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Doctor insights on: Kappa Light Chain Free Serum

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What does a high kappa/lambra ratio mean?

What does a high kappa/lambra ratio mean?

Multiple Myeloma: Kappa and lamda are classifications of light chains of immunoglobulins in humans. They are part of the "y" shaped arms of your antibodies. This ratio is used to distinguish MGUS or monoclonal gammopathy of undetermined significance from multiple myeloma. High ratio favors Multiple Myeloma ...Read more

Serum (Definition)

Serum is the component of blood that does not contain cells or clotting factors. It does contain electrolytes an ...Read more


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Kappa light chain in upep. Elevated k/l chains in serum but ratio normal. Wbc, rbc in urine with 2g/d protein. More/which workup/specialist needed?

Kappa light chain in upep. Elevated k/l chains in serum but ratio normal. Wbc, rbc in urine with 2g/d protein. More/which workup/specialist needed?

Nephrologist: You need a nephrologist to follow up on those tests, but your doctor or the doctor who ordered those tests can direct you better, wish you wellness ...Read more

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Free kappa light chain is high, FLC ratio is 2.205, no monoclonal gammopathy. IgA 389.43, lgM 125.95 and lgG 1771.02 H. Should we be worried? Thanks.

Free kappa light chain is high, FLC ratio is 2.205, no monoclonal gammopathy. IgA 389.43, lgM 125.95 and lgG 1771.02 H. Should we be worried? Thanks.

No: Abnormal FLC ratio is not diagnostic of any disease. More than 50% of the people with increased levels of gamma globulins have abnormal FLC ratio without a disorder of the plasma cells. ...Read more

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Hello, my Dr. told me my Kappa light chain is elevated at 26.. she told me not to worry and we'll check again in 3 months.. what else should I ask /?

Hello,  my Dr. told me my Kappa light chain is elevated at 26.. she told me not to worry and we'll check again in 3 months.. what else should I ask /?

Sounds reasonable: You have a minimal degree of change, this may be within the normal range. But a recheck of this test is a good idea just to be sure. it is a rare condition that you do not need to worry about unless you have some symptoms in the future.Do tell us your age as some such conditions primarily occur in older adults ...Read more

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How long can monoclonal IgM kappa light chain gammopathr stay stable?

Indefinitely.: If monoclonal igm gammopathy is fully evaluated and not associated with any malignancy (lymphoma or myeloma) then the diagnosis is mgus (monoclonal gammopathy of undetermined significance). The chances of progression are low, ranging from 0.1% to 1.0%/year. The majority of patients never get cancer. ...Read more

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Can IgM kappa light chain monoclonal gammopthy stay stable for 10 years or more?

MGUS: Many monoclonal gammopathies can be stable for many years. The only way to know is have the immunofixation and several other tests performed periodically. A referral to the hematologist is appropriate here. ...Read more

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Can a monclonal IgM kappa light chain gammopathy turn into macrogobulinemia-waldenstrom?

Yes it is possible: It would be one of differntial diagnosis. You need a bone marrow biopsy basically to check if this is caused by plasma cells or lymphplasmacytic cells etc. ...Read more

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Can a IgM kappa light chain monoclonal gammopathy turn into macroglobulinemia?

Can a IgM kappa light chain monoclonal gammopathy turn into macroglobulinemia?

IgM is macroglobulin: Macroglobulinemia is the term for monoclonal igm. However what you described is confusing/erroneous term, igm kappa is not light chain gammopathy. Igm kappa, by definition is macroglobulin. ...Read more

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24-hour urine kappa light chain 2.18 mg/dl, lambda can't be quantified, < 0.4 mg/dl. What does it mean, how do i calculate ratio/ rule out LCDD? Thx

24-hour urine kappa light chain 2.18 mg/dl, lambda can't be quantified, < 0.4 mg/dl.  What does it mean, how do i calculate ratio/ rule out LCDD? Thx

This could be MGUS: MGUS is a monoclonal antibody of uncertain significance. This may mean it will never be cancer but sometimes it can be related to cancer. Your physician can have you see a hematologist. Maybe you have seen one already. ...Read more

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Can monoclonal IgM kappa light chain gammopathy turn into multiple myeloma?

Can monoclonal IgM kappa light chain gammopathy turn into multiple myeloma?

