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Doctor insights on: Kappa

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What does a high kappa/lambra ratio mean?

What does a high kappa/lambra ratio mean?

Multiple Myeloma: Kappa and lamda are classifications of light chains of immunoglobulins in humans. They are part of the "y" shaped arms of your antibodies. This ratio is used to distinguish MGUS or monoclonal gammopathy of undetermined significance from multiple myeloma. High ratio favors Multiple Myeloma ...Read more

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If an IgG kappa paraproteinaemia is measured as 7g?

If an IgG kappa paraproteinaemia is measured as 7g?

Hopefully 7mg/L: It also depends on the ratio of kappa to lamda light chains and the presence of polyclonal or monoclonal gammopathy. That is a large amount, while 7mg/l would be normal. Please double check the measurement for grams or milligrams.

If abnormal, it can mean a plasma cell dyscrasia like multiple myeloma, amyloidosis, or Waldenstrom's anemia. Please follow up with the doctor who ordered the test. ...Read more

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Light chains KAPPA 55% & LAMBDA 39%. What are the range values?

Light chains KAPPA 55% & LAMBDA 39%. What are the range values?

Http://myeloma. Org/pdfs/U-Freelite-Eng2011_g2web. Pdf: Go to the website above for good summary of KAPPA and LAMBDA values, and significance;;

Normal levels of serum free light chains are*:
• Kappa: 3.3–19.4 mg/L*
• Lambda: 5.71–26.3 mg/L*
• Kappa/lambda ratio: 0.26–1.65**
*Note: The units here are mg/L; different
laboratories use different units. It is important to
double-check the units used when comparing
numbers in lab values.
**Further Note: In patients with renal impairment,
it is recommended to interpret the results
of the Kappa/Lambda ratio with a modified
reference range of 0.37–3.1. ...Read more

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Had abnormal k/ light chain ratio six months ago; now ratio is wnl, but kappa level remains elevated three blood panels later. Thoughts?

Had abnormal k/ light chain ratio six months ago; now ratio is wnl, but kappa level remains elevated three blood panels later. Thoughts?

I'm not sure I could: Make much of a prognostic distinction between an abnormal kappa/light chain ratio and kappa elevation. Produced within plasma cells, heavy and light chains bind together to form immunoglobulins. Typically producing more light chains than required, the plasma cells enter the blood as free light chains. The activity of myeloma/plasma cell growth is linked to the amount of free light chains in blood. ...Read more

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Hello, my Dr. Told me my Kappa light chain is elevated at 26. she told me not to worry and we'll check again in 3 months. What else should I ask /?

Hello, my Dr. Told me my Kappa light chain is elevated at 26. she told me not to worry and we'll check again in 3 months. What else should I ask /?

Sounds reasonable: You have a minimal degree of change, this may be within the normal range. But a recheck of this test is a good idea just to be sure. It is a rare condition that you do not need to worry about unless you have some symptoms in the future. Do tell us your age as some such conditions primarily occur in older adults ...Read more

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Is IGg kappa only associated with multiple myloma?

Is IGg kappa only associated with multiple myloma?

No: It is also associated with B cell lymphoma, amyloidosis, monoclonal gammopathy of undetermined significance, mycobacterium infection, superficial thrombophlebitis, and some inflammatory conditions among other things. ...Read more

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How much increase in kappa lambda ratio Wud mean worrisome?

How much increase in kappa lambda ratio Wud mean worrisome?

Kappa/lambda: Hi, the normal Kappa/lambda is approximately 0.26 to 1.65. this ratio has to be interpreted along with Serum electrophoresis and also the free light chain values (kappa and lambda), if the free chain is elevated and the ratio is elevated then that could be due to plasma cell disorders like multiple Myeloma or Primary Amyloidosis if the symptoms present. Having said that it's not easy to draw ...Read more

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Kappa 132.97 lambda 60.97 ratio serum 2.18 what does this mean?

Kappa etc: Hello ~ I don't know there's not enough information. I would make huge diagnostic mistakes if I assumed any of the absent information and you would not be pleased with anything except 100% accuracy. Thanks ...Read more

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How high is the kappa Lamda 2.64 in blood what does it indicate?

How high is the kappa Lamda 2.64 in blood what does it indicate?

Kappa/Lambda: Hi, the normal Kappa/lambda is approximately 0.26 to 1.65. this ratio has to be interpreted along with Serum electrophoresis and also the free light chain values (kappa and lambda), if the free chain is elevated and the ratio is elevated then that could be due to plasma cell disorders like multiple Myeloma or Primary Amyloidosis if the symptoms present. Having said that it's not easy to draw ...Read more

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My IgG1 is 1818, IgG total is 2714, kappa 48.6, lamda 31.0 what does all this mean?

