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Doctor insights on: Leflunomide Medication

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Can arava (leflunomide) be prescribed for lupus? What is the best medication for sle lupus when liver and kidneys are affected? Thank you very much.

Can arava (leflunomide) be prescribed for lupus? What is the best medication for sle lupus when liver and kidneys are affected? Thank you very much.

Not really: In my experience it has little or no value. The liver is not involved in lupus so look for other causes. With renal disease, a biopsy is essentially and CellCept (mycophenolate mofetil) would be the drug of choice. ...Read more

Dr. Mark Ingerman
33 Doctors shared insights

Leflunomide (Definition)

Leflunomide is an ...Read more


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Where can I buy arava (leflunomide)?

Where can I buy arava (leflunomide)?

Rx only: Arava is a prescription drug for rheumatoid arthritis. It needs to be prescribed and monitoring by a physician familiar with its use. Arava or the generic, leflunomide, can be purchased through most pharmacies and long term distribution pharmacies. ...Read more

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Can leflunomide cause bleeding?

Can leflunomide cause bleeding?

If?: It can lower platelets. If liver problems (hepatitis occurs, lower fibrinogen levels occur and can also cause bleeding. Low platelet counts are more likely. ...Read more

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Are many people with RA taken off leflunomide?

Are many people with RA taken off leflunomide?

Only: If there are specific side effects or it does not work! ...Read more

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Is arava (leflunomide) cheaper then methotrexate?

Is arava (leflunomide) cheaper then methotrexate?

Methotrexate cheaper: Generic Methotrexate is very inexpensive. If you get name brand pills it's more, but generic version of Arava (leflunomide) is more expensive than Methotrexate and Arava is the most expensive. In my experience, Methotrexate works better and has less frequent dosing (weekly instead of daily). I only use Leflunomide (arava) if Methotrexate can't be used for some reason. Side effects are similar. ...Read more

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Could leflunomide cause bleeding to the back passage?

Could leflunomide cause bleeding to the back passage?

Not unless....: If the drug causes a low platelet count, it can cause or promote bleeding anywhere. I have not seen this in my rheumatology practice, having many arthritis and psoriasis patients on this! ...Read more

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Is there anyone on leflunomide for inflammatory arthritis?

Is there anyone on leflunomide for inflammatory arthritis?

Yes!: It vis what I use next after s.C. Methotrexate, inn most situations where the drug is important! It is potentially more toxic (liver), but appropriate monitoring should minimize any risk. It is a potent and good anti-inflamatory drug. ...Read more

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I have RA and am on prednsion and arava, (leflunomide) what do you think?

I have RA and am on prednsion and arava, (leflunomide) what do you think?

Seems ok: These are known treatments for rheumatoid arthritis. They are not typically the first agents that I use and I like to try to get my patients off all steroids if I can, but I do have patients on Leflunomide (arava) if they can't take or fail Methotrexate or biologicals. ...Read more

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What are the chances of arava (leflunomide) harming a baby while pregnant?

Quite serious: Leflunomide is category X by the FDA, the highest rating for potential for birth defects. If pregnant a doctor must follow a strict protocol outlined by the FDA. There are to date no major studies regarding pregnancy outcome in actual patients. ...Read more

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Is it safe to take leflunomide while pregnant?

Ideally No: Leflunomide is used in rheumatoid arthritis. It can cause fetal birth defects. Generally we want to get you off of this medication prior to pregnancy. You should talk to your doctor before coming off of any medication however. ...Read more

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What is the definition or description of: Leflunomide allergy?

Allergy or side -: Allergy or side effect? Rash, hives, facial swelling-these are manifestations if allergy! Low white count, gastric issues, and hepatitis are examples of potentially serious side effects. This drug should be prescribed by only a handful of specialists who use it frequently! ...Read more

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What is the definition or description of: Arava (leflunomide) allergy?

What is the definition or description of: Arava (leflunomide) allergy?

Multiple answers: Allergies or what I consider side effects to Arava can range from diarrhea to a skin rash which are common problems related to Arava. Hair loss, abdominal pain, and elevated liver function tests are also common side effects Many other issues can be seen with the drug and be found in the product information. Good luck ...Read more

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What's the probability of arava (leflunomide) harming a baby while pregnant?

What's the probability of arava (leflunomide) harming a baby while pregnant?

If you have been: If you are pregnant on arava, (leflunomide) you need to notify your prescribing doctor immediately and you may need to see a high risk ob. ...Read more

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I have RA and am on prednsion and arava, (leflunomide) what do you think about being on both?

I have RA and am on prednsion and arava, (leflunomide) what do you think about being on both?

Common combination: In rheumatoid arthritis Prednisone is given with a variety of other medication during therapy. We try to taper people off Prednisone because of its long term risks and side effects. Each medication has side effects including some of these: risk of infection, bone loss, osteoporosis, cataracts, weight gain with Prednisone and blood count and liver test with (leflunomide) generic name of arava. ...Read more

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Is arava (leflunomide) effective for rheumatoid arthritis?

