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Doctor insights on: K Ras Mutation And Occupational Asbestos Exposure In Lung Cancer

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Does asbestos exposure always lead to lung cancer?

Does asbestos exposure always lead to lung cancer?

Short answer...: No. While asbestos increases the risk of lung cancer, most exposed individuals don't get lung cancer or any of the other problems linked to asbestos. Think of it like this, most traffic deaths occur in people in cars, but most people who drive/ride in cars don't die in accidents. Not the perfect analogy, but it helps convey the difference between exposure to a risk factor and getting the disease. ...Read more

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Dr. Barry Rosen
4,310 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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What kind of lung cancer does asbestos exposure cause?

What kind of lung cancer does asbestos exposure cause?

Possibly: Asbestos exposure has been shown to be related to squamous cell carcinoma, but is best known for mesothelioma. Any type of carcinoma is possible. ...Read more

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Is there something called a k ras gene that causes lung cancer?

Is there something called a k ras gene that causes lung cancer?

Yes: Mutation in the k-ras oncogene- which is the most common one found in lung cancer especially in adenocarcinoma- result in malignant transformation. Tumors with k-ras mutations tended to be smaller but more poorly differentiated, and they were associated with a significantly worse 3 year mortality rate .Attemps to overcome the impact of k-ras mutation in cancer is underway. ...Read more

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How does the k-ras gene cause lung cancer?

How does the k-ras gene cause lung cancer?

One step: When k-ras takes a mutation that makes it stuck on the "on" position, it confers an unfair growth advantage on the cell and its progeny. Kras mutated lung cancers tend to occur in smokers and make mucin. There's no medicine right now that works especially well for this subcategory of cancers and its presence suggests other good target mutations are probably not present. Good luck, stay proactive. ...Read more

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There is rare inherited mutation that gives you 1 in 3 lifetime chance of developing lung cancer even in non smokers. For someone with anxiety and lost mom to bac lung cancer should I test?

There is rare inherited mutation that gives you 1 in 3 lifetime chance of developing lung cancer even in non smokers. For someone with anxiety and lost mom to bac lung cancer should I test?

Which gene?: Egfr t790m's actual risk is unknown since nobody knows how many people without lung cancer carry the mutation. Even li fraumeni doesn't approach a 1/3 risk of lung cancer. And what would you do with this information if you had it? Hopefully you will always be a non-smoker. ...Read more

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My husband has the kras mutation for lung cancer. Is there immunotherapy that is effective?

My husband has the kras mutation for lung cancer.  Is there immunotherapy that is effective?

See below: Unfortunately, development of drugs targeting kras mutation have been a disappointment. Having said that, it is possible to enroll in immunotherapy clinical trials with drugs targeting the pd1/pdl1 pathway. These drugs seem promising and offer durable responses in some patients with nsclc; (in tumors expressing pdl1). ...Read more

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Found out today wood dust is carcinogenic. So why is sawdust treated so nonchalantly unlike asbestos dust? Worried about getting lung cancer now

Found out today wood dust is carcinogenic. So why is sawdust treated so nonchalantly unlike asbestos dust? Worried about getting lung cancer now

Pressure treated: Saw dust from regular wood is not dangerous, except if some one happens to be allergic to it. Pressure treated wood has chemicals that may be carcinogenic. See this site for more information. http://www.epa.gov/oppad001/reregistration/cca/cca_consumer_safety.htm ...Read more

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With inoperable non-small cell lung cancer, if there's a targetable genetic mutation (EGFR etc) can it be treated at stage 3A? Alongside chemo/radio?

With inoperable non-small cell lung cancer, if there's a targetable genetic mutation (EGFR etc) can it be treated at stage 3A? Alongside chemo/radio?

Yes: EGFR mutations (exon 19 or 21) in lung cancer are more common in non-smokers, Asians, and women. Upfront use of an oral tyrosine kinase inhibitor (TKI) results in better progression-free survival than chemotherapy when these mutations are present, although overall survival is not different. Discuss options with your oncologist. ...Read more

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At desk at work and work in ceiling was being done. Dust was in air and exposed for that day.Not sure if asbestos, etc? Risk of lung cancer from this?

At desk at work and work in ceiling was being done. Dust was in air and exposed for that day.Not sure if asbestos, etc? Risk of lung cancer from this?

No not at all!: Asbestos can contribute a small risk to developing Cancer but the amount of exposure has to be life long before you can think about that complication. A few days of dust exposure to you would not have any such risk. So you can relax and not worry about this problem. Go for a daily walk if you want to keep your body healthy and free of diseases. ...Read more

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Question about cancer - what is the ras mutation?

