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Doctor insights on: Long Term Effects Of Metformin

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Are there long term effects of diabetes medication (glyburide, metformin)?

Are there long term effects of diabetes medication (glyburide, metformin)?

Not many: Glyburide is a sulfonourea (it forces your pancreas to produce more insulin). Metformin does three things... It helps your Insulin work better by making the Insulin receptors in the body more sensitive, it slows glucose absorption in the intestine, and slows the production of glucose by the liver. ...Read more

Dr. David Sneid
1,046 Doctors shared insights

Metformin (Definition)

That reduces liver production of glucose- other benefits: can't cause low blood sugar when used alone, likely cariovascular benefit, may reduce complications of diabetes, may reduce cancer risk ...Read more


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What side effects are commonly associated with long term usage of glucophage (metformin) 850?

What side effects are commonly associated with long term usage of glucophage (metformin) 850?

Well tolerated: Metformin (glucophage) is effective in lowering glucose in diabetics, and treating the Insulin resistance of pcos. It can cause some diarrhea. It can cause lactic acidosis in people with kidney disease. Otherwise, it is quite well tolerated. ...Read more

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Doc has advised me to take glucophage (metformin) gor 3 months to regulate my hormones and aid in weight loss but I m wary. Will there be long term side effects?

Doc has advised me to take glucophage (metformin) gor 3 months to regulate my hormones and aid in weight loss but I m wary. Will there be long term side effects?

No: Metformin is excellent at reducing Insulin resistance, particularly when combined with diet, exercise, and weight loss. Most effective dose is 2000 md/d (1000 twice/day), but you need to work up to that dose gradually. ...Read more

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Is long term daily use of immodium to deal with diarrhea caused by metformin safe? Only take 2 immodium as directed on box

Is long term daily use of immodium to deal with diarrhea caused by metformin safe? Only take 2 immodium as directed on box

Not advisable: If Metformin is causing that much symptoms to you, you might need to check with your doctor to consider changing it.
Long term use of Immodium has its side effects on the colon and I would not advise you to do so ...Read more

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Any suggestions on supplement while taking long term metformin for PCOS/ insulin resistance? Related to reduced vitamin/mineral absorption? Thnx!

Any suggestions on supplement while taking long term metformin for PCOS/ insulin resistance? Related to reduced vitamin/mineral absorption? Thnx!

Weight loss: Getting your body to your ideal body weight is the most important step in managing PCOS. If you are overweight then work on weight control. This is the key. Mineral supplementation is not needed. ...Read more

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How long until metformin side effects stop?

How long until metformin side effects stop?

Within a week: Metformin often induces mild GI upset which subsides within a week or so of initiating or increasing the dose. If effects do not subside one should consider reducing or discontinuing the dose. ...Read more

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Metformin side effects, how long do they last?

MAYBE indefinitely: Metformin has G.I. Side effects including diarrhea and abdominal cramps. The symptoms may last as long as you are taking the medication. One solution is generic glucophage XR or er which is a long-acting medication with less side effects.
Many patients can not tolerate metformin at any dose but fortunately we have many diabetes meds --out there. Hope you are better soon! ...Read more

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How long does it take to for side effects to stop after discontinuing metformin?

Days: If they're due to metformin, they will stop within sever days. If they continue, they're due to something else. ...Read more

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How long does it take 500mg of metformin to get out of the system and what are the side effects?

How long does it take 500mg of metformin to get out of the system and what are the side effects?

Metformin: Main side effect of metformin is abdominal cramping, gas and diarrhea. 500 mg is a small dose. Talk to your doctor if you plan to stop any medication. The half life for the immediate release metformin is about 6 hours. ...Read more

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How long do I have to take metformin?

How long do I have to take metformin?

Till: The problems that caused you to be given this are resolved, but many people remain on it for decades! ...Read more

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Please tell me how long it takes for metformin to work?

A few days: You should start to see improvement in your blood sugars within a few days, and continued improvement over a few weeks. ...Read more

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How long does it take metformin to work for fertility. Or does it even work?

How long does it take metformin to work for fertility. Or does it even work?

It helps, not sure: If you have the so-called polycystic ovarian syndrome and Insulin resistance problem with lower chance of fertility, the use of metformin can help, but no one really knows how truly effective it is or how long it takes. You could be pregnant tomorrow, next month, in 6 months, a year, or even never. It is frustrating, but hang in there. Wt loss can help. Consult doc regularly and good luck to you. ...Read more

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How long does it take before you start losing weight on glucophage (metformin)?

