Doctor insights on:
Jak2 Mutation Positive
In genetics, a mutation is a change in the nucleotide sequence of the genome of an organism, virus, or extrachromosomal genetic element. Mutations result from unrepaired damage to dna or to RNA genomes (typically caused by radiation or chemical mutagens), from errors in the process of replication, or from the insertion or deletion of segments of dna ...Read more
Tumor: Monoclonal proliferation of lymphoid cells is usually an indication of tumor of the lymphoid tissue. ...Read more
I tested positive for a JAK2 mutation on a blood test and when my marrow was tested the JAK2 mutation was not found. How can this be?
Borderline result?: You are correct to wonder how a genetic test that is positive in blood can be negative in marrow, because a marrow aspirate is around 50% blood. If a blood test was borderline to begin with (due to a low percentage of positive cells), or if it was a false positive, then it may turn up negative in the marrow. ...Read more
Hiv RNA qualitative test negative; but absolute CD4 helper-879;% CD4 pos. Lymph-31.4;abs.Cd8 suppressor-1204;% cd8 pos lymph-43.0;cd4:cd8 ratio-0.73?
I wouldn't worry: Cd4 normally runs around 500-1000. Cd8 usually runs 150-1000 or so, but these ranges are set so that several percent of healthies fall outside. I'm not worried; you can repeat the RNA if you mistrust the lab. In healthy folks, the values vary chaotically. I had burning mouth for weeks after coxsackie herpangina and a viral infection may have through your cells out of kilter briefly. ...Read more
We're Getting There: In the past, we used anatomic staging alone (tumor size, lymph node involvement) to guide rx. Gene profiling allows us a completely separate measure of prognosis, and, more importantly, can predict who may or may not benefit from different chemotherapy agents. In the future, we will hopefully be able to tailor our rx to the specific cancer being treated: the elusive personalized medicine. ...Read more
1.Toxo IgM 0.68 positive-igg 141.6 positive. 2.Toxo IgM 0.70 positive-igg 134.4 positive 3.Toxo IgM 0.79 negative-igg 1513.00 positive avidity70% grey?
See details: None of those result indicate active infection. They all indicate previous exposure. ...Read more
What does a positive NEUTROPHIL CYTOPLASMIC AB.CLASSIC & NEUTROPHIL CYTOPLASMIC AB.PERINUCL & Antinuclear antibodies mean?
See details: This test must be evaluated in the context of the clinical picture. The pANCA and MPO can be positive in several different diseases. ...Read more
Unexplained high platelets (572), WBC (17.2), leukocytes, neutrophils, low hemaglobin. Bone marrow, jak2 and lupus test negative, ANA positive. Help?!
Reactive/ autoimmune: Discuss further with your hematologist. Certain conditions like iron deficiency , infection /inflammation vs autoimmune vs. Other solid tumor need to be ruled out. Need to check iron level, bcr/abl, imaging study like ct scan chest /abd/ pelvis will be needed. If you smoke - will suggest you to quit smoking., need to do work - up to find the anemia as well. If iron is low - GI w/u is needed. ...Read moreSee 2 more doctor answers
Can Philadelphia chromosome positive Chronic Myeloid Leukemia turn into Pre-B-Acute Lymphoblastic Leukemia?
Likely not much: The existing evidence does not support any strong connection between heterozygotes for either the c or a mutations of mthfr and poor pregnancy outcomes. Homozygotes may well be at greater risk. Depending on clinical history, different levels or surveillance and possible intervention can be considered. ...Read moreSee 2 more doctor answers
Gene Mutation: This is a mutation in one of the genes that help to process iron absorption. The mutation, if present in 2 copies, can cause too much iron to be absorbed. The excess iron then deposits in other organs and can cause disease - cirrhosis, diabetes, impotence. Having only one mutation may not lead to disease. You should discuss this with your doctor to see if you are at risk of developing disease. ...Read more
If report reads: estrogen reactor weakly positive, progesterone negative, her2 negative &invasive ductal carcinoma. Is this a triple negative cancer?
May be: Why were these tests done? You must have had some symptoms for your doctor to order these tests. Negative results on blood tests are not an assurance that there is no disease. Please follow your doctor's advice for follow-up care. ...Read more
The jak2 mutation is a genetic change found in about 9 out of 10 people with polycythemia vera (pv). Jak2 is part of a signaling system (like a thermostat) that helps tell the bone marrow when to start and stop making blood cells. Most people with pv have acquired a mutation(change) in their jak2. Because of this change, the bone marrow makes ...Read more