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Doctor insights on: Kahler Disease In Children

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What are the tests for kahler disease?

What are the tests for kahler disease?

Myeloma Tests: Testing for myeloma includes serum protein electrophoresis (spep) with immunofixation, free light chain kappa/lambda ratio, upep, beta-2 microglobulin, ig's, other lab tests; bone marrow biopsy, skeletal survey. Other tests may include MRI of spine/bone marrow, pet/ct. Bmb tests: fish, cytogenetics, pcli (at some centers), gene expression profiling (gep). Other research tests may be done. ...Read more

Dr. James Lin
126 Doctors shared insights

Kahler Disease (Definition)

I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more


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What is the definition or description of: kahler disease?

What is the definition or description of: kahler disease?

Multiple Myeloma: I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, bone disease; & infection. ...Read more

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What is the treatment for kahler disease?

What is the treatment for kahler disease?

Myleloma Tx: I've never called multiple myeloma "kahler's disase" but -- http://en. Wikipedia. Org/wiki/multiple_myeloma -- wiki confirms. The treatment options for multiple myeloma have become more complicated due to the number of new drugs in myeloma. This is a good thing. In general we look at transplant eligible or ineligible and personalize therapy based on risk factors. ...Read more

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Has anyone suffering from multiple myeloma been pregnant while living with this disease?

Has anyone suffering from multiple myeloma been pregnant while living with this disease?

Yes: We evaluated this recently for a patient & there have been about a dozen case reports with women diagnosed during pregnancy and also getting pregnant & delivering safely after diagnosis. Definitely rare & hi risk necessitating long discussions with hematologist & ob. ...Read more

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Do you think that multiple myeloma could cause heart disease?

It is possible: Some forms of myeloma secrete a protein called a light chain that can invade organs like the heard or liver and cause it to function poorly. Most of the problems with the heart arise from many of the early treatments of myeloma which included a drug called adriomycin. Modern chemotherapy can still cause heart problems but not at the same rate. ...Read more

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What's the reason for fever with low hemoglobin for 79 yrs old male with multiple myeloma if disease is under control after a year of velcade&melfalan?

What's the reason for fever with low hemoglobin for 79 yrs old male with multiple myeloma if disease is under control after a year of velcade&melfalan?

Myeloma, treatment: 1) fever - may be from infection with risk from myeloma itself and therapy. Bortezomib (velcade) can increase risk of herpes zoster (shingles). 2) anemia (low hemoglobin) can be from mulitple myeloma and/or the therapies uesd to control it. Check in with your physician. If confusing a repeat bone marrow biopys and other tests may be needed. ...Read more

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Can you tell me if multiple myeloma is a brain/bone cancer or a brain/bone disease?

Can you tell me if multiple myeloma is a brain/bone cancer or a brain/bone disease?

Cancer: multiple myeloma is a malignacy of the plasma cells of the marrow. It presents with bone pain and lytic lesions usually diffusely invoving the spine. It is very effectivey treated with newer chemotherapeutic agents.
p ...Read more

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What are the causes of multiple myeloma?

No simple answer: Multiple myeloma has been associated with ionizing radiation (atomic bomb level), herbicides, petroleum products, analin hair dyes, autoimmune disease but there is no clear cut association. There are a few families which show an inheritance pattern along with other lymphomas. ...Read more

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Could multiple myeloma be treated and cured?

Yes: Multiple myeloma can certainly be treated. There a variety of new drugs available. We are likely curing some myeloma patients, but we don't necessarilyl know who these peopple are when we start treatment. Check out the #mmsm tweetchat including an upcoming topic of myeloma cure. ...Read more

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What is the objective of treating multiple myeloma?

Depends...: This answer depends. That might not be as satisfying but is true. For a 90yo pt it is palliative -- keeping crab symptoms away with minimal discomfort fro m tx. A new study from dr. Campagnaro in ecog will evaluate. For most, "control" as a chronic disease. For some cure. If young, we like to obtain a "deep" response w/ complete response (cr) & now looking at minimal residual disease (mrd) by flow. ...Read more

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Whether it is always necessary to have BMT FOR multiple myeloma?

No: But it is one of the most effective therapies and for those who can get it, it is shown even in this era to add benefit to novel therapy. In USA we bank cells for two autos. ...Read more

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Is multiple myeloma hereditary?

Rarely: There are a few families where it appears hereditary. Having said this, there are families where more than one individual has the disease and the thought is that this may be due to an environmental cause. ...Read more

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How common is multiple myeloma?

How common is multiple myeloma?

Uncommon: Approximately 1% of all cancers and slightly more than 10 % of blood cancers in the United States. ...Read more

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When was multiple myeloma discovered?

"Multiple Myeloma": Just means multiple bone marrow tumors. A simple description like that does not take modern technology (though it would not be picked up early). Indeed, it has been known since ancient times. There have been a lot of discoveries along the way that explains what it is and how it arises. Here's an article on its history:
http://www. Ncbi. Nlm. Nih. Gov/pubmed/21509678 ...Read more

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What other tests for multiple myeloma?

