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Doctor insights on: Kappa Light Chain Free Serum

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What does a high kappa/lambra ratio mean?

What does a high kappa/lambra ratio mean?

Multiple Myeloma: Kappa and lamda are classifications of light chains of immunoglobulins in humans. They are part of the "y" shaped arms of your antibodies. This ratio is used to distinguish MGUS or monoclonal gammopathy of undetermined significance from multiple myeloma. High ratio favors Multiple Myeloma ...Read more

Serum (Definition)

Serum is the component of blood that does not contain cells or clotting factors. It does contain electrolytes an ...Read more


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Kappa light chain in upep. Elevated k/l chains in serum but ratio normal. Wbc, rbc in urine with 2g/d protein. More/which workup/specialist needed?

Kappa light chain in upep. Elevated k/l chains in serum but ratio normal. Wbc, rbc in urine with 2g/d protein. More/which workup/specialist needed?

Nephrologist: You need a nephrologist to follow up on those tests, but your doctor or the doctor who ordered those tests can direct you better, wish you wellness ...Read more

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Free kappa light chain is high, FLC ratio is 2.205, no monoclonal gammopathy. IgA 389.43, lgM 125.95 and lgG 1771.02 H. Should we be worried? Thanks.

Free kappa light chain is high, FLC ratio is 2.205, no monoclonal gammopathy. IgA 389.43, lgM 125.95 and lgG 1771.02 H. Should we be worried? Thanks.

No: Abnormal FLC ratio is not diagnostic of any disease. More than 50% of the people with increased levels of gamma globulins have abnormal FLC ratio without a disorder of the plasma cells. ...Read more

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Hello, my Dr. Told me my Kappa light chain is elevated at 26. she told me not to worry and we'll check again in 3 months. What else should I ask /?

Hello, my Dr. Told me my Kappa light chain is elevated at 26. she told me not to worry and we'll check again in 3 months. What else should I ask /?

Sounds reasonable: You have a minimal degree of change, this may be within the normal range. But a recheck of this test is a good idea just to be sure. It is a rare condition that you do not need to worry about unless you have some symptoms in the future. Do tell us your age as some such conditions primarily occur in older adults ...Read more

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How long can monoclonal IgM kappa light chain gammopathr stay stable?

Indefinitely.: If monoclonal igm gammopathy is fully evaluated and not associated with any malignancy (lymphoma or myeloma) then the diagnosis is mgus (monoclonal gammopathy of undetermined significance). The chances of progression are low, ranging from 0.1% to 1.0%/year. The majority of patients never get cancer. ...Read more

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Can IgM kappa light chain monoclonal gammopthy stay stable for 10 years or more?

MGUS: Many monoclonal gammopathies can be stable for many years. The only way to know is have the immunofixation and several other tests performed periodically. A referral to the hematologist is appropriate here. ...Read more

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Can a monclonal IgM kappa light chain gammopathy turn into macrogobulinemia-waldenstrom?

Yes it is possible: It would be one of differntial diagnosis. You need a bone marrow biopsy basically to check if this is caused by plasma cells or lymphplasmacytic cells etc. ...Read more

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Can a IgM kappa light chain monoclonal gammopathy turn into macroglobulinemia?

Can a IgM kappa light chain monoclonal gammopathy turn into macroglobulinemia?

IgM is macroglobulin: Macroglobulinemia is the term for monoclonal igm. However what you described is confusing/erroneous term, igm kappa is not light chain gammopathy. Igm kappa, by definition is macroglobulin. ...Read more

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24-hour urine kappa light chain 2.18 mg/dl, lambda can't be quantified, < 0.4 mg/dl. What does it mean, how do I calculate ratio/ rule out LCDD? Thx

24-hour urine kappa light chain 2.18 mg/dl, lambda can't be quantified, < 0.4 mg/dl. What does it mean, how do I calculate ratio/ rule out LCDD? Thx

This could be MGUS: MGUS is a monoclonal antibody of uncertain significance. This may mean it will never be cancer but sometimes it can be related to cancer. Your physician can have you see a hematologist. Maybe you have seen one already. ...Read more

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Can monoclonal IgM kappa light chain gammopathy turn into multiple myeloma?

Can monoclonal IgM kappa light chain gammopathy turn into multiple myeloma?

It can: Yes, it can. It will depend on how much is the quantity of the monoclonal proteine, how many plasma cells on the bone marrow and ultimately whether one has end organ damages/ whether some other organs are affected significantly by the monoclonal protein. That is why some blood work, imaging study and bone marrow biopsy need to be done. ...Read more

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What is the significance of having low serum levels of kappa and lambda free light chains? I had high ch50 and normal C3 and c4.

What is the significance of having low serum levels of kappa and lambda free light chains? I had high ch50 and normal C3 and c4.

