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Doctor insights on: Liver Cancer And Nexavar

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My dad has an advanced liver cancer an dis taking nexavar (sorafenib) for 3 months. The AFP keeps rising. Does that absolutely mean the cancer is growing?

My dad has an advanced liver cancer an dis taking nexavar (sorafenib) for 3 months. The AFP keeps rising. Does that absolutely mean the cancer is growing?

Possible: Elevation of tumor maker AFP in most of the time is an indication of additional tumor , of course a additional tests also needed to come to that conclusion , speak to his doctor for more information. ...Read more

Dr. Barry Rosen
4,214 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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Can you tell me about liver cancer (hepatocellular carcinoma) and used nexavar (sorafenib)?

Can you tell me about liver cancer (hepatocellular carcinoma) and used nexavar (sorafenib)?

Used for Stage 4: Nexavar, or sorafenib, is used to treat advanced, unresectable hepatocellular carcinoma. It is also used to treat patients with advanced kidney cancer. This drug is a multikinase inhibitor and works by decreasing tumor growth and replication, by inhibiting the formation of blood vessels that tumors rely on to get nourishment. This is not a curative treatment, prolonging survival on average 7 mo. ...Read more

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My mom, 84, if she stop her nexavar (sorafenib) for her primary liver cancer, what would her life expectancy be?

My mom, 84, if she stop her nexavar (sorafenib) for her primary liver cancer, what would her life expectancy be?

8 months: Without more details it's hard to know. Best supportive care would be 8 months. Why has she not had liver directed therapy? An elevated AFP is not a contraindication to treatment. I recently treated an 84 yo otherwise healthy woman with hcc with an AFP of 3500. The tumors are now gone and her AFP is 2! if your mom is healthy and you wish more aggressive treatment, it can be done. ...Read more

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Is liver cancer painful?

Is liver cancer painful?

Not usually: Liver cancer is usually not painful. The condition that leads to liver cancer (chronic hepatitis/cirrhosis) can cause vague pain in the right upper quadrant of the belly. Most liver cancer is picked up in asymptomatic patients by lab tests or by scans. Occasionally a patient will have painless yellowing of the skin due to liver cancer. ...Read more

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Symptoms of liver cancer?

Symptoms of liver cancer?

None: Primary liver cancer, hepatocellular carcinoma (hcc), has no symptoms early on. But most cases of hcc are associated with cirrhosis, the symptoms and signs of which include jaundice, muscle wasting, hepatosplenomegaly, variceal gasteointestinal bleeding, encephalopathy and the development of ascites. Pts with cirrhosis should be screened every 6 mo for hcc with a liver us and an AFP check. ...Read more

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Is liver cancer hereditary?

Is liver cancer hereditary?

It can be: Many factors can increase one's risk for primary liver cancer including: chronic infection with hepatitis b or c virus, type 2 diabetes, nonalcoholic fatty liver disease, heavy alcohol use, obesity, exposure to certain toxins, and inherited liver diseases that can lead to cirrhosis such as hemochromatosis, wilson's disease, tyrosinemia, Alpha 1-antitrypsin deficiency, glycogen, and porphyria. ...Read more

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Is liver cancer on the rise?

Yes: It is on the rise because more patients with hepatitis c are getting older. So the incidence of cirrhosis and liver cancer are increasing. ...Read more

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What is stage 5 liver cancer?

What is stage 5 liver cancer?

There are only 4 : Cancer is generally divided into five stages, from stage 0, in which the presence of irregular or cancer cells are known, to stage iv, in which the cancer has spread to one or several other parts of the body. The higher the number of cancer staging, the more difficult the cancer is to treat due to the progression and spread of cancer cells. According to the national comprehensive cancer network, . ...Read more

Dr. Sanjiv Kaul
2 doctors shared insights

Liver (Definition)

This organ plays a major role in metabolism and has a number of functions in the body, including glycogen storage, decomposition of red blood cells, plasma protein synthesis, hormone production, and detoxification. It lies below the diaphragm in the abdominal-pelvic region of the abdomen. It produces bile, an alkaline compound which aids in digestion via the emulsification of ...Read more


Dr. Carlo Contreras
306 doctors shared insights

Liver Cancer (Definition)

Cancer of the liver can be a primary cancer (hepatocellular cancer) & is more common in those exposed to hepatitis b or hepatitis c or cirrhosis from other causes. It can also be a secondary cancer, spread from another site such as colon, stomach, lung, etc. Some liver cancers are treated with surgery & some with chemotherapy, radiofrequency ...Read more