Doctor insights on:
Kappa/lambda FLC ratio high (2.75) w/ normal K (10.21mg/dl) & low L (3.68mg/dl). Hem-onc unsure if ratio implies K monoclonality since serum/urine IFE ok & neither chain is elevated. Could monoclonal K be suppressing L? IgA a bit high IgG &IgM a bitlow
K/L ratio is not a useful test. About one third of patients without monoclonal immunoglboulin have an abnormal ratio, usually with kappa excess. If you must, the next step would be a bone marrow examination. You may consult this article that I wrote: https://www. Ncbi. Nlm. Nih. Gov/pubmed/27473738
At your age you are unlikely to have myeloma. ...Read more
Multiple Myeloma: Kappa and lamda are classifications of light chains of immunoglobulins in humans. They are part of the "y" shaped arms of your antibodies. This ratio is used to distinguish MGUS or monoclonal gammopathy of undetermined significance from multiple myeloma. High ratio favors Multiple Myeloma ...Read more
It also depends on the ratio of kappa to lamda light chains and the presence of polyclonal or monoclonal gammopathy. That is a large amount, while 7mg/l would be normal. Please double check the measurement for grams or milligrams.
If abnormal, it can mean a plasma cell dyscrasia like multiple myeloma, amyloidosis, or Waldenstrom's anemia. Please follow up with the doctor who ordered the test. ...Read more
Http://myeloma. Org/pdfs/U-Freelite-Eng2011_g2web. Pdf:
Go to the website above for good summary of KAPPA and LAMBDA values, and significance;;
Normal levels of serum free light chains are*:
• Kappa: 3.3–19.4 mg/L*
• Lambda: 5.71–26.3 mg/L*
• Kappa/lambda ratio: 0.26–1.65**
*Note: The units here are mg/L; different
laboratories use different units. It is important to
double-check the units used when comparing
numbers in lab values.
**Further Note: In patients with renal impairment,
it is recommended to interpret the results
of the Kappa/Lambda ratio with a modified
reference range of 0.37–3.1. ...Read more
Had abnormal k/ light chain ratio six months ago; now ratio is wnl, but kappa level remains elevated three blood panels later. Thoughts?
I'm not sure I could: Make much of a prognostic distinction between an abnormal kappa/light chain ratio and kappa elevation. Produced within plasma cells, heavy and light chains bind together to form immunoglobulins. Typically producing more light chains than required, the plasma cells enter the blood as free light chains. The activity of myeloma/plasma cell growth is linked to the amount of free light chains in blood. ...Read more
Hello, my Dr. Told me my Kappa light chain is elevated at 26. she told me not to worry and we'll check again in 3 months. What else should I ask /?
Sounds reasonable: You have a minimal degree of change, this may be within the normal range. But a recheck of this test is a good idea just to be sure. It is a rare condition that you do not need to worry about unless you have some symptoms in the future. Do tell us your age as some such conditions primarily occur in older adults ...Read more
Kappa/lambda: Hi, the normal Kappa/lambda is approximately 0.26 to 1.65. this ratio has to be interpreted along with Serum electrophoresis and also the free light chain values (kappa and lambda), if the free chain is elevated and the ratio is elevated then that could be due to plasma cell disorders like multiple Myeloma or Primary Amyloidosis if the symptoms present. Having said that it's not easy to draw ...Read more
Kappa etc: Hello ~ I don't know there's not enough information. I would make huge diagnostic mistakes if I assumed any of the absent information and you would not be pleased with anything except 100% accuracy. Thanks ...Read more
Kappa/Lambda: Hi, the normal Kappa/lambda is approximately 0.26 to 1.65. this ratio has to be interpreted along with Serum electrophoresis and also the free light chain values (kappa and lambda), if the free chain is elevated and the ratio is elevated then that could be due to plasma cell disorders like multiple Myeloma or Primary Amyloidosis if the symptoms present. Having said that it's not easy to draw ...Read more
Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Talk to the doctor who ordered the tests. Having said that, your results are suggestive of chronic inflammation and may be liver disease. However, you should take it up with your doctor who knows more about your health. ...Read more
I have both elevated kappa and Lambda with normal ratio does this mean I have MM. I am scheduled to see a hem/onc, neuro, and rhemy?
Multiple myeloma: Is not an easy disease to have or to diagnose. The findings you mentioned aren't peculiar to the disease, lot of other parameters are needed to diagnose, the most important in this context is the heamatologist/oncologist, together with the other specialists you have appointments with. Can't commit to a diagnosis on this limited platform, wish you wellness ...Read more
Causes if a polyclonal gammopayhy with elevated kappa and lambda free light chains? Seems to be of the IGG type slightly elevated count.
It can be caused by numerous inflammatory, infectious, and malignant causes, for example; TB, Rheumatoid arthritis, cirrhosis of the liver, lymphoma, and MS. A more extensive list, click on Table 3 link inside article below.
http://www. Aafp. Org/afp/2005/0101/p105.html
http://www. Ncbi. Nlm. Nih. Gov/pmc/articles/PMC356447/
Mild elevation could simply be a mild cold with a rhinovirus. No worries. ...Read more
I had a IgA Heavy Light Chains (HLC), S test done. Ig K/L HLC Ratio, IgA Kappa, S and IgA Lambda, S were in normal range. What does this test mean?
