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Doctor insights on: Kappa Lambda Free Light Chain Ratio

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Pathology - Just got my blood results back says kappa / Lambda light chains free with ratio urine came 18 high / prostaglandin serum 550? What's mean

Pathology - Just got my blood results back says kappa / Lambda light chains free with ratio urine came 18 high / prostaglandin serum 550? What's mean

Unclear data: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, the data you provided does not seem to add up. What did serum and urine protein electrophoresis show? You wish to talk to the pathologist of the lab that did the tests. ...Read more

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Test results came back and say Free Kappa Lt Chains, S 34.81 Free Lambda Lt Chains, s is 29.22Kappa, lambda ratio is 1.19. Is it myeloma What is test 4

Test results came back and say Free Kappa Lt Chains, S 34.81 Free Lambda Lt Chains, s is 29.22Kappa, lambda ratio is 1.19. Is it myeloma What is test 4

Light chains: Light chains (kappa and lambda) are a part of the immunoglobulin molecues the body makes. A given plasma cell only makes one type of light chain, most commonly this is kappa. When immunoglobulin cells proliferate like a neoplasm, then one type will overwhelm the others. Your values are nearly even, and the ratio is not abnormal, so it is unlikely that you have myeloma or another Ig-producing lesion. ...Read more

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I have 549igA, 37 sedimentation rate westergren, 21.64 free kappa lt chains, s, and kappa/lambda ratio, s is 1.66 What does this mean?

I have 549igA, 37 sedimentation rate westergren, 21.64 free kappa lt chains, s, and kappa/lambda ratio, s is 1.66 What does this mean?

Any symptoms?: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, Why were these tests done? Do you have any symptoms? Kappa/lambda ratio is generally a useless test. IgA of 549, per se is not a problem. Sed rate is in the normal range.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex. ...Read more

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Kappa Lambda ratio u 1.92 (L) Free kappa LT chains ur 32.10 (H) Free Lambda LT chains ur 16.70 (H) 24 hour urine What does this mean?

Kappa Lambda ratio u 1.92 (L) Free kappa LT chains ur 32.10 (H) Free Lambda LT chains ur 16.70 (H) 24 hour urine What does this mean?

Nothing: In isolation, these mean nothing at all. If only one of the chains is being excreted, I'd worry about plasma cell myeloma. If you're leaking protein in your urine because of your diabetes, this is more concerning than light chain ratios. ...Read more

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Question about lab results from hematologist. Free kappa light chains serum 19.97 (range is 3.30-19.40mg/l) Normal lambda and ratio.

Question about lab results from hematologist. Free kappa light chains serum 19.97 (range is 3.30-19.40mg/l) Normal lambda and ratio.

What for?: What are you being tested for? All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, Serum free light chain assay and kappa/lambda ratio are unreliable tests. Better would be have serum and urine protein electrophoresis. ...Read more

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Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

False positive rate: There is 30% or so false positive rate of kappa/lambda ratio in people without MGUS, myeloma or other disorders.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex. ...Read more

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Causes if a polyclonal gammopayhy with elevated kappa and lambda free light chains? Seems to be of the IGG type slightly elevated count.

Causes if a polyclonal gammopayhy with elevated kappa and lambda free light chains? Seems to be of the IGG type slightly elevated count.

Polyclonal IgG: It can be caused by numerous inflammatory, infectious, and malignant causes, for example; TB, Rheumatoid arthritis, cirrhosis of the liver, lymphoma, and MS. A more extensive list, click on Table 3 link inside article below.

http://www. Aafp. Org/afp/2005/0101/p105.html

http://www. Ncbi. Nlm. Nih. Gov/pmc/articles/PMC356447/

Mild elevation could simply be a mild cold with a rhinovirus. No worries. ...Read more

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What is the significance of having low serum levels of kappa and lambda free light chains? I had high ch50 and normal C3 and c4.

What is the significance of having low serum levels of kappa and lambda free light chains? I had high ch50 and normal C3 and c4.

The: Concern would be low ch50 and low C3 ; c4, like in lupus. Elevations in kappa or lambda would be of concern for myeloma, not to worry about these levels. ...Read more

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Immunoglobulin free lt chains blood results : kappa free light chain 20.36 (h) lambda 12.14 normal. Kappa; dheas is 25. Crp is 2.13. Sed rate is 25.?

Immunoglobulin free lt chains blood results : kappa free light chain 20.36 (h) lambda 12.14 normal. Kappa; dheas is 25. Crp is 2.13. Sed rate is 25.?

