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We tried Clomid (clomiphene) 50mgs for our first cycle w/o results. Our doctor says to raise Clomid (clomiphene) to 100mg or try letrozole at a low dosage. What should we do?
Ask your doctor: I have my patients use 3 different doses of Clomiphene (up to 150 mg) before switching to letrozole, but some doctors prefer to start with letrozole. If you did not ovulate with 50 mg clomiphene, and you have been adequately evaulated for other causes of infertility/anovulation, then 100 mg should be safe. ...Read more
Letrozole is a commonly used medicine for the prevention/treatment of certain types of breast cancer. It is a safe medicine. It prevents the conversion of male to female hormones. It is also commonly used now for fertility treatment. It can help ovulation and can help a woman make an extra egg sometimes. It is often used instead of Clomid (clomiphene) for fertility treatment ...Read more
See below: 2.5 to 7.5 mg on cycle days 3 to 7. ...Read more
Eliminating estrogen: Letrozole like anastrazole and Exemestane is an aromatase inhibitor. In postmenopausal pts, the ovaries no longer produce estrogen but the body creates low levels of estrogen via the enzyme aromatase. The ais block this enzyme thus eliminating any estrogen. In premenopausal pts, this actually causes a feedback that stimulates the ovaries to make more estrogen thus it can't be used to treat er+. ...Read moreSee 1 more doctor answer
Wouldn't do it: Be careful, this is a prescription drug for a reason. It's used for treatment of some breast cancers, and used 'off-label' for ovulation induction. In both cases it's not wonder drug, it needs to be monitored by a doctor who can insure safety and efficacy. Proceed with caution! ...Read more