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Orthostatic hypotens: Orthostatic hypotension — also called postural hypotension — is a form of low blood pressure that happens when you stand up from sitting or lying down. In a series of 100 patients treated with levodopa, 25 developed significant orthostatic hypotension (ann intern med. 1970;72(5):751-752. Doi:10.7326/0003-4819-72-5-751). ...Read more
Does the use of the neupro patch and stalevo (carbidopa and levodopa and entacapone) 125 lessen the incidence of psycosis ?
Parkinson's Disease: These are both medications used to treat parkinson's disease, not psychosis. Some antipsychotic medications can induce parkinsonism in movements -- not true parkinson's disease. Sometimes these meds used to treat parkinson's may cause psychotic symptoms. Late-stage parkinson's disease can also involve a type of dementia with hallucinations as well. ...Read more
Def of levodopa: A drug which when it gets into the brain is converted to Dopamine that help to treat parkinson's. ...Read more
Blocks breakdown: Carbidopa acts to block the enzyme aromatic-l-amino-acid decarboxylase which converts l-dopa to dopamine. Since it cannot get into the brain it works in the rest of the body (periphery). When given in combination with l-dopa in parkinson's disease, it inhibits the conversion of l-dopa to Dopamine in the body so that more is available to be converted in the brain where it is needed. ...Read more
When taken with levodopa the dosage of azilect (rasagiline) is often reduced from 1mg to 0.5mg, why is this?
None: By "none" I don't mean no reduction, I mean no typical. Any statistics on dose reduction after DBS are descriptive not predictive; i.e. they only average out the result of a large pool of patients. The individual patient needs individualized therapy. Dose reduction can range from 100% (rare) to none (much more common). Depends on both efficacy AND tolerability of the drug. ...Read more
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