It can: Yes, it can . It will depend on how much is the quantity of the monoclonal proteine, how many plasma cells on the bone marrow and ultimately whether one has end organ damages/ whether some other organs are affected significantly by the monoclonal protein. That is why some blood work, imaging study and bone marrow biopsy need to be done. ...Read more

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What is the significance of having low serum levels of kappa and lambda free light chains? I had high ch50 and normal C3 and c4.

What is the significance of having low serum levels of kappa and lambda free light chains?  I had high ch50 and normal C3 and c4.

The: Concern would be low ch50 and low c3 ; c4, like in lupus. Elevations in kappa or lambda would be of concern for myeloma, not to worry about these levels. ...Read more

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Question about lab results from hematologist. Free kappa light chains serum 19.97 (range is 3.30-19.40mg/l) Normal lambda and ratio.

Question about lab results from hematologist. 

Free kappa light chains serum 19.97 (range is 3.30-19.40mg/l)

Normal lambda and ratio.

What for?: What are you being tested for? All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, Serum free light chain assay and kappa/lambda ratio are unreliable tests. Better would be have serum and urine protein electrophoresis. ...Read more

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Pathology - Just got my blood results back says kappa / Lambda light chains free with ratio urine came 18 high / prostaglandin serum 550 ? What's mean

Pathology - Just got my blood results back says kappa / Lambda light chains free with ratio urine came 18 high / prostaglandin serum 550 ? What's mean

Unclear data: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, the data you provided does not seem to add up. What did serum and urine protein electrophoresis show? You wish to talk to the pathologist of the lab that did the tests. ...Read more

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Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

False positive rate: There is 30% or so false positive rate of kappa/lambda ratio in people without MGUS, myeloma or other disorders. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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Kappa/lambda FLC ratio high (2.75) w/ normal K(10.21mg/dl) & low L(3.68mg/dl). Hem-onc unsure if ratio implies K monoclonality since serum/urine IFE ok & neither chain is elevated. Could monoclonal K be suppressing L? IgA a bit high IgG &IgM a bitlow

Kappa/lambda FLC ratio high (2.75) w/ normal K(10.21mg/dl) & low L(3.68mg/dl). Hem-onc unsure if ratio implies K monoclonality since serum/urine IFE ok & neither chain is elevated. Could monoclonal K be suppressing L? IgA a bit high IgG &IgM a bitlow

Useless test: K/L ratio is not a useful test. About one third of patients without monoclonal immunoglboulin have an abnormal ratio, usually with kappa excess. If you must, the next step would be a bone marrow examination. You may consult this article that I wrote: https://www.ncbi.nlm.nih.gov/pubmed/27473738 At your age you are unlikely to have myeloma. ...Read more

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What would cause free kappa &free lamba to be high but ratio normal also Immunoglobulin M, Qn, Serum high. platelets steady rising & WBC high for 1yr?

Polyclonal gammopath: Something is stimulating all the B cell lines to produce a lot of antibodies. That general condition is called polyclonal gammopathy. It can be caused by a chronic infection (virus) or 9 other broad categories of causes (liver problems, connective tissue diseases, bone marrow disorder like Waldenstrom's, drugs/meds, autoimmune probs, misc). It's too much to go into here. Use Healthtap Prime to tal ...Read more

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High KAPPA/LAMBDA LIGHT CHAIN/slightly high ratio.No Monoclonal protein immunofixation or serum electrophoresis. Is this a type of cancer?Normal WBC

High KAPPA/LAMBDA LIGHT CHAIN/slightly high ratio.No Monoclonal protein immunofixation or serum electrophoresis. Is this a type of cancer?Normal WBC

I bet it's nothing: Without free light chains or a monoclonal protein in blood or urine, the ratio's meaningless. And like most lab tests, the reference range is set so that a few percent of healthies fall outside on either end. ...Read more

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Kappa 132.97 lambda 60.97 ratio serum 2.18 what does this mean?

Kappa etc: hello ~ I dont know there's not enough information. I would make huge diagnostic mistakes if I assumed any of the absent information and you would not be pleased with anything except 100% accuracy. thanks ...Read more

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I got bloodwork done and this was the result: IMMUNOFIXATION SERUM Monoclonal protein identified as faint IgM kappa. What does this mean? Thank you

Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, what you described is consistent with benign monoclonal gammopathy of undetermined significance. About 5% of people older than 65 have these. Please follow your doctor's advice for repeat tests. ...Read more