Doctor insights on:
Lifespan Major Thalassemia
Beta: 20's to 30's: Alpha thalassemia major is fatal before birth in almost all cases. Beta thalassemia major babies look normal at birth. Symptoms start after age 6-8 months. If good treatment starts then, with regular transfusions, plus chelation to remove excess iron, patients can survive into their 20's and 30's. Medical care and technologies improve over time, so that patients today may live longer than before. ...Read more
It varies: Beta-thal major is a serious blood disorder that requires significant medical care. These children require regular blood transfusions and then treatments to keep their body from holding on to too much iron from these transfusions. Some children are cured of this disease with a bone marrow transplant, and if successful, may have a normal life span, but not all children are eligible for transplant. ...Read moreSee 1 more doctor answer
See below: The most severe form of Alpha thalassemia major causes stillbirth (death of the unborn baby during birth or the late stages of pregnancy). Children born with thalessemia major (cooley's anemia) are normal at birth, but develop severe anemia during the first year of life. Other symptoms can include: •bone deformities in the face •fatigue •growth failure •shortness of breath •yellow skin. ...Read more
Anemia symptoms: The symptoms of beta thalassemia major are those of severe anemia, which include weakness, pallor (pale appearance), decreased growth/development, rapid heart rate, exercise intolerance, thickened bones as the marrow enlarges to try to make more blood cells, enlarged spleen, etc... ...Read moreSee 1 more doctor answer
Manifestations vary: Hgb e/b-t results from inheritance of a HGB e mutation from one parent and a beta-thalassemia mutation from the other parent. The severity of HGB e/b-t varies from mild to severe. ~50% of individuals who have HGB e/b-t have severe manifestations that resemble thalassemia major. ~50% of individuals who have HGB e/b-t have symptoms similar to thalassemia intermedia. ...Read more
Yes: It's a horrible disease but the newer remedies are helping these folks live longer and better. ...Read more
I'm a beta minor thalassemia carrier. And my soon to be wife is a beta minor as well. Are there treatments to reduce the risk of getting a beta major?
Rule of inheritance: Your chance of a child with homozygous beta thalassemia are 1 in 4, for heterogeneous thalassemia (thalassemia trait) are 1 in 2, and the odds are 1 in 4 for a normal hemoglobin profile. There are procedures commercially available to eliminate the risk of beta thal major if your philosophy allows for it. We can discuss further; www.healthtap.com/dr-nnebe ...Read more
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