My IgG1 is 1818, IgG total is 2714, kappa 48.6, lamda 31.0 what does all this mean?

Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Talk to the doctor who ordered the tests. Having said that, your results are suggestive of chronic inflammation and may be liver disease. However, you should take it up with your doctor who knows more about your health. ...Read more

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I have both elevated kappa and Lambda with normal ratio does this mean I have MM. I am scheduled to see a hem/onc, neuro, and rhemy?

I have both elevated kappa and Lambda with normal ratio does this mean I have MM. I am scheduled to see a hem/onc, neuro, and rhemy?

Multiple myeloma: Is not an easy disease to have or to diagnose. The findings you mentioned aren't peculiar to the disease, lot of other parameters are needed to diagnose, the most important in this context is the heamatologist/oncologist, together with the other specialists you have appointments with. Can't commit to a diagnosis on this limited platform, wish you wellness ...Read more

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Causes if a polyclonal gammopayhy with elevated kappa and lambda free light chains? Seems to be of the IGG type slightly elevated count.

Causes if a polyclonal gammopayhy with elevated kappa and lambda free light chains? Seems to be of the IGG type slightly elevated count.

Polyclonal IgG: It can be caused by numerous inflammatory, infectious, and malignant causes, for example; TB, Rheumatoid arthritis, cirrhosis of the liver, lymphoma, and MS. A more extensive list, click on Table 3 link inside article below.

http://www. Aafp. Org/afp/2005/0101/p105.html

http://www. Ncbi. Nlm. Nih. Gov/pmc/articles/PMC356447/

Mild elevation could simply be a mild cold with a rhinovirus. No worries. ...Read more

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I had a IgA Heavy Light Chains (HLC), S test done. Ig K/L HLC Ratio, IgA Kappa, S and IgA Lambda, S were in normal range. What does this test mean?

I had a IgA Heavy Light Chains (HLC), S test done. Ig K/L HLC Ratio, IgA Kappa, S and IgA Lambda, S were in normal range. What does this test mean?

Nothing: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, The tests you mentioned have a high number of false positives and false negatives and are or questionable value.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex. ...Read more

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What is monoclonal gammopathie IgM kappa?

Plasma cell disorder: Monoclonal gammopathy refers to an abnormal production of proteins by cells in the immune system (plasma cells) that are growing out of control. It can be one of the signs of myeloma. A hematologist-oncologist can help. ...Read more

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What does mgus IgG kappa mean?

What does mgus IgG kappa mean?

Benign overgrowth: Monoclonal gammopathy of uncertain significance, made of an immunoglobulin g with a kappa light chain. It means nothing. You have a slightly increased chance of getting plasma cell myeloma when you're old. There's nothing you can do about it, so simply resolve not to worry about it. ...Read more

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Is m protein igg kappa 4.1 a low level?

Is m protein igg kappa 4.1 a low level?

Why do you ask?: If you've been found to have a paraprotein, the real question is, "Do we treat for plasma cell myeloma? " These paraproteins are very common, especially as folks get older; most never progress. The actual level of the paraprotein isn't the key. If this is grams per liter, a value below 10 is "low". If your labs are otherwise good and you feel well, I wouldn't give it another thought. Best wishes. ...Read more

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What does monoclonal igg-kappa in the blood point to?

What does monoclonal igg-kappa in the blood point to?

Immune cell problem: Igg-kappa is a type of antibody your body makes to help fight infections, etc. Normally one make lots of different types of igg-kappa. When it is monoclonal, one specific igg-kappa has become very predominant. This can happen in response to an infection, if the immune system is not regulated properly, or in certain malignancies like multiple myeloma. Talk with your doctor for more information. ...Read more

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Sed rate of 28 kappa.67 lambda 3.17 ratio 1.47...What is going on?

Sed rate of 28 kappa.67 lambda 3.17 ratio 1.47...What is going on?

I suspect nothing: As far as this pathologist is concerned, a sed rate of 28 is fine especially for an adult female like yourself. It's worthless unless very high, and even then only to confirm systemic inflammation. The new work on intact and fragmented antibodies shows a huge variability in the ratios of kappa and lambda and I would draw no conclusions whatever. You're a person, not numbers. How do you feel? ...Read more

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What does monoclonal spike known as IGg kappa mean in an immunofixation report?

What does monoclonal spike known as IGg kappa mean in an immunofixation report?