The: Concern would be low ch50 and low C3 ; c4, like in lupus. Elevations in kappa or lambda would be of concern for myeloma, not to worry about these levels. ...Read more

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Question about lab results from hematologist. Free kappa light chains serum 19.97 (range is 3.30-19.40mg/l) Normal lambda and ratio.

Question about lab results from hematologist. Free kappa light chains serum 19.97 (range is 3.30-19.40mg/l) Normal lambda and ratio.

What for?: What are you being tested for? All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, Serum free light chain assay and kappa/lambda ratio are unreliable tests. Better would be have serum and urine protein electrophoresis. ...Read more

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Pathology - Just got my blood results back says kappa / Lambda light chains free with ratio urine came 18 high / prostaglandin serum 550? What's mean

Pathology - Just got my blood results back says kappa / Lambda light chains free with ratio urine came 18 high / prostaglandin serum 550? What's mean

Unclear data: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, the data you provided does not seem to add up. What did serum and urine protein electrophoresis show? You wish to talk to the pathologist of the lab that did the tests. ...Read more

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Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

False positive rate: There is 30% or so false positive rate of kappa/lambda ratio in people without MGUS, myeloma or other disorders.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex. ...Read more

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Kappa/lambda FLC ratio high (2.75) w/ normal K (10.21mg/dl) & low L (3.68mg/dl). Hem-onc unsure if ratio implies K monoclonality since serum/urine IFE ok & neither chain is elevated. Could monoclonal K be suppressing L? IgA a bit high IgG &IgM a bitlow

Kappa/lambda FLC ratio high (2.75) w/ normal K (10.21mg/dl) & low L (3.68mg/dl). Hem-onc unsure if ratio implies K monoclonality since serum/urine IFE ok & neither chain is elevated. Could monoclonal K be suppressing L? IgA a bit high IgG &IgM a bitlow

Useless test: K/L ratio is not a useful test. About one third of patients without monoclonal immunoglboulin have an abnormal ratio, usually with kappa excess. If you must, the next step would be a bone marrow examination. You may consult this article that I wrote: https://www. Ncbi. Nlm. Nih. Gov/pubmed/27473738
At your age you are unlikely to have myeloma. ...Read more

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Test by hemotologist s t/oncologist, kappa//lambda light chain, 24he urine ratio 3.51; kappa/lambda serum ratio 1.86; Erythropoietin = 41.1?

Test by hemotologist s t/oncologist, kappa//lambda light chain, 24he urine ratio 3.51; kappa/lambda serum ratio 1.86; Erythropoietin = 41.1?

Any symptoms?: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Talk to the doctor who ordered the tests. Having said that, kappa/lambda ratio is a generally useless test.
Wish you good health! - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex, if you have sex. ...Read more

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What would cause free kappa &free lamba to be high but ratio normal also Immunoglobulin M, Qn, Serum high. Platelets steady rising & WBC high for 1yr?

Polyclonal gammopath: Something is stimulating all the B cell lines to produce a lot of antibodies. That general condition is called polyclonal gammopathy. It can be caused by a chronic infection (virus) or 9 other broad categories of causes (liver problems, connective tissue diseases, bone marrow disorder like Waldenstrom's, drugs/meds, autoimmune probs, misc). It's too much to go into here. Use Healthtap Prime to tal ...Read more

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High KAPPA/LAMBDA LIGHT CHAIN/slightly high ratio. No Monoclonal protein immunofixation or serum electrophoresis. Is this a type of cancer? Normal WBC

High KAPPA/LAMBDA LIGHT CHAIN/slightly high ratio. No Monoclonal protein immunofixation or serum electrophoresis. Is this a type of cancer? Normal WBC

I bet it's nothing: Without free light chains or a monoclonal protein in blood or urine, the ratio's meaningless. And like most lab tests, the reference range is set so that a few percent of healthies fall outside on either end. ...Read more

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Kappa 132.97 lambda 60.97 ratio serum 2.18 what does this mean?

Kappa etc: Hello ~ I don't know there's not enough information. I would make huge diagnostic mistakes if I assumed any of the absent information and you would not be pleased with anything except 100% accuracy. Thanks ...Read more

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I got bloodwork done and this was the result: IMMUNOFIXATION SERUM Monoclonal protein identified as faint IgM kappa. What does this mean? Thank you

Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, what you described is consistent with benign monoclonal gammopathy of undetermined significance. About 5% of people older than 65 have these. Please follow your doctor's advice for repeat tests. ...Read more

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Immunofixation, Serum FAH = Monoclonal IgG kappa immunoglobulin. Beta FAH = 10.5% Abnormal band, immunofixation to follow. I'm IgA deficient too.??

Immunofixation, Serum FAH = Monoclonal IgG kappa immunoglobulin. Beta FAH = 10.5% Abnormal band, immunofixation to follow. I'm IgA deficient too.??

