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Doctor insights on: Lexapro And Wellbutrin

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What're the differences between Lexapro and wellbutrin (bupropion)?

What're the differences between Lexapro and wellbutrin (bupropion)?

Differences: Lexapro is a serotonin specific reuptake inhibitor. Wellbutrin (bupropion) is a norepinephrine-dopamine reuptake inhibitor. While both are antidepressants, ssris tend to be better for anxiety conditions than wellbutrin (bupropion). Wellbutrin (bupropion) is more effective for comorbid substance use disorders. Wellbutrin (bupropion) is very weight friendly, does not tend to impair sexual function, but has a somewhat higher seizure risk. ...Read more

Dr. Alan Ali
792 Doctors shared insights

Bupropion (Definition)

Also called wellbutrin (bupropion) or zyban or aplenzin, is an atypical antidepressant & smoking cessation aid, which has mild psychostimulant action. It is a norepinephrine/dopamine reuptake inhibitor. It can lower seizure threshold at high doses, ...Read more


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Can oxycodone be taken if lexapro and Wellbutrin (bupropion) are being taken daily?

Can oxycodone be taken if lexapro and Wellbutrin (bupropion) are being taken daily?

Medications: There is always a risk of adverse effect when combining medications. That risk is increased with narcotic pain medications (like Oxycodone) and mood disorder medications such as lexapro and wellbutrin (bupropion). It is very important to fully disclose all your medications to your physician. I would recommend contacting your prescribing physician for further instructions. ...Read more

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How do I safely taper off: 10mg lipitor, 20mg lexapro, 150mg wellbutrin &. 5mg xanax?

How do I safely taper off: 10mg lipitor, 20mg lexapro, 150mg wellbutrin &. 5mg xanax?

With help: That is a very interactive combination of meds-changing one may affect how thee others work. You need help from a professional, who can change one --review the effects--then change the next most appropriate one. Usually a psychiatrist or family physician are the most appropriate for this. ...Read more

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Which antidepressant would you recommend for anxiety Lexapro or wellbutrin (bupropion)?

Which antidepressant would you recommend for anxiety Lexapro or wellbutrin (bupropion)?

Anxiety medication: Lexapro and other ssri medications are considered first line treatment for a variety of anxiety disorders. Wellbutrin, (bupropion) while often a very effective medication for depression (and off-label for add/adhd), does not have a significant serotonin effect and therefore is not considered to be a great medication to treat anxiety. It does help with depression that can be co-morbid commonly with anxiety. ...Read more

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Is lexapro and Wellbutrin (bupropion) a good combination for post partum anxiety and depression?

Is lexapro and Wellbutrin (bupropion) a good combination for post partum anxiety and depression?

Discuss w/ OBGYN, etc: Less is best if you are breastfeeding and if one works it may be better than a mix, but ask your pediatrician and OBGYN and psychiatrist if you have one. Please consider good psychotherapy since it's a big help to make these months easier - new mother support is very important! It might even make drugs less needed. Best wishes! ...Read more

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I tried celexa, effexor, cymbalta, pristiq, (desvenlafaxine) lexapro, zoloft, wellbutrin, which barely helped. What else could I try? How do u feel about paxil?

I tried celexa, effexor, cymbalta, pristiq, (desvenlafaxine) lexapro, zoloft, wellbutrin, which barely helped. What else could I try? How do u feel about paxil?

Agree w/Dr. Buggie: I agree with dr. Buggie about the need for psychiatric evaluation and ongoing treatment. Wellbutrin does not help with anxiety. Paxil (paroxetine) is a reasonable choice, but whether it's right for you I cannot say. You're also on Adderall xr, which can exacerbate anxiety in some. Psychotherapy is an important part of treatment for anxiety also -- but you didn't mention pursuing that. ...Read more

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Side effects of Lexapro wellbutrin and Xanax (alprazolam) together?

Side effects of Lexapro wellbutrin and Xanax (alprazolam) together?

Low probability: There are the possibility of low probability side effects. With respect to specific interactions, the most prominent thing to remember is that if you stop taking your xanax (alprazolam) suddenly while taking wellbutrin and Lexapro you may make it more likely that you would have a seizure. You also may find operating a motor vehicle more challenging when taking xanax (alprazolam) with any medications. ...Read more

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I will be starting back on of Lexapro tomorrow w/ wellbutrin XL 150mg. Cymbalta (duloxetine) 60mg has not been helpful for past 4mo. I hope to get the results I?

