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Doctor insights on: Kappa Lambda Light Chain

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Can a IgM kappa light chain monoclonal gammopathy turn into macroglobulinemia?

Can a IgM kappa light chain monoclonal gammopathy turn into macroglobulinemia?

IgM is macroglobulin: Macroglobulinemia is the term for monoclonal igm. However what you described is confusing/erroneous term, igm kappa is not light chain gammopathy. Igm kappa, by definition is macroglobulin. ...Read more

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I've just found out that 3 tests show low kappa/lambda ratio, with lambda light chain levels increased. Do these results mean a thing without m protein?

I've just found out that 3 tests show low kappa/lambda ratio, with lambda light chain levels increased. Do these results mean a thing without m protein?

Check with your doc: Kappa and lambda are parts of immunoglobulins which are proteins certain white blood cells make to fight infections. These are referred to as polyclonal since they come from different cells. Some blood disorders can produce lots of m (monoclonal) kappas or lambdas that come from a single, usually malignant cell. Ask your doctor who ordered the lab test to help interpret your specific results. ...Read more

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Can a monclonal IgM kappa light chain gammopathy turn into macrogobulinemia-waldenstrom?

Can a monclonal IgM kappa light chain gammopathy turn into macrogobulinemia-waldenstrom?

Yes it is possible: It would be one of differntial diagnosis. You need a bone marrow biopsy basically to check if this is caused by plasma cells or lymphplasmacytic cells etc. ...Read more

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Can monoclonal IgM kappa light chain gammopathy turn into multiple myeloma?

Can monoclonal IgM kappa light chain gammopathy turn into multiple myeloma?

It can: Yes, it can . It will depend on how much is the quantity of the monoclonal proteine, how many plasma cells on the bone marrow and ultimately whether one has end organ damages/ whether some other organs are affected significantly by the monoclonal protein. That is why some blood work, imaging study and bone marrow biopsy need to be done. ...Read more

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Light chains KAPPA 55% & LAMBDA 39%. What are the range values?

Light chains KAPPA 55% & LAMBDA 39%. What are the range values?

Http://myeloma.org/pdfs/U-Freelite-Eng2011_g2web.pdf: Go to the website above for good summary of KAPPA and LAMBDA values, and significance;; Normal levels of serum free light chains are*: • Kappa: 3.3–19.4 mg/L* • Lambda: 5.71–26.3 mg/L* • Kappa/lambda ratio: 0.26–1.65** *Note: The units here are mg/L; different laboratories use different units. It is important to double-check the units used when comparing numbers in lab values. **Further Note: In patients with renal impairment, it is recommended to interpret the results of the Kappa/Lambda ratio with a modified reference range of 0.37–3.1. ...Read more

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Immunoglobulin free lt chains blood results : kappa free light chain 20.36 (h) lambda 12.14 normal. Kappa; dheas is 25. Crp is 2.13. Sed rate is 25.?

Immunoglobulin free lt chains blood results :  kappa free light chain 20.36 (h) lambda 12.14 normal. Kappa; dheas is 25. Crp is 2.13. Sed rate is 25.?

Labs: Cannot possibly interpret lab results in the absence of a medical history and exam. If you have had these tests ordered by a doctor, discuss results with them. ...Read more

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Question about lab results from hematologist. Free kappa light chains serum 19.97 (range is 3.30-19.40mg/l) Normal lambda and ratio.

Question about lab results from hematologist. 

Free kappa light chains serum 19.97 (range is 3.30-19.40mg/l)

Normal lambda and ratio.

What for?: What are you being tested for? All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, Serum free light chain assay and kappa/lambda ratio are unreliable tests. Better would be have serum and urine protein electrophoresis. ...Read more

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How long can monoclonal IgM kappa light chain gammopathr stay stable?

Indefinitely.: If monoclonal igm gammopathy is fully evaluated and not associated with any malignancy (lymphoma or myeloma) then the diagnosis is mgus (monoclonal gammopathy of undetermined significance). The chances of progression are low, ranging from 0.1% to 1.0%/year. The majority of patients never get cancer. ...Read more

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High KAPPA/LAMBDA LIGHT CHAIN/slightly high ratio.No Monoclonal protein immunofixation or serum electrophoresis. Is this a type of cancer?Normal WBC

High KAPPA/LAMBDA LIGHT CHAIN/slightly high ratio.No Monoclonal protein immunofixation or serum electrophoresis. Is this a type of cancer?Normal WBC

I bet it's nothing: Without free light chains or a monoclonal protein in blood or urine, the ratio's meaningless. And like most lab tests, the reference range is set so that a few percent of healthies fall outside on either end. ...Read more

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Free kappa light chain is high, FLC ratio is 2.205, no monoclonal gammopathy. IgA 389.43, lgM 125.95 and lgG 1771.02 H. Should we be worried? Thanks.