Possibly: If I am understaning this right you have a monoclonal protien band?
The most important next steps here would be to identify the band (immunofixation) and then perfrom quantitvaive immunoglobulin levels. IF there is a monoclonal band, you may very well have reciprocal depriciation of alternative immunoglobulins and IgA deficiecny with an IgG monoclonal protein is possible. ...Read more

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Is elevated kappa/lambda ratio on serum FLC test inherently monoclonal, even if neither kappa or lambda is elevated? Ratio high b/c lambda is low, not because of high kappa. SPEP/UPEP & IFE normal. High IgA, low IgG. Clean marrow biopsy. Polyclonal?

Is elevated kappa/lambda ratio on serum FLC test inherently monoclonal, even if neither kappa or lambda is elevated? Ratio high b/c lambda is low, not because of high kappa. SPEP/UPEP & IFE normal. High IgA, low IgG. Clean marrow biopsy. Polyclonal?

Clinical context: The use of light chains is limited in diseases other than monoclonal gammopathies, such as myeloma or amyloidosis. If this is the context that yours got checked the results do not suggest such a condition. With no gammopathy suggested by results the question regarding clonality has no grounds. As any other test, trending the results would help in integrating it in a meaningful clinical context. ...Read more

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Serum -tiny IgM kappa monoclonal protein b2 region, urine - tiny IgM k paraproteinemia in gamma region. Was a mistake made or is lab normal?

Serum -tiny IgM kappa monoclonal protein b2 region, urine - tiny IgM k paraproteinemia in gamma region. Was a mistake made or is lab normal?

Monoclonal: multiple myeloma (g>a>m>e, d)
•primary macroglobulinemia (waldenstrøm’s, igm)
•monoclonal gammopathy of undetermined significance (mgus) (converts at 2% per year to myeloma)
•miscellaneous conditions
• (converts at 2% per year to myeloma)

these all have to be thought of by the hematologist. ...Read more

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Serum immunofixation says IgM kappa in beta2, but urine immunofixation says small discrete band noted in gamma region, no m protein. Is this mgus?

Serum immunofixation says IgM kappa in beta2, but urine immunofixation says small discrete band noted in gamma region, no m protein. Is this mgus?

MGUS: Sounds like monoclonal gammopathy of undetermined significance (mgus). Cannot say much more without knowing other clinical features -- eg lymphadenopathy, cbc, "crab" symptoms (hypercalcemia, renal insufficiency, anemia, bone disease). ...Read more

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Causes if a polyclonal gammopayhy with elevated kappa and lambda free light chains? Seems to be of the IGG type slightly elevated count.

Causes if a polyclonal gammopayhy with elevated kappa and lambda free light chains? Seems to be of the IGG type slightly elevated count.

Polyclonal IgG: It can be caused by numerous inflammatory, infectious, and malignant causes, for example; TB, Rheumatoid arthritis, cirrhosis of the liver, lymphoma, and MS. A more extensive list, click on Table 3 link inside article below.

http://www. Aafp. Org/afp/2005/0101/p105.html

http://www. Ncbi. Nlm. Nih. Gov/pmc/articles/PMC356447/

Mild elevation could simply be a mild cold with a rhinovirus. No worries. ...Read more

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Test results came back and say Free Kappa Lt Chains, S 34.81 Free Lambda Lt Chains, s is 29.22Kappa, lambda ratio is 1.19. Is it myeloma What is test 4

Light chains: Light chains (kappa and lambda) are a part of the immunoglobulin molecues the body makes. A given plasma cell only makes one type of light chain, most commonly this is kappa. When immunoglobulin cells proliferate like a neoplasm, then one type will overwhelm the others. Your values are nearly even, and the ratio is not abnormal, so it is unlikely that you have myeloma or another Ig-producing lesion. ...Read more

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Can a hematologist pls explain diff btwn serum free light chain and total flc? Serum and urine numbers are 3x high for flc, total light chain/ratio ok

Can a hematologist pls explain diff btwn serum free light chain and total flc? Serum and urine numbers are 3x high for flc, total light chain/ratio ok

Free light chains: The light chain ratio is a number that represents the ratio of kappa to lambda light chains. It tells me that one light chain is produced at higher amounts versus the other. ...Read more

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I have 549igA, 37 sedimentation rate westergren, 21.64 free kappa lt chains, s, and kappa/lambda ratio, s is 1.66 What does this mean?

I have 549igA, 37 sedimentation rate westergren, 21.64 free kappa lt chains, s, and kappa/lambda ratio, s is 1.66 What does this mean?

