Doctor insights on:
Jak2 Positive Myeloproliferative Disorder
Varaible: There are 3 main types- essential thrombocytosis (et), polycythemia vera (pv) and myelofibrosis (mf). In et, there is increased clotting and risk for strokes. In pv, there is generalized itchiness, ruddy face, and stroke risk. In mf, patients get low blood counts over time causing fatigue, large spleen, poor appetite, abdomen pain, transfusion need. ...Read more
Not able to know: We do not know who is most likely to develop a myeloproliferative disorder. It is, however, a disease that increases in incidence with age. ...Read more
See below: You may consult this site for info on this topic: http://www. Umm. Edu/health/medical/altmed/condition/myeloproliferative-disorders ...Read more
What is the prognostic significance of a jak2 mutation in a person without the defining criteria for a myeloproliferative disorder?
Need close follow-up: The specificity of the jak2 v617f pcr test for the diagnosis of myelpproliferative disorder is very high, near 100%. After excluding sample mix-up, any patient with a positive jak2 mutation should be carefully followed for the development of polycythemia vera, myelofibrosis, or essential throbocythemia. ...Read more
Abnormal (high) blood: This disorder is suspected in individuals who have a very high WBC count (Like in CML) and also has a genetic abnormality (Philadelphia Chromosome present). Other patients have Myelofibrosis where there is a very big enlargement of the spleen. Occasionally it is just very platelet count (Essential Thrombocythemia (ET) ...Read more
Too many platelets: The myeloproliferative neoplasms (mpns) involve terminal myeloid cell expansion in the peripheral blood, resulting in various combinations of erythrocytosis (rbc's), leukocytosis (wbc's), thrombocytosis (platelets), bone marrow hypercellularity/fibrosis, and splenomegaly (enlarged spleen). Essential thrombocythemia is a diagnosis of exclusion, made when other forms of mpn are ruled out. ...Read more
Too many platelets: Myeloproliferative disorders are a set of marrow malignancies characterized by excessive production of certain types of blood cells. Essential thrombocytopenia is one of them, in which marrow makes too many platelets. There are well-tolerated oral agents which help. Other myelodysplastic syndromes are polycythemia vera and chronic myelogenous leukemia. ...Read more
Is overlap myelodysplasticity myeloproliferative disorder a name for one disorder with common features of two disorders or the one blood disorder?
Spectrum of disease: Myelodyaplastic syndrome is a type of myeloproliferative disorder. So it's one disease but there is a spectrum. Myelodyaplasia means abnormal looking blood cells seen in your blood or in the bone marrow. This is usually due to an underlying bone marrow issue like infection or a possible bone marrow cancer and a bone marrow biopsy could be warranted at this point. Talk to your doctor. Take care. ...Read more
If a 91 year old has an acute transformation of his myeloproliferative disorder & is treated then would the treatment normally be given an in ICU?
Depends: Doctors usually recommend treatment based on the patients needs. ICU ensures close monitoring and fast response to any sign of major complication. For a 91 y/o it depends on his overall health status, prognosis and the extent of treatment elected by patient or his proxy. ...Read more
In general, if a 91 yr-old has acute transformation of a myeloproliferative disorder then is it worthwhile to treat the pt, if there is a treatment?
It depends: It depends on the Diagnosis of the new transformations (there are multiple ways transformation occurs...so tell us what is the new diagnosis and we can guide you further. ...Read more
Are there any treatments for acute transformation of overlap myelodysplascity/myeloproliferative disorder in an elderly patient If so, what are they?
Try hypomethylating: CMML is common form of overlap syndrome, can be treated with hypomethylating agent (VADAZA) as MDS. Efficay? If acute transformation to acute leukemia (AML), then should treat leukemia. If pt is older and not a candidate for intense induction, hypomethylating is also an option. For other acute transformation, treat them accordingly. Sometime, just supportive care or clinical trial consideration. ...Read more
Is there a medical definition of "immuncompromised"? Would someone with a neutrophil count of 14.1 x10^9 or myeloproliferative disorder qualify?
Yes: Immunocompromised means that you have an impaired immune system but the impairment may be different from one individual to another. People with myeloproliferative disorder can indeed be immune- compromised due to diminished and/or defective number of immune cells (mostly lymphocytes) produced. Low but not high neutrophils also increases the risk to get seriously ill from even minor infections. ...Read more
Hi my mother had myeloproliferative disorder or syndrome & a dr. Tod me I will eventually turn into leukemia. It doesn't have to turn into l. Rt?
The myeloproliferative disorders are polycythemia vera, essential thrombocythemia, and myelofibrosis. Of these three, only myelofibrosis is known to progress to leukemia, and only rarely.
