Doctor insights on:
Kahler Disease Signs
Myeloma Tests: Testing for myeloma includes serum protein electrophoresis (spep) with immunofixation, free light chain kappa/lambda ratio, upep, beta-2 microglobulin, ig's, other lab tests; bone marrow biopsy, skeletal survey. Other tests may include MRI of spine/bone marrow, pet/ct. Bmb tests: fish, cytogenetics, pcli (at some centers), gene expression profiling (gep). Other research tests may be done. ...Read more
I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more
Multiple Myeloma: I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, bone disease; & infection. ...Read more
Myleloma Tx: I've never called multiple myeloma "kahler's disase" but -- http://en.Wikipedia.Org/wiki/multiple_myeloma -- wiki confirms. The treatment options for multiple myeloma have become more complicated due to the number of new drugs in myeloma. This is a good thing. In general we look at transplant eligible or ineligible and personalize therapy based on risk factors. ...Read more
Yes: We evaluated this recently for a patient & there have been about a dozen case reports with women diagnosed during pregnancy and also getting pregnant & delivering safely after diagnosis. Definitely rare & hi risk necessitating long discussions with hematologist & ob. ...Read moreSee 1 more doctor answer
It is possible: Some forms of myeloma secrete a protein called a light chain that can invade organs like the heard or liver and cause it to function poorly. Most of the problems with the heart arise from many of the early treatments of myeloma which included a drug called adriomycin. Modern chemotherapy can still cause heart problems but not at the same rate. ...Read moreSee 1 more doctor answer
What's the reason for fever with low hemoglobin for 79 yrs old male with multiple myeloma if disease is under control after a year of velcade&melfalan?
Myeloma, treatment: 1) fever - may be from infection with risk from myeloma itself and therapy. Bortezomib (velcade) can increase risk of herpes zoster (shingles). 2) anemia (low hemoglobin) can be from mulitple myeloma and/or the therapies uesd to control it. Check in with your physician. If confusing a repeat bone marrow biopys and other tests may be needed. ...Read moreSee 1 more doctor answer
None: If truly smoldering myeloma, there are no signs. If there are symptoms, then it may be myeloma. Hope this helps. ...Read more
Multiple myeloma shows on my suggestions. After reviewin have many common signs. I've neglected my health for yrs. Reasonable worry for consultation?
Enjoy living: You are only 23 Y/O, it seems you have a personal experience with an MM patient. I have never seen an MM in a 23 Y/O and you need to stop worrying about you having this illness. You neglected your health for years? there is no reason to get concerned at this age.Enjoy your life. ...Read more
I seriously doubt it: I cannot say I have ever seen a patient with this association. ...Read more
"Multiple Myeloma": just means multiple bone marrow tumors. A simple description like that does not take modern technology (though it would not be picked up early). Indeed, it has been known since ancient times. There have been a lot of discoveries along the way that explains what it is and how it arises. Here's an article on its history: http://www.ncbi.nlm.nih.gov/pubmed/21509678 ...Read more
Blood/Urine/Imaging: Usually workup involves blood and urine tests (spep / upep - serum and urine protein electrophoresis). The preferred initial imaging study is the skeletal survey (x-ray of multiple sites of the body including skull, axial skeleton, and proximal long bones). Bony lesions are usually lytic. ...Read moreSee 1 more doctor answer
Multiple myeloma: Medial survival in myeloma many years ago was only 1-2 years. Nowadays, with many effective therapy such as lenalidomide, bortezomib, transplant -median survival has increased up to 7 years. Newer medications such as pomalidomide and cerfilzomib hopefully would be approved soon and more medication in pipelines are lining up - all of these would likely to increase the median survival longer. ...Read moreSee 1 more doctor answer
No simple answer: Multiple myeloma has been associated with ionizing radiation (atomic bomb level), herbicides, petroleum products, analin hair dyes, autoimmune disease but there is no clear cut association. There are a few families which show an inheritance pattern along with other lymphomas. ...Read moreSee 1 more doctor answer