How long does it take before you start losing weight on glucophage (metformin)?

Right away...but.: Glucophage (metformin) works by making Insulin work better in your body. This helps lower appetite and does not cause any weight gain. Any weight loss you have will be due to your proper attention to diet and exercise. That said, you should have better results dieting while taking the metformin than if you weren't taking it. ...Read more

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I have to have a gtt done and am on 500mg metformin how long should I stop taking metformin before taking the test as I won't to get a true reading?

I have to have a gtt done and am on 500mg metformin how long should I stop taking metformin before taking the test as I won't to get a true reading?

Doesn't sound right: To do a glucose tolerance test for a person already on metformin would be unusual.

You will need to contact your doctor's office for guidance on this specific matter. ...Read more

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Had my first B12 shot the other day. How long is it good for. And when should I get my next one. Been on Metformin for years and feel so much better.

Had my first B12 shot the other day. How long is it good for. And when should I get my next one. Been on Metformin for years and feel so much better.

Depends: How much vitamin B12 was injected? 1000 microgram dose should be good for a month, if not longer. It would be good to discuss the matter with your doctor who knows more about your health. ...Read more

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How long does it take the drug metformin to expire?

How long does it take the drug metformin to expire?

Expiration: Most drugs expiration date is a year. Some drugs less. There have been studies that looked at the efficacy of drugs post expiration and some were still effective as many as 20 years out. Best is to see your doc and see what's best for you. :) ...Read more

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How long does it take metformin to get in your system?

Soon: For lowering blood glucose, you will start to see the effects of metformin in a few days to a week. For pcos, it may take longer (several months) to see a normalization of periods, fertility, etc. ...Read more

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How long should metformin be used in pco's? will this medicine help?

How long should metformin be used in pco's? will this medicine help?

For some patients: Some patients with PCOS struggle with Insulin resistance. In this subset of PCOS patients Metformin can be used. There is not set duration for treatment and each case should be assessed individually. ...Read more

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How long does metformin stay in you’re system. I stopped using it two days ago how long until completely gone?

How long does metformin stay in you’re system. I stopped using it two days ago how long until completely gone?

It depends: It depends on whether it is the short acting or extended release form. Its effect lasts about 5 hours in most people in the short acting form. It is totally gone in about 18-24 hours. The long acting form is totally gone in 24-36 hours. ...Read more

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Does prolonged use of metformin cause kidney function to decrease?

Does prolonged use of metformin cause kidney function to decrease?

Metformin kidney: No but poorly controlled DM does and is a leading cause of kidney failure and need to go on dialysis. ...Read more

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My wife was prescribed metformin to get pregnant. How long should she continue taking it after she is pregnant.?

1st Trimester: Most physicians have women stop taking metformin sometime in the 1st trimester. Typically women on metformin also have some Insulin resistance, it's important to have a glucose tolerance test in the 1st trimester to check for gestational diabetes. I recommend women go off their metformin after getting pregnant, have the glucose test and then use more typical agents for glucose control if need. ...Read more

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My dr. Made my dose higher of metformin now I'm taking 1500mg will this help me get pregnant if so how long will it take to get pregnant.

My dr. Made my dose higher of metformin now I'm taking 1500mg will this help me get pregnant if so how long will it take to get pregnant.

The most effective: Dose of metformin is 1000 mg twice a day. If you have PCOS, it may help you get pregnant but there is no way to tell whether or how long, Diet, exercise and weight loss will help significantly. Other medications are available for specific indications. ...Read more

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I took metformin 500 mg and I was wondering how long after stopping that it was out of your system and could it cause a false positive drug test?

I took metformin 500 mg and I was wondering how long after stopping that it was out of your system and could it cause a false positive drug test?

Metformin 500: Metformin 500 is usually taken twice a day - out of your system every 12 hours.

I don't think it can cause a faulse positive test if you are monitoring your blood sugar.

If you think the metformin associated blood glucose values are too high or too low please contact your doctor. ...Read more

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How long should I space metformin and multivitamins/supplements?

No need to space: There is no need to space the use of metformin and multivitamins/supplements. They may be safely taken together at the same time. ...Read more

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How long should I take metformin I have polycystic ovaries?

Metformin: If diagnosis is correct this is appropriate medicine. The condition places you in pre or diabetic range. Place faith in your dr. To provide treatment plan. Do you have pseudoacanthosis nigrans- skin changes most notable about back neck? None the less best treatment plan based on minimal criteria you provided. ...Read more

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I have pcos how long should I take metformin kindly explain I have no diabeties?

