Doctor insights on:
K Ras Mutation And Occupational Asbestos Exposure In Lung Cancer
Short answer...: No. While asbestos increases the risk of lung cancer, most exposed individuals don't get lung cancer or any of the other problems linked to asbestos. Think of it like this, most traffic deaths occur in people in cars, but most people who drive/ride in cars don't die in accidents. Not the perfect analogy, but it helps convey the difference between exposure to a risk factor and getting the disease. ...Read moreSee 2 more doctor answers
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
Yes: Mutation in the k-ras oncogene- which is the most common one found in lung cancer especially in adenocarcinoma- result in malignant transformation. Tumors with k-ras mutations tended to be smaller but more poorly differentiated, and they were associated with a significantly worse 3 year mortality rate .Attemps to overcome the impact of k-ras mutation in cancer is underway. ...Read moreSee 1 more doctor answer
One step: When k-ras takes a mutation that makes it stuck on the "on" position, it confers an unfair growth advantage on the cell and its progeny. Kras mutated lung cancers tend to occur in smokers and make mucin. There's no medicine right now that works especially well for this subcategory of cancers and its presence suggests other good target mutations are probably not present. Good luck, stay proactive. ...Read more
There is rare inherited mutation that gives you 1 in 3 lifetime chance of developing lung cancer even in non smokers. For someone with anxiety and lost mom to bac lung cancer should I test?
Which gene?: Egfr t790m's actual risk is unknown since nobody knows how many people without lung cancer carry the mutation. Even li fraumeni doesn't approach a 1/3 risk of lung cancer. And what would you do with this information if you had it? Hopefully you will always be a non-smoker. ...Read moreSee 1 more doctor answer
See below: Unfortunately, development of drugs targeting kras mutation have been a disappointment. Having said that, it is possible to enroll in immunotherapy clinical trials with drugs targeting the pd1/pdl1 pathway. These drugs seem promising and offer durable responses in some patients with nsclc; (in tumors expressing pdl1). ...Read moreSee 2 more doctor answers
Found out today wood dust is carcinogenic. So why is sawdust treated so nonchalantly unlike asbestos dust? Worried about getting lung cancer now
Pressure treated: Saw dust from regular wood is not dangerous, except if some one happens to be allergic to it. Pressure treated wood has chemicals that may be carcinogenic. See this site for more information. http://www.epa.gov/oppad001/reregistration/cca/cca_consumer_safety.htm ...Read more
With inoperable non-small cell lung cancer, if there's a targetable genetic mutation (EGFR etc) can it be treated at stage 3A? Alongside chemo/radio?
Yes: EGFR mutations (exon 19 or 21) in lung cancer are more common in non-smokers, Asians, and women. Upfront use of an oral tyrosine kinase inhibitor (TKI) results in better progression-free survival than chemotherapy when these mutations are present, although overall survival is not different. Discuss options with your oncologist. ...Read moreSee 1 more doctor answer
At desk at work and work in ceiling was being done. Dust was in air and exposed for that day.Not sure if asbestos, etc? Risk of lung cancer from this?
No not at all!: Asbestos can contribute a small risk to developing Cancer but the amount of exposure has to be life long before you can think about that complication. A few days of dust exposure to you would not have any such risk. So you can relax and not worry about this problem. Go for a daily walk if you want to keep your body healthy and free of diseases. ...Read more
Deoxygenated blood enters the lungs from the right side of the heart and travels to the lungs. When you inspire, oxygen flows into the lungs, transverses the capilliares and attaches to hemoglobin down a gradient. At the same time, co2 diffuses into the capilaries and is expelled with exhalation. Oxygen rich blood then flows to the left side of the heart and into the ...Read more
In genetics, a mutation is a change in the nucleotide sequence of the genome of an organism, virus, or extrachromosomal genetic element. Mutations result from unrepaired damage to dna or to RNA genomes (typically caused by radiation or chemical mutagens), from errors in the process of replication, or from the insertion or deletion of segments of dna ...Read more