I will be starting back on of Lexapro tomorrow w/ wellbutrin XL 150mg. Cymbalta (duloxetine) 60mg has not been helpful for past 4mo. I hope to get the results I?

Good combo: Sounds like you're really going through a rough time. .. I really hope this combination works for you. It's one that I prescribe quite often and have seen quite a bit of success with. Unfortunately there aren't any guarantees in medicine - best to have a continuous dialogue with your psychiatrist and psychologist for the best possible outcome. Hope you feel better soon! ...Read more

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I am currently taking lexapro Wellbutrin (bupropion) and alprazolam. Is it safe to take vyvanse with these medications?

It may not be: Wellbutrin (bupropion) has a well-known potential side effect of producing seizures (usually in higher doses like 450mg/day and in seizure-prone individuals) and Vyvanse may compound that risk. I am not a fan of alprazolam use in most people, particularly those with depression. Sounds like your depression has been significant, and perhaps you should consider a second opinion from another psychiatrist. ...Read more

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I'm taking lexapro Wellbutrin (bupropion) and alprazolam. Is it safe to take a vyvanse with these medications in my system?

I'm taking lexapro Wellbutrin (bupropion) and alprazolam. Is it safe to take a vyvanse with these medications in my system?

Caution: You already have significant drug interactions with the 3 meds listed. Adding Vyvanse plus Wellbutrin (bupropion) increases risk for seizures. Vyvanse plus Lexapro increases side effects of Vyvanse and risk for serotonin syndrome. Review these meds with prescribing doctor. You need close medical supervision to take these medications. I hope this helps. ...Read more

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I am being prescribed Lexapro, wellbutrin and elavil for depression and anxiety. Is this combo safe?

I am being prescribed Lexapro, wellbutrin and elavil for depression and anxiety. Is this combo safe?

Drug Interactions: Elavil (amitriptyline) + Wellbutrin (bupropion) ^ es seizure risk. Escitalopram +amitriptyline ^'es risk of serotonin syndrome. Wellbutrin + Lexapro ^es seizure risk. I am assuming that the Elavil is added in for insomnia or pain control and not for depression/ anxiety. This does not mean that these drugs can't be used together but there are possible drug interactions. D/W your physician. ...Read more

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Can I take vinpocetine, 4-amino-3-phenylbutyric acid, 5-HTP, caffeine gamma-aminobutyric acid while on lexapro 20mg and Wellbutrin XL 150mg?

You should consult: You primary care physician before mixing of drugs and over the counter supplements, as this could cause adverse effects and bring you down off what is stable for you. ...Read more

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Is there any supplements to help a male experiencing no sex drive on 10mg Lexapro and 150mg wellbutrin (bupropion) XL for ocd/anxiety?

Is there any supplements to help a male experiencing no sex drive on 10mg Lexapro and 150mg wellbutrin (bupropion) XL for ocd/anxiety?

Female sex cream: Apricus biosciences is currently developing the product femprox, a topical cream for the treatment of female sexual arousal disorder. It contains prostaglandin e1 as the active ingredient and a permeation enhancer ddaip which facilitates the delivery of the drug into the blood stream. An existing drug, bremelanotide, has also been found to increase libido in 90% of subjects. ...Read more

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What is the best medicine for OCD. We have tried Zoloft, lexapro, wellbutrin, prozac. Side effects bad or did not work. Does Pristiq (desvenlafaxine) work for OCD?

What is the best medicine for OCD. We have tried Zoloft, lexapro, wellbutrin, prozac. Side effects bad or did not work. Does Pristiq (desvenlafaxine) work for OCD?

SSRI's failed: So one SSRI may work when another does not. Keep trying. There is a new one called Brintillex which has much greater effectiveness in the reported studies.
Also a Selegeline patch may prove effective. ...Read more

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Gained 17lbs in 7 months, not pregnant. Taking 20mg lexapro, 50mg nortriptlyne, 150mg wellbutrin (bupropion). Why? Can I take something to reduce the gain?