Did you mis-hear and the diagnosis is actually myelodysplastic syndrome? Perhaps, since myelodysplastic syndrome can turn into leukemia. Perhaps double-check and ask which kind of mpd she has. ...Read more
Infection makes it harder to recover from an acute transformation of a myeloproliferative disorder But can the antibiotics also have an adverse effect?
Yes, but necessary: Myeloproliferative disorders, especially if transforming, are associated with increased risk of serious infections because the cells do a poor job doing what they are supposed to. Antibiotics to treat infection, especially sepsis, are lifesaving. However, antibiotics can also cause side effects, such as rashes, nausea, and diarrhea, that are unpleasant. Talk to your doctor about your symptoms ...Read more
Is it safe to have cosmetic filler like botera if you have chronic myeloproliferative disorder. This is a bone marrow disorder?
Probably safe: Most dermal fillers are non allergenic and are inert. They should not react or have problems with medical issues. They are also inject superficially and not internally. ...Read more
He is suffering from myeloproliferative disorders for 6 mths. Now he has swelling in legs. Doctor told blood clot in lever and kidney. Urination probl?
Can't say: I'd like to give helpful advice, but your question doesn't give enough information for me to do so. ...Read more
Is it unusual (even if possible) for overlap myeloproliferative-myelodysplastic disorder to lower an elderly person's oral temperature below 36C for about 50% of his temp readings over 2 weeks? The temperatures are highly likely to be accurate.
Can be normal: You don't need anything at all to see this is older folks. Trusting they are not hypothyroid, but if they are getting around okay, I would draw no conclusion. Different folks have different baselines and some older folks normally run a bit cooler ...Read more
The question is not about me I understand that an acute transformation of overlap myeloproliferative/myelodyplastictiy disorder is the terminal phase of the disorder But what is a blastic transformation of the disorder? Is it the same thing as an ac?
Acute vs blastic?: In the chronic and dysplastic hematologic malignancies that you mention (CMML and MDS), the term "acute" transformation means an evolution to acute leukemia. This is defined as more than 20% "blast" cells microscopically. Therefore acute and blastic transformation are the same thing. ...Read more
A friend of mine has a myeloproliferative blood disorder, which is the overproduction of blood cells. Could this be the start of leukemia?
Is it likely that the chronicity of overlap myeloproliferative-myelodysplastic disorder would by itself cause this rising CRP (30.5 mg/L 37.8; 54.3 ; 66.0; 110.0; 126.9; 148.5; 89.6; & 147.3)? It will be investigated bit I still desire an opinion now
IF overlap myeloproliferative/myelodysplasticity disorder is cause of suspected pneumonia what changes to path results expected other than CRP & WBC?
Reviewing a case: These little text boxes are not enough to review a complex case. You might consider having a consult with a physician here on HealthTap. ...Read more
85 year-old friend has for 2 weeks had his temp < 36C 19 times out of 34 readings. I don't understand this inconsistency. WBC is moderately hi & CRP very hi & going up. Could the temps be due to his overlap myeloproliferative-myelodysplastic disorder?
Could be or infectio: He needs to be evaluated for an infection. He may be at more risk since he has the overlap syndrome. ...Read more
If an elderly pt has overlap myeloproliferative/myelodysplascticity disorder & hi WBC count & very hi CRP then could the CRP be due to the disorder?
Can hypothermia in an elderly pt be a symptom of an acute transformation of overlap myeloproliferative/myelodysplacticty disorder? Pt has hi WBC & CRP
Hypothermia/mds: Elderly often feel cooler than younger individuals. Hypothermia (how low?) may be a sign of infection /sepsis just like high fever. If one has myelodysplastic syndrome, would check for UTI, a common cause of infection, subtle pneumonia.Also check thyroid, adrenal function. Elevated WBC is a concern for sepsis and transformation. Go to the ER for blood cultures and evaluation. ...Read more
If a person has overlap myeloproliferative-myelodysplastic disorder which is causing an elevated WBC and a very high (and increasingly high) CRP, could antibiotics bring down the CRP even if there is no infection?
Antibiotics have no effect without an existing superimposed infection!
Hope this is helpful!
Dr Z ...Read more
I had a bone marrow bx to rule out a myeloproliferative illness. The pathologist recommends a trephine core biopsy. What reason would that before?
Two kinds of bone ma: There are two different ways to get a sample of the bone marrow. One is called bone marrow aspirate and the other one is called bone marrow biopsy (trephine). It seems that they may have done just a aspiration of the bone marrow initially. Biopsy is essential in some conditions like you might have and not required in others like in acute leukemia. ...Read more
Entirely possible.: Some mpd have a genetic component.Get a more detailed answer ›
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