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Doctor insights on: Lifespan Major Thalassemia

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Does beta thalassemia minor reduce life expectancy?

Does beta thalassemia minor reduce life expectancy?

Not Usually: People with beta thalassemia minor usually only have problems with mild anemia and are not typically considered to have a shorter life span than the general population. Beta thalassemia minor typically does not require any type of treatment or intervention and often goes undiagnosed. ...Read more

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Dr. Michael Engel
272 doctors shared insights

Thalassemia (Definition)

An inherited condition ...Read more


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Do beta thalassemia and sickle cell anemia always reduce life expectancy?

Do beta thalassemia and sickle cell anemia always reduce life expectancy?

Not if just 1 trait: Having either beta thalassemia trait or sickle cell trait is a mild condition and should not cause symptoms to the point of making a person frequently ill nor shortening life expectancy. Having beta thalassemia major or sickle cell disease, or both sickle cell trait and beta thalassemia trait, usually causes severe enough chronic disease symptoms to shorten lifespan an uncertain amount. ...Read more

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Is sickle cell crisis more severe in sickle cell thalassemia or sickle cell alone?

Is sickle cell crisis more severe in sickle cell thalassemia or sickle cell alone?

Most less severe: Most are less severe in sickle cell thalassemia, but depends. HbS/B(0)thal: similar to HbSS in severity maybe slightly less severe. HbS/B(+)thal: has 60% HbSS and 30% HbA, thus less severe than HbSS (sickle cell alone). HbS/A-thal: less severe than HbSS due to decreased HbSS amount. ...Read more

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Can thalassemia minor change into thalassemia major?

Can thalassemia minor change into thalassemia major?

No: Thalassemia minor is a heterozygous condition and thalassemia major is homozygous and a person is born with the defect. One does not turn into the other. ...Read more

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Do hb e/beta thalassemia anemia reduce life expectancy?

Do hb e/beta thalassemia anemia reduce life expectancy?

Not necessarily: Did you look at the website reference i sent? It is quite informative. You will be best served with a visit to a specialist to get all your questions answered. It is clear you are so worried about this, and it would be so much more reassuring to have a face to face visit with someone who can answer all your great questions. ...Read more

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What is the life expectancy with sickle cell anemia?

What is the life expectancy with sickle cell anemia?

close to normal : Scd is many types , the most severe is the ss-disease . Even among patients with ss disease, there are risin the past it was about 4decades. With the improved care, prevention of serious complications by early diagnosis, blood transfusion, exchange for stroke patients and the use of hydroxy urea, life expectancy is becoming close to normal in many patients with scd who are under good medical care. ...Read more

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Is beta thalassemia major andd hb e/beta thalassemia same?

Not the same.: Hemoglobin e is found in the asian population frequently and may be seen with thal trait. Thal major is a serious problem requiring much intervention, including transfusions and frequently splenectomy. Your doctor should be your guiding you. Pregnancy needs to be discussed with your doctor. ...Read more

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Is hgb e/beta thalassemia is dangerous for survive?Is it major thalassemia?

Manifestations vary: Hgb e/b-t results from inheritance of a HGB e mutation from one parent and a beta-thalassemia mutation from the other parent. The severity of HGB e/b-t varies from mild to severe. ~50% of individuals who have HGB e/b-t have severe manifestations that resemble thalassemia major. ~50% of individuals who have HGB e/b-t have symptoms similar to thalassemia intermedia. ...Read more

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What's the life expectancy of someone with sickle cell anemia?

What's the life expectancy of someone with sickle cell anemia?

Shortened. : Depends on the complications experienced as a child. Those with numerous complications will love shorter lives than those without complications. Those without complications can live into their 60s the average lifespan of someone with sickle cell is probably in the mid to late 40s we are still trying to understand why some people have so many troubles and others do not. ...Read more

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Does thalassemia alpha shorten life?

Depends: There are four grades of severity of alpha thalassemia. Lack of one or two genes would not affect the life span. Lack of three genes may alter health and life span. Lack of all four genes is generally not compatible with life. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex, if you have sex. Get HPV vaccine. ...Read more

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Is sickle cell anemia purely a genetic disorder?

Is sickle cell anemia purely a genetic disorder?

I Don't Think So: I'm guessing a bit as to what you mean by your question. Sickle cell anemia is caused by a gene mutation on both copies of the beta globin gene. In that sense it is a genetic disease. However, a number of other factors, some of them environmental, can influence the type and severity of problems that patients with ssa have. ...Read more

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Is there a treatment available for people with sickle cell trait and alpha thalassemia?

Is there a treatment available for people with sickle cell trait and alpha thalassemia?

Yes: Hematologists (blood specialists) evaluate persons with both sickle cell trait and Alpha thalassemia disease. The sickling should not be a problem, because the person is only sickle trait, and Alpha thal. Mutations seem to lessen the tendency of blood cells to sickle from the sickle cell mutation. Persons with both sickle trait and Alpha thal. Trait probably won't have symptoms needing treatment. ...Read more

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What's the life span of someone with sickle cell anemia?

What's the life span of someone with sickle cell anemia?

Variable : The problem with sickle cell anemia is prognosis varies. Most are living longer because of better infection control, newer medication like hydrea, (hydroxyurea) and improved follow up managment. Some patients can have sickle cell and greater levels of hbf and they tend to do better. Predictors can include sausage digits, stroke, renal failure, anemia level less then 7, leukocytosis. The best answer is it varies. ...Read more

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Is sickle cell anemia prevalent where malaria doesn't exist?

Only here in the US: If you compare a MAP of malaria prevalence (number of cases) to a MAP of sickle cell disease prevalence, they are almost super-imposable with one exception; the United States. The prevalence of sickle cell anemia in the us is as high as some african countries with lower malaria frequencies, but our only malaria comes from travelers. ...Read more

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What chromosome carries the gene for sickle cell anemia?

What chromosome carries the gene for sickle cell anemia?

Chromosome No. 11: Point mutation at beta-globin gene located at chromosome no. 11 results in production of defective hemoglobin, sickle hemoglobin. ...Read more

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How is living with sickle cell anemia/disease?

Depends on the sever: It all depends on what kinds of sickle cell anemia you have and how severe it is. For instance someone with sickle cell trait may have no problems whatsoever. ...Read more

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Does alpha thalassemia trait have gene therapy available?

Does alpha thalassemia trait have gene therapy available?

No: Alpha thalassemia trait only causes mild anemia, and the person usually has no symptoms. Gene therapy is not available and would not be needed. ...Read more

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Can an alpha thalassemia carrier marry a beta thalassemia carrier?

Can an alpha thalassemia carrier marry a beta thalassemia carrier?

Of course you can: A person can marry anyone they like. From a thalassemia perspective, and assuming your Alpha thal trait is in cis, your child has a 50/50 chance of being Alpha thal trait vs. Normal and a 50/50 chance of being beta thal trait vs. Normal. Given there is consideration of inheriting two distinct trait states, it would be prudent to sit with a genetic counselor to understand the implications clearly. ...Read more

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Is sickle-cell anemia a recessive, sex-linked trait?

Yes and no: Sickle cell disease is recessive; you need to inherit a sickle gene from both parents to get the disease. It is not x-linked, however; if it were it would affect only boys. Boys and girls are equally affected by sickle cell disease. ...Read more

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