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Orthostatic hypotens: Orthostatic hypotension — also called postural hypotension — is a form of low blood pressure that happens when you stand up from sitting or lying down. In a series of 100 patients treated with levodopa, 25 developed significant orthostatic hypotension (ann intern med. 1970;72(5):751-752. Doi:10.7326/0003-4819-72-5-751). ...Read more
Def of levodopa: A drug which when it gets into the brain is converted to Dopamine that help to treat parkinson's. ...Read more
Blocks breakdown: Carbidopa acts to block the enzyme aromatic-l-amino-acid decarboxylase which converts l-dopa to dopamine. Since it cannot get into the brain it works in the rest of the body (periphery). When given in combination with l-dopa in parkinson's disease, it inhibits the conversion of l-dopa to Dopamine in the body so that more is available to be converted in the brain where it is needed. ...Read more
None: By "none" I don't mean no reduction, I mean no typical. Any statistics on dose reduction after DBS are descriptive not predictive; i.e. they only average out the result of a large pool of patients. The individual patient needs individualized therapy. Dose reduction can range from 100% (rare) to none (much more common). Depends on both efficacy AND tolerability of the drug. ...Read more
How long does Levodopa take to work with Dopamine-responsive dystonia? what's the usual dose for this?
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