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Doctor insights on: Long Term Effects Zoloft

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Dr. Heidi Fowler
1,074 doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


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Are there any long term side effects for zoloft (sertraline)? Like months after taking it?

Are there any long term side effects for zoloft (sertraline)? Like months after taking it?

Yes, but...: Two common longer term side effects are: 1) sexual [difficulty having an orgasm, reduced sex drive, difficulty having an erection] and 2) weight gain [although weight gain on zoloft (sertraline) is less than another similar antidepressant like paroxetine]. All this being said, there are approaches to minimize side effects that you should speak with your doctor about. Hope this answer helps. ...Read more

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What are the short term and long term effects of consuming alcohol while on 200mg of Zoloft (sertraline)? Is 4 to 5 drinks only once in awhile okay?

What are the short term and long term effects of consuming alcohol while on 200mg of Zoloft (sertraline)? Is 4 to 5 drinks only once in awhile okay?

Not ok.: Zoloft (sertraline) and alcohol should not be mixed per the drug manufacturer. Zoloft (sertraline) may enhance the effect of alcohol. The combination may impact both motor skills and depressive symptoms. Drinking four to five drinks in a sitting is not considered moderation. ...Read more

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What is the max amt of time one should take Zoloft and buspar (buspirone)?What are the long term effects of taking these.

What is the max amt of time one should take Zoloft and buspar (buspirone)?What are the long term effects of taking these.

As long as necessary: In conjunction with the prescribing physician you should take these medications as long as is necessary to successful treat the condition for which they are prescribed. There are no significant long term adverse effects. ...Read more

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What are the long term effects on the body of Zoloft & Xanax (alprazolam) use for my anxiety & panic disorder?

What are the long term effects on the body of Zoloft & Xanax (alprazolam) use for my anxiety & panic disorder?

Depedence: Xanax (alprazolam) is a benzodiazepine and can causr dependece and withdrawel if stopped suddenly zoloft make cause liver and other problems depending on dose and time. ...Read more

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I've been taking Adderall for 10 years (30 mg 2xday). What are the long-term effects of central nervous system stimulants?#nqlu i'm 57 & in addition to adderall, take Zoloft (50 mg), Armour Thyroid (90 mg), bystolic (10 mg), and tamoxifen (20 mg).

I've been taking Adderall for 10 years (30 mg 2xday). What are the long-term effects of central nervous system stimulants?#nqlu i'm 57 & in addition to adderall, take Zoloft (50 mg), Armour Thyroid (90 mg), bystolic (10 mg), and tamoxifen (20 mg).

Usually not many: Some doctors recommend having "holidays" from stimulants, for times when not having the best concentration and focus might not matter as much - like weekends, vacations etc. There is little or no evidence that long-term medicinal stimulants taken as prescribed cause any significant damage to the cns, although sleep disturbance/anxiety and hopelessness (depression) may be related. Talk to your doc. ...Read more

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Where can I find the long term effects of sertraline drug esp in patients that have been taking it since teens (long meaning >7yr)?

Where can I find the long term effects of sertraline drug esp in patients that have been taking it since teens (long meaning >7yr)?

Nat Library of Med: Doing a literature search in the national library of medicine shows the adverse events reported with sertraline were most likely to occur early in the course of treatment and there was no evidence of any increase in events in the elderly or with longer-term treatment. Sertraline was not associated with excess of death from any cause, suicides, suicide attempts or serious life-threatening events. ...Read more

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I'm currently taking 300 mg of Zoloft (sertraline) and my dr. may move up to 400. Are there long term side effects for these doses?

Psychiatrist: This dose is a high dose and you should be under the supervision of a psychiatrist who has experience with this medication and who will follow you closely and monitor its effects and will be able to detect any adverse effects or intolerance on your part. Definite symptoms and syndromes are at times noted with this medication. ...Read more

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How does increased ambient heat affect side effects of long term psychotropic drugs like zoloft (sertraline)?

Doesn't matter: Long term use of medications shouldn't be affected by ambient temperature unless you're referring to its storage in which case usually cool dark cabinet should be fine. Ambient temperature is more a matter of comfort. What's warm for you might be cool for someone else. But temperature shouldn't affect effectiveness nor side effect profile of medications. ...Read more

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What are the consequences in the short & long term..... If i used "zoloft 50mg" for 1 month for my anxiety and then i decided to give up ?

What are the consequences in the short & long term..... If i used "zoloft 50mg" for 1 month for my anxiety and then i decided to give up ?

Zoloft (sertraline) consequences: There are no direct consequences from having taken zoloft (sertraline) for one month. However, what concerns me is that i believe that would be a mistake to not try either a different medication or getting into psychotherapy, yoga, acupuncture, meditation, neural feedback, or any of the other modalities that are capable of treating anxiety. Chronic anxiety is a miserable experience. Take it from one who's been there. ...Read more

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Will I get the same calming effect from Zoloft (sertraline) as I do from Valium but it will take a few weeks to work ? GP doesn't want me on Valium long term.