What other tests for multiple myeloma?

Blood/Urine/Imaging: Usually workup involves blood and urine tests (spep / upep - serum and urine protein electrophoresis). The preferred initial imaging study is the skeletal survey (x-ray of multiple sites of the body including skull, axial skeleton, and proximal long bones). Bony lesions are usually lytic. ...Read more

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Multiple myeloma & longevity if treated?

Multiple myeloma: Medial survival in myeloma many years ago was only 1-2 years. Nowadays, with many effective therapy such as lenalidomide, bortezomib, transplant -median survival has increased up to 7 years. Newer medications such as pomalidomide and cerfilzomib hopefully would be approved soon and more medication in pipelines are lining up - all of these would likely to increase the median survival longer. ...Read more

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Can anjeer be taken in multiple myeloma..

Anjeer in myeloma: Anjeer is another name for fig. As far as I am aware, you should be fine eating this. ...Read more

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What is the symptoms for multiple myeloma?

Many symptoms: There may be no symptoms in some people who are found to have myeloma on routine blood tests. Common symptoms include back pain, fatigue, bone fractures. Nausea and vomiting can occur related to kidney or electrolyte problems. ...Read more

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What is Multiple myeloma a risk factor for?

Multiple issues: It can lead to anemia, increased calcium, renal failure, bone pain and fractures to name a few ...Read more

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What are some of the tests for Multiple myeloma?

The tests for Multiple myeloma include:: Albumin, Basic metabolic panel, Bone marrow biopsy, Complete blood count, Ionized calcium, Lactate dehydrogenase, MRI, Skeletal survey, C reactive protein, Protein electrophoresis, 24 hour urine protein electrophoresis, Free kappa lambda light chains, Beta 2 microglobulin. ...Read more

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What is a young age for multiple myeloma? Under 50 years?

MM and age: Mm is a disease of older adults. The median age at diagnosis is 66 years; only 10% and 2% of patients are younger than 50 and 40 years, respectively. ...Read more

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What is the definition or description of: multiple myeloma?

Plasma cell cancer: Multiple myeloma is a cancer of plasma cells (pcs). Pcs are the specialized b lymphocytes that produce antibodies. When there is a cancer or one (mono-) clone (= monoclonal, m) PC population they can product m-proteins. Symptoms include crab - hypercalcemia, renal (kidney) insufficiency, anemia, bone disease; also infection and pain.
More: http://www. Cancer. Net/cancer-types/multiple-myeloma. ...Read more

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What are the common symptoms of smoldering multiple myeloma?

None: No symptoms by definition. Smoldering multiple myeloma (SMM) is asymptomatic. If it is "symptomatic" then it is (symptomatic) multiple myeloma (MM). A new International Myeloma Working Group definition of SMM and MM was just published...http://www. Thelancet. Com/journals/lanonc/article/PIIS1470-2045 (14)70442-5/abstract Ultra high risk SMM is now called MM. The trial E3A06 looks at SMM. ...Read more

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Is it possible for multiple myeloma to be treated and cured?

No: It does not appear that we have a reliable cure for multiple myeloma. We can control it for a long period of time, and we continue to better understand treatment options and make new discoveries. Hopefully the day will come when we can cure multiple myeloma as well as we cure some leukemias and lymphomas. ...Read more

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Which groups are most frequently affected by multiple myeloma?

Blacks in US: Twice the incidence in african americans than caucasians. Some families have a higher incidence. ...Read more

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Can you tell me which are the signs of smoulding multiple myeloma?

None: If truly smoldering myeloma, there are no signs. If there are symptoms, then it may be myeloma. Hope this helps. ...Read more

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How can the presence of multiple myeloma be recognized in teenagers?

How can the presence of multiple myeloma be recognized in teenagers?

Disease of adults: Multiple myeloma is not a very common disease. It accounts for approximately 1% of all cancers
multiple myeloma is a disease of older adults. The median age at diagnosis is 66 years; only 10 and 2 % of patients are younger than 50 and 40 years, respectively. It is not a disease of teenager. ...Read more

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My sister was diagnosed with multiple myeloma idg. What does this mean?

Plasma cell cancer: From the National Cancer Institute --> What You Need To Know Aboutâ„¢ - What is Multiple #Myeloma - via @theNCI http://ow. Ly/o7CJR #mmsm and Snapshot: http://ow. Ly/ungNs

The IgG is the type of immunoglobulin heavy chain involved and can be used to follow the cancer in the blood. ...Read more

Dr. Liawaty Ho
754 Doctors shared insights

Multiple Myeloma (Definition)

A cancer of the plasma cells, which are responsible for producing antibodies for your body. Symptoms include kidney insufficiency, anemia, bone ...Read more