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Doctor insights on:
Lactic Acidosis
Lactic Acidosis (Overview)
Lactic acidosis is the buildup of lactic acid in the blood, either from an increase in the body's production or the kidney being unable to remove lactic acid effectively. The most common causes are intense exercise (increased production of lactic acid) or kidney failure (unable to effectively remove lactic acid from blood). Other causes include blood infections (sepsis) and inability to breathe effectively (respiratory failure).
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What causes lactic acidosis? Is it from metformin? How to avoid lactic acidosis?
Lactic acidosis: Most cases of type a lactic acidosis are due to marked tissue hypoperfusion in shock or during cardiopulmonary arrest. In type b lactic acidosis, systemic tissue hypoperfusion is not apparent. Metformin therapy for type ii diabetes can cause it, although the likelihood of this is relatively low. Risk factors for this include impaired kidney function and liver disease or concurrent alcohol abuse. ...Read more
Lactic Acidosis (Overview)
Lactic acidosis is the buildup of lactic acid in the blood, either from an increase in the body's production or the kidney being unable to remove lactic acid effectively. The most common causes are intense exercise (increased production of lactic acid) or kidney failure (unable to effectively remove lactic acid from blood). Other causes include blood infections (sepsis) and inability to breathe effectively (respiratory failure).
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Does food change lactic acidosis levels?
Yes: Many foods are acidic in nature and so anything acidic can make an acidosis worse. Alkaline diets (increasing avocado, kale, spinach, cucumber, celery for example) can help balance and acidic condition. Meats are very acidic, by the way. ...Read more
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How do we treat lactic acidosis?
Lactic acidosis: Severe lactic acidosis (la) is often associated with poor prognosis. Recognition and correction of the underlying process is the major step in the treatment of this serious condition. Intravenous administration of sodium bicarbonate (sb) has been the mainstay in the treatment of lactic acidosis. Dialysis, peritoneal in particular, can also be used in some cases to avoid a massive sb load. ...Read more
4
Is onglyza (saxagliptin) safe for long term treatment? Possible pancreatitis and thyroid cancer? How to avoid pancreatitis, lactic acidosis, & ketoacidosis?
Pancreatitis: No medication is safe. However you should consult with your endocrinologist if you are unsure about taking this medication. ...Read more
5
How do you get lactic acidosis, I've just started boxing and the day after im aching allovr and im worried about this cos I have a fatty liver anyways?
Lactic acidosis: Although accumulation of Lactic Acid in muscles during anaerobic exercise may cause temporary burning, I don't think your soreness is related to lactic acidosis. It is more likely a result of using muscles that you haven't used for a while. Boxing is very strenuous. Lactic acidosis in hospitalized patients usually results from impaired tissue oxygenation due to tissue hypoperfusion in shock. ...Read more
6
What's lactic acidosis?
Lactate + low pH: Lowered ph in your blood accompanied with a build-up of lactate. ...Read more
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How do we treat lactic acidosis?
Lactic acidosis: Severe lactic acidosis (la) is often associated with poor prognosis. Recognition and correction of the underlying process is the major step in the treatment of this serious condition. Intravenous administration of sodium bicarbonate (sb) has been the mainstay in the treatment of lactic acidosis. Dialysis, peritoneal in particular, can also be used in some cases to avoid a massive sb load. ...Read more
8
Does food change lactic acidosis levels?
Yes: Many foods are acidic in nature and so anything acidic can make an acidosis worse. Alkaline diets (increasing avocado, kale, spinach, cucumber, celery for example) can help balance and acidic condition. Meats are very acidic, by the way. ...Read more
9
I'm confused, what is lactic acidosis?
Dangerous condition: The body generates energy by breaking down fat and sugar thru a very efficient mechanism that uses oxygen and produces carbon dioxide and water. When this mechanism fails, there is another inefficient back up system that generates lactic acid. Poor blood flow, low oxygen, medications, poisons, excessive exercise can cause this lactic acidosis. It should be corrected promptly. ...Read more
10
Can taking one Metaformin cause lactic acidosis?
Unlikely: Theoretically Metformin can cause lactic acidosis but in setting of normal kidney function it is extremely unlikely. Liver disease and concurrent alcohol use can also increase the risk. Talk to your health care provider if you have any of the above risk factors to determine the risk of lactic acidosis. ...Read more
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What does doc do in case of lactic acidosis?
Determine cause: Many causes of this. Treatment is directed at the underlying cause. The underlying cause is often apparent from simple review of history and observation of patient. Common causes - hypovolemia, heart failure, sepsis, alcohol, diabetes and metformin.... ...Read more
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What is the biochemical mechanism of lactic acidosis in diabetes?
Lactic acidosis:
Please go online to "www. Ncbi. Nlm. Nih. Gov/" and look up lactic acidosis and diabetes.
It won't be easy reading but worth a look.
You can also go to PubMed and search for lactic acidosis and diabetes.
Take your time learning about this.
...Read more
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What's the pathophysiology of lactic acidosis in von gierki's disease?
