Doctor insights on:
Long Term Effects Of Sickle Cell Anemia
Sickle cell future: As we better understand sickle cell disease, we hope to increase the quality of life for those affected by this disease. It is essential for those who have this disease to see a physician who specializes in sickle cell. For those with very severe disease, bone marrow transplantation may offer a cure. For others, screening and healthy lifestyle choices will help manage their disease. ...Read more
This is a genetic disorder in which hemoglobin is abnormally made., more common in people of african descent. This abnormality causes red blood cells to become stiff and fall apart. This can cause very specific symptoms: pain, pneumonias, strokes, spleen problems, and many other problems. Some have mild disease, some ...Read more
Is anemia always present in sickle cell anemia? And for how long can i experience pain without this being a crisis for sickle cell?
They call it sickle: Cell anemia because, indeed, patients essentially all have anemia. The anemia actually improves the rheologic (flow) properties of blood in these patients, whose rbcs are otherwise rigid with reduced degrees of freedom for deformability. Sickle cell pain occurs due to microvascular occlusion and tissue compromise. Oral opiates/ nsaids may provide relief, but IV opiates may be needed (pain crisis). ...Read moreSee 1 more doctor answer
Many.: Basically, sickle cell disease causes disturbance of the blood vessels, typically smaller vessels. Over time, this can cause many problems. Painful episodes, eye problems, lung problems (similar to pneumonia), strokes, decreased spleen function (which can cause severe infections), kidney problems, and o ther problems. Sickle cell disease is not the same in all people. Some have milder symptoms. ...Read moreSee 1 more doctor answer
Which treatment: There are many treatments for sickle cell. I will discuss one. Doctors are studying the long-term effects of Hydroxyurea on people who have sickle cell anemia. Studies in very young children have shown that Hydroxyurea can be given safely and that it improves anemia and Hemoglobin F levels while reducing complications of sickle cell anemia. ...Read more
Sickle cell disease: There have only been a couple of studies examining life expectancy in patients with sickle cell disease. One study i know of found a median age at death of 42 for men and 48 for women with sickle cell disease. However, there are many variables impacting prognosis and survival from one patient to the next. ...Read moreSee 1 more doctor answer
You can't prevent it: Sickle cell dz is a constitutional disease caused by a mutation in codon 6 of the beta globin gene that changes glutamate to valine in the encoded protein. There is no way to prevent it. The best advice is for you to receive regular care in a comprehensive center by expert teams who manage sickle cell dz and care for its sequelae. Sequelae are both acute and chronic with progressive features. ...Read more
Possibly: Other indications would include a recent splenic sequestration crisis (occurs in childhood), or in a patient receiving chronic transfusions for complications of sickle cell disease whose transfusion requirement increases due to collection and destruction of blood cells in an abnormally enlarged spleen. The latter is rare in sickle cell disease. ...Read moreSee 1 more doctor answer
Please see doctor: Infants with sickle cell disease (or anemia--same), should be followed by a pediatric hematologist. The infants usually do very well on antibiotic prophylaxis and folic acid. Sickle cell disease is caused by the s hemoglobin gene given to the new baby by each parent. One gene would produce the sickle trait from one parent. Fever with the disease is an emergency and must be seen immediately. ...Read moreSee 1 more doctor answer
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