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Doctor insights on: Kappa Light Chain

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Can a IgM kappa light chain monoclonal gammopathy turn into macroglobulinemia?

Can a IgM kappa light chain monoclonal gammopathy turn into macroglobulinemia?

IgM is macroglobulin: Macroglobulinemia is the term for monoclonal igm. However what you described is confusing/erroneous term, igm kappa is not light chain gammopathy. Igm kappa, by definition is macroglobulin. ...Read more

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Immunoglobulin free lt chains blood results : kappa free light chain 20.36 (h) lambda 12.14 normal. Kappa; dheas is 25. Crp is 2.13. Sed rate is 25.?

Immunoglobulin free lt chains blood results :  kappa free light chain 20.36 (h) lambda 12.14 normal. Kappa; dheas is 25. Crp is 2.13. Sed rate is 25.?

Labs: Cannot possibly interpret lab results in the absence of a medical history and exam. If you have had these tests ordered by a doctor, discuss results with them. ...Read more

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Hello, my Dr. told me my Kappa light chain is elevated at 26.. she told me not to worry and we'll check again in 3 months.. what else should I ask /?

Hello,  my Dr. told me my Kappa light chain is elevated at 26.. she told me not to worry and we'll check again in 3 months.. what else should I ask /?

Sounds reasonable: You have a minimal degree of change, this may be within the normal range. But a recheck of this test is a good idea just to be sure. it is a rare condition that you do not need to worry about unless you have some symptoms in the future.Do tell us your age as some such conditions primarily occur in older adults ...Read more

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How long can monoclonal IgM kappa light chain gammopathr stay stable?

How long can monoclonal IgM kappa light chain gammopathr stay stable?

Indefinitely.: If monoclonal igm gammopathy is fully evaluated and not associated with any malignancy (lymphoma or myeloma) then the diagnosis is mgus (monoclonal gammopathy of undetermined significance). The chances of progression are low, ranging from 0.1% to 1.0%/year. The majority of patients never get cancer. ...Read more

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Can IgM kappa light chain monoclonal gammopthy stay stable for 10 years or more?

MGUS: Many monoclonal gammopathies can be stable for many years. The only way to know is have the immunofixation and several other tests performed periodically. A referral to the hematologist is appropriate here. ...Read more

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My haematologist says my kappa lambda ratio is seriously skewed. Kappa light chains @580 paraproteins 30. Does this imply a poor outcome?

My haematologist  says my kappa lambda ratio is  seriously skewed. Kappa light chains @580  paraproteins 30. Does this imply  a poor outcome?

Bad ratio: I am surprised you do not ask your oncologist questions about your outcome. Did you not ask? If you did, did you not get a response that you understood. You oncologist (o) knows your case best of all. Give your o a call and get your answer from the physician who knows you best of all. ...Read more

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Can a monclonal IgM kappa light chain gammopathy turn into macrogobulinemia-waldenstrom?

Yes it is possible: It would be one of differntial diagnosis. You need a bone marrow biopsy basically to check if this is caused by plasma cells or lymphplasmacytic cells etc. ...Read more

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Free kappa light chain is high, FLC ratio is 2.205, no monoclonal gammopathy. IgA 389.43, lgM 125.95 and lgG 1771.02 H. Should we be worried? Thanks.

No: Abnormal FLC ratio is not diagnostic of any disease. More than 50% of the people with increased levels of gamma globulins have abnormal FLC ratio without a disorder of the plasma cells. ...Read more

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Can a IgM kappa light chain monoclonal gammopathy turn into macroglobulinemia?

IgM is macroglobulin: Macroglobulinemia is the term for monoclonal igm. However what you described is confusing/erroneous term, igm kappa is not light chain gammopathy. Igm kappa, by definition is macroglobulin. ...Read more

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Question about lab results from hematologist. Free kappa light chains serum 19.97 (range is 3.30-19.40mg/l) Normal lambda and ratio.

Question about lab results from hematologist. 

Free kappa light chains serum 19.97 (range is 3.30-19.40mg/l)

Normal lambda and ratio.

What for?: What are you being tested for? All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, Serum free light chain assay and kappa/lambda ratio are unreliable tests. Better would be have serum and urine protein electrophoresis. ...Read more