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Doctor insights on: L Tryptophan Vs 5 Htp Depression

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Should I take 5htp for depression or tryptophan?

Should I take 5htp for depression or tryptophan?

Neither: Frankly, there is little evidence that either chemical treats depression. Both substances may get absorbed from the intestine, but they don't change brain levels of serotonin. Even if they did, depression is much more complicated than 'low serotonin'. Many people get a placebo boost from taking such products, double blind studies don't show them to be effective. ...Read more

Dr. Pamela Pappas
4,589 Doctors shared insights

Depression (Definition)

Depression is a mood disorder that can affect behavior and emotions. Symptoms of depression include feeling down most of the time, losing interest in previously enjoyable activities, increase or decrease in appetite or weight, sleeping more or less, becoming easily agitated or lethargic, feeling worthless, feeling guilty, having difficulty concentrating, thinking more about death and dying. Depression can sometimes result in suicidal thoughts and plans. In this case, emergent ...Read more


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I am struggling with anxiety, panic attacks insomnia and depression although I don't know what triggered it, maybe stress at work? This has not happened to me before. My Dr prescribed tryptophan to help sleep and told me to take vit d. Tryptophan made me

I am struggling with anxiety, panic attacks insomnia and depression although I don't know what triggered it, maybe stress at work? This has not happened to me before. My Dr prescribed tryptophan to help sleep and told me to take vit d. Tryptophan made me

May need more: It sounds like your symptoms are recent and reactive and that your doctor suggested an initial approach. Another supplement which helps with sleep is melatonin. However, I would check with your doctor about this. If your, symptoms persist, you may want to speak with a therapist about stress management. In addition, your doctor can prescribe an antidepressant if all of these options don't solve ...Read more

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5 htp and l tyrosine stack for anxiety and depression?

5 htp and l tyrosine stack for anxiety and depression?

Beware long term use: No scientific evidence that these herbal supplements are useful against psychosocial stressors. In fact, a 2007 Canadian study warned against the effects of long term use. No shortcut here, so better to exercise, relaxation technique and prescription if necessary. ...Read more

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If 5-htp causes anxiety, isn't it a little pointless to take it for depression?

If 5-htp causes anxiety, isn't it a little pointless to take it for depression?

Not so simple: Stimulating different 5ht receptors will have different effects. 5ht1a receptors will alleviate depression and anxiety. 5ht2a and c may induce anxiety. 5-htp stimulates all those receptors. Regardless, I agree that it's pointless to take 5-htp at all. It is unlikely to treat depression or anxiety any better than a sugar pill. Serotonin isn't the only answer and it's an incomplete one at that. ...Read more

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Is 5 htp or l-tyrosine effective for depression and anxiety?

Is 5 htp or l-tyrosine effective for depression and anxiety?

Probably not: This has been studied, and 5-htp, the precursor for serotonin, is sold in healthfood stores for this purpose. The idea is to flood the body and brain with precursor to increase serotonin (or with tyrosine, norepinephrine), having the same effect as getting an antidepressant. Problem is, you flood the whole body, not just specific parts of the brain, so lots of se not much specific benefits. ...Read more

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Can I try 5 HTP in morning for depression if I take a 50mg of Tramadol in early afternoon? Thank you.

Can I try 5 HTP in morning for depression if I take a 50mg of Tramadol in early afternoon? Thank you.

No! - Advise against: There's a serious interaction of increased risk of serotonin syndrome and that's not a good thing. "Trying" to find ways to feel better is a wonderful idea. But the ways that involve powerful chemicals are not for D.I.Y. (I'm not comfortable even when pros do it.) Search for changes in daily/social routines, scenes. Consider a new leisure activity, etc. Therapy support can really help. Be careful! ...Read more

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Which natural depression remedy is better st john's work. 5 htp or sam e for getting off methamphetimes?

Which natural depression remedy is better st john's work. 5 htp or sam e for getting off methamphetimes?

Need recovery progrm: Getting of meth - or any drug - is best done by being in a recovery program. Chemicals will not get you off chemicals. Addiction is a disease of disconnection. Recovery is generally not possible on your own, support from others who have been there is crucial. Try aa, na, lifering, sos, and treatment programs in your area. Also, it is important to abstain from all drugs, including alcohol. ...Read more

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What's 5-htp, and is it an implication for weight control, social anxiety, and depression?

What's 5-htp, and is it an implication for weight control, social anxiety, and depression?

No go.: 5-htp is a precursor to tryptophan the Amino Acid used to create serotonin. The national institute of health recommends not to use 5-htp until more is known. 5-htp might be unsafe. Some people who have taken it have come down with eosinophilia-myalgia syndrome (ems), a serious condition involving extreme muscle tenderness (myalgia) and blood abnormalities (eosinophilia). ...Read more

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Does 5-htp help fibromyelgia patients? If so, how does it help? I'm having a hard time finding something that helps me. All other meds I've been on I get bad side effects or depression.