Labs: Cannot possibly interpret lab results in the absence of a medical history and exam. If you have had these tests ordered by a doctor, discuss results with them. ...Read more

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I had a IgA Heavy Light Chains (HLC), S test done. Ig K/L HLC Ratio, IgA Kappa, S and IgA Lambda, S were in normal range. What does this test mean?

I had a IgA Heavy Light Chains (HLC), S test done. Ig K/L HLC Ratio, IgA Kappa, S and IgA Lambda, S were in normal range. What does this test mean?

Nothing: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, The tests you mentioned have a high number of false positives and false negatives and are or questionable value.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex. ...Read more

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Can you get all amyloidosis if you have kappa rather than lambda light chains? I also have a kappa lambda ratio of 175

Can you get all amyloidosis if you have kappa rather than lambda light chains? I also have a kappa lambda ratio of 175

Yes: Listen, Jane. I'm worried about you. You're already on cyclophosphamide and dexamethasone -- extremely potent medications -- yet you list no illness for which they are indicated. It's not for your thyroid cancer. You have a duty to find out exactly what is happening with you, including getting a 2nd opinion from a physician who's explain clearly. Amyloid is confusing; be proactive. ...Read more

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My haematologist says my kappa lambda ratio is seriously skewed. Kappa light chains @580 paraproteins 30. Does this imply a poor outcome?

My haematologist says my kappa lambda ratio is seriously skewed. Kappa light chains @580 paraproteins 30. Does this imply a poor outcome?

Bad ratio: I am surprised you do not ask your oncologist questions about your outcome. Did you not ask? If you did, did you not get a response that you understood. You oncologist (o) knows your case best of all. Give your o a call and get your answer from the physician who knows you best of all. ...Read more

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I've just found out that 3 tests show low kappa/lambda ratio, with lambda light chain levels increased. Do these results mean a thing without m protein?

I've just found out that 3 tests show low kappa/lambda ratio, with lambda light chain levels increased. Do these results mean a thing without m protein?

Check with your doc: Kappa and lambda are parts of immunoglobulins which are proteins certain white blood cells make to fight infections. These are referred to as polyclonal since they come from different cells. Some blood disorders can produce lots of m (monoclonal) kappas or lambdas that come from a single, usually malignant cell. Ask your doctor who ordered the lab test to help interpret your specific results. ...Read more

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Kappa chain is 40.8 (H) and lambda is 23.3 (normal). kappa/lambda ratio is 1.75 (H). also low platelets. These #'s be possible of plasma cell disease?

Kappa chain is 40.8 (H) and lambda is 23.3 (normal). kappa/lambda ratio is 1.75 (H). also low platelets. These #'s be possible of plasma cell disease?

Unreliable test: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Talk to the doctor who ordered the tests. Having said that, Serum free light chain assay is an unreliable test for detecting plasma cell disease. Did you have a protein electrophoresis of serum and urine? ...Read more

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24-hour urine kappa light chain 2.18 mg/dl, lambda can't be quantified, < 0.4 mg/dl. What does it mean, how do I calculate ratio/ rule out LCDD? Thx

24-hour urine kappa light chain 2.18 mg/dl, lambda can't be quantified, < 0.4 mg/dl. What does it mean, how do I calculate ratio/ rule out LCDD? Thx

This could be MGUS: MGUS is a monoclonal antibody of uncertain significance. This may mean it will never be cancer but sometimes it can be related to cancer. Your physician can have you see a hematologist. Maybe you have seen one already. ...Read more

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Kappa/lambda FLC ratio high (2.75) w/ normal K (10.21mg/dl) & low L (3.68mg/dl). Hem-onc unsure if ratio implies K monoclonality since serum/urine IFE ok & neither chain is elevated. Could monoclonal K be suppressing L? IgA a bit high IgG &IgM a bitlow

Kappa/lambda FLC ratio high (2.75) w/ normal K (10.21mg/dl) & low L (3.68mg/dl). Hem-onc unsure if ratio implies K monoclonality since serum/urine IFE ok & neither chain is elevated. Could monoclonal K be suppressing L? IgA a bit high IgG &IgM a bitlow

Useless test: K/L ratio is not a useful test. About one third of patients without monoclonal immunoglboulin have an abnormal ratio, usually with kappa excess. If you must, the next step would be a bone marrow examination. You may consult this article that I wrote: https://www. Ncbi. Nlm. Nih. Gov/pubmed/27473738
At your age you are unlikely to have myeloma. ...Read more

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Increased (3x normal) kappa lambda chains with normal ratio. Recurring fever that goes away with plaquenil (hydroxychloroquine). Is this babesiosis, malaria or parasitic?

Increased (3x normal) kappa lambda chains with normal ratio. Recurring fever that goes away with plaquenil (hydroxychloroquine). Is this babesiosis, malaria or parasitic?