No: Abnormal FLC ratio is not diagnostic of any disease. More than 50% of the people with increased levels of gamma globulins have abnormal FLC ratio without a disorder of the plasma cells. ...Read more

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Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

False positive rate: There is 30% or so false positive rate of kappa/lambda ratio in people without MGUS, myeloma or other disorders. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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Resent blood work states IgM 875, an appearant polyclonal glammopathy IgM, kappa and Lambda light chains appear increased. Possible Multiple myeloma?

No: Myeloma is monoclonal. I trust you do not have urinary light chains. Most polyclonal stuff means nothing. If you are symptomatic, look for another cause of any symptoms. ...Read more

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Kappa light chain in upep. Elevated k/l chains in serum but ratio normal. Wbc, rbc in urine with 2g/d protein. More/which workup/specialist needed?

Kappa light chain in upep. Elevated k/l chains in serum but ratio normal. Wbc, rbc in urine with 2g/d protein. More/which workup/specialist needed?

Nephrologist: You need a nephrologist to follow up on those tests, but your doctor or the doctor who ordered those tests can direct you better, wish you wellness ...Read more

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Immunofixation, Serum FAH = Monoclonal IgG kappa immunoglobulin. Beta FAH = 10.5% Abnormal band, immunofixation to follow. I'm IgA deficient too. ??

Possibly: If I am understaning this right you have a monoclonal protien band? The most important next steps here would be to identify the band (immunofixation) and then perfrom quantitvaive immunoglobulin levels. IF there is a monoclonal band, you may very well have reciprocal depriciation of alternative immunoglobulins and IgA deficiecny with an IgG monoclonal protein is possible. ...Read more

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My haematologist says my kappa lambda ratio is seriously skewed. Kappa light chains @580 paraproteins 30. Does this imply a poor outcome?

My haematologist  says my kappa lambda ratio is  seriously skewed. Kappa light chains @580  paraproteins 30. Does this imply  a poor outcome?

Bad ratio: I am surprised you do not ask your oncologist questions about your outcome. Did you not ask? If you did, did you not get a response that you understood. You oncologist (o) knows your case best of all. Give your o a call and get your answer from the physician who knows you best of all. ...Read more

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Immunifixation identifies m spike as IGg Kappa polyclonal gamma globulin to consist mainly of IGg Kappa n Lamda with fair amounts of Iga means what?

?? Chronic Infection: M spike of polyclonal IgG (kappa & lambda) globulin mostly suggest chronic infectious or inflammatory process & rarely hematologic malignancies. You need a complete work up for ch. liver disease, hepatitis B/C, ch.bacterial, viral & fungal infection, HIV, autoimmune diseases & if negative then evaluate for hematological disorder. CHECK FOR Ch. INFECTION & HEPATITIS. Update me with your result. ...Read more

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Is elevated kappa/lambda ratio on serum FLC test inherently monoclonal, even if neither kappa or lambda is elevated? Ratio high b/c lambda is low, not because of high kappa. SPEP/UPEP & IFE normal. High IgA, low IgG. Clean marrow biopsy. Polyclonal?

Is elevated kappa/lambda ratio on serum FLC test inherently monoclonal, even if neither kappa or lambda is elevated? Ratio high b/c lambda is low, not because of high kappa. SPEP/UPEP & IFE normal. High IgA, low IgG. Clean marrow biopsy. Polyclonal?

Clinical context : The use of light chains is limited in diseases other than monoclonal gammopathies, such as myeloma or amyloidosis. If this is the context that yours got checked the results do not suggest such a condition. With no gammopathy suggested by results the question regarding clonality has no grounds. As any other test, trending the results would help in integrating it in a meaningful clinical context. ...Read more

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Can a hematologist pls explain diff btwn serum free light chain and total flc? Serum and urine numbers are 3x high for flc, total light chain/ratio ok

Can a hematologist pls explain diff btwn serum free light chain and total flc? Serum and urine numbers are 3x high for flc, total light chain/ratio ok

Free light chains: The light chain ratio is a number that represents the ratio of kappa to lambda light chains. It tells me that one light chain is produced at higher amounts versus the other . ...Read more

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Are IgG lambda monoclonal bands common?

IgG lambda rare: Only 20% of all human igg use lambda light chains. Monoclonal bands are not common in general and may be benign or a sign of myeloma. Most a kappa. ...Read more

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Kappa Lambda ratio u 1.92(L) Free kappa LT chains ur 32.10 (H) Free Lambda LT chains ur 16.70 (H) 24 hour urine What does this mean?

Kappa Lambda ratio u 1.92(L) Free kappa LT chains ur 32.10 (H) Free Lambda LT chains ur 16.70 (H)  24 hour urine  What does this mean?

Nothing: In isolation, these mean nothing at all. If only one of the chains is being excreted, I'd worry about plasma cell myeloma. If you're leaking protein in your urine because of your diabetes, this is more concerning than light chain ratios. ...Read more