Doctor insights on:
Jak2 Negative Polycythemia Vera
Sometimes.: Most patients with polycythemia vera develop the condition in adulthood, most commonly from an acquired mutation in the jak2 gene, and are not born with it. However, there are families who pass on the tendency to have a high red blood cell count through a variety of genetic mutations. It is usually well known in the family when that is the case. ...Read more
Polycythemia: Polycythemia rubra vera and polycythemia vera are the same thing - a myeloproliferative disorder which causes production of too many red cells (and usually white cells and platelets also). Polycythemia or erythrocytosis just means someone has too many red cells, whether due to prv, high altitude, sleep apnea, emphysema, certain cancers, or certain congenital abnormalities of red cell production. ...Read more
No: Pv by itself does'nt cause low grade fevers. However, pv can increase your risk to have blood clots and blood clots can give you low grade fevers also, pv can transform into other condition i.E myelofibrosis as well as mds/ acute leukemia in about 20%-30%). Low grade fevers occur quite commonly in myelofibrosis and acute leukemia. See your md to rule out other condition i.e. Autoimmune , infection. ...Read more
Is there a possible link between hereditary hemochromatosis, polycythemia vera (primary jak2 mutation), & idiopathic pulmonary arterial hypertension?
Unexplained high platelets (572), WBC (17.2), leukocytes, neutrophils, low hemaglobin. Bone marrow, jak2 and lupus test negative, ANA positive. Help?!
Reactive/ autoimmune: Discuss further with your hematologist. Certain conditions like iron deficiency , infection /inflammation vs autoimmune vs. Other solid tumor need to be ruled out. Need to check iron level, bcr/abl, imaging study like ct scan chest /abd/ pelvis will be needed. If you smoke - will suggest you to quit smoking., need to do work - up to find the anemia as well. If iron is low - GI w/u is needed. ...Read moreSee 2 more doctor answers
Your Doctor is guide: P. Vera is a rare condition. It is not difficult to diagnose provided you have consulted a specialist...A hematologist is the right specialist to help you with this issue. It typically manifests with high hemoglobin( >17 grams) and often has high white blood cell count as well as high platelets associated with high hemoglobin levels. ...Read more
Red blood cells-5.9, hematocrit- 55%, hemaglobin-18.0, esr-2, ldh-199, white blood cells- 9.0 (high neutrophils) & platlets-285, 000 polycythemia vera?
Can't tell. need w/u: Normal range will vary -depending on the range used on each lab. On my lab, hb of 18 is still normal for male. Your white blood cell and platelet are also within normal range. I don't see any problem there-except you said you have high neutrophils- which can be caused by many things. However, if you are worried about p.Vera- go to see a hematologist and she/he will be able to help you. ...Read more
Can patient with Polycythemia vera have normal hemoglobin and hematocrit count but abnormal JAK2 result ? what is definitive test for PV ?
See below: There is more than one factor that needs to be taken into consideration. High hemoglobin, low erthyropoietin and JACK 2 all need to be looked at. You may consult this site for more information on this topic. http://www.mayoclinic.org/diseases-conditions/polycythemia-vera/basics/definition/con-20031013 ...Read more
Polycythemia: Polycythemia is a terminology used for a condition where your hemoglobin is elevated above the normal range.It does not tell you what the cause of the condition- which could be caused by a primary bone marrow problem -( which is called polycythemia rubra vera -abbreviated as polycythemia vera) vs some other secondary conditions such as chronic lung problem, sleep apnea, liver mass/renal mass et. ...Read more
Yes: PRV is hypercoaguable conditionGet a more detailed answer ›
Controversial: There is a risk of transformation to acute leukemia just from having P Vera. But it is very low. Whether hydroxyurea increases that risk has not be definitively answered. Most hematologists find the benefit of controlling the disease greatly outweighs the risk. There is a new drug - Jakafi (ruxolitinib) - just approved for PV if not well controlled or if side effects of HU too great. Talk to your hematologist. ...Read more
How is polycythemia rubra vera differentiated from polycythemia associated with stress? RBC only elevated once in life. HGB/HCT elevated often.
Stress?: Stress doesn't cause polycythemia. Being dehydrated is a common cause. If your Hgb/Hct is only slightly elevated, stop worrying -- reference ranges are set so that several percent of healthy folks fall outside. If it's well above, consider a workup for the causes, including a variant hemoglobin and a subtle right-to-left shunt. ...Read more
Neg c-anca & p-anca, but pos pr3 & pos mpo by ELISA 5 consecutive tests. Sed/bun/creatinine good. Neutrophils 76% @ 60 days prednisone .Thoughts?
No: My understanding is that Jakafi (ruxolitinib) would not have benefit in JAK-negative PV. Overactive JAK pathway signaling is a key driver to the excess cell production seen in polycythemia vera. Jakafi (ruxolitinib) blocks or inhibits this pathway. Apparently there are a small number of people, such as yourself, for whom this JAK pathway is not the principle mechanism. Other treatments need pursuing. Good wishes:) ...Read more
Elevated RBC: Polycythemia refers to abnormally high of hemoglobin/hematocrit or .Rbc. There are many factors that can explain polycythemia-primary bone marrow problem- i.e. Polycythemia vera (pv) -vs. Other condition such as- problems with lung/sleep apnea that can result in decrease o2 level in the body ( hypoxia), other condition is kidney/liver, familial disorder etc. See and discuss further with your md. ...Read more
Confused by lab results.Dr thinking rheumatoid arthritis. Low hem, hemotricot, mcv,mch,mchc,creatine.High platelet,rdw,esr,c reactive protein. ?
You have anemia of: the chronic diseases which includes RA. Get a CCP antibody test to put aside the confusion for good. If CCP antibody is positive then your doctor probably made the right diagnosis which is RA. If you have still doubts or has queries and want to send me an e-mail click here --> https://www.healthtap.com/experts/12714048-dr-vahe-yetimyan ...Read moreSee 1 more doctor answer
Cbc~wbc17.2, plate476 ab-high>neut10.2, lymph5.13, mono1.37, baso0.17 low>iron31, bun8, lap#13(15-85range) jak2 neg. Cml ph-neg? Something else?
Suspect?: Please send us your serial WBC counts done so far. You need to do some more CBC tests and see how your WBC count would change over a few months before we can be certain as to what is causing the high WBC counts. There is no rush for doing any other tests for the next few months unless WBC count keeps rising. ...Read more
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