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Doctor insights on: Lipase Inhibitor

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Lipase Inhibitor (Overview)

A lipase inhibitor is a medication that blocks lipases, the digestive enzymes that break down the fat a person eats, so that the fat can be absorbed into the body. A person who takes a lipase inhibitor will not absorb some fat from his intestines, and will not gain as many calories from his meals. The unabsorbed fats become part of his stool and sometimes causes diarrhea.


Lipase Inhibitor (Overview)

A lipase inhibitor is a medication that blocks lipases, the digestive enzymes that break down the fat a person eats, so that the fat can be absorbed into the body. A person who takes a lipase inhibitor will not absorb some fat from his intestines, and will not gain as many calories from his meals. The unabsorbed fats become part of his stool and sometimes causes diarrhea.


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Has anyone used lipase inhibitors successfully?

Yes and no: As a physician, the first time it came out. Yes, it was a success. ...Read more

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Why do lipase inhibitors not stop 100% of the fat?

Not enough amounts: Quantity and concentration related, and you get nasty foul smelling greasy stools. ...Read more

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How do lipase inhibitors stop the fat in the diet being absorbed?

How do lipase inhibitors stop the fat in the diet being absorbed?

Orlistat: Orlistat is lipase inhibiter and is used to loose weight in over weight individuals with low fat, low calorie diet and exercise.So fat is in not absorped in its entirity and is passed undigested in stools.So total calorie absorption is reduced and because of the side effects which are not pleasant people cut down on their fat intake and that helps too. ...Read more

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Why do lipase inhibitors not stop 100% of the fat from being absorbed?

Probably yes.: Lipase inhibitors are used to reduce the activity of lipases in the intestine to reduce fat absorption in the gut. They can have side effects like oily spotting, fecal inconsistence, flatus with discharge and abdominal cramping. Additionally, higher blood pressure, dry mouth, constipation, headache, and insomnia were reported. A malabsorption of fat soluble vitamins may develop. See comment. ...Read more

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Why do lipase inhibitors not completely stop all the fat from being absorbed?

Orlistst lipase inhi: Orlistat is a lipase inhibiter and has a role in fat absorption, but the dosage approved by fda, are not enough to affect 100% blockage of fat absorption.Only 25 to 30% of fat is not absorped by taking the approved doses of orlistat. ...Read more

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Why don't lipase inhibitors not stop 100% of the fat in the diet from being absorbed?

Why don't lipase inhibitors not stop 100% of the fat in the diet from being absorbed?

Orlistst lipase inhi: Orlistat is a lipase inhibiter and has a role in fat absorption, but the dosage approved by fda, are not enough to affect 100% blockage of fat absorption.Only 25 to 30% of fat is not absorped by taking the approved doses of orlistat. ...Read more

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What are lipase inhibitors (orlistat)?

Orlistat: Orlistat is lipase inhibiter and is used to loose weight in over weight individuals with low fat, low calorie diet and exercise.So fat is in not absorped in its entirity and is passed undigested in stools. ...Read more

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How are lipase inhibitors (orlistat) used as a fat blocking medication?

How are lipase inhibitors (orlistat) used as a fat blocking medication?

Orlistat stool chang: No every body who takes orlistat has fatty stools, that how it works by blocking the absorption of fats orlistat blocks the absorprtion of fats and fats are in the stools undigested and there is limited absorption. ...Read more

Dr. Todd Igel
347 doctors shared insights

Lipase (Definition)

Lipases, such as lipoprotein lipase and endothelial lipase, are enzymes that breakdown circulating triglycerides (tg). Specifically, lipases degrade tg rich lipoproteins including chylomicrons, very low density lipoprotein (vldl) and remnant particles produced by breakdown of chylomicron and vldl particles. Decreased lipase function leads to accumulation of ...Read more