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Doctor insights on: Leukodystrophy

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Dr. Michel Philippart
18 doctors shared insights

Leukodystrophy (Overview)

Leukodystrophy is a condition in which a person has progressive degeneration of the white part of the brain over time. The white part of the brain is white due to the fatty insulation material around the nerves.


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What exactly is aldrino leukodystrophy?

What exactly is aldrino leukodystrophy?

Genetic disorder: Adrenoleukodystrophy is genetic disorder that mainly affects males and results in the accumulation of very-long chain fatty acids in tissues throughout the body, mainly the central nervous system and the adrenal cortex, causing progressive neurodegenrative changes and adrenal insufficiency respectively. Prognosis not good unfortunately. ...Read more

Dr. Michel Philippart
18 doctors shared insights

Leukodystrophy (Overview)

Leukodystrophy is a condition in which a person has progressive degeneration of the white part of the brain over time. The white part of the brain is white due to the fatty insulation material around the nerves.


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What are the symptoms of leukodystrophy?

What are the symptoms of leukodystrophy?

Leukodystrophy signs: gait disturbances •memory deficits •seizures (may be present) •loss of motor developmental milestones •decreased attention span •speech disturbances •decline in school performance the early juvenile form includes the following: •gait disturbances •tremors •clumsiness •loss of previously achieved skills •intellectual decline •behavioral changes •seizures (possible) the late juvenile and adult for. ...Read more

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How much is duration of life for patients newly diagnosed with leukodystrophy?

How much is duration of life for patients newly diagnosed with leukodystrophy?

Depends on type/form: For example, infantile metachromatic leukodystrophy onset is by age 2, with 50-60% morbidity by 5. Juvenile onset between age 4-10 (20-30% of cases) has slower progression. There are 2 adult-onset forms, one starts with neurologic/motor problems, the other with behavioral challenges. Please ask the attending specialist. ...Read more

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What are the tests for leukodystrophy?

What are the tests for leukodystrophy?

Leukodystrophy tests: Neurodevelopmental tests demonstrate the following findings in patients with infantile or early juvenile metachromatic leukodystrophy: •loss of previously achieved developmental milestones •tremors •truncal ataxia •hyperreflexia progressing to hyporeflexia •hypotoniagait abnormalities •optic atrophy neurocognitive tests demonstrate other abnormalities. ...Read more

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Are leukodystrophies like metachromatic leukodystrophy (mld) treatable?

Are leukodystrophies like metachromatic leukodystrophy (mld) treatable?

Leukodystrophy: There is no cure for mld. Bone marrow transplantation may delay progression of the disease in some cases. Other treatment is symptomatic and supportive. Considerable progress has been made with regard to gene therapy in an animal model of mld. (http://www.Ninds.Nih.Gov/disorders/metachromatic_leukodystrophy/metachromatic_leukodystrophy.Htm). ...Read more

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What is the treatment for leukodystrophy?

What is the treatment for leukodystrophy?

Leukodystrophy Rx: Treatment there is no cure for mld. Care focuses on treating the symptoms and preserving the patient's quality of life with physical and occupational therapy. Research is studying techniques to replace the missing enzyme (arylsulfatase a). http://www.ncbi.nlm.nih.gov/pubmedhealth/pmh0002185/. ...Read more

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Are there any possible treatments for leukodystrophy?

Are  there any possible treatments for leukodystrophy?

Leukodystrophy Rx: Treatment there is no cure for mld. Care focuses on treating the symptoms and preserving the patient's quality of life with physical and occupational therapy. Research is studying techniques to replace the missing enzyme (arylsulfatase a). http://www.ncbi.nlm.nih.gov/pubmedhealth/pmh0002185/. ...Read more

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Are there any homeopathic cures for leukodystrophy?

Doubt it: I do not know of any effective homeopathic treatments for any illness, let alone one as serious as leukodystrophy. ...Read more

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Is there any cure for genetic disease called leukodystrophy?

Leukodystrophy Rx: Treatment there is no cure for mld. Care focuses on treating the symptoms and preserving the patient's quality of life with physical and occupational therapy. Research is studying techniques to replace the missing enzyme (arylsulfatase a). http://www.ncbi.nlm.nih.gov/pubmedhealth/pmh0002185/. ...Read more