Is arava (leflunomide) effective for rheumatoid arthritis?

It may be...: Again, this is a question for the treating specialist, most likely a rheumatologist. When treating a disorder like ra, there are a variety of medications that have been effective; as with everything else in medicine, no one size fits all, and the right drug or combo for each must be assessed over time by a specialist. ...Read more

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Why do I need to stop methotrexate & arava (leflunomide) before alif surgery? I can't take it for 2 months after, why?

See details: Two months is an unusually long period to hold Methotrexate after surgery. Three weeks is more the usual but it is ultimately up to your surgeon. ...Read more

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What are my chances of getting liver disease while taking arava (leflunomide) and methotrexate together?

What are my chances of getting liver disease while taking arava (leflunomide) and methotrexate together?

See details: Studies of this combination have shown increased risk of liver disease over taking just one of these meds alone. The exact risk is open to debate. I personally never prescribe this combination of meds although other rheumatologists do. ...Read more

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I have been on cholestyramine for 10 days to clear arava (leflunomide) from my system. How long will this non-stop itching last?

Discontinue: You may be having a histaminic reaction to the cholestyramine. I'd stop the medication or take Benadryl (diphenhydramine) to see if the itching improves. Tell the prescribing doctor, they will likely switch you to a different drug. ...Read more

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On enbrel 50mg weekly for 3 mos, methotrexate 25mg weekly 3mos, arava (leflunomide) 20mg 1 month, still have psoriasis lesions. Is this possible&willl psor. Ever clear?

On enbrel 50mg weekly for 3 mos, methotrexate 25mg weekly 3mos, arava (leflunomide) 20mg 1 month, still have psoriasis lesions. Is this possible&willl psor. Ever clear?

Still a bit early: So many of these medications requires several weeks or months to start working. Enbrel and Arava usually works around 3 months after starting it, and Methotrexate can take as long as 6 months before working.

I would give it another month, then reconsider. There are other good medicines that could work for you including stelara (ustekinumab). ...Read more

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Is it ok to take both prednisone and arava (leflunomide) for ra?

Is it ok to take both prednisone and arava (leflunomide) for ra?

Yes!: I have many pts. On both drugs, but I never use more than 5mg of prednisone. I would use Methotrexate before Arava (leflunomide), but that combination has been used very successfully. ...Read more

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Hello doctor I suffer from rhumatoid. I am on emthexate2.5 (8pills once a week) and arava leflunomide (a pill every two days) my liver aches. Thank u?

Hello doctor I suffer from rhumatoid. I am on emthexate2.5 (8pills once a week) and arava leflunomide (a pill every two days) my liver aches. Thank u?

Severe liver injury: Including fatal liver failure, has been reported in some patients treated with arava (leflunomide). Patients with pre-existing acute or chronic liver disease, or those with serum alanine aminotransferase (alt) > 2xuln before initiating treatment, should not be treated with arava (leflunomide). Use caution when Arava (leflunomide) is given with other potentially hepatotoxic drugs. Also emthexate2.5 have liver sisde effects but as much. ...Read more

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Read that it's advisable to stop taking arava (leflunomide) while on antibiotics to allow its effectiveness after surgery (due to infections & faster recovery). Tx?

See details: Arava (leflunomide) stays in your system for months after it is stopped. Therefore, if you need to treat a serious infection, the Arava (leflunomide) should be washed out by taking cholestyramine. Stopping it without the washout is worthless. ...Read more

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I have psa im on embrel 50mg weekly leflunomide 20mg daily pednisone 10mg daily. Still crippling pain what else can I do? Tryd mtx remicade (infliximab) humara

I have psa im on embrel 50mg weekly leflunomide 20mg daily pednisone 10mg daily. Still crippling pain what else can I do? Tryd mtx remicade (infliximab) humara

Several Rxs!: You should be on an nsaid! Cymbalta (duloxetine) may also help your pain. Also do not exclude the benefits that can accrue from metatarsal bars (feet), outsole adjustments (knees), and other non-drug interventions can make with your arthritis. ...Read more

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Alt high 60, AST high 45 on methotrexate 25mg, arava (leflunomide) 20mg, enbrel weekly. Should I be concerned? Never had pblm.

Alt high 60, AST high 45 on methotrexate 25mg, arava (leflunomide) 20mg, enbrel weekly. Should I be concerned? Never had pblm.

Talk to your doctor: Those are not terribly high lab values for alt and ast. Such modestly elevated labs that measure liver irritation (or damage/disease when > 2-3 times the upper limit of normal) can be temporarily caused by common viral infections, alcohol consumption, or interactions with other meds that affect the liver. Getting labs checked within 48hrs of Methotrexate can also result in higher lab values. ...Read more

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My mom, 60, is on methotrex 10 mg per week and leflunomide 10 mg/day for her r.A. For 1 year. Does she require folinic acid or is folate (folic acid) 5mg/day ok?

