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Doctor insights on: Long Term Effects Of Lupron

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What are the long term effects of lupron (leuprolide)? Why are so many women asking to have it taken off the market?

What are the long term effects of lupron (leuprolide)?  Why are so many women asking to have it taken off the market?

Bone loss: Prolonged use can cause bone loss. It mimics a menopausal status, thus with lupron, (leuprolide) estrogen and Progesterone levels are lower than would be expected during the reproductive years. ...Read more

Dr. Lonnie Smith
155 doctors shared insights

Leuprolide Acetate (Definition)

Leuprolide acetate is a GnRH stimulator which is a kind of women's ...Read more


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I was given Provera 2x a day (08/01 to 08/26) to stop bleeding eventhough I had Lupron shot last 06/26. Any bad effects of long term use of Provera?

I was given Provera 2x a day (08/01 to 08/26) to stop bleeding eventhough I had Lupron shot last 06/26. Any bad effects of long term use of Provera?

Provera: Provera can be used safely for various times depending on what problem is being addressed. Since you have been treated with Lupron and Provera it sounds like your issue may be fairly complex. Consider scheduling follow up with your Obgyn to clarify the diagnosis, the treatment plan and the time line for treatment ...Read more

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How long do the side effects of lupron (leuprolide) typically last?

How long do the side effects of lupron (leuprolide) typically last?

1 or 3 months: Lupron (leuprolide) comes in 1 or 3 month doses (3.75 or 11.25 mg) and these injections usually cause menopause symptoms which I've seen as both mild or severe. It rarely continues beyond the treatment period & is a good way to pre-treat or reverse endometriosis or to shrink fibroid tumors prior to surgery. Discuss with your doc if your symptoms are severe or if you need estrogen to counter the severe effects. ...Read more

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How long does it take fo the effects of lupron (leuprolide) to wear off?

How long does it take fo the effects of lupron (leuprolide) to wear off?

Varies: There are three forms of lupron, (leuprolide) one is a subcutaneous injection daily which will wear off very quickly. The second type is a depot form which last for approximately 30 days in the body, and lastly there is a 90-day form. A woman will usually ovulate 2 to 4 weeks after the effects of the Lupron (leuprolide) has worn off. ...Read more

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How long after stopping lupron (leuprolide) for endometriosis will it take for your body to go back to normal?

How long after stopping lupron (leuprolide) for endometriosis will it take for your body to go back to normal?

Few days: Even though half-life of Lupron (leuprolide) is only 3 to 4 hrs plasama levels will remain high for few more days ( missing one dose is not a big problem). ...Read more

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How long till 11.25mg lupron (leuprolide) wears off? I don't feel symptoms from it last shot was sept my husband & I want ttc should we wait? If so, how long ttc?

How long till 11.25mg lupron (leuprolide) wears off? I don't feel symptoms from it last shot was sept my husband & I want ttc should we wait? If so, how long ttc?

3 months: The shot lasts 3 months. It can have some effects a little longer. You don't have to wait at all. There is no danger in becoming pregnant but you may not ovulate. ...Read more

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How long does one lupron (leuprolide) shot last?

How long does one lupron (leuprolide) shot last?

Depends: Leuprolide acetate is available in two long-acting formulations as Lupron (leuprolide) depot. It is available in a 1-month and a 3-month version. Microdose Lupron (leuprolide) as used for ivf is generally very short acting, but the pharmacology is too complex to explain here. ...Read more

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Complcations with long use of lupron (leuprolide)?

Complcations with long use of lupron (leuprolide)?

Yes: Long term use of Lupron can weaken the bone. Anyone on long term Lupron should be on add back therapy to prevent bone loss as well as calcium and vitamin d. Long term Lupron can also predispose to heart disease and so estrogen add back should be considered to prevent this risk. ...Read more

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My husband has been on lupron (leuprolide) x 3 years how long can he take this drug?

My husband has been on lupron (leuprolide) x 3 years how long can he take this drug?

No time limit: It really depends upon its benefit to your husband. Men with metastatic disease can have long term benefit. ...Read more

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How long should you wait after the 3 month Lupron (leuprolide) injection to try to conceive?

How long should you wait after the 3 month Lupron (leuprolide) injection to try to conceive?

Depends: Why are you taking the Lupron (leuprolide)? Is the underlying condition such that it is safe to proceed? You need to discuss this with your doctor who I suppose operated on you to diagnose the condition. In general, yes,after 3 months passes you might start ovulating and it will be a chance to get pregnant ...Read more

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How long do lupron (leuprolide) injections work to increase chances of getting pregnant?

How long do lupron (leuprolide) injections work to increase chances of getting pregnant?

It depends: Lupron (leuprolide) does not directly improve pregnancy rates. It actually works to suppress ovulation and prevent pregnancy. There is a misperception that it can be used to improve pregnancy rates in people with endometriosis. Lupron (leuprolide) can be used as an adjunct in fertility treatments. If you have a fertility problem, it is best to see a specialist — a reproductive endocrinologist. ...Read more

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How long does it take for lupron (leuprolide) depot to get out of your system, trying to conceive?

Depends on the dose: If you had the three month it could be up to four months. If you had the monthly, more than likely ok at six weeks. ...Read more

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After having a 3 months dose of lupron (leuprolide) injection, after how long till my menstrual cycle be back to normal?

After having a 3 months dose of lupron (leuprolide) injection, after how long till my menstrual cycle be back to normal?

Variable: Lupron (leuprolide) suppresses estrogen production from the ovary. Ovulation usually does not occur but Lupron (leuprolide) is not considered a contraceptive hormone. Menstrual bleeding does not normally occur with Lupron (leuprolide) administration but periods should resume within six months of stopping this medication. ...Read more

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How long does it usually take for lupron (leuprolide) depot to begin altering a woman's menstrual cycle?

How long does it usually take for lupron (leuprolide) depot to begin altering a woman's menstrual cycle?

Different for All: In general, Lupron (leuprolide) will stop menstruations but exactly when it takes effect is a bit debatable and likely different for all women. In general the effect is seen after 2 weeks (following an initial hormonal surge). ...Read more

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I'm taking lupron (leuprolide) 3.75mg and just took the 6th shot. How long before ttc? Is it safe for the baby if I get pregnant on the 1st month after last shot?

I'm taking lupron (leuprolide) 3.75mg and just took the 6th shot. How long before ttc? Is it safe for the baby if I get pregnant on the 1st month after last shot?

Make sure: You know (and are treating), your mthfr genotype status. At 35, you are at high risk. 84% of the population has at least one gene problem which causes increased risk for miscarriage, neural tube defects, and add or autism spectrum disorders. If +, do not take a prenatal vitamin with regular folic acid, it blocks the receptors, needs to be l-methylfolate. Neevodha is an option. Sorry tangent from? ...Read more

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I am on lupron in order to shrink my submicous fibroid and also control prolonged bleeding, wht are chances that I can get pregnant while on lupron.

I am on lupron in order to shrink my submicous fibroid and also control prolonged bleeding, wht are chances that I can get pregnant while on lupron.

Possible...: The chance of getting pregnant while on Lupron Depot is low; however, if you do get pregnant, Lupron can cause birth defects in your baby. It's best to do something to prevent pregnancy while on Lupron. Best wishes! ...Read more

Dr. AARATHI Cholkeri-Singh
165 doctors shared insights

Lupron (Definition)

Lupron is a GnRH stimulator which is a kind of women's ...Read more