Does 5-htp help fibromyelgia patients? If so, how does it help? I'm having a hard time finding something that helps me. All other meds I've been on I get bad side effects or depression.

Fibromyalgia: Fibromyalgia, sometimes is not a simple disease to treat, a lot of excersice could help, the more exercise the better it works. 5 htp is an over the counter food product, not a medication, that like many claim results in many areas, depresion, fibromyalgia and many other. I am not an expert on these products and believe that fibromyalgia is a medical condition that requieres medical care.
If none of the medication worked, increse exercise progresively until control, try yoga and thai chi. ...Read more

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Do the supplements 5-HTP and L-TYROSINE affect the birth control pill? I am on levlen (ethinyl estradiol and levonorgestrel) ED. I'm taking the supplements due to my anxiety and depression.

Ask your OB: I don't see these meds on the contraindication list for this combination pill, but I think the prescribing doctor should have explained what to avoid if you told them what medications you are currently taking. Just to make sure, ask the prescribing OB GYN if this is alright ...Read more

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What is your experience with patients with mild/moderate depression using 5-htp for treatment? I am taking 100mg & plan to slowly increase to 200mg

What is your experience with patients with mild/moderate depression using 5-htp for treatment? I am taking 100mg & plan to slowly increase to 200mg

5-HTP for depression: 5-HTP is a chemical by-product of the protein building block L-Tryptophan
5-HTP works in the brain and central nervous system by increasing production of Serotonin, an important hormone for regulating mood.
It can be helpful in mild depression.
For Moderate Depression, See a Psychiatrist for Diagnosis; discuss Therapy, 5-HTP and other medications for depression, their benefits and side effects. ...Read more

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I've been wrestling with depression for five years now. Is there anything I can do to help ease my depression?

Any treatment?: In this wrestling with depression, what treatment have you had? Are you using medications, alcohol, or other substances? Have you had a general physical checkup? There are good treatments for depression -- both medications if needed, as well as talk therapies that are effective. On your own, regular aerobic exercise, consistent sleep, and connecting with others will help. See your doc! ...Read more

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Five years ago, I was suffering from depression, and took Paroxetine for about half a year, then recovery. A month ago, it seem to relapse, but is not serious. I have take Lumiday for two weeks, it is useful for me. Now I have a question. Can I take Lu

Five years ago, I was suffering from depression, and took Paroxetine for about half a year, then recovery. A month ago, it seem to relapse, but is not serious. I have take Lumiday for two weeks, it is useful for me. Now I have a question. Can I take Lu

Daily? No proof: Lumiday is a dietary supplement marketed in States for natural mood enhancement. However, unlike prescription & OTC medications, there is no requirement to prove safety & effectiveness prior to selling product. So your guess is as good as mine. Better yet, go see your Family Doc or whoever prescribed Paroxetine 5yrs ago. Ask for referral for Cognitive Behavioral Therapy which is as good as drugs ...Read more

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Could I have the postpartum depression five months after my delivery?

Could I have the postpartum depression five months after my delivery?

Yes: Post-partum depression can occur up to a year after delivery. Please do not hesitate to talk to your ob/gyn or primary care doctor if you think that symptoms of depression are starting to affect your health and well-being. ...Read more

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Can I commit myself to a hospital at 15 if I'm suicidal and have been dealing with severe depression for five years?

Can I commit myself to a hospital at 15 if I'm suicidal and have been dealing with severe depression for five years?

Suicidal: I am very glad that you recognize your need for help. Talk to your parents or guardians to take you to the hospital to get the help you need. You will be proud of yourself for having done that. ...Read more

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I do masturbate four to five times in a week. If not do I fell restless, boring. And after masturbate I suffer from anxiety, depression. What can I do? ..

I do masturbate four to five times in a week. If not do I fell restless, boring. And after masturbate I suffer from anxiety, depression. What can I do? ..

Be careful: You may be setting up bad "sexual" habits, as it appears that you are using sex/masturbation as a means of addressing stress/anxiety. This can make future sexual relationships difficult. You should seek help from your doctor as they may be able to set you up with a therapist that can work to help you develop alternative coping mechanisms. ...Read more

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Am I better off hiding the real extent of my psychiatric problems from psychiatrists? I've had major depression for much of my life, including a few hospitalizations. After a suicide attempt five years ago, my then-psychiatrist asked me to seek psychiatri

Am I better off hiding the real extent of my psychiatric problems from psychiatrists? I've had major depression for much of my life, including a few hospitalizations. After a suicide attempt five years ago, my then-psychiatrist asked me to seek psychiatri

Full: Full disclosure of your history is key to successful treatment. Be completely honest with your doctor about your past, your issues with previous doctors, and what you think went wrong. Hopefully the doctor will be able to sort through all the issues and come up with an appropriate treatment plan; if not then ask for a direct referral to someone who can help you.
All the best. ...Read more

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Took 20mg of prednisone for five days. I have bipolar and it threw me into a deep depression. How long will effects last before it is out of system?

