . ?
Not usually: Dehydration causes dry mouth, fatigue and weakness. Your hormone problems from your chronic diseases and medications can cause muscle soreness. Low Estrogen and Testosterone can cause Tenderness of muscle. Discuss your symptoms with your doctor for a plan to stay active and comfortable. ...Read more
Which pain-causing diseases/disorders cause malfunction in transient receptor potential cation channels of subclass a type (trpa1)? Autoantibodies?
TRPA1 Gene Family: The best article i've read on this gene family is ===> http://www.Genecards.Org/cgi-bin/carddisp.Pl?Gene=trpa1. The clinical significance of mutations in this gene has been related to caffeine and nicotine sensitivity disorders, and rare environmentally-triggered pain disorders. The complete function of this gene family is not known. ...Read more
Hypoglycemia, blood : blood glucose level < 70, = medical condition requiring diagnostic evaluation for its cause. Panic attack = sudden episode of intense fear from no apparent cause that triggers at least 4 physical reactions.It can recur in Panic Disorder & other psychiatric disorders. Heat Stroke= Body temp 104 degrees or > with shock & possible organ damage/death from prolonged exposure/exertion in hot weather. ...Read more
Are mild auditory hallucinations linked to withdrawal from mood disorder medications, serotonin reuptake inhibitors in particular?
What are the dangers of inhibiting the cytokine cascade that is initiated by bartonella? Can your immune system still kill the bartonella?
Bartonella: Most people get bartonella infections when they are immunocomprised, so it really depends on the persons individual immune system. The standard is to treat with antibiotics. Do you know what illness is involved? Cat scratch fever? Bartonella can be found in fleas, ticks, biting flies, mosquitoes, lice, mites, and chiggers. ...Read more
A vaccine induced food "intolerance", whereby food now causes irrational savage rage...& the vaccine caused full-body dysesthesia & memory loss. Why?
Can hemolytic anemia cause low blood vol. Thereby causing autonomic dysfunction? Does body see hemolysis as trauma thereby triggering stress hormones?
Whoa: Hemolytic anemia won't affect blood volume but will affect oxygen carrying capacity. Further, if the cause is microangiopathy, lupus, malaria, or any of a variety of others, there may be a huge number of different problems. I'm glad you have an inquiring mind, but there's no need to invoke "stress hormones"; you'd do well to stop reading "pop" explanations if someone's actually seriously sick. ...Read more
Many: Too many to list, there are probably hundreds of mediators that are thought to play some role in septic shock, not just one. A gas called Nitric Oxide made by many different kinds of cells is important in causing the low blood pressure since it causes blood vessels to dilate, but there are multiple other substances involved. ...Read moreSee 1 more doctor answer
Could every breath of polluted air you take contribute to your dioxin body burden, causing mutagenic, carcinogenic, and neurotoxic effects?
Whoa: You're reading disinformation. Dioxins aren't even mutagens. I'm sorry you found this stuff -- which is made up by "advocates" to get political benefits -- and that it's gotten you all worried. But you can't go through life like this. Look around you. People in the developed world have never been healthier. Be grateful, and stop letting your mind be darkened in this way. ...Read more
Relationship btwn autoimmunedisorder and cytokine? As in: does having an a.D. Raise/lower the risk of cytokine storm due to infection? Anti inflam. Diet beneficial for helping either?
Cytokine storm: Cytokine storm is caused by the release of over 150 proinflammatory products including cytokines. It is uncommon in autoimmune disorders unless an infection such as sars or swine flu or severe influenza is also present. Sometimes the cause is unclear. There is no confirmation that an anti-cytokine diet is helpful under those circumstances. Gemfibrozole, ok40 igg, anti tnf agents may help experimen. ...Read moreSee 2 more doctor answers
No, but: Metromine is chlorpheniramine, a systemic antihistamine. It does not cause muscle cramps. Lovastatin, a "statin" (an hmg reductase co-enzyme inhibitor) also doesn't cause muscle cramps but can cause diffuse, flu-like, muscle aching. Lowering the dose often relieves it. A 2 week drug holiday can help determine if it's contributing to muscle pain if you're uncertain. ...Read more
Possible: Any dose of a cholesterol medication can cause muscle issues but is less common than reports in the media. Your doctor can do some lab work to make sure the medication is not causing a harmful side effect for you that would need you to stop it. Don't stop your medicine without speaking to your doctor first .There are other choices to help cholesterol if needed ...Read more
I have taken a statin for 20 years. In the last year, zocor (simvastatin) caused severe muscle cramps. Now lovastatin does too. What alternative to stations?
Statin Alternatives: This is one of the most common issues that come up in my practice. Before changing any statin drugs - it is imperative to know why you are on them. However, there are other drugs choices available - namely Zetia (ezetimibe) - and niacin. Some non-medical alternatives i often discuss with my patients are exercise as well as the use of soluble fiber such as oatmeal and Metamucil on a daily basis. ...Read moreSee 1 more doctor answer
Generally not: Mevacor (lovastatin) or Lovastatin is a very popular cholesterol lowering medication and has been around for many years. It was previously thought to increase the rate of cataract formation but studies in the early 90s essentially disproved this. In large studies, approximately 1% of patients note blurry vision, but it's not clear whether this is related to use of Mevacor (lovastatin) or some other unrelated cause. ...Read more
Yes: Any drug in this class "statins", used for high cholesterol, can have side effects. Even a usual dose can cause liver inflammation, muscle inflammation and muscle weakness. In general, these are safe and effective drugs- on the market for a long time. Monitoring by your doctor is important for both safety and efficacy. ...Read more
MANY....: Statin drugs such as Mevacor (lovastatin) are way overprescribed &cause muscle weakness, cramps, and weakness, but also cause joint pain, mental slowing, depression, aggressive behavior, and are now implicated in causing cancers, alzheimers, parkinsons disease. Be sure you are taking coq10 100-200mg a day while on a med like this. Read "the great cholesterol con". Huge controversy that most don't know about. ...Read more
Mevacor (lovastatin): See: http://www.drugs.com/sfx/mevacor-side-effects.htmlGet a more detailed answer ›
Mevacor (lovastatin): Hypersensitivity to any component of med. Active liver disease or unexplained persistent elevations of serum transaminases . Concomitant administration with strong CYP3A4 inhibitors (e.g., itraconazole, ketoconazole, posaconazole, voriconazole, HIV protease inhibitors, boceprevir, telaprevir, erythromycin, clarithromycin, telithromycin, nefazodone, and cobicistat-containing products. See: ...Read more