I have pcos how long should I take metformin kindly explain I have no diabeties?

Well, the: Rationale is that u likely have elevated insulin, that is generally a big part of pcos. Using metformin, goal is 1500 mg per day, helps to lower Insulin which is very similar to growth factor, making wt loss difficult. It may be best u stay on this especially if u have a family hx of type 2 diabetes. 30% of women will ovulate at 1500 mg and it may help prevent diabetes and help to prevent weigh. ...Read more

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Is taking metformin with pioglitazone and glimperide tablets safe for long time use?

Is taking metformin with pioglitazone and glimperide tablets safe for long time use?

Yes, unless: Hi. Yes, in general that 3-drug cocktail is safe. Exceptions would be metformin at a certain level of kidney disease, pioglitazone in heart failure, and glimepiride if it's causing hypoglycemia. That 3-drug regimen will likely lose efficacy over time. Keep your diabetes, blood pressure, and lipids tightly controlled. Don't smoke! Good luck! ...Read more

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Is tiredness a symptom of taking metformin? How long does it start work and help inferility?

Generally not: But it can be a symptom of pcos. Metformin, particularly at a full dose of 2000 mg/day can be effective at restoring normal menses and even fertility in weeks to months -- however, if you are taking birth control pills you'll never know it's working. ...Read more

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How long does it take for metformin to start working on high blood sugar once you start on it?

How long does it take for metformin to start working on high blood sugar once you start on it?

Good drug: Metformin, essential medication (who) help glucose utilization, reaches peak levels in 1 to 3 hrs, with half life of elimination in 6 hrs, complete in 24 hrs. ...Read more

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Other than diabetes, what good does metformin do? Does it cause cancer if taken for a long time?

Other than diabetes, what good does metformin do? Does it cause cancer if taken for a long time?

Very helpful: It's a very effective medication used to treat Insulin resistance. It does not cause cancer. In fact, it can decrease risk of developing cancers in diabetic pts. ...Read more

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Is glumetza better than metformin? Does it cause cancer if taken for a long time? How long has it been in existence?

Is glumetza better than metformin? Does it cause cancer if taken for a long time? How long has it been in existence?

Glumetza or metformi: If you don't need Glumetza don't take it.
If you don't use Metformin don't take it.

Cancer is unlikely. What is necessary is a discussion with your doctor about your diabetes meds.

At age 40 you most likely have type 2 diabetes. This is a good time to start planning to rid yourself completely from diabetes. I suggest you see a dietitian to help you. ...Read more

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So scared to take metformin why I am such a chicken I don't know. Ugh I know the long run will be good. How do I do it?

I have no way: Of knowing why you are scared. It's a very safe drug that has been around for decades. Talk w/your physician and make sure you control your diabetes with whatever regimen is necessary. Never let fear control your actions. Don't get your medical information from friends, tv or the internet. ...Read more

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How long does it take metformin 500 mg to regulate a period? I've been on it once a day for a week now & have nothing but spotting. Is this normal?

Unusual choice: Metformin is a very unusual choice to control a menstrual cycle. Are you sure you are getting the right medication or that is really the reason it was prescribed? It's typically prescribed for diabetes control. You may want to check with your provider and/or pharmacist to ensure this isn't medication error. ...Read more

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Should I try new diabetic medicine since metformin taken too long & I want my A1c to go to 5.5? Mine is 6.6. Do we have better med. Than metformin?

Get more input: I'd urge you to get a couple of physicians' opinions as to whether it's really helpful or in your best interest to try to lower you hgba1c as you've indicated. My reading of the recent medical literature has left me unpersuaded that this is something you'd want. Especially, I want to congratulate you for the good result you'd had so far. ...Read more

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My partner and I trying for a baby. I'm taking Metformin for pcos I want to know how long do I keep on taking them for.

Debatable: You can continue metformin during pregnancy depending on your doctors opinion. It is not harmful. Sometimes it is stopped when pregnancy is confirmed. Your risk of gestational diabetes is increased with PCOS ...Read more

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How long it may take to get pregnant with pcos I m at metformin for 4 months?

Pregnancy: Is not guaranteed just because you're on metformin. Make sure you're on the most effective dose of 2, 000 mg/day. Usually menses return to normal in several months, and fertility follows soon after, but not in all women. Check w/your doctor for further therapy if needed. ...Read more

Dr. Walter Futterweit
695 Doctors shared insights

Glucophage (Definition)

Glucophage is a diabetes-related agent which is a kind of ...Read more