Question about cancer - what is the ras mutation?

Oncogene: All mammalian cells express 3 related Ras proteins, termed H-Ras, K-Ras, and N-Ras, that promote oncogenesis when they are mutationally activated. K-Ras mutations are frequently observed in cancer, and each isoform displays preferential coupling to particular cancer types. Mutations of the K-Ras gene occur in over 90% of pancreatic carcinomas. ...Read more

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Can asbestos exposure cause thyroid cancer?

Can asbestos exposure cause thyroid cancer?

Mesothelioma (lung): No doubt. Asbestos exposure - especially long term - causes mesothelioma. It is not safe and harms health in many ways, but there is no established connection to any of the thyroid cancers. Here's a related link: http://scottieleemeyers.Com/2012/01/05/post-office-employees-battle-thyroid-cancer/ best wishes for your health. ...Read more

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Might exposure to second hand smoke during childhood cause an increased risk of lung cancer in my later years?

Might exposure to second hand smoke during childhood cause an increased risk of lung cancer in my later years?

Yes: Second hand smoking can cause an increased risk of cancer. Google us department of health and human services the health consequences of smoking: a report of the surgeon general. Atlanta, georgia: centers for disease control and prevention, office on smoking and health, 2004. ...Read more

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Can exposure to second hand smoke during childhood lead to an increased risk of lung cancer in my later years?

Yes: Second hand smoke can increase risk of lung cancer. 3000 americans die each year of lung cancer related to second hand smoker. Best is not to start smoking and avoid smokers when they are lighting up. ...Read more

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I clean my toilet with 20 toilet wipes my lungs hurt afterwards also use a lot of anti bac on surfaces and bleach. Exposure 1.5-2hrs lung cancer risk?

I clean my toilet with 20 toilet wipes my lungs hurt afterwards also use a lot of anti bac on surfaces and bleach. Exposure 1.5-2hrs lung cancer risk?

Probably not, but...: You state that you are exposing yourself to several hours per day of fumes which irritate your lungs. Known carcinogens are tobacco smoke, both active and passive, and radioactive gas (radon) in a tightly sealed basement. Best single thing you can do for yourself is to stop smoking and avoid people who do! ...Read more

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10 years exposure of toxic black mold.suffer from all kinds of symptoms. Lately really bad breathing with chestpain, blue clubbing nails. lung Cancer?

10 years exposure of toxic black mold.suffer from all kinds of symptoms. Lately really bad breathing with chestpain, blue clubbing nails. lung Cancer?

Not necessarily: you need to be evaluated and followed up by pulmonologists and allergists, given the few information you provided, unfortunately we cannot be of much help on this platform except guiding you which way to go, good luck ...Read more

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My parents smoked in the house until i was 7 years old. I'm not 27. Am i at risk of lung cancer because of this exposure?

My parents smoked in the house until i was 7 years old. I'm not 27. Am i at risk of lung cancer because of this exposure?

Second hand: Smoke exposure is a risk for lung cancer, but when you calculate how much time you and parents were in home and car together, you may have slight increase risk, but not enough to do anything different other than obviously not smoke yourself. ...Read more

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My dad smoked until I was 6. He stayed home with me for 18 months when I was 1. Does this mean I'm at a high risk of lung cancer from exposure?

No: Tobacco is extremely dangerous to the smoker, and poses some danger to those around smokers, but this isn't going to put you at any measurable extra risk. I'm glad your dad was able to quit. ...Read more

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What are the risk of childhood asbestos exposure? I was exposed to asbestos as a child. I'm now a middle-aged adult. Is there a risk i'll develop cancer?

What are the risk of childhood asbestos exposure? I was exposed to asbestos as a child. I'm now a middle-aged adult. Is there a risk i'll develop cancer?

Yes: Depending on the amount of exposure, you can be at risk of developing cancer as an adult from your childhood asbestos exposure. Please discuss this further with your doctor for surveillance. ...Read more

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Lung (Definition)

Deoxygenated blood enters the lungs from the right side of the heart and travels to the lungs. When you inspire, oxygen flows into the lungs, transverses the capilliares and attaches to hemoglobin down a gradient. At the same time, co2 diffuses into the capilaries and is expelled with exhalation. Oxygen rich blood then flows to the left side of the heart and into the ...Read more


Mutation (Definition)

In genetics, a mutation is a change in the nucleotide sequence of the genome of an organism, virus, or extrachromosomal genetic element. Mutations result from unrepaired damage to dna or to RNA genomes (typically caused by radiation or chemical mutagens), from errors in the process of replication, or from the insertion or deletion of segments of dna ...Read more