Doctor insights on:
Long Term Effects Of Glyburide
Not many: Glyburide is a sulfonourea (it forces your pancreas to produce more insulin). Metformin does three things... It helps your Insulin work better by making the Insulin receptors in the body more sensitive, it slows glucose absorption in the intestine, and slows the production of glucose by the liver.
Overdosed w/glyburide (190pills) dec2011, now I'm experiencing a lot of nausea (not pregnant).Could it be a long term affect from the overdose?
Doubtful: The meds are out of your system. It is unlikely you would have a long-term reaction. Follow up with your doc.
Varies (1 - 2 hours): Depending on the formulation ingested (micronized (glynase) or conventional Glyburide (diabeta, micronase)) onset of action ranges from about 1 to 2 hours with a maximum reduction of blood sugar seen within 3-4 hours. May last in body for over 18 to 24 hours. Should be taken with breakfast or main meal of the day to help reduce symptoms of low blood sugar (tremors, sweating, irritable, fatigue).
Glucovance (glyburide and metformin): Hi. Glucovance (glyburide and metformin) (metformin + glyburide combination) is not one of my preferred type 2 drugs. But it's inexpensive and will help for awhile before losing effective. Metformin side effects (assuming normal kidney function) are GI (things like nausea, diarrhea). Glyburide side effect is low but real risk of hypoglycemia. If you have decent insurance, there are better type 2 drugs out there. Good luck!
Probably: B"sd In general glyburide and other sulfonamides are well documented to increase risk of MI about 20% - there are safer options. Invokana is a SGLTP2i- sodium glucose transport protein inhibitor, that results in sugar in the urine. It has actually been shown to protect kidney function over the long term. It also has a diuretic effect so should skip if you are dehdrated from scan or other reason
An insulin releaser: Glyburide (called glibenclamide outside the U.S.) Is a sulfonylurea anti-diabetic agent. It causes the pancreas to release insulin. It can do this even in the absence of food, so can cause the sugar to get too low. Glyburide can be a problem in the elderly, again because of the risk for low blood sugar. If you take this medicine, it could be dangerous to skip meals.See 3 more doctor answers
Many options: When choosing a diet, make sure it's one that you can maintain lifelong so do not do anything drastic. In general, you should eat lots of vegetable and fruits. Non-starchy vegetables are best: spinach, carrots, broccoli or green beans. Eat whole grain foods instead of processed food (whole wheat over white breads) add fish to your meals 2-3 times per week. Dry beans & lentils are good protein...
Same family: Hi. Glyburide is a second generation sulfonylurea and glimepiride is a 3rd generation. They work at the same receptors on the beta cell (the pancreatic cells that make insulin) and stimulate insulin release. Glimepiride is preferable because of less metabolite build up in kidney disease, but they're VERY similar. I never use them. In my opinion, based on good science, we have much better drugs.
Diabetes: Either glyburide or glimepiride can be prescribed for management of diabetes. There may be a cost difference in your favor or you doctor may have a good reason to prescribe one or the other. More important - you need to take control of your eating habits, your weight (if overweight), and your exercise. Also please remember to measure your blood sugar regularly. Your doctor will advise you on dose
Either wth or after: Just so you don't skip meals to avoid hypoglycemia.
Similar mechanisms: Hi. Glyburide & glimepiride (& glipizide & others in the sulfonylurea class, for that matter) all work by the same mechanism to stimulate endogenous insulin release. They differ in duration of action, metabolites, accumulation in kidney disease, etc. They're archaic drugs that I never use anymore. There are much better type 2 drugs out there. Their one benefit - they're cheap.
Possibly: Its possible that any one of these medications or any combination could cause mood swings. Call your doctor.
Diabetes pill.: Diabeta is a brand of the medication glyburide. It is an effective treatment for type 2 diabetes. It is available as generic Glyburide (lower in cost). It may not be the safest of this class, known as sulfonylurea medications, however (concerns about hypoglycemia in patients with kidney disease and heart effects in patients with heart disease).
Hypoglycemia: Prolonged hypoglycemia (mild to severe -low blood sugar- noted as tremor, sweating, headache, fatigue, confusion) is the most common/ concerning side effect of glyburide, this is due to its long half- life / active metabolite compared to other 2nd generation sulfonylureas. Minor weight gain seen. Nausea, heartburn (GI) are transient/ dose related. Rash/itching may occur. Liver injury is rare.
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