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Doctor insights on: Lactic Acidosis

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Dr. Julie Abbott
33 doctors shared insights

Lactic Acidosis (Overview)

Lactic acidosis is the buildup of lactic acid in the blood, either from an increase in the body's production or the kidney being unable to remove lactic acid effectively. The most common causes are intense exercise (increased production of lactic acid) or kidney failure (unable to effectively remove lactic acid from blood). Other causes include blood infections (sepsis) and inability to breathe effectively (respiratory failure).


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What causes lactic acidosis? Is it from metformin? How to avoid lactic acidosis?

What causes lactic acidosis? Is it from metformin?  How to avoid lactic acidosis?

Lactic acidosis: Most cases of type a lactic acidosis are due to marked tissue hypoperfusion in shock or during cardiopulmonary arrest. In type b lactic acidosis, systemic tissue hypoperfusion is not apparent. Metformin therapy for type ii diabetes can cause it, although the likelihood of this is relatively low. Risk factors for this include impaired kidney function and liver disease or concurrent alcohol abuse. ...Read more

Dr. Julie Abbott
33 doctors shared insights

Lactic Acidosis (Overview)

Lactic acidosis is the buildup of lactic acid in the blood, either from an increase in the body's production or the kidney being unable to remove lactic acid effectively. The most common causes are intense exercise (increased production of lactic acid) or kidney failure (unable to effectively remove lactic acid from blood). Other causes include blood infections (sepsis) and inability to breathe effectively (respiratory failure).


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Does food change lactic acidosis levels?

Does food change lactic acidosis levels?

Yes: Many foods are acidic in nature and so anything acidic can make an acidosis worse. Alkaline diets (increasing avocado, kale, spinach, cucumber, celery for example) can help balance and acidic condition. Meats are very acidic, by the way. ...Read more

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How do we treat lactic acidosis ?

How do we treat lactic acidosis ?

Lactic acidosis: Severe lactic acidosis (la) is often associated with poor prognosis. Recognition and correction of the underlying process is the major step in the treatment of this serious condition. Intravenous administration of sodium bicarbonate (sb) has been the mainstay in the treatment of lactic acidosis. Dialysis, peritoneal in particular, can also be used in some cases to avoid a massive sb load. ...Read more

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How do you get lactic acidosis, I've just started boxing and the day after im aching allovr and im worried about this cos I have a fatty liver anyways?

How do you get lactic acidosis, I've just started boxing and the day after im aching allovr and im worried about this cos I have a fatty liver anyways?

Lactic acidosis: Although accumulation of Lactic Acid in muscles during anaerobic exercise may cause temporary burning, i don't think your soreness is related to lactic acidosis. It is more likely a result of using muscles that you haven't used for a while. Boxing is very strenuous. Lactic acidosis in hospitalized patients usually results from impaired tissue oxygenation due to tissue hypoperfusion in shock. ...Read more

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What's lactic acidosis?

Lactate + low pH: Lowered ph in your blood accompanied with a build-up of lactate. ...Read more

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How do we treat lactic acidosis ?

Lactic acidosis: Severe lactic acidosis (la) is often associated with poor prognosis. Recognition and correction of the underlying process is the major step in the treatment of this serious condition. Intravenous administration of sodium bicarbonate (sb) has been the mainstay in the treatment of lactic acidosis. Dialysis, peritoneal in particular, can also be used in some cases to avoid a massive sb load. ...Read more

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Does food change lactic acidosis levels?

Yes: Many foods are acidic in nature and so anything acidic can make an acidosis worse. Alkaline diets (increasing avocado, kale, spinach, cucumber, celery for example) can help balance and acidic condition. Meats are very acidic, by the way. ...Read more

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I'm confused, what is lactic acidosis?

Dangerous condition: The body generates energy by breaking down fat and sugar thru a very efficient mechanism that uses oxygen and produces carbon dioxide and water. When this mechanism fails, there is another inefficient back up system that generates lactic acid. Poor blood flow, low oxygen, medications, poisons, excessive exercise can cause this lactic acidosis. It should be corrected promptly. ...Read more

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Can taking one Metaformin cause lactic acidosis?

Unlikely: Theoretically Metformin can cause lactic acidosis but in setting of normal kidney function it is extremely unlikely. Liver disease and concurrent alcohol use can also increase the risk. Talk to your health care provider if you have any of the above risk factors to determine the risk of lactic acidosis. ...Read more

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What does doc do in case of lactic acidosis ?

Determine cause: Many causes of this. Treatment is directed at the underlying cause. The underlying cause is often apparent from simple review of history and observation of patient. Common causes - hypovolemia, heart failure, sepsis, alcohol, diabetes and metformin.... ...Read more

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What is the biochemical mechanism of lactic acidosis in diabetes?

What is the biochemical mechanism of lactic acidosis in diabetes?

Lactic acidosis: Please go online to "www.ncbi.nlm.nih.gov/" and look up lactic acidosis and diabetes. It won't be easy reading but worth a look. You can also go to PubMed and search for lactic acidosis and diabetes. Take your time learning about this. ...Read more

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What's the pathophysiology of lactic acidosis in von gierki's disease?

See below: La arises from impairment of gluconeogenesis. Lactic acid is generated both in the liver and muscle and is oxidized to pyruvic acid and then converted via the gluconeogenenic pathway to g6p. Accumulation of g6p inhibits conversion of lactate to pyruvate. The Lactic Acid level rises during fasting as glucose falls. In people with gsd i, it may not fall entirely to normal even when gluc levels r nml. ...Read more

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I have just been diagnosid with d-lactic acidosis. Im having a hard time learning about it. Can u please help me understand it better?

Unusual diagnosis: Caused by production and absorption of d-lactic acid in colon. This occurs when glucose and carbohydrates are delivered to the colon and are metabolized by gram positive anaerobes (lactobacillus). Resulting d- Lactic Acid is absorbed into bloodstream but not broken down by enzymes which only recognize l-lactic acid. So you become acidotic. Episodes of acidemia occur with carbohydrate loads. ...Read more

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What causes lactic acidosis? Is it from metformin? How to avoid lactic acidosis?

Lactic acidosis: Most cases of type a lactic acidosis are due to marked tissue hypoperfusion in shock or during cardiopulmonary arrest. In type b lactic acidosis, systemic tissue hypoperfusion is not apparent. Metformin therapy for type ii diabetes can cause it, although the likelihood of this is relatively low. Risk factors for this include impaired kidney function and liver disease or concurrent alcohol abuse. ...Read more

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How likely is it to develop lactic acidosis while on diaphormin for pcos?

How likely is it to develop lactic acidosis while on diaphormin for pcos?

Unlikely: It is very unlikely to develop lactic acidosis while on metformin unless you have definite renal impairment. You doctor should be able to advise you. ...Read more

Acidosis (Definition)

Normally our body chemistry is kept in a narrow range, and in particular the amount of acid in the body is kept within a narrow range. The amount of acid is measured by a value called the ph. It is normally a value between 7.35 and 7.45, values below 7.35 are considered to be "acidotic" a patient with this value of the blood chemistry ...Read more