Doctor insights on:
James Wilson Adrenal
Adrenal cortex: The adrenal cortex makes lots of hormones. Very important are cortisol and aldosterone which help maintain life and salt balance. Addison's disease is caused by adrenal cortex damage rendering it unable to make these hormones anymore, mostly autoimmune cause in us. Patients often have a bronzed look. Hydrocortisone replacement is a lifesaving necessity. Fludrocortisone may also become necessary. ...Read more
Treatable killer: This may be the most treacherous of all diagnoses. 1 in ~60000 people have this defect in copper metabolism that may have no symptoms or look like something else until it ruins the liver and brain. It's picked up on lab testing and even these are fraught with pitfalls. Diagnosed, it's very easy to treat. I wish you luck and hope your workup is done well. ...Read more
Confusion: Clinically and under the microscope, wilson's (rare) can look treacherously like alcoholic liver disease or non-alcoholic steatohepatitis (nash, very common). In fact, even weighing the copper in the liver can be misleading because the biopsy may be regenerative nodules. A urinary copper check is part of my preferred workup, and consider a genetic check. ...Read more
Genetic causes- splenomegaly, fatty liver, seizures, fatigue, psychosis and ataxia?
Neg. For np a/b/c, lupus, wilson's and ashkenazi diseases
This is a lot: I wish my answer was as good as your question. Some of your symptoms could be part of an immunologically mediated illness. These as you know can have a genetic basis. You have looked in some important areas. Your evaluation may be a variety of laboratory studies genetics studies and tissue biopsies to help clarify. ...Read more
PCOS, Hashi's, elev. Gliadin Abs, IgA (unconfirmed Celiac). 2 yrs. gluten-free. Still fatigue, brain fog, memory, depression. Still dietary? Adrenal?
Yes: Should there be loss of adrenocortical function, steroid replacement is advocated to rebuild the normal stamina. ...Read more
Can my heterozygotes status of congenital adrenal hyperplasia (21-Hydrolaxe deficiency, salt-wasting) explain hirsurtism & symptoms like polydipsia?
Maybe: Hydroxylase deficiency is actually a continuum, and there are many alleles. A workup is probably not worthwhile. Manage unwanted body hair with electrolysis or lasers -- you're doing yourself a favor. If your urinalysis (chemical, sediment), renal functions (BUN, creatinine) and concentrating ability (SG >1.020) while thirsty) are normal, I would not recommend further studies. ...Read more
Would standard process adrenal supplements (drenatrophin pmg and adrenal desiccated) affect labs – cmp, tsh, free t3, (liothyronine) free t4?
Adrenal supplements: 46F asks about lab effects of adrenal supplements on CMP,TSH,FT3 and Free T4. This has likely never been studied as there is no regulation of adrenal supplements & makers can put anything in them until a bunch gets sick & reported to FDA. I would avoid these unless you need to waste money. I would also avoid a Dr who prescribes them. But need more information. Consult with me. ...Read more
What autoimmune or infiltrative diseases affect the pituitary gland? being worked up for pituitary hyperplasia and hyperprolactinemia. virgin. 22yo.
It can be.: One cause of adrenal insufficiency, addison's disease, is an auto-immune disorder. The immune system mistakenly makes antibodies targeting one or more proteins in the adrenal cortex, and winds up destroying the adrenal cortex, so that the adrenals can no longer make cortisol, or other hormones. As is true for most auto-immune disorders, a tendency to develop addison's can run in families. ...Read moreSee 1 more doctor answer
No, Wilson's syndrome, also referred to as Wilson's temperature syndrome, isn't an accepted diagnosis: Rather, Wilson's syndrome is a label applied to a collection of nonspecific symptoms in people whose thyroid hormone levels are normal. Proponents of Wilson's syndrome believe it to be a mild form of thyroid hormone deficiency (hypothyroidism) that responds to treatment with a preparation of a thyroid hormone called triiodothyronine (T-3). However, the American Thyroid Association has found no scientific evidence supporting the existence of Wilson's syndrome. In a public health statement, the American Thyroid Association concluded: The diagnostic criteria for Wilson's syndrome — low body temperature and nonspecific signs and symptoms, such as fatigue, irritability, hair loss, insomnia, headaches and weight gain — are imprecise. , There's no scientific evidence that T-3 performs better than placebo in people with nonspecific symptoms, such as those described in Wilson's syndrome. . Hypothyroidism can be diagnosed by blood tests that detect insufficient levels of thyroid hormone. Wilson's syndrome shouldn't be confused with Wilson's disease — a rare, inherited disorder that causes too much copper to accumulate in certain organs. Although it's frustrating to have persistent symptoms your doctor can't readily explain, it could be worse to accept an unrecognized diagnosis from an unqualified practitioner. Unproven therapies for so-called Wilson's syndrome may leave you feeling sicker, while a treatable condition — such as fibromyalgia or depression — goes undiagnosed. ...Read more
U/s confirmed many nodules.Bx schedules, high platelets, wbc, pot. &anemic.Chronic fever.Low acth 3. Checking addison's, cancer, hashimotos. Any thoughts?
Can my carrier status of congenital adrenal hyperplasia (21-Hydrolaxe deficiency, salt-wasting) explain my high basal cortisol?
No: Spot "basal cortisol" levels mean nothing except in context. They help rule some things in and some things out. The highest basal cortisol levels have been found in soldiers in the battlefield and medical students in exams. Ignore all "pop" sites relating to pituitary / adrenal disease and remember that reference ranges are set so that many healthies fall outside on either end. ...Read more
Not usually: The leading causes of Addison' disease in the US are: autoimmune; metastatic cancer; bleeding into adrenal glands; infectious infiltration (such as tuberculosis). Only the autoimmune type may possibly run in families, whose members typically have other autoimmune disorders such as type 1 diabetes, hypothyroidism, vitiligo, pernicious anemia, or myasthenia gravis, to name a few. ...Read more
Ace levels high, liver enzymes high, possible sarcoidosis dx, can sarcoidosis cause fatty liver on ultrasound. Dr scheduling liver& lymph biopsy.
Sarcoidosis - Liver: The most common radiographic finding of hepatic sarcoidosis is hepatomegaly. Ultrasound can show diffuse increased homogeneous or heterogeneous echogenicity in hepatic sarcoidosis appearing similar to fatty liver. Focal liver nodules (thought to represent coalescence of small granulomas) can also be seen in hepatic sarcoidosis. Liver involvement by sarcoidosis typically responds well to steroids. ...Read more
Not exactly: Addison' s disease is a state of adrenal insufficiency but not vice versa as there are many other causes besides ad ( an autoimmune disease) that can lead to cortisol deficiency state such as tuberculosis of the adrenals, hemorrhage of the adrenals, certain genetic storage syndromes and hypopituitarism. ...Read moreSee 1 more doctor answer
Any: Any competent primary care physician can diagnose and arrange for treatment hemochromatosis. You may get sent to the gastroenterologist, cardiologist, endocrinologist and geneticist. The key is that if this is common hemochromatosis, you have the serious disease out of all of them that's easiest to manage effectively. ...Read more
Feed your adrenals : Cortisol - as are all corticosteroids is derived from cholesterol. Studies have shown that a high saurated fat, low polyunsaturated fat diet will increase corticosteroid levels. Also supplementation with pregnenolone will increase ability of your adrenals to make cortisol, progesterone, estrogen, testosterone and other corticoids. Reduce all forms of stress. Get sleep and sunlight. ...Read moreSee 3 more doctor answers