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Doctor insights on: Kappa Light Chain And Lambda Test For Lupus

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24-hour urine kappa light chain 2.18 mg/dl, lambda can't be quantified, < 0.4 mg/dl. What does it mean, how do i calculate ratio/ rule out LCDD? Thx

24-hour urine kappa light chain 2.18 mg/dl, lambda can't be quantified, < 0.4 mg/dl.  What does it mean, how do i calculate ratio/ rule out LCDD? Thx

This could be MGUS: MGUS is a monoclonal antibody of uncertain significance. This may mean it will never be cancer but sometimes it can be related to cancer. Your physician can have you see a hematologist. Maybe you have seen one already. ...Read more

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Crp 0.4 but hs-crp showing 8.5 in the same week. Any explanation? Can spondylitis or lupus cause monoclonal light chain in urine lambda type? K/l 1.5

Crp 0.4 but hs-crp showing 8.5 in the same week. Any explanation? Can spondylitis or lupus cause monoclonal light chain in urine lambda type? K/l 1.5

Many issues: CRP is measured in mg/dL and hsCRP is measured in mg/L. if the later is converted to CRP, the two values would be 0.4 and 0.8 and that is not that great a difference. K/L ratio of 1.5 is normal. The autoimmune disorders you mentioned may have an oligoclonal pattern and could result in monoclonal lambda chain in urine, without there being any cancer. About 10% of people your age have a benign monoclonal gammopathy. ...Read more

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How long can monoclonal IgM kappa light chain gammopathr stay stable?

How long can monoclonal IgM kappa light chain gammopathr stay stable?

Indefinitely.: If monoclonal igm gammopathy is fully evaluated and not associated with any malignancy (lymphoma or myeloma) then the diagnosis is mgus (monoclonal gammopathy of undetermined significance). The chances of progression are low, ranging from 0.1% to 1.0%/year. The majority of patients never get cancer. ...Read more

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Can IgM kappa light chain monoclonal gammopthy stay stable for 10 years or more?

MGUS: Many monoclonal gammopathies can be stable for many years. The only way to know is have the immunofixation and several other tests performed periodically. A referral to the hematologist is appropriate here. ...Read more

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Can a monclonal IgM kappa light chain gammopathy turn into macrogobulinemia-waldenstrom?

Yes it is possible: It would be one of differntial diagnosis. You need a bone marrow biopsy basically to check if this is caused by plasma cells or lymphplasmacytic cells etc. ...Read more

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Free kappa light chain is high, FLC ratio is 2.205, no monoclonal gammopathy. IgA 389.43, lgM 125.95 and lgG 1771.02 H. Should we be worried? Thanks.

No: Abnormal FLC ratio is not diagnostic of any disease. More than 50% of the people with increased levels of gamma globulins have abnormal FLC ratio without a disorder of the plasma cells. ...Read more

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Hello, my Dr. told me my Kappa light chain is elevated at 26.. she told me not to worry and we'll check again in 3 months.. what else should I ask /?

Hello,  my Dr. told me my Kappa light chain is elevated at 26.. she told me not to worry and we'll check again in 3 months.. what else should I ask /?

Sounds reasonable: You have a minimal degree of change, this may be within the normal range. But a recheck of this test is a good idea just to be sure. it is a rare condition that you do not need to worry about unless you have some symptoms in the future.Do tell us your age as some such conditions primarily occur in older adults ...Read more

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Can a IgM kappa light chain monoclonal gammopathy turn into macroglobulinemia?

Can a IgM kappa light chain monoclonal gammopathy turn into macroglobulinemia?

IgM is macroglobulin: Macroglobulinemia is the term for monoclonal igm. However what you described is confusing/erroneous term, igm kappa is not light chain gammopathy. Igm kappa, by definition is macroglobulin. ...Read more

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Can monoclonal IgM kappa light chain gammopathy turn into multiple myeloma?

Can monoclonal IgM kappa light chain gammopathy turn into multiple myeloma?

It can: Yes, it can . It will depend on how much is the quantity of the monoclonal proteine, how many plasma cells on the bone marrow and ultimately whether one has end organ damages/ whether some other organs are affected significantly by the monoclonal protein. That is why some blood work, imaging study and bone marrow biopsy need to be done. ...Read more

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Kappa light chain in upep. Elevated k/l chains in serum but ratio normal. Wbc, rbc in urine with 2g/d protein. More/which workup/specialist needed?

Kappa light chain in upep. Elevated k/l chains in serum but ratio normal. Wbc, rbc in urine with 2g/d protein. More/which workup/specialist needed?

Nephrologist: You need a nephrologist to follow up on those tests, but your doctor or the doctor who ordered those tests can direct you better, wish you wellness ...Read more