See below: La arises from impairment of gluconeogenesis. Lactic acid is generated both in the liver and muscle and is oxidized to pyruvic acid and then converted via the gluconeogenenic pathway to g6p. Accumulation of g6p inhibits conversion of lactate to pyruvate. The Lactic Acid level rises during fasting as glucose falls. In people with gsd i, it may not fall entirely to normal even when gluc levels r nml. ...Read more
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Does exercise increase the chance of getting lactic acidosis while taking metformin?
Not necessarily: Unless yo develop tissue breakdown or get dehydrated. Remain hydrated ...Read more
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I had a blood test, I was experiencing several symptoms of lactic acidosis. Could that have caused the high reading?
Unclear question: High reading of what? What are "symptoms of lactic acidosis"? What did you have the test for? ...Read more
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I have just been diagnosid with d-lactic acidosis. I'm having a hard time learning about it. Can u please help me understand it better?
Unusual diagnosis: Caused by production and absorption of d-lactic acid in colon. This occurs when glucose and carbohydrates are delivered to the colon and are metabolized by gram positive anaerobes (lactobacillus). Resulting d- Lactic Acid is absorbed into bloodstream but not broken down by enzymes which only recognize l-lactic acid. So you become acidotic. Episodes of acidemia occur with carbohydrate loads. ...Read more
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If a person is on 2000mg of metformin a day, how long would it take for lactic acidosis to develop? (i know not necessarily but let's assume it does)
Z: Does not depend on only metformin dose. Depends on the sugar control and other factors like infection or other comorbid illnesses. ...Read more
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I take 500mg metformin daily for 2 weeks now and feel fine. What are the chances of lactic acidosis? Does it happen at any time or during the beginning?
No, if healthy: If you're healthy, kidney function is normal, not in heart failure, not dehydrated; then the risk of lactic acidosis is very low. The association of metformin and lactic acidosis is actually somewhat controversial, it was seen in a different drug of the same class that has since been discontinued, but physicians and pharmacists still warn about it just in case. ...Read more
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What causes lactic acidosis? Is it from metformin? How to avoid lactic acidosis?
Lactic acidosis: Most cases of type a lactic acidosis are due to marked tissue hypoperfusion in shock or during cardiopulmonary arrest. In type b lactic acidosis, systemic tissue hypoperfusion is not apparent. Metformin therapy for type ii diabetes can cause it, although the likelihood of this is relatively low. Risk factors for this include impaired kidney function and liver disease or concurrent alcohol abuse. ...Read more
21
How likely is it to develop lactic acidosis while on diaphormin for pcos?
Unlikely: It is very unlikely to develop lactic acidosis while on metformin unless you have definite renal impairment. You doctor should be able to advise you. ...Read more
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What're symptoms of pancreatitis, kidney issues, lactic acidosis & ketoacidosis?
Symptoms: All these have manifestation similar but also different. Pain is typically seen in pancreatitis. ...Read more
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How common is lactic acidosis with metformin use? What should I look for in terms of symptoms? I take 1500mg metformin and 100mg Januvia
Lactic acidosis: There are numerous reasons why metformin is prescribed and there is too little information that you have given. You should really have a discussion with your doc or come back with much more detailed information. ...Read more
24
Can diarreah from Lactulose syrup lead to lactic acidosis?
Lactic acidosis: No, it washes ammonia from colon and helps constipation but do not take everyday for constipation ...Read more
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Can consuming alcohol while taking metformin cause lactic acidosis?
No: Though it is a black box warning I've not seen lactic acidosis in over 20 years in people who are not alcoholics. Talk to your doctor about how much you drink. ...Read more
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M58, started Metformin 500 mg from last seven days, from yesterday I am feeling moderate itching, is this serious side effect (lactic acidosis).
Unlikely: Metformin can cause a rash, but I don't believe itching is a sign of lactic acidosis. ...Read more
28
I suspect d lactic acidosis will this resolve itself after I stop the probiotics on its on or do I have to see a doctor?
Lactic Acidosis: You didn't say WHY you suspect Lactic Acidosis. It can be easily ruled out. Therefore go and get worked up. ...Read more
29
How do you get lactic acidosis, I've just started boxing and the day after im aching allovr and im worried about this cos I have a fatty liver anyways?
Lactic acidosis: Although accumulation of Lactic Acid in muscles during anaerobic exercise may cause temporary burning, I don't think your soreness is related to lactic acidosis. It is more likely a result of using muscles that you haven't used for a while. Boxing is very strenuous. Lactic acidosis in hospitalized patients usually results from impaired tissue oxygenation due to tissue hypoperfusion in shock. ...Read more
30
How common is lactic acidosis with sepsis?
With septic shock: It is a marker for end organ damage due to inadequate oxygen reception or utilization. When sepsis progresses to shock we will follow lactate (its pka is 4, so its never really acid in the blood) as a marker of our success in getting blood and oxygen to the peripheral tissues. So... In sepsis itself (without shock) it is rare, but in septic shock lactate is almost always elevated. ...Read more
Acidosis (Definition)
Normally our body chemistry is kept in a narrow range, and in particular the amount of acid in the body is kept within a narrow range. The amount of acid is measured by a value called the ph. It is normally a value between 7.35 and 7.45, values below 7.35 are considered to be "acidotic" a patient with this value of the blood chemistry ...Read more