Doctor insights on:
Liver Cancer And Nexavar
My dad has an advanced liver cancer an dis taking nexavar (sorafenib) for 3 months. The AFP keeps rising. Does that absolutely mean the cancer is growing?
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
Used for Stage 4: Nexavar, or sorafenib, is used to treat advanced, unresectable hepatocellular carcinoma. It is also used to treat patients with advanced kidney cancer. This drug is a multikinase inhibitor and works by decreasing tumor growth and replication, by inhibiting the formation of blood vessels that tumors rely on to get nourishment. This is not a curative treatment, prolonging survival on average 7 mo. ...Read more
A 50 yr-old male patient has liver cancer, used to take Sorafenib.he couldn't take it anymore because of the heavy side effect. Is PD-1 suitable for him?
Liver cancer: A lot more information would need to be taken into account by a specialist who deals with Anti PD-1 drugs before that can be answered. Were you aware that this question went to the health education site of Health Tap? We provide medical education and can not provide diagnosis or treatment plans. ...Read more
Does advanced liver cancer mean anything but death? Is there any chance to survive? My father has been taking nexavar (sorafenib) for 2 months...
If the cancer is: A single lesion, it can sometimes be completely resected( cut out), and one can be cured. ...Read more
My mom, 84, if she stop her nexavar (sorafenib) for her primary liver cancer, what would her life expectancy be?
8 months: Without more details it's hard to know. Best supportive care would be 8 months. Why has she not had liver directed therapy? An elevated AFP is not a contraindication to treatment. I recently treated an 84 yo otherwise healthy woman with hcc with an AFP of 3500. The tumors are now gone and her AFP is 2! if your mom is healthy and you wish more aggressive treatment, it can be done. ...Read moreSee 1 more doctor answer
Stage 4 liver cancer,cirrhosis,cancer also in spine. Diagnosed in Jan.Half dose Nexavar (sorafenib) 3 mths. Prognosis?
It's not great but-: -this is a question for your treating physician. He/she is aware of your situation. ...Read more
Not usually: Liver cancer is usually not painful. The condition that leads to liver cancer (chronic hepatitis/cirrhosis) can cause vague pain in the right upper quadrant of the belly. Most liver cancer is picked up in asymptomatic patients by lab tests or by scans. Occasionally a patient will have painless yellowing of the skin due to liver cancer. ...Read moreSee 1 more doctor answer
None: Primary liver cancer, hepatocellular carcinoma (hcc), has no symptoms early on. But most cases of hcc are associated with cirrhosis, the symptoms and signs of which include jaundice, muscle wasting, hepatosplenomegaly, variceal gasteointestinal bleeding, encephalopathy and the development of ascites. Pts with cirrhosis should be screened every 6 mo for hcc with a liver us and an AFP check. ...Read moreSee 1 more doctor answer
It can be: Many factors can increase one's risk for primary liver cancer including: chronic infection with hepatitis b or c virus, type 2 diabetes, nonalcoholic fatty liver disease, heavy alcohol use, obesity, exposure to certain toxins, and inherited liver diseases that can lead to cirrhosis such as hemochromatosis, wilson's disease, tyrosinemia, Alpha 1-antitrypsin deficiency, glycogen, and porphyria. ...Read more
There are only 4 : Cancer is generally divided into five stages, from stage 0, in which the presence of irregular or cancer cells are known, to stage iv, in which the cancer has spread to one or several other parts of the body. The higher the number of cancer staging, the more difficult the cancer is to treat due to the progression and spread of cancer cells. According to the national comprehensive cancer network, . ...Read more
Depends: Hepatocellular cancer can be cured in some patients who have limited resectable disease or who qualify for transplantation. Transplant is typically only offered to patients who have single tumors less than 5cm in size or up to 3 less than 3cm. Other techniques like ablation and chemoembolization sometimes work, but have less chance at achieving a cure. Multidisciplinary review is recommended. ...Read more
Silent cancer: Unfortunately, liver cancer does not produce symptoms until very advanced stages. In order to catch liver cancer in its early and curable stages, it is very important for patients at high-risk to undergo screening imaging. Just like how women need mammograms, patients with hepb or cirrhosis need routine imaging to check for liver cancer. This usually involves an MRI or a ct scan every 6 months. ...Read moreSee 1 more doctor answer
Late detection and: Related pathology. Primary liver cancer often arises in patients with cirrhosis and is not detected early enough for a curative resection. There are no effective chemotherapy or radiation treatment. Most liver cancers are metastatic lesions from other cancers which by definition are incurable. ...Read more
Multiple: The symptoms of liver cancer really depend on what the cancer is from and where in the liver it is. Some have no symptoms at all. Sometimes they can cause abdominal pain. Others could be jaundice, swollen abdomen, easy bleeding or bruising, swollen legs, fatigue, weight loss. Some are because of the tumor and some are because of the loss of function of the liver from whatever caused the tumor. ...Read moreSee 1 more doctor answer
Various: Hepatocellular carcinoma is famously caused by chronic hepatitis b, c and iron overload; if alcohol is a risk it's less. Angiosarcomas from vinyl chloride. The thorotrast nightmare is mostly over. Cholangiocarcinomas flourish where there are liver flukes, and in autoimmune bile duct disease. ...Read more
This organ plays a major role in metabolism and has a number of functions in the body, including glycogen storage, decomposition of red blood cells, plasma protein synthesis, hormone production, and detoxification. It lies below the diaphragm in the abdominal-pelvic region of the abdomen. It produces bile, an alkaline compound which aids in digestion via the emulsification of ...Read more