Kappa lambda chains: You come with a question which still I do not have the correct answer. Went to Webb MD, searched all the possibilities and came with this response.
Do you have a copy of 'Understanding Serum Free Light Chain Assays' from the International Myeloma Foundation (IMF)? It clearly goes into all aspects of the Bence Jones issue. Under the Serum Free Light Chain Assays: Normal Versus Abnormal it says:
"Normal levels of serum free light chains are*:
Kappa: 3.3 -19.4 mg/L*
Lambda: 5.7 -26.3 mg/L*
Kappa/lambda ratio: 0.26- 1.65
*NOTE: The units here are mg/L; different laboratories use different units It is important t double-check the units used when comparing numbers in lab values.
The Kappa/Lambda Ratio
1. The kappa/lambda ratio is as important for diagnosis and monitoring of myeloma as are the levels of kappa and lambda. 2. When the level of either kappa or lambda is very high and the other chain is normal or low, then the ratio is abnormal and indicates that the myeloma is active. 3. If levels of both kappa and lambda light chains are increased, the ratio may be within the normal range, and this generally indicates a disease other than myeloma, such as poor kidney function. When the kidneys are not working properly, both types of light chains are retained in the blood and are not removed by the kidneys. The result is increased levels of both kappa and lambda in the blood. In this situation, in general, the abnormally increased levels are not themselves a direct result of currently active myeloma. 4. If the kappa and lambda levels are both within the normal range, sometimes the ratio may be abnormal. In this situation there may be a persistent low level of active myeloma with excess production of the abnormal light chain. 5. A normal kappa/lambda ratio after treatment is particularly good remission and is termed a stringent complete response. Normalization of the kappa/lambda ratio correlates with possible longer remission and studies are in progress to investigate more about the nature of this relationship,
Yana, this comes directly from the afore named booklet. You can get a complete set of myeloma information from the IMF by going online and ordering it -- for FREE! Its a great resource and they have many other things relative to myeloma patients and carers -- the site is well worth a look!! I don't know if this answers your question, but its a good place to start. ...Read more

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Test by hemotologist s t/oncologist, kappa//lambda light chain, 24he urine ratio 3.51; kappa/lambda serum ratio 1.86; Erythropoietin = 41.1?

Test by hemotologist s t/oncologist, kappa//lambda light chain, 24he urine ratio 3.51; kappa/lambda serum ratio 1.86; Erythropoietin = 41.1?

Any symptoms?: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Talk to the doctor who ordered the tests. Having said that, kappa/lambda ratio is a generally useless test.
Wish you good health! - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex, if you have sex. ...Read more

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High KAPPA/LAMBDA LIGHT CHAIN/slightly high ratio. No Monoclonal protein immunofixation or serum electrophoresis. Is this a type of cancer? Normal WBC

High KAPPA/LAMBDA LIGHT CHAIN/slightly high ratio. No Monoclonal protein immunofixation or serum electrophoresis. Is this a type of cancer? Normal WBC

I bet it's nothing: Without free light chains or a monoclonal protein in blood or urine, the ratio's meaningless. And like most lab tests, the reference range is set so that a few percent of healthies fall outside on either end. ...Read more

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Mcv low rdw, tsat, lymph, platelets, high gran/wbc recurring fever and increased kappa lambda chains with normal ratio. Can this by due to malaria?

Mcv low rdw, tsat, lymph, platelets, high gran/wbc recurring fever and increased kappa lambda chains with normal ratio. Can this by due to malaria?

Increased kappa lambda chains: Antibodies are produced by B lymphocytes, each expressing only one class of light chain. Once set, light chain class remains fixed for the life of the B lymphocyte. In a healthy individual, the total kappa to lambda ratio is roughly 3:1 in serum (measuring intact whole antibodies) or 1:1.5 if measuring free light chains, with a highly divergent ratio indicative of

The exact normal ratio of kappa ...Read more

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Light chains KAPPA 55% & LAMBDA 39%. What are the range values?

Light chains KAPPA 55% & LAMBDA 39%. What are the range values?

Http://myeloma. Org/pdfs/U-Freelite-Eng2011_g2web. Pdf: Go to the website above for good summary of KAPPA and LAMBDA values, and significance;;

Normal levels of serum free light chains are*:
• Kappa: 3.3–19.4 mg/L*
• Lambda: 5.71–26.3 mg/L*
• Kappa/lambda ratio: 0.26–1.65**
*Note: The units here are mg/L; different
laboratories use different units. It is important to
double-check the units used when comparing
numbers in lab values.
**Further Note: In patients with renal impairment,
it is recommended to interpret the results
of the Kappa/Lambda ratio with a modified
reference range of 0.37–3.1. ...Read more

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In lymphocyte phenotyping of periferial blood, what is the normal percentage for Kappa and Lambda light chains?