Took 20mg of prednisone for five days. I have bipolar and it threw me into a deep depression. How long will effects last before it is out of system?

As long as weeks: Unless you abruptly stop it and/or utilize appropriate medications to alleviate the depression - antipsychotics, mood stabilizers, or even brief trial of an antidepressant. Even then it may be prolonged. If you were not aware of it you may want to try any other available option in treatment in the future knowing you have this susceptibility. Also, inform your md of your reaction and diagnosis. ...Read more

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If after five years of treatment for depression my lack of concentration persists over and over again. Could it be adhd?

If after five years of treatment for depression my lack of concentration persists over and over again. Could it be adhd?

Lack of concentratio: Further evaluation to confirm/rule out the cause can warrant further interventions. ...Read more

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We hv been trying to conceive since five months but vain I have retroverted uterus please suggest anything ill die with depression please help?

We hv been trying to conceive since five months but vain I have retroverted uterus please suggest anything ill die with depression please help?

Please don't worry: We don't start to get concerned until a couple have been 'trying' to conceive for a year. See tips and pearls re getting pregnant. If not pregnant after 1 yr, see your ob-gyn or a specialist in infertility. Male's sperm count will be checked first, then u will undergo several tests to check your uterus, tubes and ovaries. If u r menstruating regularly, you are ovulating regularly. Good luck. ...Read more

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I have suffered from generalized anxiety syndrome and depression. For years. I was on Paxil for 12 years symptom free, but because of weight gain was put on Zoloft five years ago, which gave up after 2 years. Then Lexapro, which worked for only 1 year,

I have suffered from generalized anxiety syndrome and depression. For years. I was on Paxil for 12 years symptom free, but because of weight gain was put on Zoloft five years ago, which gave up after 2 years. Then Lexapro, which worked for only 1 year,

Additional info need: Your question was cut off. I assume you are under the care of a psychiatrist. It may be helpful to consult with another provider if you feel you need a second opinion. Also, therapy is very helpful talking through your concerns. ...Read more

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Levothyroxin 50 five days a week and other 2 days 75. Still feeling depressed and my memory is shot... I can't remember things I'm being taught in school. .. Have autoimmune disease/ hypothyroidism been on meds for 7 months. What should I do I'm lost dr

Levothyroxin 50 five days a week and other 2 days 75. Still feeling depressed and my memory is shot... I can't remember things I'm being taught in school. .. Have autoimmune disease/ hypothyroidism been on meds for 7 months. What should I do I'm lost dr

See psychiatrist: You mention being treated for hypothyroidism and autoimmune problems, but if you're also depressed the levothyroxin alone will not completely resolve your symptoms. I don't know other medicines you might be taking as well, but please consider seeing a psychiatrist to review these and your own symptoms. S/he may be able to help you over the depression hump. Good luck to you. ...Read more

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Extreme cramps 3 days before I bleed happens every month. I'm so tired and depressed I'm always out of it for at least 4 to five days. I thought I had fibroids or cysts just left the doctor yesterday she found nothing... so lost I am vegan been vegan for

Extreme cramps 3 days before I bleed happens every month. I'm so tired and depressed I'm always out of it for at least 4 to five days. I thought I had fibroids or cysts just left the doctor yesterday she found nothing... so lost I am vegan been vegan for

Primary dysmenorrhea: If your gyn exam and pelvic sonogram are normal, your most likely diagnosis is "primary dysmenorrhea", a bizarre condition of unclear cause often attributed by excess or abnormal prostaglandins produced by your endometrium. A 3 months trial of continuous contraceptive pills and/ or antiprostaglandin pills like ibuprofen, anaprox, naproxen, mefenamic acid; laparoscopy and other tests may help too. ...Read more

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L tyrosine, has anyone ever used this for depression and how efective?

L tyrosine, has anyone ever used this for depression and how efective?

Not optimal: It is not a standard treatment and falls in the category of alternative medicine, which is not necessarily a bad thing, but not necessarily a good thing either. It can increase anxiety. If your depression is severe enough to affect your functioning (work, relationships. Etc.) or cause significant distress, see a mental health professional for an assessment and develop a meaningful treatment plan. ...Read more

Dr. Paul Newhouse
243 Doctors shared insights

Tryptophan (Definition)

Tryptophan is an amino acid. It is the precursor to the production of serotonin. The GI system will convert tryptophan to 5 hydroxytrptophan to cross the blood brain barrier and then convert the 5htp into serotonin. It does many other things in the body, but this is what it ...Read more