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Doctor insights on: Kappa Lambda Light Chains Urine

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Kappa Lambda ratio u 1.92(L) Free kappa LT chains ur 32.10 (H) Free Lambda LT chains ur 16.70 (H) 24 hour urine What does this mean?

Kappa Lambda ratio u 1.92(L) Free kappa LT chains ur 32.10 (H) Free Lambda LT chains ur 16.70 (H)  24 hour urine  What does this mean?

Nothing: In isolation, these mean nothing at all. If only one of the chains is being excreted, I'd worry about plasma cell myeloma. If you're leaking protein in your urine because of your diabetes, this is more concerning than light chain ratios. ...Read more

Urine (Definition)

Urine is the product of the kidneys, which is produced to eliminate the waste products of metabolism, manage body fluid balance, &maintain acid-base balance. The blood is first filtered by the kidneys, and the composition of the resulting fluid is then altered depending on the body's needs. It is composed of mostly water, and breakdown products from blood cells impart ...Read more


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24-hour urine kappa light chain 2.18 mg/dl, lambda can't be quantified, < 0.4 mg/dl. What does it mean, how do i calculate ratio/ rule out LCDD? Thx

24-hour urine kappa light chain 2.18 mg/dl, lambda can't be quantified, < 0.4 mg/dl.  What does it mean, how do i calculate ratio/ rule out LCDD? Thx

This could be MGUS: MGUS is a monoclonal antibody of uncertain significance. This may mean it will never be cancer but sometimes it can be related to cancer. Your physician can have you see a hematologist. Maybe you have seen one already. ...Read more

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Kappa (4 vs ref 2mg/dl) and sometimes lambda light chain in 24hr urine without mm. What can be suspected? Anemia, worsening ckd, improves with na co3

Kappa (4 vs ref 2mg/dl) and sometimes lambda light chain in 24hr urine without mm.  What can be suspected? Anemia, worsening ckd, improves with na co3

K+L chains in ua: hello, the fact that you are having this checked in your urine means that some person is already onto the fact that you may have MGUS or multiple myeloma. The worsening anemia and kidney deterioration is more indicative of myeloma. BUT you need the whole urine and blood protein electrophoresis to look at before making the diagnosis. You shd request referral to a Heme-Onc specialist to decide.thx ...Read more

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Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

False positive rate: There is 30% or so false positive rate of kappa/lambda ratio in people without MGUS, myeloma or other disorders. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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I had a IgA Heavy Light Chains (HLC), S test done. Ig K/L HLC Ratio, IgA Kappa, S and IgA Lambda, S were in normal range. What does this test mean?

I had a IgA Heavy Light Chains (HLC), S test done.  Ig K/L HLC Ratio, IgA Kappa, S and IgA Lambda, S were in normal range.  What does this test mean?

Nothing: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, The tests you mentioned have a high number of false positives and false negatives and are or questionable value. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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Test results came back and say Free Kappa Lt Chains, S 34.81 Free Lambda Lt Chains, s is 29.22Kappa,lambda ratio is 1.19. Is it myeloma What is test 4

Test results came back and say Free Kappa Lt Chains, S 34.81 Free Lambda Lt Chains, s is 29.22Kappa,lambda ratio is 1.19. Is it myeloma What is test 4

Light chains: Light chains (kappa and lambda) are a part of the immunoglobulin molecues the body makes. A given plasma cell only makes one type of light chain, most commonly this is kappa. When immunoglobulin cells proliferate like a neoplasm, then one type will overwhelm the others. Your values are nearly even, and the ratio is not abnormal, so it is unlikely that you have myeloma or another Ig-producing lesion. ...Read more

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Causes if a polyclonal gammopayhy with elevated kappa and lambda free light chains? Seems to be of the IGG type slightly elevated count.

Causes if a polyclonal gammopayhy with elevated kappa and lambda free light chains? Seems to be of the IGG type slightly elevated count.

Polyclonal IgG: It can be caused by numerous inflammatory, infectious, and malignant causes, for example; TB, Rheumatoid arthritis, cirrhosis of the liver, lymphoma, and MS. A more extensive list, click on Table 3 link inside article below. http://www.aafp.org/afp/2005/0101/p105.html http://www.ncbi.nlm.nih.gov/pmc/articles/PMC356447/ Mild elevation could simply be a mild cold with a rhinovirus. No worries. ...Read more

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Light chains KAPPA 55% & LAMBDA 39%. What are the range values?

Light chains KAPPA 55% & LAMBDA 39%. What are the range values?

Http://myeloma.org/pdfs/U-Freelite-Eng2011_g2web.pdf: Go to the website above for good summary of KAPPA and LAMBDA values, and significance;; Normal levels of serum free light chains are*: • Kappa: 3.3–19.4 mg/L* • Lambda: 5.71–26.3 mg/L* • Kappa/lambda ratio: 0.26–1.65** *Note: The units here are mg/L; different laboratories use different units. It is important to double-check the units used when comparing numbers in lab values. **Further Note: In patients with renal impairment, it is recommended to interpret the results of the Kappa/Lambda ratio with a modified reference range of 0.37–3.1. ...Read more

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Can you get all amyloidosis if you have kappa rather than lambda light chains? I also have a kappa lambda ratio of 175

Can you get all amyloidosis if you have kappa rather than lambda light chains?  I also have a kappa lambda ratio of 175

Yes: Listen, Jane. I'm worried about you. You're already on cyclophosphamide and dexamethasone -- extremely potent medications -- yet you list no illness for which they are indicated. It's not for your thyroid cancer. You have a duty to find out exactly what is happening with you, including getting a 2nd opinion from a physician who's explain clearly. Amyloid is confusing; be proactive. ...Read more

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In lymphocyte phenotyping of periferial blood, what is the normal percentage for Kappa and Lambda light chains?

In lymphocyte phenotyping of periferial blood, what is the normal percentage for Kappa and Lambda light chains?

0.26-1.65 K/L ratio: Free light chains will normally be present in the blood at low levels, with a kappa/lambda ratio of about 0.26 to 1.65. Increased kappa free light chains and a higher kappa/lambda ratio may mean a plasma cell disorder producing excess monoclonal kappa chains. Increased lambda free light chains and a lower kappa/lambda ratio may mean a plasma cell disorder producing excess monoclonal lambda chains. ...Read more