Doctor insights on:
Multiple Myeloma: Kappa and lamda are classifications of light chains of immunoglobulins in humans. They are part of the "y" shaped arms of your antibodies. This ratio is used to distinguish MGUS or monoclonal gammopathy of undetermined significance from multiple myeloma. High ratio favors Multiple Myeloma ...Read more
Hopefully 7mg/L: It also depends on the ratio of kappa to lamda light chains and the presence of polyclonal or monoclonal gammopathy.That is a large amount, while 7mg/l would be normal. Please double check the measurement for grams or milligrams. If abnormal, it can mean a plasma cell dyscrasia like multiple myeloma, amyloidosis, or Waldenstrom's anemia. Please follow up with the doctor who ordered the test. ...Read more
Http://myeloma.org/pdfs/U-Freelite-Eng2011_g2web.pdf: Go to the website above for good summary of KAPPA and LAMBDA values, and significance;; Normal levels of serum free light chains are*: • Kappa: 3.3–19.4 mg/L* • Lambda: 5.71–26.3 mg/L* • Kappa/lambda ratio: 0.26–1.65** *Note: The units here are mg/L; different laboratories use different units. It is important to double-check the units used when comparing numbers in lab values. **Further Note: In patients with renal impairment, it is recommended to interpret the results of the Kappa/Lambda ratio with a modified reference range of 0.37–3.1. ...Read more
Need more info: What did your serum protein electrohphoresis show? What is your serum creatinine level? What is your hemoglobin level? Do you have any symptoms? Was a bone x-ray done? All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Talk to the doctor who ordered the tests. ...Read more
Had abnormal k/ light chain ratio six months ago; now ratio is wnl, but kappa level remains elevated three blood panels later. Thoughts?
I'm not sure I could: make much of a prognostic distinction between an abnormal kappa/light chain ratio and kappa elevation. Produced within plasma cells, heavy and light chains bind together to form immunoglobulins. Typically producing more light chains than required ,the plasma cells enter the blood as free light chains. The activity of myeloma/plasma cell growth is linked to the amount of free light chains in blood. ...Read more
Hello, my Dr. told me my Kappa light chain is elevated at 26.. she told me not to worry and we'll check again in 3 months.. what else should I ask /?
Sounds reasonable: You have a minimal degree of change, this may be within the normal range. But a recheck of this test is a good idea just to be sure. it is a rare condition that you do not need to worry about unless you have some symptoms in the future.Do tell us your age as some such conditions primarily occur in older adults ...Read more
Kappa/lambda: Hi, the normal Kappa/lambda is approximately 0.26 to 1.65. this ratio has to be interpreted along with Serum electrophoresis and also the free light chain values (kappa and lambda), if the free chain is elevated and the ratio is elevated then that could be due to plasma cell disorders like multiple Myeloma or Primary Amyloidosis if the symptoms present. Having said that it's not easy to draw ...Read more
Kappa etc: hello ~ I dont know there's not enough information. I would make huge diagnostic mistakes if I assumed any of the absent information and you would not be pleased with anything except 100% accuracy. thanks ...Read more
Kappa/Lambda: Hi, the normal Kappa/lambda is approximately 0.26 to 1.65. this ratio has to be interpreted along with Serum electrophoresis and also the free light chain values (kappa and lambda), if the free chain is elevated and the ratio is elevated then that could be due to plasma cell disorders like multiple Myeloma or Primary Amyloidosis if the symptoms present. Having said that it's not easy to draw ...Read more
Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Talk to the doctor who ordered the tests. Having said that, your results are suggestive of chronic inflammation and may be liver disease. However, you should take it up with your doctor who knows more about your health. ...Read more
I have both elevated kappa and Lambda with normal ratio does this mean I have MM. I am scheduled to see a hem/onc, neuro, and rhemy?
Multiple myeloma : Is not an easy disease to have or to diagnose. The findings you mentioned aren't peculiar to the disease, lot of other parameters are needed to diagnose, the most important in this context is the heamatologist/oncologist, together with the other specialists you have appointments with. Can't commit to a diagnosis on this limited platform, wish you wellness ...Read more
Causes if a polyclonal gammopayhy with elevated kappa and lambda free light chains? Seems to be of the IGG type slightly elevated count.
Polyclonal IgG: It can be caused by numerous inflammatory, infectious, and malignant causes, for example; TB, Rheumatoid arthritis, cirrhosis of the liver, lymphoma, and MS. A more extensive list, click on Table 3 link inside article below. http://www.aafp.org/afp/2005/0101/p105.html http://www.ncbi.nlm.nih.gov/pmc/articles/PMC356447/ Mild elevation could simply be a mild cold with a rhinovirus. No worries. ...Read more
I had a IgA Heavy Light Chains (HLC), S test done. Ig K/L HLC Ratio, IgA Kappa, S and IgA Lambda, S were in normal range. What does this test mean?
Nothing: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, The tests you mentioned have a high number of false positives and false negatives and are or questionable value. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more
Benign overgrowth: Monoclonal gammopathy of uncertain significance, made of an immunoglobulin g with a kappa light chain. It means nothing. You have a slightly increased chance of getting plasma cell myeloma when you're old. There's nothing you can do about it, so simply resolve not to worry about it. ...Read more
Why do you ask?: If you've been found to have a paraprotein, the real question is, "Do we treat for plasma cell myeloma?" These paraproteins are very common, especially as folks get older; most never progress. The actual level of the paraprotein isn't the key. If this is grams per liter, a value below 10 is "low". If your labs are otherwise good and you feel well, I wouldn't give it another thought. Best wishes. ...Read more
Immune cell problem: Igg-kappa is a type of antibody your body makes to help fight infections, etc. Normally one make lots of different types of igg-kappa. When it is monoclonal, one specific igg-kappa has become very predominant. This can happen in response to an infection, if the immune system is not regulated properly, or in certain malignancies like multiple myeloma. Talk with your doctor for more information. ...Read more
I suspect nothing: As far as this pathologist is concerned, a sed rate of 28 is fine especially for an adult female like yourself. It's worthless unless very high, and even then only to confirm systemic inflammation. The new work on intact and fragmented antibodies shows a huge variability in the ratios of kappa and lambda and i would draw no conclusions whatever. You're a person, not numbers. How do you feel? ...Read more
See details: A monoclonal spike is suggestive of a plasma cell disorder. It may be relatively benign (mgus) or much more serious (myeloma, Waldenstrom's) ...Read more