Any symptoms?: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, Why were these tests done? Do you have any symptoms? Kappa/lambda ratio is generally a useless test. IgA of 549, per se is not a problem. Sed rate is in the normal range.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex. ...Read more

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Kappa Lambda ratio u 1.92 (L) Free kappa LT chains ur 32.10 (H) Free Lambda LT chains ur 16.70 (H) 24 hour urine What does this mean?

Kappa Lambda ratio u 1.92 (L) Free kappa LT chains ur 32.10 (H) Free Lambda LT chains ur 16.70 (H) 24 hour urine What does this mean?

Nothing: In isolation, these mean nothing at all. If only one of the chains is being excreted, I'd worry about plasma cell myeloma. If you're leaking protein in your urine because of your diabetes, this is more concerning than light chain ratios. ...Read more

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What is the best test to point toward (or rule out) possible al amyloidosis? Serum free light chain assays or urine free light chain assays?

What is the best test to point toward (or rule out) possible al amyloidosis? Serum free light chain assays or urine free light chain assays?

Amyloidosis: They are both useful in helping physicians monitor the disease, but a tissue biopsy may be necessary to completely rule out the disease. ...Read more

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Read that Bence Jones Protein can sometimes appear in 24 hr urine and be missed/normal in serum Free Light Chain Assay? Normal SPEP but no UPEP done..

Read that Bence Jones Protein can sometimes appear in 24 hr urine and be missed/normal in serum Free Light Chain Assay? Normal SPEP but no UPEP done..

No consensus: The serum free light chain assay is newer and is supposed to detect free light chains in serum even before they are detectable in urine. The old protocol was with plasma electrophoresis and urine protein immunofixation. It all depends now on the hematologist's confidence level in the new test. ...Read more

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Serum free light chains increased ratio normal. Lambda immunofixation with 4% m spike in beta 2 region in urine only. Recommended next step 4 anemia?

Serum free light chains increased ratio normal. Lambda immunofixation with 4% m spike in beta 2 region in urine only. Recommended next step 4 anemia?

Spike in UPEP: If you have an abnormal M spike on your urine protein electrophoresis (UPEP), that suggests there is some abnormal cells making excess gamma globulin (a monoclonal gammopathy). A next step would normally include a bone marrow aspirate and biopsy - this reveals what the abnormality of the blood forming cells causing this is. ...Read more

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Immunoglobulin free lt chains blood results : kappa free light chain 20.36 (h) lambda 12.14 normal. Kappa; dheas is 25. Crp is 2.13. Sed rate is 25.?

Labs: Cannot possibly interpret lab results in the absence of a medical history and exam. If you have had these tests ordered by a doctor, discuss results with them. ...Read more

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Light chains KAPPA 55% & LAMBDA 39%. What are the range values?

Light chains KAPPA 55% & LAMBDA 39%. What are the range values?

Http://myeloma. Org/pdfs/U-Freelite-Eng2011_g2web. Pdf: Go to the website above for good summary of KAPPA and LAMBDA values, and significance;;

Normal levels of serum free light chains are*:
• Kappa: 3.3–19.4 mg/L*
• Lambda: 5.71–26.3 mg/L*
• Kappa/lambda ratio: 0.26–1.65**
*Note: The units here are mg/L; different
laboratories use different units. It is important to
double-check the units used when comparing
numbers in lab values.
**Further Note: In patients with renal impairment,
it is recommended to interpret the results
of the Kappa/Lambda ratio with a modified
reference range of 0.37–3.1. ...Read more

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I had a IgA Heavy Light Chains (HLC), S test done. Ig K/L HLC Ratio, IgA Kappa, S and IgA Lambda, S were in normal range. What does this test mean?

I had a IgA Heavy Light Chains (HLC), S test done. Ig K/L HLC Ratio, IgA Kappa, S and IgA Lambda, S were in normal range. What does this test mean?

Nothing: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, The tests you mentioned have a high number of false positives and false negatives and are or questionable value.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex. ...Read more

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Had abnormal k/ light chain ratio six months ago; now ratio is wnl, but kappa level remains elevated three blood panels later. Thoughts?

I'm not sure I could: Make much of a prognostic distinction between an abnormal kappa/light chain ratio and kappa elevation. Produced within plasma cells, heavy and light chains bind together to form immunoglobulins. Typically producing more light chains than required, the plasma cells enter the blood as free light chains. The activity of myeloma/plasma cell growth is linked to the amount of free light chains in blood. ...Read more

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Can you get all amyloidosis if you have kappa rather than lambda light chains? I also have a kappa lambda ratio of 175

Yes: Listen, Jane. I'm worried about you. You're already on cyclophosphamide and dexamethasone -- extremely potent medications -- yet you list no illness for which they are indicated. It's not for your thyroid cancer. You have a duty to find out exactly what is happening with you, including getting a 2nd opinion from a physician who's explain clearly. Amyloid is confusing; be proactive. ...Read more