Doctor insights on:
Are the essg and amor criteria charts the generally accepted diagnostic tool for spondyloarthropathy?
Partly: These are excellent tools. Spondyloarthropathy is diagnosed primarily by history and physical exam. X-rays and MRI can help but may not detect early disease. The hla-b27 blood test needs to be interpreted with caution as it does not prove or disprove the diagnosis of spondyloarthropathy by itself. ...Read more
Positive for hla-b27.This procedure rules out the b27:06 & 27:09 alleles which lit suggests arent associated w/ spondyloarthropathies.What this mean?
Spondyloarthritis: Hlab27 is a generic marker that is in 8% of the caucasian population. Many people with diseased called spondyloarthropathies (ankylosing spondylitis, psoriatic arthritis, and crohns/uc related arthritis) will have a positive b27, but not all those with b27 will develop issues (in fact, the vast majority don't). The larger question is are the symptoms consistent with spondyloarthropathy. ...Read more
29 yr old male, undifferentiated spondyloarthropathy, 6 weeks on humira (adalimumab) (biweekly) so far very successful treatmen. Is methotrexate necessary? Evidence?
Maybe Not: Methotrexate does not work very well for spondyloarthropathies, but there is a chance that it would reduce the odds of developing drug-inactivating antibodies against the humira (adalimumab). In any case, discuss any medication changes with the prescribing md before proceeding. ...Read moreSee 1 more doctor answer
My doctor said me that i am suffering from seronegative spondyloarthropathy. My crp is high 27. My hla-b27 report is also positive.
Dr suspects AS; I have the HLA gene and nearly all SpA features. I had a normal lumbar MRI 3 years ago, does this rule out spondyloarthropathy?
Almost the same: Many people with psoriatic arthritiw have back problems similar to classic ankylosing spondylitis. The meds used for these are the same and include sulfasalazine, methotrexate, biologics including humira, remicade, (infliximab) etc. Occasionally the arthritis goes into remission (stops) if the skin is cleared, but this isn't common. Nonsteroids such as indomethecin are quite helpful. ...Read more