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Doctor insights on: Long Term Effects Of Bupropion

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Are there long-term effects of wellbutrin (bupropion)?

Are there long-term effects of wellbutrin (bupropion)?

Officially, none: No warnings about long-term use of wellbutrin (bupropion) have been issued. But, you have to realize that its makeup is similar to amphetamine, and is dopamine-enhancing. It can cause jitteriness, twitching, and seizures even in short-term. It can be difficult to wean from, because of irritability and anger -- not unlike nicotine withdrawal for which it is used (as zyban). Ongoing need should be reviewed. ...Read more

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Dr. Alan Ali
757 doctors shared insights

Bupropion (Definition)

Also called wellbutrin (bupropion) or zyban or aplenzin, is an atypical antidepressant & smoking cessation aid, which has mild psychostimulant action. It is a norepinephrine/dopamine reuptake inhibitor. It can lower seizure threshold at high doses, ...Read more


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Anyone have problems with long term wellbutrin (bupropion) use?

Anyone have problems with long term wellbutrin (bupropion) use?

Generally no: Wellbutrin (bupropion) as a long term medication to treat and prevent major depression is generally safe and does not cause any known harm. ...Read more

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Is taking 100mg of nortriptalyne with 150mg of bupropion X-R long term safe? Is this a healthy liver combo for someone who used to drink very heavily?

Is taking 100mg of nortriptalyne with 150mg of bupropion X-R long term safe? Is this a healthy liver combo for someone who used to drink very heavily?

Discuss with MD: You should discuss these questions with your prescribing doctor. There are risks and benefits to every medication, your doctor will know your history and weigh the risks and benefits. ...Read more

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My doc has prescribed me 1mg Xanax, (alprazolam) 10mg Lexapro and just added 150mg Wellbutrin XL. Is this allowed? Will this cause long term problems?!

My doc has prescribed me 1mg Xanax, (alprazolam) 10mg Lexapro and just added 150mg Wellbutrin XL.  Is this allowed? Will this cause long term problems?!

Medication effects: I understand your concern. Reflect on symptoms of Anxiety and Depression effect on your relationships, work and personal life; medication need for anxiety or depression; then discuss medication interactions, benefits and side effects; Therapy. Wellbutrin with Lexapro may increase the risk of seizures. Using Xanax (alprazolam) with Lexapro may increase dizziness, confusion, and difficulty concentrating. ...Read more

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What are the risks of taking wellbutrin (bupropion) and Zoloft long term? Being used to treat ADHD and OCD respectively

What are the risks of taking wellbutrin (bupropion) and Zoloft long term?  Being used to treat ADHD and OCD respectively

Not clear: There is conflicting data regarding use of antidepressants later in life and all cause mortality although there is the notion that the medications are relatively benign. There is always going to be a risk benefit analysis that is necessary in addition to the number needed to treat or a number needed to harm with any medication reflecting the capacity to do both good and bad things to patients. ...Read more

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I just started on 100mg of wellbutrin (bupropion) for 5 days then up to 300mg. How long before I feel the effects?

I just started on 100mg of wellbutrin (bupropion) for 5 days then up to 300mg. How long before I feel the effects?

Depends...: Most antidepressants take about 2 weeks or so before you notice the therapeutic effects. However you can experience side effects after the 1st dose. ...Read more

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How long does it take to feel the effects of Wellbutrin (bupropion)? I've been on it for 5 weeks and still feeling down.

4-6 Weeks: Bupropion is an antidepressant that works primarily by increasing dopamine. If you have had absolutely no improvement in your depression, you may be on too low of a dose, or this may just be a medication that doesn't work for you. Also make sure you have the right diagnosis. Do NOT discontinue this without consulting your psychiatrist, but I would bring this up with him/her. ...Read more

Wellbutrin (Definition)

Bupropion is an addiction reducing agent and an antidepressant which are both a ...Read more


Dr. Mark Ingerman
175 doctors shared insights

Zyban (Definition)

Zyban is an addiction reducing agent which is a ...Read more