All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, The tests you mentioned have a high number of false positives and false negatives and are or questionable value.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex. ...Read more
Plasma cell disorder: Monoclonal gammopathy refers to an abnormal production of proteins by cells in the immune system (plasma cells) that are growing out of control. It can be one of the signs of myeloma. A hematologist-oncologist can help. ...Read more
Benign overgrowth: Monoclonal gammopathy of uncertain significance, made of an immunoglobulin g with a kappa light chain. It means nothing. You have a slightly increased chance of getting plasma cell myeloma when you're old. There's nothing you can do about it, so simply resolve not to worry about it. ...Read more
Why do you ask?: If you've been found to have a paraprotein, the real question is, "Do we treat for plasma cell myeloma? " These paraproteins are very common, especially as folks get older; most never progress. The actual level of the paraprotein isn't the key. If this is grams per liter, a value below 10 is "low". If your labs are otherwise good and you feel well, I wouldn't give it another thought. Best wishes. ...Read more
Immune cell problem: Igg-kappa is a type of antibody your body makes to help fight infections, etc. Normally one make lots of different types of igg-kappa. When it is monoclonal, one specific igg-kappa has become very predominant. This can happen in response to an infection, if the immune system is not regulated properly, or in certain malignancies like multiple myeloma. Talk with your doctor for more information. ...Read more
I suspect nothing: As far as this pathologist is concerned, a sed rate of 28 is fine especially for an adult female like yourself. It's worthless unless very high, and even then only to confirm systemic inflammation. The new work on intact and fragmented antibodies shows a huge variability in the ratios of kappa and lambda and I would draw no conclusions whatever. You're a person, not numbers. How do you feel? ...Read more
See details: A monoclonal spike is suggestive of a plasma cell disorder. It may be relatively benign (mgus) or much more serious (myeloma, Waldenstrom's) ...Read more
Can you get all amyloidosis if you have kappa rather than lambda light chains? I also have a kappa lambda ratio of 175
Yes: Listen, Jane. I'm worried about you. You're already on cyclophosphamide and dexamethasone -- extremely potent medications -- yet you list no illness for which they are indicated. It's not for your thyroid cancer. You have a duty to find out exactly what is happening with you, including getting a 2nd opinion from a physician who's explain clearly. Amyloid is confusing; be proactive. ...Read more
Test results came back and say Free Kappa Lt Chains, S 34.81 Free Lambda Lt Chains, s is 29.22Kappa, lambda ratio is 1.19. Is it myeloma What is test 4
Light chains: Light chains (kappa and lambda) are a part of the immunoglobulin molecues the body makes. A given plasma cell only makes one type of light chain, most commonly this is kappa. When immunoglobulin cells proliferate like a neoplasm, then one type will overwhelm the others. Your values are nearly even, and the ratio is not abnormal, so it is unlikely that you have myeloma or another Ig-producing lesion. ...Read more
Free kappa light chain is high, FLC ratio is 2.205, no monoclonal gammopathy. IgA 389.43, lgM 125.95 and lgG 1771.02 H. Should we be worried? Thanks.
No: Abnormal FLC ratio is not diagnostic of any disease. More than 50% of the people with increased levels of gamma globulins have abnormal FLC ratio without a disorder of the plasma cells. ...Read more
Is elevated kappa/lambda ratio on serum FLC test inherently monoclonal, even if neither kappa or lambda is elevated? Ratio high b/c lambda is low, not because of high kappa. SPEP/UPEP & IFE normal. High IgA, low IgG. Clean marrow biopsy. Polyclonal?
Clinical context: The use of light chains is limited in diseases other than monoclonal gammopathies, such as myeloma or amyloidosis. If this is the context that yours got checked the results do not suggest such a condition. With no gammopathy suggested by results the question regarding clonality has no grounds. As any other test, trending the results would help in integrating it in a meaningful clinical context. ...Read more
MGUS iggLambda. 19 for 1yr. FLC lambda8.04 stable. Kappa drop<1 from 4.2 no ratio calculable. IGM 27 SPEPGammaGlob. 63 Doc not avail SLE tooThoughts?
There are multiple issues regarding your health. MGUS is actually the simplest. With spike at a concentration of 0.19 and stable, you are at no immediate risk. The risk of myeloma is about 1%/year, but it does require regular follow-up. See this site for info.
http://www. Mayoclinic. Org/diseases-conditions/mgus/basics/definition/CON-20026422 ...Read more
Indefinitely.: If monoclonal igm gammopathy is fully evaluated and not associated with any malignancy (lymphoma or myeloma) then the diagnosis is mgus (monoclonal gammopathy of undetermined significance). The chances of progression are low, ranging from 0.1% to 1.0%/year. The majority of patients never get cancer. ...Read more
MGUS: Many monoclonal gammopathies can be stable for many years. The only way to know is have the immunofixation and several other tests performed periodically. A referral to the hematologist is appropriate here. ...Read more