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Doctor insights on: Levodopa Uses

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Can you explain the mechanism of orthostatic hypotension that occures due to use levodopa?

Can you explain the mechanism of orthostatic hypotension that occures  due to use levodopa?

Orthostatic hypotens: Orthostatic hypotension — also called postural hypotension — is a form of low blood pressure that happens when you stand up from sitting or lying down. In a series of 100 patients treated with levodopa, 25 developed significant orthostatic hypotension (ann intern med. 1970;72(5):751-752. Doi:10.7326/0003-4819-72-5-751). ...Read more

Levodopa (Definition)

A drug which when it gets into the brain is converted to Dopamine that ...Read more


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Does the use of the neupro patch and stalevo (carbidopa and levodopa and entacapone) 125 lessen the incidence of psycosis ?

Does the use of the neupro patch and stalevo (carbidopa and levodopa and entacapone) 125 lessen the incidence of psycosis ?

Parkinson's Disease: These are both medications used to treat parkinson's disease, not psychosis. Some antipsychotic medications can induce parkinsonism in movements -- not true parkinson's disease. Sometimes these meds used to treat parkinson's may cause psychotic symptoms. Late-stage parkinson's disease can also involve a type of dementia with hallucinations as well. ...Read more

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When did levodopa become available?

1960s: Taken from Parkinson Foundation web site: •Levodopa was developed in the late 1960s and was the first medication proven effective in treating a chronic neurodegenerative disease like PD. ...Read more

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What is the definition or description of: levodopa?

What is the definition or description of: levodopa?

Def of levodopa: A drug which when it gets into the brain is converted to Dopamine that help to treat parkinson's. ...Read more

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How long it takes levodopa to be absorbed into the body?

How long it takes levodopa to be absorbed into the body?

Drug absorbtion: Levadopa is absorbed in the duodenum and is only about 30% boavalable, The general time to peak plasma concentration following an oral dose is 30-60min ...Read more

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How does the drug carbidopa affect levodopa?

Blocks breakdown: Carbidopa acts to block the enzyme aromatic-l-amino-acid decarboxylase which converts l-dopa to dopamine. Since it cannot get into the brain it works in the rest of the body (periphery). When given in combination with l-dopa in parkinson's disease, it inhibits the conversion of l-dopa to Dopamine in the body so that more is available to be converted in the brain where it is needed. ...Read more

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When taken with levodopa the dosage of azilect (rasagiline) is often reduced from 1mg to 0.5mg, why is this?

When taken with levodopa the dosage of azilect (rasagiline) is often reduced from 1mg to 0.5mg, why is this?

Increase side effect: When Azilect (rasagiline) is used with carbidopa/levodopa the potential side effects of Levodopa are increased, thus one of the doses of Azilect (rasagiline) or carbidopa/levodopa are decreased from the dose that would be used with either drug alone. ...Read more

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What is the typical reduction in levodopa after DBS surgery?

What is the typical reduction in levodopa after DBS surgery?

None: By "none" I don't mean no reduction, I mean no typical. Any statistics on dose reduction after DBS are descriptive not predictive; i.e. they only average out the result of a large pool of patients. The individual patient needs individualized therapy. Dose reduction can range from 100% (rare) to none (much more common). Depends on both efficacy AND tolerability of the drug. ...Read more