Can't predict: Sertraline is a 1st-generation SSRI like Prozac (fluoxetine). Diazepam is a benzodiazepine - chemically very different. BZDs cause psychological not physical dependence meaning that abruptly stopping (not recommended) won't kill you, you'll only wish you were dead. Temporarily, of course. Only way to know is to try it. Your brain doesn't run Windows 8.1; no predicting. ...Read more

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Is it ok to be on Zoloft (sertraline) long term? Been on for 11 months, its helped me. ButHow likely is it to get a permanant sexual disorder after discontinuing?

Is it ok to be on Zoloft (sertraline) long term? Been on for 11 months, its helped me. ButHow likely is it to get a permanant sexual disorder after discontinuing?

Zoloft (sertraline) can be: used long-term. When I have taken patients with SSRI induced sexual side effects off the SSRI - the sexual side effect normally resolves. Take care. ...Read more

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Is it safe to take ashwagandha with zoloft long term, for anxiety?

Is it safe to take ashwagandha with zoloft long term, for anxiety?

Talk to doc first.: There is not enough evidence to say whether it will help with anxiety. Ginseng interacts with lots of other medications. And may cause acute seritonin syndrome, a bad thing. So talk to your doc first! See: http://www.mayoclinic.org/diseases-conditions/serotonin-syndrome/symptoms-causes/dxc-20305673 ...Read more

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Can you get serotonin syndrome from long term Zoloft (sertraline) use?

Can you get serotonin syndrome from long term Zoloft (sertraline) use?

Combo or high dose: Serotonin syndrome is too much serotonin in the brain. If you have tolerated zoloft (sertraline) for a long time, than your chances of developing the syndrome are low, unless your dose was increased or another med added. Other psychotropics, pain meds (e.g. Ultram), migraine meds (triptans), HIV meds, stimulants & hallucinogens w/ zoloft (sertraline) can raise the risk. Inform your doctor of all the meds you're taking. ...Read more

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Is it ok to be on Zoloft (sertraline) long term? Ive been on Zoloft (sertraline) for almost a year now. It's helped alot w/ my severe panic attacks so I dont wanna get off it.?

Is it ok to be on Zoloft (sertraline) long term? Ive been on Zoloft (sertraline) for almost a year now. It's helped alot w/ my severe panic attacks so I dont wanna get off it.?

Zoloft (sertraline): seems to be doing the trick. Unless you plan on becoming pregnant on your current meds I see no reason for making a change (other than completely coming of Xanax (alprazolam) under the supervision of your psychiatrist). ...Read more

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Should I take my Zoloft (sertraline) 75 mg long term or should I consult my doctor to find something else to take for maintenance ?

Should I take my Zoloft (sertraline) 75 mg long term or should I consult my doctor to find something else to take for maintenance ?

Zoloft (sertraline) isn't a short: term fix. It is an SSRI, a selective serotonin reuptake inhibitor. For it to be effective, you need to establish & maintain a steady-state in your blood/body. You may not have given it enough of a chance to work yet. Don't stop "cold turkey," ie suddenly. Will be uncomfortable. At that dose, you'll definitely want a supervised gentle taper. Discuss with your prescriber. ...Read more

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Agoraphobic. Tried zoloft (sertraline). Mind raced & couldn't sleep. 0.5mg klonopin/day works wonderfully. Don't need it everyday. Adequate long term solution?

Agoraphobic.  Tried zoloft (sertraline).  Mind raced & couldn't sleep.  0.5mg klonopin/day works wonderfully.  Don't need it everyday. Adequate long term solution?

Depends: on how often you take it. 0.5 mg is a very low dose but tolerance is a major problem with benzodiazepines especially if take frequently. If sertraline is the only other Ned you have tried there are many other options which may help with depression and insomnia as well. I would be happy to see you on my concierge practice through email, or live audio or visual consultation if you wish ...Read more

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Are Ssris bad for the Brain and the body when used in long term ? I'm on Zoloft (sertraline) for anxiety but I'm very nervous that it might damage or change me when used for a few years or longer ?!

Are Ssris bad for the Brain and the body when used in long term ? I'm on Zoloft (sertraline) for anxiety but I'm very nervous that it might damage or change me when used for a few years or longer ?!

Usually a great med: 100,000s if not millions of people have used this type of medication for such a time period. There are many studies which show it is safe. Of course there are possible side effects and occasional drug interactions that your doctor would recognize if you discussed any concerns with him or her. Sometimes psychotherapy is needed in addition or instead of meds Discuss your concerns with your doctor. ...Read more

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Dr. Alan Ali
1,029 doctors shared insights

Zoloft (Definition)

Zoloft is a serotonin reuptake blocker which is a kind of ...Read more