Doctor insights on:
Lambert Eaton: syndrome is an uncommon disorder of neuromuscular junction transmission with the primary clinical manifestation of muscle weakness. Knowledge of subtle clinical features and laboratory abnormalities that accompany LEMS permits the early identification of the disorder. Early recognition is particularly important because of its strong association with small cell lung cancer. ...Read more
LEMS: This disease is caused by antibodies directed against the Voltage Gated Calcium Channel (VGCC) of the presynaptic neuron. These antibodies block normal calcium flux and therefore prevent the release of acetycholine into the synapse. Antibodies can arise idiopathically, but at least 50% of LEMS cases are related to small cell lung cancer. Apparently SCLC cells express VGCC on their surface. ...Read more
A Neurologist: Lambert-Eaton syndrome is a disorder of the neuromuscular junction that can cause weakness similar to myasthenia gravis. People with LEMS have depressed or absent or absent reflexes and experience AUTONOMIC symptoms such as impotence. Neurologists will often order nerve stimulation and conduction studies and guide treatment depending on the cause.See a Neurologist. ...Read more
Neurology - not diagnosed looking for info - how quickly does Lambert Eaton Myasthenic Syndrome (LEMS) progress from experiencing the initial symptom?
Start here: Start with http://www.m.webmd.com/a-to-z-guides/lambert-eaton-myasthenic-syndromeGet a more detailed answer ›
Neurology - how quickly does Lambert Eaton Myasthenic Syndrome (LEMS) progress from experiencing the initial symptoms to when it becomes debilitating?
Do you have it?: Please repost & state whether you've been diagnosed with LEMS. It's an EXTREMELY rare condition, almost always associated with cancer, usually lung cancer. Even neuro-oncologists see it only rarely. Not being a neuro-oncologist, I think I've seen maybe one case in my entire career, and I'm not even sure about that one. ...Read more
Most tx's are nonsurgical
+p/qcalcium channel antibody. Possible lambert eaton syndrome doc thinks. No malignancy. Being treated w/ ivig & starting rituxan (rituximab). ? What is this etc.
Get a second opinion: I do not understand your health problem because we need a lot more information to make a correct diagnosis of such rare conditions as you have listed. I would advise you to seek a second opinion from a hematologist /oncologist in order to find out what exactly is wrong with you, before taking such powerful medicines as you have listed.. ...Read more
Neurology question concerning a abnormal paraneoplastic panel i was told that my panel had abnormalities in it and that I should have a chest CT scan done and a lambert eaton test and a never conduction study as well. I went to the neurologist because my
Lambert-eaton syndrome is a neuromuscular disorder associated with abnormal antibodies to what are called voltage gated calcium channels. These are channels in the membrane of the nerve part of the nerve-muscle junction. When a signal travels along the nerve to a muscle cell the tip of the nerve makes contact with the muscle cell and forms what is called a neuro-muscular junction. A substance called acetylcholine (a neuro-transmitter) is released into the neuromuscular junction and attaches to receptors on the muscle. The acetylcholine then causes potential changes in the membrane and the muscle cell is activated. The role of the voltage gated channels are to allow for the release of the acetylcholine. If abnormal antibodies are attached to the channels, the acetylcholine can't be released. This results in les. Les is sometimes confused with myasthenia gravis, a condition in which other antibodies are attacking the receptor sites at the nerve muscle junction. Both conditions can cause muscle weakness because both affect the function of the nerve muscle junction. The vgcc (voltage gated calcium channel) antibodies are often seen in people with certain types of lung and thymus tumors sometimes long before the tumor is actually found. A chest ct scan would be done to look for a tumor. An EMG and nerve conduction test would help distinguish between les and mg.
There is an association between autoimmune disorders and les not related to small cell tumors of the lung. There are treatments available. It is good that you don't have ms. Good luck to you. ...Read more
Without getting into:
minutia of detrimental and incremental repetitive nerve stimulation testing (there is a difference from a neuroelectrodiagnostic standpoint) , Eaton Lambert Syndrome is seen as a manifestation of cancer, where as Myasthenia gravis is a distinct clinical neuromuscular disorder (albeit occasionally associated with thymoma)
Sorry for the extremely long sentence. Thank you for trusting Health Tap. ...Read more
Some thoughts...: Successful diets require that a person stick to a plan for months or years, so easier goals and small milestones are good. She must be happy with the foods she gets to eat, so severe calorie restriction is not successful. Eat vegetables with little sauce or dressing. Look for healthier oils. Don't use clarified butter (an animal fat) or eat too many egg yolks. Sugar is unhealthy; try to avoid it. ...Read more
Follow the following: Exercise most days of the week (aerobic work), eat fruits and vegetables liberally, limit saturated fats, increase fish and fish oil intake, have fiber with each meal, keep your weight in check, don't smoke at all or drink excessively (one or two drinks weekly). The lower the better on LDL and the higher the better on HDL. You have to eat, just keep it healthy and you'll be fine. ...Read more
Yes, but why???: Haven't heard of any regulations against the eating of raw lamb, but why would one not cook his meat. Undercooked meat has bacteria, viruses, and parasites that are bad for people. One can enjoy a healthier lifestyle by cooking to death all those "germs", before eating. ...Read more
Why not? It is yummy: Unless you are allergic to chocolate (or cannot swallow), there is no reason why you can't. I suspect that you really mean how much can you eat? Dark chocolates contain good amount of flavenoids which have good health benefits, but like anything else, excess is not a good thing. If you have trouble with diabetes, then more restriction is needed. Consult doc regularly. Good luck. ...Read more
Wrong Forum: That answer would take up an entire book. This site allows us to give you an answer in four hundred characters or less. You must have a simple specific problem and not a general question such as yours to be successful here. Your question is way too broad and non-specific. ...Read more