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Doctor insights on: Long Term Effects Of Methotrexate

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What are the long term effects for using methotrexate? What are the side effects

What are the long term effects for using methotrexate? What are the side effects

See details: You have asked this question before. Side effects include GI irritation, infection risk, hair loss, allergic cough and pneumonitis, reduced blood counts, liver inflammation and increased risk of lymphoma. Do not permit this to scare you off. The advantages at preventing joint destruction far outweigh the risks. ...Read more

Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


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Are there any long term effects for a 6y/o to take 22.5mg of methotrexate for jra for long term? Also please list any side effects

Unfortunately: This is regarded as standard treatment but jra is a disease that actually responds to nutlritional treatment. First stop all forms of sugar and sweeteners and look up acam@acam.Org for a physician who uses nutrients in his/her practice. ...Read more

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How safe is methotrexate taken orally for long term? Are side effects likely? What are they?

Reasonably safe: Methotrexate is a relatively safe drug, even over the long term. I have patients taking it over 20 years without problems. You need to have lab tests done routinely and should be on Folic Acid as well. ...Read more

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My age is 29yrs. For psoriasis, i'm taking methotrexate 7.5 mg since 7yrs. Using this, what are the side effects to me in long term.Plz suggest?

Probably not much: This is a small dose of methotrexate. Assuming you have blood tests to screen for medication toxicity and these tests are normal, the long term risk is small. Make sure blood is screened for liver toxicity and reduced blood counts every 3 months. ...Read more

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Can too much folic acid inhibit methotrexate?Was on 1mg folic acid/day & great long time.Due to side effects, increased to 3mg folic acid & now flaring

Too much folic acid: Imo, doses above 1 mg daily are a waste of money. Higher doses simply get excreted in the urine. Many rheumatologists do not routinely prescribe Folic Acid with Methotrexate unless there is evidence of Methotrexate toxicity. ...Read more

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How long does methotrexate stay in your system?

Not enough data: Methotrexate has a half life of 15 hours. It should be totally gone from the blood fairly quickly but can remain in the liver longer. We do not have human studies to say how long that it. ...Read more

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How long does methotrexate stay in your body for?

How long does methotrexate stay in your body for?

Depends on…: Dose & how long you were on it. Mtx's half life (amount of time for active med to be reduced by 1/2) is given as 3-15 hours but varies according the dose. It takes at least 4-5 half lives for a drug to be eliminated from the system, assuming there is normal liver & kidney function. ...Read more

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How long should you be off methotrexate before you start drinking?

How long should you be off methotrexate before you start drinking?

Depends on…: Dose & how long you were on it. Mtx's half life (amount of time for active med to be reduced by 1/2) is given as 3-15 hours but varies according the dose. Whether there has been liver damage also depends on length of time the drug has been taken. See your doc about checking your liver enzymes & ask when it would be safe for you to have alcoholic drinks. ...Read more

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How long before methotrexate injections start working when used for jra?

How long before methotrexate injections start working when used for jra?

See details: That is difficult to answer because it depends on the dose. I will generally increase the Methotrexate dose if there has not been a response in 6 weeks. ...Read more

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Dr. Robert Lowe
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