In lymphocyte phenotyping of periferial blood, what is the normal percentage for Kappa and Lambda light chains?

0.26-1.65 K/L ratio: Free light chains will normally be present in the blood at low levels, with a kappa/lambda ratio of about 0.26 to 1.65. Increased kappa free light chains and a higher kappa/lambda ratio may mean a plasma cell disorder producing excess monoclonal kappa chains. Increased lambda free light chains and a lower kappa/lambda ratio may mean a plasma cell disorder producing excess monoclonal lambda chains. ...Read more

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Light chains elevated. Kappa 300 mg/dL lambda 200. Creat 1.5 CRP 1, ana 160:1. No MM. What diseases can cause this, rule out secondary amyloidosis?

Chronic inflammation: Chronic inflammation from any cause can cause increase in serum immunoglobulins, polyclonal hypergammaglobulinemia and many of those patients have elevated serum free light chains. Some of these patients even have abnormal K/L ratio which you do not. The results you described are not diagnostic of any illness. ...Read more

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Resent blood work states IgM 875, an appearant polyclonal glammopathy IgM, kappa and Lambda light chains appear increased. Possible Multiple myeloma?

No: Myeloma is monoclonal. I trust you do not have urinary light chains. Most polyclonal stuff means nothing. If you are symptomatic, look for another cause of any symptoms. ...Read more

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Kappa (4 vs ref 2mg/dl) and sometimes lambda light chain in 24hr urine without mm. What can be suspected? Anemia, worsening ckd, improves with na co3

Kappa (4 vs ref 2mg/dl) and sometimes lambda light chain in 24hr urine without mm. What can be suspected? Anemia, worsening ckd, improves with na co3

K+L chains in ua: Hello, the fact that you are having this checked in your urine means that some person is already onto the fact that you may have MGUS or multiple myeloma. The worsening anemia and kidney deterioration is more indicative of myeloma. BUT you need the whole urine and blood protein electrophoresis to look at before making the diagnosis. You shd request referral to a Heme-Onc specialist to decide. Thx ...Read more

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Reasons for 3x normal kappa lambda light chain b2m=4.4 elevations in CKD? Oncologist says no myeloma or mgus. Asking because doctors couldn't answer.

Reasons for 3x normal kappa lambda light chain b2m=4.4 elevations in CKD? Oncologist says no myeloma or mgus. Asking because doctors couldn't answer.

Second opinion: You live in NYC. I don't know where you went but there are great oncologists in the City. Take your lab data with you and go to MSKCC or Columbia or Cornell or NYU. Somebody doesn't have their thinking cap on! ...Read more

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Kappa 132.97 lambda 60.97 ratio serum 2.18 what does this mean?

Kappa etc: Hello ~ I don't know there's not enough information. I would make huge diagnostic mistakes if I assumed any of the absent information and you would not be pleased with anything except 100% accuracy. Thanks ...Read more

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Sed rate of 28 kappa.67 lambda 3.17 ratio 1.47...What is going on?

Sed rate of 28 kappa.67 lambda 3.17 ratio 1.47...What is going on?

I suspect nothing: As far as this pathologist is concerned, a sed rate of 28 is fine especially for an adult female like yourself. It's worthless unless very high, and even then only to confirm systemic inflammation. The new work on intact and fragmented antibodies shows a huge variability in the ratios of kappa and lambda and I would draw no conclusions whatever. You're a person, not numbers. How do you feel? ...Read more

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How much increase in kappa lambda ratio Wud mean worrisome?

How much increase in kappa lambda ratio Wud mean worrisome?

Kappa/lambda: Hi, the normal Kappa/lambda is approximately 0.26 to 1.65. this ratio has to be interpreted along with Serum electrophoresis and also the free light chain values (kappa and lambda), if the free chain is elevated and the ratio is elevated then that could be due to plasma cell disorders like multiple Myeloma or Primary Amyloidosis if the symptoms present. Having said that it's not easy to draw ...Read more

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I have both elevated kappa and Lambda with normal ratio does this mean I have MM. I am scheduled to see a hem/onc, neuro, and rhemy?

I have both elevated kappa and Lambda with normal ratio does this mean I have MM. I am scheduled to see a hem/onc, neuro, and rhemy?

Multiple myeloma: Is not an easy disease to have or to diagnose. The findings you mentioned aren't peculiar to the disease, lot of other parameters are needed to diagnose, the most important in this context is the heamatologist/oncologist, together with the other specialists you have appointments with. Can't commit to a diagnosis on this limited platform, wish you wellness ...Read more