See your MD ASAP: 30 year old lady concerned about recent weight gain of 17 lbs over 7 months. You are currently taking three antidepressants: Escitalopram, Nortriptyline, and Bupropion. Is your psychiatrist aware that you are on all three? Are you on all three for depression or anxiety? One of these agents, preferably the SSRI, can be used at the proper dose and the other two medicines should be tapered off asap ...Read more

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My male fiance has had no sexual desire since starting on 10mg of Lexapro and 150mg of wellbutrin (bupropion). Would horny goat weed or tongkat ali help at all?

My male fiance has had no sexual desire since starting on 10mg of Lexapro and 150mg of wellbutrin (bupropion). Would horny goat weed or tongkat ali help at all?

Reduced sexual desir: I agree with dr. Wartenburg on the need to be careful with herbs here in the us, and speaking with your husband's physician before adding any of these. There are no interactions between horny goat weed, tongkat ali (actually eurycoma longifolia), lexapro, and wellbutrin (bupropion). There is also not sufficient research data to assure that either of these herbs will work for the intended purpose. ...Read more

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My doc has prescribed me 1mg Xanax, (alprazolam) 10mg Lexapro and just added 150mg Wellbutrin XL. Is this allowed? Will this cause long term problems?!

Medication effects: I understand your concern.
Reflect on symptoms of Anxiety and Depression effect on your relationships, work and personal life; medication need for anxiety or depression; then discuss medication interactions, benefits and side effects; Therapy.

Wellbutrin with Lexapro may increase the risk of seizures.
Using Xanax (alprazolam) with Lexapro may increase dizziness, confusion, and difficulty concentrating.
...Read more

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I have had severe anxiety/panic for years. I have taken prozac, zoloft, wellbutrin, lexapro, and now viibryd (vilazodone hydrochloride). Nothing seems to work. What should I do?

I have had severe anxiety/panic for years. I have taken prozac, zoloft, wellbutrin, lexapro, and now viibryd (vilazodone hydrochloride). Nothing seems to work. What should I do?

Try counseling: While some medications will not work there are meds that will but along with counseling as well. Anxiety and depression are best treated with both behavior modification and medication. Give it some thought and discuss with your provider. ...Read more

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Does wellbutrin (bupropion) have fewer side effects than lexapro?

Different: Wellbutrin (bupropion) does not cause weight gain and it does not have sexual side effects. It does carry a small but increased risk for seizures and may be more likely to make anxiety worse among other side effects. ...Read more

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I am currently on Wellbutrin (bupropion) XL and Lexapro and was prescribed Tramadol. Wanted to see if there was a bad interaction if taken together?

I am currently on Wellbutrin (bupropion) XL and Lexapro and was prescribed Tramadol. Wanted to see if there was a bad interaction if taken together?

Requires Tact: Combination of SSRI such as Lexapro can apparently cause serotonin syndrome. In addition, the manufacturer of tramadol notes concomitant therapy with SSRI increases risk of seizures. Furthermore, both Tramadol and Wellbutrin (bupropion) can lower the seizure threshold. PGT testing to determine CYP2D6 status may be able to guide treatment. The prescribing physician (s) should be informed of this combination. ...Read more

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Will taking wellbutrin (bupropion) with Lexapro help OCD and intrusive thoughts without making me gain weight?

Will taking wellbutrin (bupropion) with Lexapro help OCD and intrusive thoughts without making me gain weight?

Probably not: Wellbutrin (bupropion) will probably not make you gain weight -- but it's also unlikely to help with ocd and intrusive thoughts. Others like ssri's (like lexapro) are much better for ocd, and some are more weight-neutral (lexapro) than others. See a psychiatrist for an evaluation and discussion of options. ...Read more

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I have been on wellbutrin 150xl for 5 weeks and clonazepam as needed. Anxiety is still bad. My pdoc wants to add lexapro 10mg. Is this common?

I have been on wellbutrin 150xl for 5 weeks and clonazepam as needed. Anxiety is still bad. My pdoc wants to add lexapro 10mg. Is this common?

Yes: You are balancing the chemicals in the brain that when out of balance cause this anxiety. I hope you are also getting psychological counseling to address non medication approaches to address this as well, so you can avoid the panic which often accompanies your condition. ...Read more

Wellbutrin (Definition)

Bupropion is an addiction reducing agent and an antidepressant which are both a ...Read more