The tests for Multiple myeloma include:: Albumin, Basic metabolic panel, Bone marrow biopsy, Complete blood count, Ionized calcium, Lactate dehydrogenase, MRI, Skeletal survey, C reactive protein, Protein electrophoresis, 24 hour urine protein electrophoresis, Free kappa lambda light chains, Beta 2 microglobulin. ...Read more
Depends...: This answer depends. That might not be as satisfying but is true. For a 90yo pt it is palliative -- keeping crab symptoms away with minimal discomfort fro m tx. A new study from dr. Campagnaro in ecog will evaluate. For most, "control" as a chronic disease. For some cure. If young, we like to obtain a "deep" response w/ complete response (cr) & now looking at minimal residual disease (mrd) by flow. ...Read moreSee 1 more doctor answer
Plasma cell cancer: Multiple myeloma is a cancer of plasma cells (pcs). Pcs are the specialized b lymphocytes that produce antibodies. When there is a cancer or one (mono-) clone (= monoclonal, m) pc population they can product m-proteins. Symptoms include crab - hypercalcemia, renal (kidney) insufficiency, anemia, bone disease; also infection and pain. More: http://www.Cancer.Net/cancer-types/multiple-myeloma. ...Read more
None: No symptoms by definition. Smoldering multiple myeloma (SMM) is asymptomatic. If it is "symptomatic" then it is (symptomatic) multiple myeloma (MM). A new International Myeloma Working Group definition of SMM and MM was just published...http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(14)70442-5/abstract Ultra high risk SMM is now called MM. The trial E3A06 looks at SMM. ...Read more
No: It does not appear that we have a reliable cure for multiple myeloma. We can control it for a long period of time, and we continue to better understand treatment options and make new discoveries. Hopefully the day will come when we can cure multiple myeloma as well as we cure some leukemias and lymphomas. ...Read more
Quite a bit: Of variability , but on average 5-7 years. ...Read more
Disease of adults: Multiple myeloma is not a very common disease. It accounts for approximately 1% of all cancers multiple myeloma is a disease of older adults. The median age at diagnosis is 66 years; only 10 and 2 % of patients are younger than 50 and 40 years, respectively. It is not a disease of teenager. ...Read moreSee 1 more doctor answer
Plasma cell cancer: From the National Cancer Institute --> What You Need To Know About™ - What is Multiple #Myeloma - via @theNCI http://ow.ly/o7CJR #mmsm and Snapshot: http://ow.ly/ungNs The IgG is the type of immunoglobulin heavy chain involved and can be used to follow the cancer in the blood. ...Read more
See below: Treatment for multiple myeloma has improved markedly and drug treatment alone or drug treatment with auto or donor stem cell transplants can produce decades long remissions. See this site for more info. http://www.mayoclinic.org/diseases-conditions/multiple-myeloma/basics/definition/con-20026607 ...Read more
Multiple Myeloma: While there is no defined "cure" for multiple myeloma, chemotherapy and autologous stem cell transplants have been shown to cause remission in many cases. With regard to cost, chemotherapy is expensive if paying cash and autologous stem cell transplant may cost over 100K, so it is important to check with insurance providers regarding this. ...Read moreSee 1 more doctor answer
Does personalized medicine apply to diagnosis of typical conditions like multiple myeloma? What tests are needed?
Absolutely: Yes, absolutely . Molecular analysis with different methods are done to find some specific molecular markers/genes abnormality- this can be obtained from bone marrow and peripheral blood. This helps us in prognostication as well as in selecting medication. ...Read moreSee 1 more doctor answer
My partner has just found out that he has the start of multiple myeloma how long does someone live that has just been diagnosed with myeloma thanks.
Depends...: There are different types and stages of multiple myeloma that affect prognosis. It is highly treatable but rarely curable. The median survival in the prechemotherapy era was about 7 months. Newer therapy now has median survivals now exceeding 45 to 60 months. Multiple myeloma is potentially curable when it presents as a solitary plasmacytoma of bone or as an extramedullary plasmacytoma. ...Read moreSee 1 more doctor answer