My mom, 60, is on methotrex 10 mg per week and leflunomide 10 mg/day for her r.A. For 1 year. Does she require folinic acid or is folate (folic acid) 5mg/day ok?

Folic acid ok!: She will do fine with the folic acid! 10mg of mtx is a low dose. By the way, recent paper suggested that the drugs your mom takes very effective for ra. Just read it today! ...Read more

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Spinal fusion 9 weeks ago, RA 13yrs, on mtx, plaquinil & arava, (leflunomide) still not under control. Would biologics interefere with bone growth? Have bone stimulat

Perhaps: Several medications used to treat RA can interfere with bone growth. You should talk to both your rheumatologist and to your surgeon about what you are taking and whether it should be stopped or changed while your bones are fusing. ...Read more

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Saw rheumy. Today. Gave me arava (leflunomide) 20mg+methotrexate 25mg+enbrel for psoriasis/psor. Arthritis. Is it safe, r all 3 used frequently/sometimes, opinion please?

Psoriatic Arthritis: Methotrexate (trexall) is the most common dmard used to treat psoriatic arthritis. However, it has potentially serious side effects, including lung, kidney and liver problems. Using Arava and Methotrexate together my increase the risk of hepatotoxicity & leukopenia.I would just use a biologic like Remicade or Humira or Enbrel or stelara (ustekinumab) which should control your disease but this is my opinion. ...Read more

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I have ra, am taking leflunomide 20 mg, prednisone 2.5 and plaquenil (hydroxychloroquine) 200 mg. I don't have ins. What will happen if I can't afford to continue my meds?

See below: Try going to your local hospital preferably county and go to the social work department and discuss the situation about your medications. Other options try getting some samples from your medical physician if he could contact the representative from the pharmaceutical company. Also contact the pharmaceutical company and see if they have any patient assistance programs and see if you qualify for them it is important to stay on your medications for your disease otherwise you'll have episodes of pain and further progression of your disease and disability good luck thank you. ...Read more

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Psa have tried mtx w /remicade& w/ humara no help methotrexate caused blood issues but worked better. Now embrel/leflunomide. No relief frustrated help?

Psa have tried mtx w /remicade& w/ humara no help methotrexate caused blood issues but worked better. Now embrel/leflunomide. No relief frustrated help?

MTX sc?: Mtx causes less liver issues given sc versus oral. Also mtx has more potent metabolites that take 10 weeks to develop. You did not specify what tests where abnormal. But you suggest that mtx was given alone. Was it? Mtx and Humira (adalimumab) are a good combo for psoriatic arthritis. ...Read more

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On arava (leflunomide) 20mg, enbrel 50mg weekly, methotrexate 25mg. Any other rheumatologist prescribed this for psoriasis/psor. Arthitis? I'm worried about my liver.

On arava (leflunomide) 20mg, enbrel 50mg weekly, methotrexate 25mg. Any other rheumatologist prescribed this for psoriasis/psor. Arthitis? I'm worried about my liver.

Follow laboratory: You are correct that liver problems are risk with this regimen. Your physician needs to be certain that you are followed closely and correctly. Your own responsibility is to refrain from alcohol, and be certain no additional medicines you take do not worsen this risk. If you are concerned you need to discuss this with your physician. There are other therapy choices available. ...Read more

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My mother is having Leflunomide, prednisolone & Sulphasalazine but her blood pressure is 150/100. For her BP she is having atenolol. But still unstable?

My mother is having Leflunomide, prednisolone & Sulphasalazine but her blood pressure is 150/100. For her BP she is having atenolol. But still unstable?

What is diagnosis?: What illness is being treated? Rheumatoid Arthritis?
Prednisone could increase the blood pressure but she needs more intensive blood pressure therapy. We need more information as to the remainder of her health issues, her kidney function, her age etc. ...Read more

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Bruises on leg currently taking leflunomide & sulfasalazine & B12 injection per month & metroprolol (betablocker) what is the cause of bruises in legs?

Bruises on leg currently taking leflunomide & sulfasalazine & B12 injection per month & metroprolol (betablocker) what is the cause of bruises in legs?

Bruising: Most likely cause of your leg bruises is probably the sulfasalazine, which has anti inflammatory effects and similar to aspirin can cause easy bruising. As long as you are not having serious bleeding problems you are probably ok to continue to take the medicine ...Read more

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Stomach pain and acidity after stopping rabeprazole sodium is it due to stopping it or else? Currently taking leflunomide & sulfasalazine for arthritis

Stomach pain and acidity after stopping rabeprazole sodium is it due to stopping it or else? Currently taking leflunomide & sulfasalazine for arthritis

You benefited...: ---symptomatically from a reduction in stomach acid while taking rabeprazole. Now that your acid production has resumed off the drug, you've again noticed acid-related symptoms. Every drug has advantages and disadvantages to long term use--discuss with your provider whether restarting an acid blocker in your case has more "pro" than "con.". ...Read more

Dr. Dariush Saghafi
28 Doctors shared insights

Arava (Definition)

Arava is an ...Read more