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Doctor insights on: Lipase

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Dr. Todd Igel
358 Doctors shared insights

Lipase (Overview)

Lipases, such as lipoprotein lipase and endothelial lipase, are enzymes that breakdown circulating triglycerides (tg). Specifically, lipases degrade tg rich lipoproteins including chylomicrons, very low density lipoprotein (vldl) and remnant particles produced by breakdown of chylomicron and vldl particles. Decreased lipase function leads to accumulation of tg rich lipoprotein particles.


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What are lipase inhibitors (orlistat)?

What are lipase inhibitors (orlistat)?

Orlistat: Orlistat is lipase inhibiter and is used to loose weight in over weight individuals with low fat, low calorie diet and exercise.So fat is in not absorped in its entirity and is passed undigested in stools.

Dr. Todd Igel
358 Doctors shared insights

Lipase (Overview)

Lipases, such as lipoprotein lipase and endothelial lipase, are enzymes that breakdown circulating triglycerides (tg). Specifically, lipases degrade tg rich lipoproteins including chylomicrons, very low density lipoprotein (vldl) and remnant particles produced by breakdown of chylomicron and vldl particles. Decreased lipase function leads to accumulation of tg rich lipoprotein particles.


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Can you tell me in a poor pt with epigastric pain of 4 days, if you had to order just one test, which would you choose- amylase or lipase?

Can you tell me in a poor pt with epigastric pain of 4 days, if you had to order just one test, which would you choose- amylase or lipase?

Depends: If the suspicion was for pancreatitis, I would choose lipase. But the choice would depend on your history, physical findings and any other data that may be available.

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What information does lipase and amalyse blood tests gives to a doctor about a patient's health?

What information does lipase and amalyse blood tests gives to a doctor about a patient's health?

Pancreas: Lipase is a little bit more specific than amylase but both can be elevated in acute or chronic pancreatitis. They are often ordered to evaluate the cause of abdominal pain along with other tests.

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Had some blood work done today and hoping what these levels represent, Lipase is 88 and Amylase is 39. Been a heavy drinker.

Had some blood work done today and hoping what these levels represent, Lipase is 88 and Amylase is 39. Been a heavy drinker.

Appear normal: First thing is to compare your results to the reference "normal" values on the lab report. These results are normal for our lab, but may not be for a lab using different methods or different units to express them, hence the need to check the range for the lab. If both normal it reassures that you are unlikely to have seriously damaged your pancreas by previous drinking. Keep alcohol intake low!

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Blood test: measure serum lipase fasting, then measure again 30 min after lundh meal. How much should lipase rise?

Blood test: measure serum lipase fasting, then measure again 30 min after lundh meal. How much should lipase rise?

Negligible: All else being normal one would not expect there to be a rise in lipase beyond laboratory normals. Amylase (also a salivary enzyme) may be elevated but still within laboratory normal limits, .

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Is it dangerous to live with a lipase deficiency?

Can be: Lipase deficiency is unlikely to be an isolated defect. The commonest cause is likely to be destruction of pancreas due to cystic fibrosis or chronic pancreatitis. In any case lipase deficiency will cause malabsorption of fats and fat soluble vitamins. Oral enzyme supplements are available to address the pancreatic enzyme deficiencies.

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Can pancreatic enzymes with protease, amylase and lipase hurt or help cancer?

Health fraud: Giving the pancreatic enzymes that help in pancreatic insufficiency (cystic fibrosis, chronic pancreatic scarring) as a cancer treatment is a cynical, cruel fraud. It's often packaged with "detoxification" and coffee enemas. Don't pay money to the people who've tried to deceive you on the thought "what if it did work? ".

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What does having a high lipase mean?

Pancreatitis: High serum levels of lipase, at about three times the upper limit of normal, is usually associated with pancreatitis.

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Normal lipase levels means healthy pancreas?

Not really: All it means is that you don't have pancreatitis at the time of the blood draw. If the pancreas were damaged by previous episodes of pancreatitis, the lipase would still be normal.

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My wife is called in to see her doc...Apparently she has high lipase and sodium levels...What does this mean?

Pancreas: High lipase levels are associated with pancreatic injury, inflammation, obstruction etc. High sodium may or may not be related to high lipase. Keep the appointment with your doctor as more tests are likely to be needed.

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Discomfort on the up abdomen rad to the back, but showed high total bilirubin (1.5 mg/dL); low amylase (24 U/L), and low lipase (12 U/L).  What is it?

Discomfort on the up abdomen rad to the back, but showed high total bilirubin (1.5 mg/dL); low amylase (24 U/L), and low lipase (12 U/L).  What is it?

Many Possibilities: There are many unanswered questions, ei: characteristic of pain, relieving factors, precipitating factors and duration of pain to name a few. Having said this, the slightly elevated total bilirubin might suggest a gallbladder issue, ei:biliary colic from gallstones. See you primary doctor and answer the above questions, this will guide appropriate work up and treatment.

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I was admitted to hospital monday with pancreatitis. My lipase was 14, 000. I was releases wednesday with a normal lipase. I am still in pain.?

Pancreatitis: Of course you are. This dangerous inflammation or infection of the pancreas can take quite some time to repair and resolve. The hospital would have sent you home with instructions on fluids and when you can resume a diet. You should have a follow up scheduled to make sure your post hospital course has continued to be one of improvement.

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What causes low lipase?

No disease: Low lipase is not a pathologic state. You did not state the actual level and the normal ranges that the lab would have reported.

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What does having a high lipase mean?

Pancreatitis: High serum levels of lipase, at about three times the upper limit of normal, is usually associated with pancreatitis.

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Is a lipase lvl of 360 units of normal range?

No: The level is higher than normal. You may consult this site for information on this topic: https://medlineplus. Gov/ency/article/003465.htm

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What is the definition or description of: lipase?

What is the definition or description of: lipase?

Triglyceride: Lipases, such as lipoprotein lipase and endothelial lipase, are enzymes that breakdown circulating triglycerides (tg). Specifically, lipases degrade tg rich lipoproteins including chylomicrons, very low density lipoprotein (vldl) and remnant particles produced by breakdown of chylomicron and vldl particles. Decreased lipase function leads to accumulation of tg rich lipoprotein particles.

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Chronic lipase elevation. Negative EUS. Possible causes?

Ignore it: Some people's lipase always runs high, and if the amylase is normal and there's nothing else to suggest pancreatitis on imaging or maldigestion / pancreatic insufficiency clinically, this is probably a false lead.