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Doctor insights on: Jo 1 Antibody

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What causes an elevated jo-1 antibody? I am taking medication for rheumatoid arthritis. Is this related, or does it indicate other disease activity?

What causes an elevated jo-1 antibody? I am taking medication for rheumatoid arthritis. Is this related, or does it indicate other disease activity?

Usually not RA.: Myositis can be associated with several types of autoantibodies: anti-jo1 antibodies are a type of anti-nuclear antibody. Anti-srp antibodies are mainly associated with, but are not specific for, polymyositis. The ccp antibody is most specific for ra. Keep in mind that certain meds for RA also work in myositis, such as Methotrexate and steroids. ...Read more

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Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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Anyone know if the jo-1 antibody is common?

Anyone know if the jo-1 antibody is common?

Not common.: It is associated with polymyositis and dermatomyosiis, but diagnostic. A positive test for this, coupled with normal muscle enzumes would mean it is probably not an issue. But to directly\answer your question, it is one of the least common abs associated with a poitive ana. ...Read more

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Living with Type 1 Diabetes (Checklist)

Hypoglycemia is common with type 1 diabetes
once
Check your blood glucose before and after 2 hours after eating
once
Hypoglycemia is likely if the post meal glucose is lower than premeal
once
If you do not feel hypo symptoms, consider use of a continuous sensor
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I have recurring flares of rashes, joint pain, muscle aches, debilitating fatigue, dizziness. I have photosensitity and one episode of my WBC at 2.0 years back. My ANA is 6:40. I'm on plaquenil. Why are all my other antibodies neg for lupus?

I have  recurring flares of  rashes, joint pain, muscle aches, debilitating fatigue, dizziness. I have photosensitity and one episode of my WBC at 2.0 years back.  My ANA is 6:40.  I'm on plaquenil. Why are all my other antibodies neg for lupus?

Maybe SLE maybe not.: Diagnosis of rheumatologic disease is generally based on symptoms with support from lab. Sounds like you have a rheumatologic disease and are being treated with a rheumatologic agent perhaps by a rheumatologist. They can explain your particular situation better, but suffice it to say tests are not always right and a single test does not generally make or break a diagnosis. ...Read more

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Anyone know if the jo-1 antibody is common?

Not common.: It is associated with polymyositis and dermatomyosiis, but diagnostic. A positive test for this, coupled with normal muscle enzumes would mean it is probably not an issue. But to directly\answer your question, it is one of the least common abs associated with a poitive ana. ...Read more

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Caring for an Elderly Loved One (Checklist)

Check your loved one's balance
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Remove obstructions that could cause falls
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Organize medications
monthly
Add railings for support
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Is a jo-1 antibody is common in fibromyalgia?

Is a  jo-1 antibody is common in fibromyalgia?

No: The jo-1 antibody can be associated with a form of polymyositis which is an autoimmune inflammatory muscle disease. Fibromyalgia is a very painful condition in which muscles, ligaments, and tendons are highly sensitive and can hurt but the condition is neither autoimmune nor inflammatory. ...Read more

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My 9 year old son has a positive ANA with ENA positive showing Jo-1 antibodies. Is this definitive of myositis? He is being investigated for pain and

My 9 year old son has a positive ANA with ENA positive showing Jo-1 antibodies. Is this definitive of myositis? He is being investigated for pain and

Jo-1: is a myositis specific antibody most commonly seen in idiopathic inflammatory myopathies seen in 20-30% pts and in interstitial pulm fibrosis this antibody is against trna synthetase your child needs a pediatric rheumatologist to treat and follow his illness ...Read more

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What causes an elevated jo-1 antibody? I am taking medication for rheumatoid arthritis. Is this related, or does it indicate other disease activity?

Usually not RA.: Myositis can be associated with several types of autoantibodies: anti-jo1 antibodies are a type of anti-nuclear antibody. Anti-srp antibodies are mainly associated with, but are not specific for, polymyositis. The ccp antibody is most specific for ra. Keep in mind that certain meds for RA also work in myositis, such as Methotrexate and steroids. ...Read more

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Can anything other than myositis cause elevated jo 1 antibody? Possible false positive? Could I have been wrongly diagnosed w/ rheumatoid arthritis?

Can anything other than myositis cause elevated jo 1 antibody? Possible false positive? Could I have been wrongly diagnosed w/ rheumatoid arthritis?

Usually not RA.: Myositis can be associated with several types of autoantibodies: anti-jo1 antibodies are a type of anti-nuclear antibody. Anti-srp antibodies are mainly associated with, but are not specific for, polymyositis. The ccp antibody is most specific for ra. Keep in mind that certain meds for RA also work in myositis, such as Methotrexate and steroids. ...Read more