See details: A monoclonal spike is suggestive of a plasma cell disorder. It may be relatively benign (mgus) or much more serious (myeloma, Waldenstrom's) ...Read more

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Can you get all amyloidosis if you have kappa rather than lambda light chains? I also have a kappa lambda ratio of 175

Yes: Listen, Jane. I'm worried about you. You're already on cyclophosphamide and dexamethasone -- extremely potent medications -- yet you list no illness for which they are indicated. It's not for your thyroid cancer. You have a duty to find out exactly what is happening with you, including getting a 2nd opinion from a physician who's explain clearly. Amyloid is confusing; be proactive. ...Read more

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Test results came back and say Free Kappa Lt Chains, S 34.81 Free Lambda Lt Chains, s is 29.22Kappa, lambda ratio is 1.19. Is it myeloma What is test 4

Test results came back and say Free Kappa Lt Chains, S 34.81 Free Lambda Lt Chains, s is 29.22Kappa, lambda ratio is 1.19. Is it myeloma What is test 4

Light chains: Light chains (kappa and lambda) are a part of the immunoglobulin molecues the body makes. A given plasma cell only makes one type of light chain, most commonly this is kappa. When immunoglobulin cells proliferate like a neoplasm, then one type will overwhelm the others. Your values are nearly even, and the ratio is not abnormal, so it is unlikely that you have myeloma or another Ig-producing lesion. ...Read more

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What is IgA kappa monoclonal protein?

What is IgA kappa monoclonal protein?

IgA paraprotein: An IgA kappa monoclonal protein represents a single clone of bone marrow cells that have reproduced in an aberrant fashion. If this is what is found on immunofixation then a hematologist should be consulted for further workup. ...Read more

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How long can monoclonal IgM kappa light chain gammopathr stay stable?

How long can monoclonal IgM kappa light chain gammopathr stay stable?

Indefinitely.: If monoclonal igm gammopathy is fully evaluated and not associated with any malignancy (lymphoma or myeloma) then the diagnosis is mgus (monoclonal gammopathy of undetermined significance). The chances of progression are low, ranging from 0.1% to 1.0%/year. The majority of patients never get cancer. ...Read more

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Can IgM kappa light chain monoclonal gammopthy stay stable for 10 years or more?

MGUS: Many monoclonal gammopathies can be stable for many years. The only way to know is have the immunofixation and several other tests performed periodically. A referral to the hematologist is appropriate here. ...Read more

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How frequently does a person ned to have his blood checked when he has IgG kappa mgus?

How frequently does a person ned to have his blood checked when he has IgG kappa mgus?

Monoclonal Gammopath: I would want this checked twice a year until I see enough stability that perhaps I could reduce testing to annual. I would also make sure that light chains were tested on blood & urine as well. ...Read more

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In lymphocyte phenotyping of periferial blood, what is the normal percentage for Kappa and Lambda light chains?

In lymphocyte phenotyping of periferial blood, what is the normal percentage for Kappa and Lambda light chains?

0.26-1.65 K/L ratio: Free light chains will normally be present in the blood at low levels, with a kappa/lambda ratio of about 0.26 to 1.65. Increased kappa free light chains and a higher kappa/lambda ratio may mean a plasma cell disorder producing excess monoclonal kappa chains. Increased lambda free light chains and a lower kappa/lambda ratio may mean a plasma cell disorder producing excess monoclonal lambda chains. ...Read more

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I have 549igA, 37 sedimentation rate westergren, 21.64 free kappa lt chains, s, and kappa/lambda ratio, s is 1.66 What does this mean?

I have 549igA, 37 sedimentation rate westergren, 21.64 free kappa lt chains, s, and kappa/lambda ratio, s is 1.66 What does this mean?

Any symptoms?: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, Why were these tests done? Do you have any symptoms? Kappa/lambda ratio is generally a useless test. IgA of 549, per se is not a problem. Sed rate is in the normal range.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex. ...Read more

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My haematologist says my kappa lambda ratio is seriously skewed. Kappa light chains @580 paraproteins 30. Does this imply a poor outcome?

My haematologist says my kappa lambda ratio is seriously skewed. Kappa light chains @580 paraproteins 30. Does this imply a poor outcome?

Bad ratio: I am surprised you do not ask your oncologist questions about your outcome. Did you not ask? If you did, did you not get a response that you understood. You oncologist (o) knows your case best of all. Give your o a call and get your answer from the physician who knows you best of all. ...Read more

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My IgG is mod low. My dr said I wasn't making antibodies either. Now it shows gamma in my urine and elevated kappa/lamba ratio of 18.25.Whats the cause?

My IgG is mod low. My dr said I wasn't making antibodies either. Now it shows gamma in my urine and elevated kappa/lamba ratio of 18.25.Whats the cause?

Pls c a hematologist: If u haven't seen a hematologist already, u better arrange to c someone soon, ur doctor would help u in that aspect, if he/she is a hematologist, ask 4 more clarification and a side consult of a clinical immunologist would help too, good luck. ...Read more